公开(公告)号：US09441642B2

公开(公告)日：2016-09-13

申请号：US13634022

申请日：2010-07-09

申请人： Zewei Rao ,  Zhenjian Yang ,  Xiaoming Li

发明人： Zewei Rao ,  Zhenjian Yang ,  Xiaoming Li

IPC分类号： F04D29/44 ,  F04D29/66 ,  F04D29/42 ,  F04D29/16

CPC分类号： F04D29/665 ,  F04D29/162 ,  F04D29/4226 ,  F04D29/441 ,  F04D29/663

摘要： Disclosed is a structure for reducing noise of a ventilating fan. The structure includes an orifice plate fixed on a scroll casing and is shaped to be an annular and semi-surrounding hollow structure in order to match with the shape of an air inlet of the scroll casing, and to cover only the air inlet of the scroll casing. The noise generated by an air blower of the ventilating fan can be directed along a bell mouth of the scroll casing of the ventilating fan after being emitted from the air inlet of the scroll casing, and then can be smoothly sucked by the orifice plate. The sucked-in noise can repeatedly collide with the orifice plate and be diffused, thereby the energy being gradually weakened and the sound pressure thereof being decreased.

摘要翻译： 公开了一种减少通风扇噪音的结构。 该结构包括固定在涡旋壳体上的孔板，并且成形为环形和半周围的中空结构，以便与涡旋壳体的空气入口的形状相匹配，并且仅覆盖涡旋件的空气入口 套管。 通风扇的鼓风机产生的噪声可以从涡旋壳体的空气入口排出后沿通风扇的涡旋壳体的喇叭口引导，然后可以被孔板平滑地吸入。 吸入的噪音可以与孔板反复碰撞并扩散，从而能量逐渐减弱，声压降低。

公开(公告)号：US20150293544A1

公开(公告)日：2015-10-15

申请号：US14439157

申请日：2013-12-19

申请人： Xiaoming LI

发明人： Xiaoming Li

IPC分类号： G05F1/147

CPC分类号： G05F1/147 ,  H01F29/04 ,  H01H9/0005 ,  H01H9/542

摘要： A terminal I thereof is respectively connected with transition switches, and a terminal II is respectively connected with transition switches; the other terminals of the transition switches are jointly connected and are connected with the terminal through a saturable reactor and a thyristor switch; the other terminals of the transition switches are jointly connected and are connected with the terminal through a linear reactor, a saturable reactor and an overvoltage triggering thyristor circuit; an odd-numbered side main contact is respectively connected with the terminal I and a common terminal, and an even-numbered side main contact is respectively connected with the terminal II and the common terminal; the terminals of non-common terminals of a main path and a transition path are further connected with a bidirectional voltage stabilizing circuit.

摘要翻译： 其端子I分别与转换开关连接，端子II分别与转换开关连接; 转换开关的其他端子共同连接，并通过可饱和电抗器和晶闸管开关与端子连接; 转换开关的其他端子共同连接，并通过线性电抗器，可饱和电抗器和过电压触发晶闸管电路与端子连接; 奇数侧主触点分别与端子I和公共端子连接，偶数侧主触头分别与端子II和公共端子连接; 主路径和过渡路径的非公共端子的端子还与双向稳压电路连接。

公开(公告)号：US08717093B2

公开(公告)日：2014-05-06

申请号：US12655879

申请日：2010-01-08

申请人： Xiaoming Li ,  Surinderjit S. Dhaliwal

发明人： Xiaoming Li ,  Surinderjit S. Dhaliwal

IPC分类号： G05F1/10

CPC分类号： H01L23/50 ,  H01L2924/0002 ,  H01L2924/00

摘要： There is provided a semiconductor package configured for externally controlled power management. Instead of integrating voltage regulation on-chip as done conventionally, power regulation is moved externally to the PCB level, providing numerous package advantages including size, simplicity, power efficiency, integration flexibility, and thermal dissipation. In particular, the use of flip-chip package configurations provides ready access to power supply bumps, which also allows the use of a universal receiving PCB and power supply through simple reconfiguring of voltage traces. As a result, flexible power management can be implemented, and portions of semiconductor packages may be managed for performance or thermal considerations, which may be of particular use for applications such as multi-core processors.

摘要翻译： 提供了一种配置用于外部控制电源管理的半导体封装。 功率调节不是像以往那样集成电压调节片上，而是将功率调节从外部移到PCB级，提供了许多封装优势，包括尺寸，简单性，功率效率，集成灵活性和散热。 特别地，使用倒装芯片封装配置可以方便地访问电源突点，这也允许通过简单重新配置电压迹线来使用通用接收PCB和电源。 因此，可以实现灵活的功率管理，并且可以管理半导体封装的部分以用于性能或热考虑，这可能对于诸如多核处理器的应用特别有用。

公开(公告)号：US20130079323A1

公开(公告)日：2013-03-28

申请号：US13394985

申请日：2010-09-10

申请人： Christopher J. Creighton ,  Leslie William Tari ,  Zhiyong Chen ,  Mark Hilgers ,  Thanh To Lam ,  Xiaoming Li ,  Michael Trzoss ,  Junhu Zhang ,  John Finn ,  Daniel Bensen

发明人： Christopher J. Creighton ,  Leslie William Tari ,  Zhiyong Chen ,  Mark Hilgers ,  Thanh To Lam ,  Xiaoming Li ,  Michael Trzoss ,  Junhu Zhang ,  John Finn ,  Daniel Bensen

IPC分类号： C07D487/04 ,  C07D471/04 ,  C07D491/048 ,  C07D487/16 ,  C07D513/04

CPC分类号： C07D519/00 ,  C07D471/04 ,  C07D471/16 ,  C07D487/04 ,  C07D487/16 ,  C07D491/048 ,  C07D513/04

摘要： Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth. Compounds of Formula (I), are disclosed: Formula (I), wherein Y is N or CH; Z is N or CR5; R5 is H, a substituted or unsubstituted hydrocarbyl residue (1-3C) containing 0-2 heteroatoms selected from O, S and N, or is an inorganic residue; L is O, S, NR7, or CR8R9; R7 is H or C1-3 alkyl; R8 and R9 are each independently H or C1-3 alkyl; R2 is H, a hydrocarbyl residue (1-40C) containing 0-10 heteroatoms selected from O, S and N optionally substituted with an inorganic residue; R4 is H, an inorganic residue, or a hydrocarbyl residue (1-30C) containing 0-12 heteroatoms selected from O, S and N and containing 0-10 inorganic residues, wherein R5 and R4 together may join to form a fused ring; and R6 is selected from the group consisting of H, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, halo C1-5 alkyl, halo C2-5 alkenyl, halo C2-5 alkynyl, C1-5 hydroxyalkyl, C1-5 alkyl chloride, C2-5 alkenyl chloride, and C2-5 alkynyl chloride; or a pharmaceutically-acceptable salt, ester, or prodrug thereof.

摘要翻译： 新型促旋酶抑制剂和相关组合物和方法可用于阻止细菌生长。 公开了式（I）的化合物：式（I），其中Y是N或CH; Z为N或CR5; R5是H，含有0-2个选自O，S和N的杂原子的取代或未取代的烃基残基（1-3C），或是无机残基; L是O，S，NR7或CR8R9; R7是H或C1-3烷基; R 8和R 9各自独立地为H或C 1-3烷基; R2是H，含有0-10个选自O，S和N的杂原子的烃基残基（1-40℃），任选被无机残基取代; R4是H，无机残基或含有0-12个选自O，S和N的杂原子并含有0-10个无机残基的烃基残基（1-30C），其中R 5和R 4可以连接形成稠环; 并且R 6选自H，C 1-5烷基，C 2-5烯基，C 2-5炔基，卤代C 1-5烷基，卤素C 2-5烯基，卤代C 2-5炔基，C 1-5羟基烷基，C 1 -5烷基氯，C2-5烯基氯和C2-5炔基氯; 或其药学上可接受的盐，酯或前药。

公开(公告)号：US20120274293A1

公开(公告)日：2012-11-01

申请号：US13457831

申请日：2012-04-27

申请人： Yuancheng Ren ,  Eric Yang ,  Qian Ouyang ,  Xiaoming Li

发明人： Yuancheng Ren ,  Eric Yang ,  Qian Ouyang ,  Xiaoming Li

IPC分类号： G05F1/00

CPC分类号： H02M3/1584 ,  H02M2003/1586

摘要： In one embodiment, a multiphase converter is disclosed. The multiphase converter may comprise a plurality of phase circuits and a plurality of phase control circuits. Each phase circuit may comprise a switch having a control terminal, and the control terminal of the switch may be configured to receive a drive signal. Each phase control circuit may be corresponding to one of the phase circuits, and each phase control circuit may be configured to provide a phase control signal to adjust an ON-time period or a reference signal for the corresponding phase circuit. The phase control signal may be responsive to the drive signal of the corresponding phase circuit.

摘要翻译： 在一个实施例中，公开了一种多相转换器。 多相转换器可以包括多个相电路和多个相位控制电路。 每相电路可以包括具有控制端的开关，并且开关的控制端可被配置为接收驱动信号。 每个相位控制电路可以对应于一个相位电路，并且每个相位控制电路可以被配置为提供相位控制信号以调整相应相位电路的接通时间周期或参考信号。 相位控制信号可以响应相应的相位电路的驱动信号。

公开(公告)号：US20120049809A1

公开(公告)日：2012-03-01

申请号：US13218355

申请日：2011-08-25

申请人： Xiaoming Li ,  Yunping Lang

发明人： Xiaoming Li ,  Yunping Lang

IPC分类号： G05F1/10

CPC分类号： H02M3/157 ,  H02M3/33515 ,  H02M2001/0012

摘要： The embodiments of the present invention illustrate a means for digitally controlling a converter system and associated method. Wherein the means for digitally controlling a converter system comprises a means for generating a digital error signal according to an output voltage of the converter system and a reference voltage, a means for generating a digital control signal according to a digital reference signal and the digital error signal, and a means for generating a PWM signal according to the digital control signal in order to control the converter system. The means for digitally controlling a converter system and associated method at least alleviate the problem of limit-cycle oscillation, and promote the performance of system transient response and accuracy.

摘要翻译： 本发明的实施例示出了用于数字控制转换器系统和相关方法的装置。 其中用于数字控制转换器系统的装置包括用于根据转换器系统的输出电压和参考电压产生数字误差信号的装置，用于根据数字参考信号和数字误差产生数字控制信号的装置 信号，以及用于根据数字控制信号产生PWM信号以便控制转换器系统的装置。 用于数字控制转换器系统和相关方法的手段至少减轻了极限循环振荡的问题，并提高了系统瞬态响应和精度的性能。

公开(公告)号：US20120020951A1

公开(公告)日：2012-01-26

申请号：US13135817

申请日：2011-07-15

申请人： Harold Michael Shepard ,  Curtis Thompson ,  Xiaoming Li ,  Gregory I. Frost

发明人： Harold Michael Shepard ,  Curtis Thompson ,  Xiaoming Li ,  Gregory I. Frost

IPC分类号： A61K31/573 ,  A61P17/02 ,  A61P19/00 ,  A61P1/00 ,  A61P17/06 ,  C12N11/08 ,  A61K39/395 ,  A61K48/00 ,  A61K38/02 ,  A61K35/76 ,  A61K38/47 ,  A61P35/00 ,  A61P9/10

CPC分类号： A61K47/60 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/37 ,  A61K31/42 ,  A61K31/573 ,  A61K38/47 ,  C12Y302/01035 ,  A61K2300/00

摘要： Provided herein are methods for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject. The methods involve systemically administering a PEGylated hyaluronan degrading enzyme, particularly a PEGylated hyaluronidase, such as any of the animal or bacterial hyaluronidases, to the subject and administering an amount of a corticosteroid sufficient to ameliorate the adverse effect. Also provided are method of treating a hyaluronan-associated disease or condition for single-agent therapy or combination therapy.

摘要翻译： 本文提供了用于改善全身给药PEG透明质酸降解酶对受试者的不利影响的方法。 所述方法包括全身施用聚乙二醇化透明质酸降解酶，特别是聚乙二醇化透明质酸酶，例如任何动物或细菌透明质酸酶，并给予足以改善不利作用的量的皮质类固醇。 还提供了治疗单药治疗或联合治疗的透明质酸相关疾病或病症的方法。

公开(公告)号：US20090273074A1

公开(公告)日：2009-11-05

申请号：US12387133

申请日：2009-04-27

申请人： Xiaoming Li

发明人： Xiaoming Li

IPC分类号： H01L23/49 ,  H01L23/488 ,  H01L21/60

CPC分类号： H01L24/49 ,  H01L23/552 ,  H01L24/48 ,  H01L2223/6611 ,  H01L2224/05554 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/48233 ,  H01L2224/48237 ,  H01L2224/484 ,  H01L2224/49171 ,  H01L2224/4943 ,  H01L2924/00014 ,  H01L2924/01005 ,  H01L2924/01033 ,  H01L2924/01082 ,  H01L2924/014 ,  H01L2924/14 ,  H01L2924/181 ,  H01L2924/19107 ,  H01L2924/30107 ,  H01L2924/3011 ,  H01L2924/3025 ,  H01L2924/00 ,  H01L2224/45099 ,  H01L2224/05599 ,  H01L2924/00012

摘要： Semiconductor dies embodying electronic circuits are enclosed and protected within a package. To electrically access the die, the package includes external electrical leads which in turn connect to internal bond wires. The bond wires electrically connect the package to the die. As die density and circuit complexity increase, bond wire are placed in greater proximity. As a result, signal coupling between adjacent bond wires also increases and this coupling reduces circuit performance and input/output rates. A dissipation bond wire is provided adjacent the signal or supply bond wire acting as an aggressor. The dissipation bond wire has a first end connecting to the package and the second end connecting to the die or the package to form a conductive loop which dissipates unwanted coupling from an aggressor bond wire before the coupling couples into victim bond wire. The dissipation bond wire may be grounded.

摘要翻译： 体现电子电路的半导体芯片在封装内被封装和保护。 为了对模具进行电气接入，封装件包括外部电引线，其又连接到内部接合线。 接合线将封装电连接到管芯。 随着管芯密度和电路复杂性的增加，接合线放置得更接近。 结果，相邻接合线之间的信号耦合也增加，并且该耦合降低了电路性能和输入/输出速率。 在作为侵略者的信号或电源接合线附近提供耗散接合线。 耗散接合线具有连接到封装的第一端和连接到管芯或封装的第二端，以形成导电回路，其在耦合耦合到受阻接合线之前消散来自侵蚀性接合线的不需要的耦合。 耗散接合线可能接地。

公开(公告)号：US20050267136A1

公开(公告)日：2005-12-01

申请号：US11090148

申请日：2005-03-28

申请人： Eric Brown ,  Xiaoming Li ,  Gerard Wright ,  Jonathan Cechetto ,  Michela Juran ,  Rebecca Hartlen ,  Ranjana Pathania

发明人： Eric Brown ,  Xiaoming Li ,  Gerard Wright ,  Jonathan Cechetto ,  Michela Juran ,  Rebecca Hartlen ,  Ranjana Pathania

IPC分类号： A61K31/17 ,  A61K31/517 ,  A61K31/53 ,  A61P31/04

CPC分类号： A61K31/53 ,  A61K31/17 ,  A61K31/517 ,  Y02A50/473 ,  Y02A50/481

摘要： A novel screening assay for identifying therapeutic agents and their cellular targets is described. The assay is useful in developing new antibacterial, antifungal, antiparasitic and anti cancer therapeutics. New inhibitors of dihydrofolate reductase (DHFR) have been identified and their cellular target confirmed using the assay of the present invention. Methods of treating diseases that benefit from an inhibition of DHFR are also described.

摘要翻译： 描述了用于鉴定治疗剂及其细胞靶标的新型筛选试验。 该测定法可用于开发新的抗菌，抗真菌，抗寄生虫和抗癌药物。 已经鉴定了二氢叶酸还原酶（DHFR）的新抑制剂，并且使用本发明的测定确认了它们的细胞靶。 还描述了治疗受到抑制DHFR的疾病的方法。

公开(公告)号：US20050250823A1

公开(公告)日：2005-11-10

申请号：US11176156

申请日：2005-07-07

申请人： Kraig Yager ,  Shaosong Chu ,  Krzysztof Appelt ,  Xiaoming Li

发明人： Kraig Yager ,  Shaosong Chu ,  Krzysztof Appelt ,  Xiaoming Li

IPC分类号： A61P31/04 ,  C07D417/14 ,  C07D487/08 ,  C07D417/04 ,  A61K31/427

CPC分类号： C07D417/14 ,  C07D487/08

摘要： Compounds comprising an indazolyl group and a thiazolyl group, preferably 7-substituted 3-(thiazol-2-yl)-1H-indazole compounds in which the indazolyl group and a thiazolyl group are each independently optionally substituted, are useful for the treatment or prophylaxis of bacterial infections in mammals. The compounds are believed to function by inhibiting gyrase B.