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    METHOD FOR OBTAINING PANCREATIC PROGENITOR CELL USING NEPH3
    23.
    发明申请
    METHOD FOR OBTAINING PANCREATIC PROGENITOR CELL USING NEPH3 有权
    使用NEPH3获得胰腺癌细胞的方法

    公开(公告)号：US20110256548A1

    公开(公告)日：2011-10-20

    申请号：US13141063

    申请日：2009-12-18

    申请人： Yuichi Ono ,  Tomoya Nakatani ,  Yasuko Nakagawa

    发明人： Yuichi Ono ,  Tomoya Nakatani ,  Yasuko Nakagawa

    IPC分类号： C12Q1/68 ,  C12N5/071 ,  G01N33/567

    CPC分类号： C12N5/0678

    摘要： The present invention provides markers that can selectively distinguish pancreatic progenitor cells. The present invention also provides methods for distinguishing pancreatic progenitor cells by using the markers as an indicator, and reagents to be used in the methods.The present inventors successfully identified the surface marker Nephrin-like 3 (Neph3) which is specifically expressed in pancreatic progenitor cells, and isolated pancreatic progenitor cells using the marker as an indicator or such. Viable pancreatic progenitor cells can be selected by using Neph3 as an indicator without using translated products and transcripts of any foreign genes. The marker is useful in preparing and identifying pancreatic progenitor cells which are applied to regenerative medicine or such for treatment of pancreatic diseases.

    摘要翻译： 本发明提供了可以选择性区分胰腺祖细胞的标志物。 本发明还提供了通过使用标记作为指标来区分胰腺祖细胞的方法，以及用于该方法的试剂。 本发明人成功地鉴定了在胰腺祖细胞中特异性表达的表面标记物Nephrin样3（Neph3），以及使用该标记作为指示剂的分离的胰腺祖细胞。 可以通过使用Neph3作为指标来选择可行的胰腺祖细胞，而不使用翻译的产物和任何外来基因的转录物。 该标记物可用于制备和鉴定适用于再生医学或胰腺疾病治疗的胰腺祖细胞。

    BLOCK COPOLYMER AND POLYMER LIGHT-EMITTING DEVICE
    25.
    发明申请
    BLOCK COPOLYMER AND POLYMER LIGHT-EMITTING DEVICE 审中-公开
    嵌段共聚物和聚合物发光装置

    公开(公告)号：US20100096980A1

    公开(公告)日：2010-04-22

    申请号：US12525140

    申请日：2008-02-01

    申请人： Tomoya Nakatani ,  Hidenobu Kakimoto

    发明人： Tomoya Nakatani ,  Hidenobu Kakimoto

    IPC分类号： H01J1/62 ,  H01B1/14 ,  C08G73/06

    CPC分类号： C09K11/06 ,  C08G61/12 ,  C08G61/122 ,  C08G2261/126 ,  C08G2261/3142 ,  C08G2261/3162 ,  C08G2261/3223 ,  C08G2261/3246 ,  C08L65/00 ,  C09D11/00 ,  C09K2211/1416 ,  C09K2211/1425 ,  C09K2211/1433 ,  C09K2211/145 ,  C09K2211/1458 ,  C09K2211/1466 ,  C09K2211/1475 ,  C09K2211/1483 ,  C09K2211/1491 ,  H01L51/0036 ,  H01L51/0039 ,  H01L51/0043 ,  H01L51/5012 ,  H01L51/5048 ,  H05B33/14

    摘要： Disclosed is a block copolymer characterized by comprising a block (A) containing a repeating unit composed of a divalent heterocyclic group containing a five-membered ring and a repeating unit composed of an arylene group, and a block (B) containing a repeating unit composed of an arylene group and two different repeating units each composed of a specific divalent aromatic amine residue. Also disclosed is a composition containing the block copolymer, and one of a solvent, a light-emitting material other than the block copolymer, a hole transporting material other than the block copolymer and an electron transporting material other than the block copolymer, or alternatively, a combination of two or more of them. Further disclosed are a luminescent thin film characterized by containing the block copolymer, and a polymer light-emitting device characterized by comprising an anode, a cathode, and an organic layer containing the block copolymer and arranged between the anode and the cathode.

    摘要翻译： 公开了一种嵌段共聚物，其特征在于包含含有由含有五元环的二价杂环基和由亚芳基构成的重复单元构成的重复单元的嵌段（A）和含有重复单元的嵌段（B） 的亚芳基和两个不同的重复单元，每个重复单元由特定的二价芳族胺残基组成。 还公开了含有嵌段共聚物，溶剂，嵌段共聚物以外的发光材料，嵌段共聚物以外的空穴传输材料和嵌段共聚物以外的电子输送材料的组合物，或者， 两个或更多的组合。 进一步公开了特征在于含有嵌段共聚物的发光性薄膜，其特征在于，包含阳极，阴极和含有所述嵌段共聚物并且配置在阳极与阴极之间的有机层的高分子发光元件。

    DOPAMINERGIC NEURON PROLIFERATIVE PROGENITOR CELL MARKER Nato3
    26.
    发明申请
    DOPAMINERGIC NEURON PROLIFERATIVE PROGENITOR CELL MARKER Nato3 失效
    多巴胺神经元增殖型细胞标记Nato3

    公开(公告)号：US20100028866A1

    公开(公告)日：2010-02-04

    申请号：US12064018

    申请日：2006-08-18

    申请人： Yuichi Ono ,  Yasuko Nakagawa ,  Tomoya Nakatani ,  Yoshimasa Sakamoto

    发明人： Yuichi Ono ,  Yasuko Nakagawa ,  Tomoya Nakatani ,  Yoshimasa Sakamoto

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07K16/00 ,  C12N5/02

    CPC分类号： C07K16/18 ,  C07K14/47 ,  C12Q1/6881 ,  C12Q2600/158 ,  G01N33/5073

    摘要： The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of a Nato3 gene, or a complementary sequence thereto, and an antibody against a Nato3 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.

    摘要翻译： 本发明是用于检测多巴胺能神经元增殖祖细胞的探针，引物和抗体。 根据本发明，提供了用于检测或选择多巴胺能神经元增殖祖细胞的多核苷酸探针和多核苷酸引物，其可与由Nato3基因的核苷酸序列或互补的多核苷酸组成的多核苷酸杂交 序列，以及针对Nato3蛋白或其部分的抗体用于检测或选择多巴胺能神经元增殖祖细胞。

    Methods of Distinguishing Types of Spinal Neurons Using Corl1 Gene as an Indicator
    28.
    发明申请
    Methods of Distinguishing Types of Spinal Neurons Using Corl1 Gene as an Indicator 审中-公开
    使用Corl1基因作为指标区分脊髓神经元类型的方法

    公开(公告)号：US20080213757A1

    公开(公告)日：2008-09-04

    申请号：US11574115

    申请日：2005-08-23

    申请人： Yuichi Ono ,  Yasuko Nakagawa ,  Tomoya Nakatani

    发明人： Yuichi Ono ,  Yasuko Nakagawa ,  Tomoya Nakatani

    IPC分类号： C12Q1/68 ,  G01N33/567

    CPC分类号： C12Q1/6876 ,  C12Q2600/158 ,  G01N33/5026 ,  G01N33/5058 ,  G01N33/5073

    摘要： As a result of screening for genes that are selectively expressed in fetal mouse brain region by subtraction method, the present inventors obtained a cDNA fragment encoding Corl1. The expression of Corl1 was examined by RT-PCR, in situ hybridization, and immunostaining using polyclonal antibodies. The results demonstrated that Corl1 was especially expressed at a high level of selectively in the central nervous system during embryonic stages. The expression patterns of Corl1 determined using various markers in embryonic spinal cord were compared to identify types of neurons expressing Corl1. The results revealed that Corl1 was specifically expressed in spinal cord interneurons dI4, dI5, dILA, and dILB. Accordingly, the present invention provides for discrimination between dI4 and dI6, neurons which previously could only be discriminated based on developmental location, using the expression of Corl1 as an indicator.

    摘要翻译： 作为筛选通过减法法在胎儿小鼠脑区域中选择性表达的基因的结果，本发明人获得了编码Corl1的cDNA片段。 通过RT-PCR，原位杂交和使用多克隆抗体的免疫染色检测Corl1的表达。 结果表明，Corl1在胚胎期期间在中枢神经系统的高水平选择性表达。 比较使用胚胎脊髓中各种标记物测定的Corl1的表达模式，以鉴定表达Corl1的神经元的类型。 结果表明，Corl1在脊髓中间神经元dI4，dI5，dILA和dILB中特异性表达。 因此，本发明提供了使用Corl1的表达作为指标的dI4和dI6之间的区别，以前仅可以基于发育位置鉴别神经元。

    POLYMER COMPOUND AND LIGHT EMITTING DEVICE USING SAME
    30.
    发明申请
    POLYMER COMPOUND AND LIGHT EMITTING DEVICE USING SAME 审中-公开
    聚合物化合物和发光装置

    公开(公告)号：US20140183414A1

    公开(公告)日：2014-07-03

    申请号：US14238892

    申请日：2012-08-10

    申请人： Yoshikazu Umemoto ,  Tomoya Nakatani

    发明人： Yoshikazu Umemoto ,  Tomoya Nakatani

    IPC分类号： H01L51/00

    CPC分类号： H01L51/0043 ,  C08G61/12 ,  C08G2261/124 ,  C08G2261/148 ,  C08G2261/3142 ,  C08G2261/3162 ,  C08G2261/411 ,  C08G2261/512 ,  C08G2261/5222 ,  C08G2261/95 ,  C08L65/00 ,  C08L2205/02 ,  H01L51/0035 ,  H01L51/0039 ,  H01L51/5012

    摘要： A polymer compound comprising a repeating unit represented by the formula (1): wherein, E1, E2, E3 and E4 represent each independently an aryl group, a mono-valent heterocyclic group or the like, a, b, c, d and e represent each independently 1 or 2, and f represents an integer of 0 to 3, and when f=0, then, 5≦a+b+c+e≦8 and at least one of b and c is 2, and when there are a plurality of d, these may be the same or different, m, n, o, p, q and l represent each independently an integer of 0 to 4, and when there are a plurality of m, n, o, p and q, these may be the same or different, respectively, j and k represent each independently an integer of 0 to 5.

    摘要翻译： 一种包含式（1）表示的重复单元的高分子化合物：其中，E1，E2，E3和E4各自独立地表示芳基，1价杂环基等，a，b，c，d和e 每个独立地表示1或2，f表示0〜3的整数，当f = 0时，5＆lt; 1lE; a + b + c + e＆nlE; 8，b和c中的至少一个为2， 是多个d，它们可以相同或不同，m，n，o，p，q和l各自独立地表示0〜4的整数，当有多个m，n，o，p和 q，这些可以分别相同或不同，j和k各自独立地表示0〜5的整数。