公开(公告)号：US06697434B1

公开(公告)日：2004-02-24

申请号：US09487226

申请日：2000-01-19

申请人： Chul Woo Kim

发明人： Chul Woo Kim

IPC分类号： H04B1406

CPC分类号： H04N19/19 ,  H04N19/126 ,  H04N19/147 ,  H04N19/176 ,  H04N19/60 ,  H04N19/61

摘要： A method for tracing an optimal path by employing a Trellis-based adaptive quantizer can accelerate quantization path tracing and simplify computation thereof, by preventing the quantization path tracing after an turning point of distortion in the Trellis-based adaptive quantizer and after an optimal quantization level to non-zero at a branch positioned from a zero node to a non-zero node. The conventional Trellis-based adaptive quantizer selects the optimal path by tracing and examining all the paths, and thus computation is complicated. In addition, a high speed quantization algorithm is difficult to perform. According to the present invention, in a Trellis-based adaptive quantizer of Trellis run length coding and entropy constraining coefficients generated by performing discrete cosine transformation (DCT) on image signals in block units, a method for tracing an optimal path by employing a Trellis-based adaptive quantizer, includes: a step for preventing quantization path tracing of branches after a variation position of distortion, on the basis of arrangement of a quantization period and monotonic increasing of a code word length, in a Trellis structure of generating one stage whenever the coefficients are quantized one by one from a predetermined node; and a step for preventing path tracing after an optimal coding level to non-zero at the branches positioned from zero to non-zero, based on independence of the respective stages, when quantizing non-zero coefficients from the predetermined node.

摘要翻译： 通过采用基于网格的自适应量化器来跟踪最佳路径的方法可以通过防止在基于网格的自适应量化器中的失真转折点之后并且在最佳量化级之后的量化路径跟踪来加速量化路径跟踪并简化其计算 在从零节点到非零节点的分支处非零。 传统的基于网格的自适应量化器通过跟踪和检查所有路径来选择最优路径，从而计算复杂。 此外，难以执行高速量化算法。 根据本发明，在通过以块为单位对图像信号执行离散余弦变换（DCT）而产生的网格游程长度编码和熵约束系数的基于网格的自适应量化器中，通过采用网格轨迹追踪最佳路径的方法， 基于自适应量化器的步骤包括：根据量化周期的配置和代码字长度的单调增加来防止在失真的变化位置之后的分支的量化路径跟踪的步骤，每当产生一个阶段的网格结构 系数从预定节点逐个量化; 以及当从所述预定节点量化非零系数时，基于各个级的独立性，在从零到非零的分支的最优编码电平到非零之后防止路径跟踪的步骤。

公开(公告)号：US08399426B2

公开(公告)日：2013-03-19

申请号：US13030860

申请日：2011-02-18

申请人： Chul Woo Kim ,  Ji Young Jang

发明人： Chul Woo Kim ,  Ji Young Jang

IPC分类号： A61K31/70 ,  C07H21/04

CPC分类号： A61K31/713

摘要： The present invention relates to adenine nucleotide translocator 2 (ANT2) siRNA (small interfering RNA) or ANT2 shRNA (short hairpin RNA) suppressing the expression of ANT2 gene expression and anticancer agent containing the same. Furthermore, the present invention relates to methods for treating breast cancers or stem cells of a breast cancer by treating the same with ANT2 siRNA or ANT2 shRNA. In addition, the invention provides a method for inhibiting metastasis of breast cancer cells with ANT2 siRNA or ANT2 shRNA.

摘要翻译： 本发明涉及抑制ANT2基因表达的腺嘌呤核苷酸转运蛋白2（ANT2）siRNA（小干扰RNA）或ANT2 shRNA（短发夹RNA）和含有其的抗癌剂。 此外，本发明涉及通过用ANT2 siRNA或ANT2 shRNA处理乳腺癌的乳腺癌或干细胞的方法。 此外，本发明提供了用ANT2 siRNA或ANT2 shRNA抑制乳腺癌细胞转移的方法。

公开(公告)号：US08120520B2

公开(公告)日：2012-02-21

申请号：US12719256

申请日：2010-03-08

申请人： Chan Yong Jeong ,  Chul Woo Kim ,  Ho Kyu Lee ,  Chul Gyun Park

发明人： Chan Yong Jeong ,  Chul Woo Kim ,  Ho Kyu Lee ,  Chul Gyun Park

IPC分类号： H04M1/34

CPC分类号： H03M1/1215 ,  H03M1/46

摘要： A successive approximation analog/digital converter includes a sample & hold part sampling and holding an intensity of an analog input signal using a single clock cycle of a clock signal; a first comparator comparing the intensity of the analog input signal with comparison voltages determined according to estimated digital values per clock cycle following an operating clock cycle of the sample & hold part; a second comparator comparing the intensity of the analog input signal with a value equal to ½ of a preset reference voltage in the latter half of the operating clock cycle of the sample & hold part; a successive approximation register determining a value of an MSB of a digital value to be converted according to the comparison result of the second comparator and values of bits successive to the MSB according to the comparison result of the first comparator, and generating the estimated digital values by applying estimated values to undetermined bits; and a digital/analog converter generating the comparison voltages using the estimated digital values and the reference voltage.

摘要翻译： 逐次逼近模拟/数字转换器包括使用时钟信号的单个时钟周期采样和保持模拟输入信号的强度的采样和保持部分; 比较所述模拟输入信号的强度与根据所述采样保持部的工作时钟周期之后的每时钟周期的估计数字值确定的比较电压的第一比较器; 比较模拟输入信号的强度和等于采样保持部分的工作时钟周期的后半部分中的预设参考电压的1/2的值的第二比较器; 逐次逼近寄存器，根据第二比较器的比较结果确定要转换的数字值的MSB的值，以及根据第一比较器的比较结果与MSB相连的比特值，并产生估计的数字值 通过将估计值应用于未确定的位; 以及使用所估计的数字值和参考电压产生比较电压的数/模转换器。

公开(公告)号：US20110102219A1

公开(公告)日：2011-05-05

申请号：US12719256

申请日：2010-03-08

申请人： Chan Yong Jeong ,  Chul Woo Kim ,  Ho Kyu Lee ,  Chul Gyun Park

发明人： Chan Yong Jeong ,  Chul Woo Kim ,  Ho Kyu Lee ,  Chul Gyun Park

IPC分类号： H03M1/38

CPC分类号： H03M1/1215 ,  H03M1/46

摘要： A successive approximation analog/digital converter includes a sample & hold part sampling and holding an intensity of an analog input signal using a single clock cycle of a clock signal; a first comparator comparing the intensity of the analog input signal with comparison voltages determined according to estimated digital values per clock cycle following an operating clock cycle of the sample & hold part; a second comparator comparing the intensity of the analog input signal with a value equal to ½ of a preset reference voltage in the latter half of the operating clock cycle of the sample & hold part; a successive approximation register determining a value of an MSB of a digital value to be converted according to the comparison result of the second comparator and values of bits successive to the MSB according to the comparison result of the first comparator, and generating the estimated digital values by applying estimated values to undetermined bits; and a digital/analog converter generating the comparison voltages using the estimated digital values and the reference voltage.

摘要翻译： 逐次逼近模拟/数字转换器包括使用时钟信号的单个时钟周期采样和保持模拟输入信号的强度的采样和保持部分; 比较所述模拟输入信号的强度与根据所述采样保持部的工作时钟周期之后的每时钟周期的估计数字值确定的比较电压的第一比较器; 比较模拟输入信号的强度和等于采样保持部分的工作时钟周期的后半部分中的预设参考电压的1/2的值的第二比较器; 逐次逼近寄存器，根据第二比较器的比较结果确定要转换的数字值的MSB的值，以及根据第一比较器的比较结果与MSB相连的比特值，并产生估计的数字值 通过将估计值应用于未确定的位; 以及使用所估计的数字值和参考电压产生比较电压的数/模转换器。

公开(公告)号：US07759303B2

公开(公告)日：2010-07-20

申请号：US11482401

申请日：2006-07-07

申请人： Baik Lin Seong ,  Seong-Il Choi ,  Hang Cheol Shin ,  Ki-Sun Ryu ,  Kyoung Sim Han ,  Chul Woo Kim ,  Byung Hee Kim

发明人： Baik Lin Seong ,  Seong-Il Choi ,  Hang Cheol Shin ,  Ki-Sun Ryu ,  Kyoung Sim Han ,  Chul Woo Kim ,  Byung Hee Kim

IPC分类号： C07K14/00 ,  C07H21/02 ,  C12N15/00

CPC分类号： C07H21/04 ,  C07H21/02 ,  C07K2319/35 ,  C07K2319/85 ,  C12N15/62 ,  C12P21/02

摘要： Disclosed is a method for improving folding efficiency and solubility of a target protein linked to a RNA-binding protein by using RNA molecule as a molecular chaperone, wherein the RNA molecule interacts with the RNA-binding protein. More particularly, the present invention discloses method for improving folding efficiency and solubility of a target protein by transformation of a host cell with a expression vector comprising a polynucleotide encoding the target protein linked to an RNA-binding protein; culturing the transformed host cell in an appropriate culture medium under the condition that an RNA molecule either resident inside the host cell or provided by cotransformation of the host cell with polynucleotide encoding the RNA molecule interacts with the RNA-binding protein; and purifying the soluble protein from host cell lysate. The method of the present invention is very useful for production of soluble proteins for therapeutic, prophylactic and diagnostic applications.

摘要翻译： 公开了通过使用RNA分子作为分子伴侣来提高与RNA结合蛋白质连接的靶蛋白的折叠效率和溶解度的方法，其中RNA分子与RNA结合蛋白相互作用。 更具体地，本发明公开了通过用包含编码与RNA结合蛋白连接的靶蛋白的多核苷酸的表达载体转化宿主细胞来提高靶蛋白的折叠效率和溶解度的方法。 在宿主在宿主细胞内的RNA分子或通过宿主细胞与编码RNA分子的多核苷酸共转化的RNA分子与RNA结合蛋白相互作用的条件下，在适当的培养基中培养转化的宿主细胞; 并从宿主细胞裂解液纯化可溶性蛋白质。 本发明的方法对于用于治疗，预防和诊断应用的可溶性蛋白质的生产非常有用。

公开(公告)号：US20090018026A1

公开(公告)日：2009-01-15

申请号：US12281086

申请日：2006-12-28

申请人： Chul Woo Kim ,  Syng-Yup Ohn ,  Mi Young Han ,  Yong-Sung Shin

发明人： Chul Woo Kim ,  Syng-Yup Ohn ,  Mi Young Han ,  Yong-Sung Shin

IPC分类号： C40B30/00 ,  C12Q1/02 ,  C07K1/26

CPC分类号： G01N33/57446 ,  G06F19/00

摘要： The present invention relates to protein markers for diagnosing stomach cancer and a diagnostic kit using the same, more precisely protein markers screened by two-dimensional gel electrophoresis and bioinformatics and a diagnostic kit using the same. The markers of the invention can be effectively used for diagnosing stomach cancer and evaluating the extent of progress of the cancer by confirming the expression levels of those marker proteins whose expressions differ in stomach cancer patients from in normal healthy people.

摘要翻译： 本发明涉及用于诊断胃癌的蛋白质标记物和使用该蛋白质的诊断试剂盒，更确切地说，涉及通过二维凝胶电泳和生物信息学筛选的蛋白质标记物以及使用其的诊断试剂盒。 本发明的标记物可以有效地用于诊断胃癌，并通过确认胃癌患者的表达在正常健康人中表达不同的那些标记蛋白的表达水平来评价癌症进展的程度。