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公开(公告)号:US20070191332A1
公开(公告)日:2007-08-16
申请号:US11502116
申请日:2006-08-10
申请人: Zhaoning Zhu , Robert Mazzola , Wensheng Yu , Joseph Kozlowski
发明人: Zhaoning Zhu , Robert Mazzola , Wensheng Yu , Joseph Kozlowski
IPC分类号: A61K31/4709 , A61K31/4178 , A61K31/4025 , A61K31/405 , C07D403/02
CPC分类号: C07D401/12
摘要: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, wherein n, M, V, T, W, X, U, R1 and R2 are as disclosed in the present specification, and which compounds are useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物或异构体,其中n,M,V,T,W,X,U,R 1和R 2, SUP> 2如本说明书中所公开的,哪些化合物可用于治疗由MMPs,TNF-α或其组合介导的疾病或病症。
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公开(公告)号:US20060252778A1
公开(公告)日:2006-11-09
申请号:US11142601
申请日:2005-06-01
申请人: Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert Mazzola , Tin-Yau Chan , Henry Vaccaro , Brian McKittrick , Joseph Kozlowski , Brian Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline Ting , Kristin Rosner , Gerald Shipps , M. Siddiqui , David Belanger , Chaoyang Dai , Dansu Li , Vinay Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
发明人: Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert Mazzola , Tin-Yau Chan , Henry Vaccaro , Brian McKittrick , Joseph Kozlowski , Brian Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline Ting , Kristin Rosner , Gerald Shipps , M. Siddiqui , David Belanger , Chaoyang Dai , Dansu Li , Vinay Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
IPC分类号: C07D471/02 , C07D498/02 , A61K31/519 , A61K31/506 , A61K31/4709 , A61K31/43 , A61K31/4245
CPC分类号: C07D409/14 , C07C235/06 , C07C235/08 , C07C235/10 , C07C2601/08 , C07D207/20 , C07D207/26 , C07D209/44 , C07D215/14 , C07D217/06 , C07D263/32 , C07D295/185 , C07D307/52 , C07D333/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04
摘要: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂化物或异构体,其可用于治疗由MMP,ADAM,TACE,TNF-α或其组合介导的疾病或病症。
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公开(公告)号:US07879997B2
公开(公告)日:2011-02-01
申请号:US11502116
申请日:2006-08-10
IPC分类号: C07D205/08 , A61K31/397
CPC分类号: C07D401/12
摘要: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, wherein n, M, V, T, W, X, U, R1 and R2 are as disclosed in the present specification, and which compounds are useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物或异构体,其中n,M,V,T,W,X,U,R 1和R 2如本说明书中所公开的, 哪些化合物可用于治疗由MMPs,TNF-α或其组合介导的疾病或病症。
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公开(公告)号:US07652020B2
公开(公告)日:2010-01-26
申请号:US11142601
申请日:2005-06-01
申请人: Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, Jr. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
发明人: Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, Jr. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
IPC分类号: A61K31/519 , A61K31/506 , A61K31/4709 , A61K31/43 , A61K31/4245 , C07D413/00 , C07D241/36 , C07D471/00 , C07D295/00 , C07D471/02 , C07D401/00 , C07D513/00 , C07D277/22 , C07D277/62 , C07D263/30 , C07D261/06 , C07D235/00 , C07D209/04 , C07D207/00 , C07D205/00 , C07D409/00 , C07D307/00
CPC分类号: C07D409/14 , C07C235/06 , C07C235/08 , C07C235/10 , C07C2601/08 , C07D207/20 , C07D207/26 , C07D209/44 , C07D215/14 , C07D217/06 , C07D263/32 , C07D295/185 , C07D307/52 , C07D333/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04
摘要: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物或异构体,其可用于治疗由MMP,ADAM,TACE,TNF-α或其组合介导的疾病或病症。
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公开(公告)号:US20100145048A1
公开(公告)日:2010-06-10
申请号:US12582341
申请日:2009-10-20
申请人: Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, JR. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
发明人: Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, JR. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
IPC分类号: C07D405/12 , C07D417/12 , C07D413/14 , C07D409/12
CPC分类号: C07D409/14 , C07C235/06 , C07C235/08 , C07C235/10 , C07C2601/08 , C07D207/20 , C07D207/26 , C07D209/44 , C07D215/14 , C07D217/06 , C07D263/32 , C07D295/185 , C07D307/52 , C07D333/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04
摘要: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物或异构体,其可用于治疗由MMP,ADAM,TACE,TNF-α或其组合介导的疾病或病症。
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公开(公告)号:US09828365B2
公开(公告)日:2017-11-28
申请号:US15104584
申请日:2014-12-15
申请人: MERCK SHARP & DOHME CORP. , Joseph Kozlowski , Craig Coburn , Wensheng Yu , Ling Tong , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Tao Ji
发明人: Joseph Kozlowski , Craig Coburn , Wensheng Yu , Ling Tong , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Tao Ji
IPC分类号: C07D493/04 , C07D405/14 , A61K45/06 , A61K31/4985 , A61K31/7072 , A61K31/4178
CPC分类号: C07D405/14 , A61K31/4155 , A61K31/4178 , A61K31/4985 , A61K31/7072 , A61K45/06 , C07D493/04 , A61K2300/00
摘要: The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula I: (I), wherein A, A′, R2A, R2B, R7, R8, R9, and R10 are defined herein. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HCV and the prophylaxis, treatment, or delay in the onset of disease caused by HCV. The present invention also relates to pharmaceutical compositions comprising at least one Fused Tetracyclic Heterocyclic Compound, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines, and methods of using the Fused Tetracyclic Heterocyclic Compounds for treating or preventing HCV infection in a patient.
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公开(公告)号:US20170217940A1
公开(公告)日:2017-08-03
申请号:US15104584
申请日:2014-12-15
申请人: Joseph KOZLOWSKI , Craig COBURN , Wensheng YU , Bin HU , Bin ZHONG , Jinglai HAO , Dahai WANG , Tao JI , MERCL SHARP & DOHME CORP.
发明人: Joseph Kozlowski , Craig Coburn , Wensheng Yu , Ling Tong , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Tao Ji
IPC分类号: C07D405/14 , A61K31/4178 , A61K31/7072 , A61K45/06 , A61K31/4985
CPC分类号: C07D405/14 , A61K31/4155 , A61K31/4178 , A61K31/4985 , A61K31/7072 , A61K45/06 , C07D493/04 , A61K2300/00
摘要: The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula I: (I), wherein A, A′, R2A, R2B, R7, R8, R9, and R10 are defined herein. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HCV and the prophylaxis, treatment, or delay in the onset of disease caused by HCV. The present invention also relates to pharmaceutical compositions comprising at least one Fused Tetracyclic Heterocyclic Compound, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines, and methods of using the Fused Tetracyclic Heterocyclic Compounds for treating or preventing HCV infection in a patient.
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公开(公告)号:US20070265299A1
公开(公告)日:2007-11-15
申请号:US11653798
申请日:2007-01-16
申请人: Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Aneta Micula , Seong-Heon Kim , De-Yi Yang , Razia Rizvi
发明人: Brian Lavey , Joseph Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael Wong , Bandarpalle Shankar , Neng-Yang Shih , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Aneta Micula , Seong-Heon Kim , De-Yi Yang , Razia Rizvi
IPC分类号: A61K31/44 , A61K31/4152 , A61K31/4412 , A61K31/4709 , A61K35/00 , A61P11/00 , A61P11/08 , A61P17/06 , A61P3/14 , A61P37/00 , A61P37/08 , A61P9/00 , A61P9/10 , C07D215/06 , C07D233/02 , C07D401/06 , C07D471/02
CPC分类号: C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPS, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂化物或异构体,其可用于治疗由MMPS,ADAM,TACE,聚集蛋白聚糖蛋白酶,TNF-α或其组合介导的疾病或病症 。
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公开(公告)号:US20070219218A1
公开(公告)日:2007-09-20
申请号:US11653676
申请日:2007-01-16
申请人: Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Aneta Micula , Robert Feltz
发明人: Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar , M. Siddiqui , Kristin Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay Girijavallabhan , Dansu Li , Razia Rizvi , Aneta Micula , Robert Feltz
IPC分类号: A61K31/497 , A61K31/506 , A61K31/4709 , A61K31/4741 , A61K31/4745 , A61K31/4178 , C07D403/14 , C07D491/02 , C07D471/02
CPC分类号: C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
摘要: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂化物,酯或异构体,其可用于治疗由MMP,ADAM,TACE,聚集蛋白聚糖酶,TNF-或组合介导的疾病或病症 其中。
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公开(公告)号:US20060205797A1
公开(公告)日:2006-09-14
申请号:US11180863
申请日:2005-07-13
申请人: Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar
发明人: Wensheng Yu , Ling Tong , Lei Chen , Joseph Kozlowski , Brian Lavey , Neng-Yang Shih , Vincent Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael Wong , De-Yi Yang , Seong Kim , Bandarpalle Shankar
IPC分类号: A61K31/425 , A61K31/4178 , C07D417/02 , C07D403/02
CPC分类号: C07D401/14 , C07D403/06 , C07D409/14 , C07D413/14 , C07D417/14
摘要: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF—combinations thereof.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物或异构体,其可用于治疗由MMP,ADAM,TACE,TNF-组合介导的疾病或病症。
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