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    Optical system with plano convex lens
    21.
    发明授权
    Optical system with plano convex lens 有权
    带平凸透镜的光学系统

    公开(公告)号：US07663817B1

    公开(公告)日：2010-02-16

    申请号：US11625204

    申请日：2007-01-19

    申请人： Jing Xu ,  Roman C. Gutierrez

    发明人： Jing Xu ,  Roman C. Gutierrez

    IPC分类号： G02B7/02

    CPC分类号： G02B7/102

    摘要： An optical system for a miniature camera is disclosed. The optical system can have a lens holder including mounting features to position a plurality of lenses. The mounting features can include mounting features that are configured to position a first plastic lens proximate an aperture end portion of the lens holder and/or mounting features that are configured to position a glass plano-convex lens along an optical path through an interior of the lens holder with a substantially planar surface of the glass plano-convex lens positioned toward the aperture end portion of the lens holder.

    摘要翻译： 公开了一种用于微型照相机的光学系统。 光学系统可以具有透镜架，其包括安装特征以定位多个透镜。 安装特征可以包括安装特征，其被配置成将第一塑料透镜靠近透镜保持器的孔端部定位和/或安装特征，其被配置为沿着光路定位玻璃平凸透镜，穿过其内部 透镜保持器，其具有朝向透镜保持器的孔端部定位的玻璃平凸透镜的基本平坦的表面。

    Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
    22.
    发明申请
    Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo 有权
    重组人EPO-Fc融合蛋白具有延长的半衰期和增强体内红细胞生成活性

    公开(公告)号：US20070178112A1

    公开(公告)日：2007-08-02

    申请号：US11340661

    申请日：2006-01-27

    申请人： Haitao Wang ,  Yong Du ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

    发明人： Haitao Wang ,  Yong Du ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

    IPC分类号： A61K39/395 ,  C12P21/06 ,  C07K16/46 ,  C07H21/04 ,  C12N5/06

    CPC分类号： C07K14/505 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/6811 ,  C07K2317/53 ,  C07K2319/30

    摘要： A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy.

    摘要翻译： 描述了包含与免疫球蛋白肽部分连接的人促红细胞生成素肽部分的重组融合蛋白。 与天然存在的或重组的天然人促红细胞生成素相比，融合蛋白在体内具有延长的半衰期。 在本发明的一个实施方案中，蛋白质的体内半衰期比天然人促红细胞生成素高至少三倍。 与天然人促红细胞生成素相比，融合蛋白也表现出增强的红细胞生物活性。 在一个实施方案中，融合蛋白包含人促红细胞生成素（EPO）分子的完整肽序列和人免疫球蛋白IgG1的Fc片段的肽序列。 融合蛋白中的Fc片段包括人免疫球蛋白IgG1的铰链区，CH2和CH3结构域。 EPO分子可以直接连接到Fc片段，以避免外来的肽接头并且当在体内施用时减轻免疫原性应答的风险。 在一个实施方案中，铰链区是在氨基酸6具有非半胱氨酸残基的人Fc片段变体。本发明还涉及编码融合蛋白和转染细胞系的核酸和氨基酸序列以及用于产生融合蛋白的方法。 本发明还包括包含融合蛋白的药物组合物和使用融合蛋白和/或药物组合物的方法，例如刺激需要治疗的受试者的红细胞生成。

    Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
    23.
    发明授权
    Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo 有权

    公开(公告)号：US10117949B2

    公开(公告)日：2018-11-06

    申请号：US12162320

    申请日：2007-01-25

    申请人： Haitao Wang ,  Yong Du ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

    发明人： Haitao Wang ,  Yong Du ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

    IPC分类号： C07K14/505 ,  A61K38/18 ,  A61K39/00 ,  A61K47/48 ,  A61K38/00

    摘要： A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy.

    Medium voltage DC collection system
    24.
    发明授权
    Medium voltage DC collection system 有权
    中压直流采集系统

    公开(公告)号：US09300132B2

    公开(公告)日：2016-03-29

    申请号：US13364550

    申请日：2012-02-02

    申请人： Jiuping Pan ,  Hongrae Kim ,  Jun Li ,  Jing Xu ,  Jyoti Sastry ,  Waqas Arshad

    发明人： Jiuping Pan ,  Hongrae Kim ,  Jun Li ,  Jing Xu ,  Jyoti Sastry ,  Waqas Arshad

    IPC分类号： H02J1/10 ,  H02J3/38 ,  H02J4/00 ,  H02J3/36 ,  H02M7/483

    CPC分类号： H02J1/102 ,  H02J3/36 ,  H02J3/386 ,  H02J4/00 ,  H02M2007/4835 ,  Y02E10/763 ,  Y02E60/60 ,  Y10T307/707

    摘要： A power generation system includes at least one generator having at least two sets of stator windings, an active rectifier comprising power cell based modular converters associated with each set of generator windings. Each set of windings is connected to an AC voltage side of the associated active rectifier, with each active rectifier having a positive DC voltage output and a negative DC voltage output. The DC voltage outputs of active rectifiers are connected to each other in series. A medium voltage DC (MVDC) collection network comprises positive pole cables and negative pole cables, wherein each positive pole cable is connected to the positive DC voltage output of a first active rectifier and each negative pole cable is connected to the negative DC voltage output of a last active rectifier. A substation receives the negative and positive pole cables of the MVDC collection network for further transformation and transmission.

    摘要翻译： 发电系统包括具有至少两组定子绕组的至少一个发电机，包括与每组发电机绕组相关联的基于功率单元的模块转换器的有源整流器。 每组绕组连接到相关的有源整流器的AC电压侧，每个有源整流器具有正的直流电压输出和负的直流电压输出。 有源整流器的直流电压输出串联连接。 中压直流（MVDC）采集网络包括正极电缆和负极电缆，其中每个正极电缆连接到第一有源整流器的正直流电压输出，每个负极电缆连接到负极直流电压输出 最后一个有源整流器。 变电站接收MVDC收集网络的负极和正极电缆，用于进一步的变换和传输。

    Generating a predictive model from multiple data sources
    27.
    发明授权
    Generating a predictive model from multiple data sources 有权
    从多个数据源生成预测模型

    公开(公告)号：US08996452B2

    公开(公告)日：2015-03-31

    申请号：US13545817

    申请日：2012-07-10

    申请人： Marius I. Danciu ,  Fan Li ,  Michael McRoberts ,  Jing-Yun Shyr ,  Damir Spisic ,  Jing Xu

    发明人： Marius I. Danciu ,  Fan Li ,  Michael McRoberts ,  Jing-Yun Shyr ,  Damir Spisic ,  Jing Xu

    IPC分类号： G06F7/00 ,  G06F17/00 ,  G06Q10/06

    CPC分类号： G06Q10/06

    摘要： Techniques are disclosed for generating an ensemble model from multiple data sources. In one embodiment, the ensemble model is generated using a global validation sample, a global holdout sample and base models generated from the multiple data sources. An accuracy value may be determined for each base model, on the basis of the global validation dataset. The ensemble model may be generated from a subset of the base models, where the subset is selected on the basis of the determined accuracy values.

    摘要翻译： 公开了用于从多个数据源生成集合模型的技术。 在一个实施例中，使用全局验证样本，全局保持样本和从多个数据源生成的基本模型来生成集合模型。 可以基于全局验证数据集为每个基本模型确定精度值。 集合模型可以从基本模型的子集生成，其中基于确定的精度值选择子集。

    Base station aided mobile-relay candidate pre-selection and pre-deployment
    28.
    发明授权
    Base station aided mobile-relay candidate pre-selection and pre-deployment 有权
    基站辅助移动中继候选人预选和预部署

    公开(公告)号：US08938197B2

    公开(公告)日：2015-01-20

    申请号：US13578753

    申请日：2010-02-26

    申请人： Bin Zhou ,  Jing Xu ,  Haifeng Wang ,  Zhenhong Li

    发明人： Bin Zhou ,  Jing Xu ,  Haifeng Wang ,  Zhenhong Li

    IPC分类号： H04B7/185 ,  H04B7/26 ,  H04B7/155 ,  H04W76/02 ,  H04W88/04

    CPC分类号： H04B7/2606 ,  H04B7/15507 ,  H04W76/14 ,  H04W88/04

    摘要： In one exemplary embodiment a network node (such as a base station BS) determines that a plurality of user equipments UEs are available for use as mobile relays MRs, and selects a subset of the plurality of UEs and configures the subset of the plurality of UEs as MRs. In another exemplary embodiment, an indication is sent (for example from a UE) that a UE is willing to operate as a MR, a response is received that the UE is selected to be a MR1 and then periodically there is sent a beacon advertising that the UE is a MR. In this manner UEs are pre-configured in a cell as MRs, regardless of any specific UE need for relay services. Any UE later needing relay service listens for the beacon. The BS can limit which UEs it pre-configures as MRs to avoid closely spaced UEs being both active MRs. Locations need not be signaled.

    摘要翻译： 在一个示例性实施例中，网络节点（例如基站BS）确定多个用户设备UE可用作移动中继站MR，并且选择多个UE的子集并且配置多个UE的子集 作为MR。 在另一个示例性实施例中，UE（例如，从UE）发出指示，该UE指示UE愿意作为MR操作，接收到响应被选择为MR1，然后周期性地发送信标， UE是MR。 以这种方式，UE在小区中被预配置为MR，而不管UE对于中继服务的任何特定UE的需求。 任何UE后来需要中继服务监听信标。 BS可以限制预先配置为MR的哪些UE，以避免紧密间隔的UE是主动MR。 地点不需要发出信号。

    Missing value imputation for predictive models
    29.
    发明授权
    Missing value imputation for predictive models 有权
    预测模型缺失值插补

    公开(公告)号：US08843423B2

    公开(公告)日：2014-09-23

    申请号：US13403863

    申请日：2012-02-23

    申请人： Yea J. Chu ,  Sier Han ,  Jing-Yun Shyr ,  Jing Xu

    发明人： Yea J. Chu ,  Sier Han ,  Jing-Yun Shyr ,  Jing Xu

    IPC分类号： G06F15/18 ,  G06N5/02

    CPC分类号： G06N5/025 ,  G06F15/18 ,  G06N5/04 ,  G06N99/005

    摘要： Provided are techniques for imputing a missing value for each of one or more predictor variables. Data is received from one or more data sources. For each of the one or more predictor variables, an imputation model is built based on information of a target variable; a type of imputation model to construct is determined based on the one or more data sources, a measurement level of the predictor variable, and a measurement level of the target variable; and the determined type of imputation model is constructed using basic statistics of the predictor variable and the target variable. The missing value is imputed for each of the one or more predictor variables using the data from the one or more data sources and one or more built imputation models to generate a completed data set.

    摘要翻译： 提供了用于估算每个一个或多个预测变量的缺失值的技术。 从一个或多个数据源接收数据。 对于一个或多个预测变量中的每一个，基于目标变量的信息构建插补模型; 基于一个或多个数据源，预测变量的测量水平和目标变量的测量水平来确定构造的插补模型的类型; 并使用预测变量和目标变量的基本统计量构建确定的插补模型。 使用来自一个或多个数据源的数据和一个或多个内置插补模型来为每个一个或多个预测变量估计缺失值，以生成完成的数据集。

    Compressed hybrid automatic repeat request feedback for device to device cluster communications
    30.
    发明授权
    Compressed hybrid automatic repeat request feedback for device to device cluster communications 有权
    压缩混合自动重复请求反馈，用于设备到设备集群通信

    公开(公告)号：US08842611B2

    公开(公告)日：2014-09-23

    申请号：US13582446

    申请日：2010-03-03

    申请人： Jinling Du ,  Ting Zhou ,  Jing Xu ,  Zhenhong Li ,  Haifeng Wang

    发明人： Jinling Du ,  Ting Zhou ,  Jing Xu ,  Zhenhong Li ,  Haifeng Wang

    IPC分类号： H04Q7/00 ,  H04Q7/24 ,  H04L1/18 ,  H04L1/00

    CPC分类号： H04L1/1887 ,  H04L2001/0093

    摘要： A method can include receiving at a cluster head, a multicast/broadcast packet from a base station. The method can also include monitoring, at the cluster head, to detect whether any members of a cluster of the cluster head responds to the multicast/broadcast packet with a negative acknowledgment directed to the cluster head. The method can further include, when a result of the monitoring is no detection of any negative acknowledgments, and the cluster head successfully received the multicast/broadcast packet, sending, by the cluster head, a general acknowledgment of the multicast/broadcast packet to the base station.

    摘要翻译： 一种方法可以包括在簇头处接收来自基站的多播/广播分组。 该方法还可以包括在簇头处监视簇头的簇的任何成员是否以针对簇头的否定确认来响应多播/广播分组。 该方法还可以包括：当监视结果不检测到任何否定的确认，并且簇头成功接收到多播/广播分组时，由簇头将多播/广播分组的一般确认发送到 基站。