摘要:
The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.
摘要:
The invention discloses a traceable card holder, comprising a first clamp plate, a second clamp plate, an elastic band, top cover components, bottom cover components, a tracker and an elastic clamp; the first clamp plate is arranged oppositely to the second clamp plate, the elastic band is connected respectively with the first clamp plate and the second clamp plate, and the elastic band is used to drive the first clamp plate and the second clamp plate to move towards each other for clamping; the top cover components are detachably mounted on one side of the first clamp plate which is away from the second clamp plate, and the tracker is detachably mounted on the top cover components.
摘要:
An electronic device (100) and method for operating the same. The electronic device (100) comprises at least two working modes and comprises a connection state acquisition unit (110) and a mode switching unit (12). The connection state acquisition unit (110) is used for acquiring the connection state between the electronic device (100) and a remote control unit, and the remote control unit is used for remotely controlling the electronic device (100). The mode switching unit (12) is used for switching the working mode of the electronic device (100) according to the connected state.
摘要:
A method for the determination of an analyte in a sample, the method comprising: (a) providing a catalytic polynucleotide; (b) contacting the catalytic polynucleotide with the sample so that the catalytic polynucleotide may bind to the analyte; (c) providing assay conditions such that the catalytic polynucleotide produces an optically detectable signal in the presence of the analyte; and (d) detecting the signal, thereby determining the presence of the analyte in the sample. One application of the method is for the detection of telomerase in a biological sample.
摘要:
A novel process is provided for the preparation of 3-(5,6,7,8-tetrahydro-[1,8]-naphthyridin-2-yl)-propylamine which is useful in the synthesis of &agr;v integrin receptor antagonists. Also provided are useful intermediates obtained from the process.
摘要:
A porous conductive thin film includes a layer of metal nanoparticles decorated on a layer of conductive carbon nanomaterials. The thin film can be supported by a porous support. The porous support can be a MCE paper upon which a metallic or semi-metallic single-walled carbon nanotube (SWCNT) layer is decorated with gold nanoparticles (AuNPs) or platinum nanoparticles (PtNPs). The thin film can be constructed by filtering a dispersion of SWCNTs onto MCE filter paper followed by the filtration of a citrate stabilized dispersion of AuNPs or PtNPs onto the SWCNT layer.
摘要:
The invention provides a general “signal-on” architecture for oligonucleotide-based detectors that leads to order of magnitude increases in signal gain and sensitivity as compared to prior art detectors. The detectors of the invention rely on base pairing between two oligonucleotide strands, the sensor strand and the blocker strand. In the ‘off’ position of the detector, i.e., in the absence of target, the blocker strand and sensor strand are base-paired. As shown in FIG. 1, the formation of comparatively rigid, duplex DNA prevents the redox moiety from approaching the electrode surface, thereby suppressing Faradaic currents. When target is added to the system, the target displaces the blocker strand, binds to the sensor strand, liberating the end of the redox-labeled oligonucleotide to produce a flexible element. This, in turn, allows the redox moiety to collide with the electrode surface, producing a readily detectable Faradaic current.
摘要:
The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.
摘要:
The invention provides a general “signal-on” architecture for oligonucleotide-based detectors that leads to order of magnitude increases in signal gain and sensitivity as compared to prior art detectors. The detectors of the invention rely on base pairing between two oligonucleotide strands, the sensor strand and the blocker strand. In the ‘off’ position of the detector, i.e., in the absence of target, the blocker strand and sensor strand are base-paired. As shown in FIG. 1, the formation of comparatively rigid, duplex DNA prevents the redox moiety from approaching the electrode surface, thereby suppressing Faradaic currents. When target is added to the system, the target displaces the blocker strand, binds to the sensor strand, liberating the end of the redox-labeled oligonucleotide to produce a flexible element. This, in turn, allows the redox moiety to collide with the electrode surface, producing a readily detectable Faradaic current.
摘要:
The invention discloses a traceable card holder, comprising a first clamp plate, a second clamp plate, an elastic band, top cover components, bottom cover components, a tracker and an elastic clamp; the first clamp plate is arranged oppositely to the second clamp plate, the elastic band is connected respectively with the first clamp plate and the second clamp plate, and the elastic band is used to drive the first clamp plate and the second clamp plate to move towards each other for clamping; the top cover components are detachably mounted on one side of the first clamp plate which is away from the second clamp plate, and the tracker is detachably mounted on the top cover components.