公开(公告)号：US20050261253A1

公开(公告)日：2005-11-24

申请号：US10832811

申请日：2004-04-26

申请人： Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Manoj Desai ,  Maria Fardis ,  Thorsten Kirschberg ,  Richard Mackman ,  Sundaramoorthi Swaminathan ,  William Watkins

发明人： Carina Cannizzaro ,  James Chen ,  Xiaowu Chen ,  Aesop Cho ,  Lee Chong ,  Manoj Desai ,  Maria Fardis ,  Thorsten Kirschberg ,  Richard Mackman ,  Sundaramoorthi Swaminathan ,  William Watkins

IPC分类号： A61K31/66 ,  A61K31/662 ,  A61K47/48 ,  C07F9/02 ,  C07F9/58 ,  C07F9/6561

CPC分类号： A61K31/662 ,  A61K47/54 ,  A61K47/548 ,  C07F9/58 ,  C07F9/6561

摘要： The invention is related to phosphorus substituted kinase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及磷取代的激酶抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20050209254A1

公开(公告)日：2005-09-22

申请号：US10996814

申请日：2004-11-24

申请人： Weibo Wang ,  Liana Lagniton ,  Ryan Constantine ,  Manoj Desai

发明人： Weibo Wang ,  Liana Lagniton ,  Ryan Constantine ,  Manoj Desai

IPC分类号： A61K31/517 ,  C07D239/40 ,  C07D239/90 ,  C07D401/06 ,  C07D43/02

CPC分类号： C07D401/06 ,  C07D239/90

摘要： Quinazolinone compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the quinazolinone compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the quinazolinone compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.

摘要翻译： 喹唑啉酮化合物，其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种喹唑啉酮化合物的组合物，单独或与至少一种另外的治疗剂组合。 单独使用喹唑啉酮化合物或与至少一种其它治疗剂组合使用的方法可用于预防或治疗增殖性疾病。

公开(公告)号：US06743815B2

公开(公告)日：2004-06-01

申请号：US10134302

申请日：2002-04-25

申请人： Verena D. Huebner ,  Xiaodong Lin ,  Ian James ,  Liya Chen ,  Manoj Desai ,  Jennifer C. Moore ,  Beata Krywult ,  Thayalan Navaratnam ,  Rajinder Singh ,  Rob Trainor ,  Liang Wang

发明人： Verena D. Huebner ,  Xiaodong Lin ,  Ian James ,  Liya Chen ,  Manoj Desai ,  Jennifer C. Moore ,  Beata Krywult ,  Thayalan Navaratnam ,  Rajinder Singh ,  Rob Trainor ,  Liang Wang

IPC分类号： A61K3142

CPC分类号： C07D261/10 ,  C07D261/08 ,  C07D261/18 ,  C07D261/20 ,  C07D413/04 ,  C07D413/12

摘要： Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.