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公开(公告)号：US20190256839A1
公开(公告)日：2019-08-22
申请号：US16404392
申请日：2019-05-06
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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公开(公告)号：US10154874B2
公开(公告)日：2018-12-18
申请号：US15881414
申请日：2018-01-26
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , John H. Rossmeisl , Paulo A. Garcia
Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
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公开(公告)号：US12059197B2
公开(公告)日：2024-08-13
申请号：US17172731
申请日：2021-02-10
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Paulo A. Garcia , John L. Robertson , John H. Rossmeisl , Robert E. Neal, II
CPC classification number: A61B18/1477 , A61B18/1206 , A61N1/327 , C12N13/00 , A61B2018/00446 , A61B2018/00613 , A61N1/05
Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
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公开(公告)号：US11655466B2
公开(公告)日：2023-05-23
申请号：US14808679
申请日：2015-07-24
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
CPC classification number: C12N13/00 , A61B18/12 , A61B34/10 , A61B2018/00613 , A61B2034/104 , A61B2034/105 , A61N1/0412 , G16H50/50
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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公开(公告)号：US11254926B2
公开(公告)日：2022-02-22
申请号：US16404392
申请日：2019-05-06
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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Patent Agency Ranking
公开(公告)号：US10959772B2
公开(公告)日：2021-03-30
申请号：US16275429
申请日：2019-02-14
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Rafael V. Davalos , Paulo A. Garcia , John L. Robertson , John H. Rossmeisl , Robert E. Neal, II
Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
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公开(公告)号：US20210022795A1
公开(公告)日：2021-01-28
申请号：US17069359
申请日：2020-10-13
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , John H. Rossmeisl , Paulo A. Garcia
Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
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公开(公告)号：US10828086B2
公开(公告)日：2020-11-10
申请号：US16232962
申请日：2018-12-26
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , John H. Rossmeisl , Paulo A. Garcia
Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
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29.发明申请公开(公告)号：US20190233809A1
公开(公告)日：2019-08-01
申请号：US16375878
申请日：2019-04-05
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
CPC classification number: C12N13/00 , A61B34/10 , A61B2018/00613 , A61B2034/104 , A61B2034/105 , A61N1/0412 , G16H50/50
Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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公开(公告)号：US10272178B2
公开(公告)日：2019-04-30
申请号：US15424335
申请日：2017-02-03
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Rafael V. Davalos , Paulo A. Garcia , John H. Rossmeisl
Abstract: The present invention provides engineered tissue scaffolds, engineered tissues, and methods of using them. The scaffolds and tissues are derived from natural tissues and are created using non-thermal irreversible electroporation (IRE). Use of IRE allows for ablation of cells of the tissue to be treated, but allows vascular and neural structures to remain essentially unharmed. Use of IRE thus permits preparation of thick tissue scaffolds and tissues due to the presence of vasculature within the scaffolds. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
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