公开(公告)号：US07598242B2

公开(公告)日：2009-10-06

申请号：US11255130

申请日：2005-10-20

申请人： Zhaoning Zhu ,  Robert Mazzola ,  Zhuyan Guo ,  Brian J. Lavey ,  Lisa Sinning ,  Joseph Kozlowski ,  Brian McKittrick ,  Neng-Yang Shih

发明人： Zhaoning Zhu ,  Robert Mazzola ,  Zhuyan Guo ,  Brian J. Lavey ,  Lisa Sinning ,  Joseph Kozlowski ,  Brian McKittrick ,  Neng-Yang Shih

IPC分类号： A61K31/535 ,  A61K31/497 ,  C07D401/12 ,  C07D413/04 ,  C07D295/02 ,  C07D217/06 ,  C07C255/03 ,  C07C69/76

CPC分类号： C07D213/30 ,  C07C62/34 ,  C07C69/757 ,  C07C235/40 ,  C07C255/54 ,  C07C259/08 ,  C07C279/08 ,  C07C311/29 ,  C07C317/22 ,  C07C323/19 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07D213/40 ,  C07D213/73 ,  C07D213/74 ,  C07D215/06 ,  C07D215/14 ,  C07D215/18 ,  C07D215/233 ,  C07D215/26 ,  C07D215/38 ,  C07D219/02 ,  C07D221/16 ,  C07D233/60 ,  C07D233/64 ,  C07D251/10 ,  C07D277/24 ,  C07D277/64 ,  C07D311/04 ,  C07D311/58 ,  C07D317/08 ,  C07D317/64 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  Y02P20/582

摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物或异构体，其可用于治疗由MMP，TNF-α或其组合介导的疾病或病症。

公开(公告)号：US20070191332A1

公开(公告)日：2007-08-16

申请号：US11502116

申请日：2006-08-10

申请人： Zhaoning Zhu ,  Robert Mazzola ,  Wensheng Yu ,  Joseph Kozlowski

发明人： Zhaoning Zhu ,  Robert Mazzola ,  Wensheng Yu ,  Joseph Kozlowski

IPC分类号： A61K31/4709 ,  A61K31/4178 ,  A61K31/4025 ,  A61K31/405 ,  C07D403/02

CPC分类号： C07D401/12

摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, wherein n, M, V, T, W, X, U, R1 and R2 are as disclosed in the present specification, and which compounds are useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其中n，M，V，T，W，X，U，R 1和R 2， SUP＆gt; 2如本说明书中所公开的，哪些化合物可用于治疗由MMPs，TNF-α或其组合介导的疾病或病症。

公开(公告)号：US20060252778A1

公开(公告)日：2006-11-09

申请号：US11142601

申请日：2005-06-01

申请人： Zhuyan Guo ,  Peter Orth ,  Zhaoning Zhu ,  Robert Mazzola ,  Tin-Yau Chan ,  Henry Vaccaro ,  Brian McKittrick ,  Joseph Kozlowski ,  Brian Lavey ,  Guowei Zhou ,  Sunil Paliwal ,  Shing-Chun Wong ,  Neng-Yang Shih ,  Pauline Ting ,  Kristin Rosner ,  Gerald Shipps ,  M. Siddiqui ,  David Belanger ,  Chaoyang Dai ,  Dansu Li ,  Vinay Girijavallabhan ,  Janeta Popovici-Muller ,  Wensheng Yu ,  Lianyun Zhao

发明人： Zhuyan Guo ,  Peter Orth ,  Zhaoning Zhu ,  Robert Mazzola ,  Tin-Yau Chan ,  Henry Vaccaro ,  Brian McKittrick ,  Joseph Kozlowski ,  Brian Lavey ,  Guowei Zhou ,  Sunil Paliwal ,  Shing-Chun Wong ,  Neng-Yang Shih ,  Pauline Ting ,  Kristin Rosner ,  Gerald Shipps ,  M. Siddiqui ,  David Belanger ,  Chaoyang Dai ,  Dansu Li ,  Vinay Girijavallabhan ,  Janeta Popovici-Muller ,  Wensheng Yu ,  Lianyun Zhao

IPC分类号： C07D471/02 ,  C07D498/02 ,  A61K31/519 ,  A61K31/506 ,  A61K31/4709 ,  A61K31/43 ,  A61K31/4245

CPC分类号： C07D409/14 ,  C07C235/06 ,  C07C235/08 ,  C07C235/10 ,  C07C2601/08 ,  C07D207/20 ,  C07D207/26 ,  C07D209/44 ,  C07D215/14 ,  C07D217/06 ,  C07D263/32 ,  C07D295/185 ,  C07D307/52 ,  C07D333/20 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D513/04

摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物或异构体，其可用于治疗由MMP，ADAM，TACE，TNF-α或其组合介导的疾病或病症。

公开(公告)号：US20110082153A1

公开(公告)日：2011-04-07

申请号：US12673858

申请日：2008-09-04

申请人： Robert G. Aslanian ,  Xianhai Huang ,  Anandan Palani ,  JUn Qin ,  Wei Zhou ,  Xiaohong Zhu ,  Robert Mazzola ,  Pawan Dhondi ,  William J. Greenlee

发明人： Robert G. Aslanian ,  Xianhai Huang ,  Anandan Palani ,  JUn Qin ,  Wei Zhou ,  Xiaohong Zhu ,  Robert Mazzola ,  Pawan Dhondi ,  William J. Greenlee

IPC分类号： A61K31/501 ,  C07D403/12 ,  C07D237/14 ,  A61K31/50 ,  C07D401/12 ,  A61K31/4439 ,  C07D403/14 ,  A61P25/28 ,  A61P27/06 ,  A61P9/00 ,  A61P29/00

CPC分类号： C07D403/12 ,  C07D237/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I).

摘要翻译： 本发明提供了作为γ分泌酶调节剂的新型化合物。 化合物具有式（I）。 还公开了使用式（I）化合物调节γ-分泌酶活性和治疗阿尔茨海默病的方法的方法。

公开(公告)号：US09947221B1

公开(公告)日：2018-04-17

申请号：US15430533

申请日：2017-02-12

申请人： Robert Mazzola

发明人： Robert Mazzola

IPC分类号： G08G1/16 ,  G08G1/0967 ,  G07C5/00 ,  B60Q9/00 ,  B60K35/00

CPC分类号： G08G1/096783 ,  B60K35/00 ,  B60K2350/1084 ,  B60K2350/965 ,  B60Q9/00 ,  G07C5/008 ,  G08G1/096716 ,  G08G1/096775 ,  G08G1/096791

摘要： Vehicular communication systems and methods are disclosed, including one or more media devices. A host device inside a vehicle is coupled to a media device that is adaptable to being mounted to the vehicle. The media device includes a display configured to display a default image. The host device is configured to receive data associated with a predefined direction of the vehicle from vehicle operation sensors on the vehicle and receive traffic data from one or more application servers. In response to the data, the host device determines a vehicle status and transmits media content to be presented on the display, including at least one road sign. The host device is further configured to establish a link with a second media device including a display and transmit instructions to project the media content.

公开(公告)号：US20200282902A9

公开(公告)日：2020-09-10

申请号：US15922717

申请日：2018-03-15

申请人： Robert Mazzola

发明人： Robert Mazzola

IPC分类号： B60Q1/48 ,  B60Q1/26 ,  B60Q1/50

摘要： Vehicular communication systems and methods are disclosed, including one or more media devices. A host device inside a vehicle is coupled to a media device that is adaptable to being mounted to the vehicle. The media device includes a display configured to display a default image. The host device is configured to receive data associated with a predefined direction of the vehicle from vehicle operation sensors on the vehicle and receive traffic data from one or more application servers. In response to the data, the host device determines a vehicle status and transmits media content to be presented on the display, including at least one road sign. The host device is further configured to establish a link with a second media device including a display and transmit instructions to project the media content.

公开(公告)号：US20220063485A1

公开(公告)日：2022-03-03

申请号：US17500847

申请日：2021-10-13

申请人： Robert Mazzola

发明人： Robert Mazzola

IPC分类号： B60Q1/48 ,  B60Q1/50 ,  B60Q1/26

摘要： Vehicular communication systems and methods are disclosed, including one or more media devices. A host device inside a vehicle is coupled to a media device that is adaptable to being mounted to the vehicle. The media device includes a display configured to display a default image. The host device is configured to receive data associated with a predefined direction of the vehicle from vehicle operation sensors on the vehicle and receive traffic data from one or more application servers. In response to the data, the host device determines a vehicle status and transmits media content to be presented on the display, including at least one road sign. The host device is further configured to establish a link with a second media device including a display and transmit instructions to project the media content.

公开(公告)号：US20190283665A1

公开(公告)日：2019-09-19

申请号：US15922717

申请日：2018-03-15

申请人： Robert Mazzola

发明人： Robert Mazzola

IPC分类号： B60Q1/48 ,  B60Q1/26 ,  B60Q1/50

摘要： Vehicular communication systems and methods are disclosed, including one or more media devices. A host device inside a vehicle is coupled to a media device that is adaptable to being mounted to the vehicle. The media device includes a display configured to display a default image. The host device is configured to receive data associated with a predefined direction of the vehicle from vehicle operation sensors on the vehicle and receive traffic data from one or more application servers. In response to the data, the host device determines a vehicle status and transmits media content to be presented on the display, including at least one road sign. The host device is further configured to establish a link with a second media device including a display and transmit instructions to project the media content.