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    PURIFICATION OF PLASTICIZERS
    22.
    发明申请
    PURIFICATION OF PLASTICIZERS 审中-公开

    公开(公告)号：US20180002301A1

    公开(公告)日：2018-01-04

    申请号：US15540458

    申请日：2016-01-05

    Applicant: ARCHER DANIELS MIDLAND COMPANY

    Inventor： Naveen SUNDHARSAN

    IPC: C07D301/32 ,  C08K5/1515 ,  B01D17/04

    Abstract: Plasticizers are purified by contact with a coalescing filter to effect removal of ions, metals, monohydric alcohols, and polyhydric alcohols. The resulting purified plasticizer compositions are suitable for use in PVC due to their low levels of impurities that reduce PVC utility.

    Diallyl ethers of anhydrohexitols and processes for making the same
    26.
    发明授权
    Diallyl ethers of anhydrohexitols and processes for making the same 有权
    脱水己二醇的二烯丙基醚及其制备方法

    公开(公告)号：US09463448B2

    公开(公告)日：2016-10-11

    申请号：US14401138

    申请日：2013-04-18

    Applicant: ARCHER DANIELS MIDLAND COMPANY

    Inventor： Kenneth Stensrud

    IPC: C07D493/04 ,  B01J31/02 ,  G06F1/16

    CPC classification number: G06F1/1632 ,  C07D493/04

    Abstract: The invention concerns diallylisoidide in a first aspect, and in a related aspect concerns an improved method for making the diallyl ether derivatives of anhydrohexitols generally, whether isosorbide, isomannide, isoidide or a mixture of two or all three of these, whereby these derivatives may be produced efficiently up to quantitative yields.

    Abstract translation: 本发明在第一方面涉及二烯丙基醚，在相关方面涉及一般制备脱氢己二醇的二烯丙基醚衍生物的改进方法，无论是异山梨醇，异甘露聚糖，异氰酸酯或其两种或全部三种的混合物，由此这些衍生物可以是 高效地产生定量产量。

    Genes conferring tolerance to ethanol and high temperature for yeasts
    27.
    发明授权
    Genes conferring tolerance to ethanol and high temperature for yeasts 有权
    赋予酵母对乙醇耐受性高的基因

    公开(公告)号：US09428559B2

    公开(公告)日：2016-08-30

    申请号：US14358876

    申请日：2013-01-11

    Applicant: ARCHER DANIELS MIDLAND COMPANY

    Inventor： Charles Abbas ,  Andriy Sibirny ,  Andriy Voronovsky ,  Olena Ishchuk

    IPC: C12N15/81 ,  C07K14/39 ,  C12P7/06 ,  C12Q1/68

    CPC classification number: C12P7/06 ,  C07K14/39 ,  C07K14/395 ,  C12N15/81 ,  C12N15/815 ,  C12Q1/6811 ,  Y02E50/17

    Abstract: Methods of identifying genes conferring ethanol tolerance in yeasts, genes that confer ethanol tolerance, and mutant strains used to identify such genes are described. A gene herein designated HpETT1 was isolated from the yeast Hansenula polymorpha. Expression of HpETT1 in an ethanol sensitive mutant H. polymorpha strain designated 7E complimented ethanol sensitivity of the mutant. When multiple copies of the HpETT1 were integrated into the genome and overexpressed, the transformed strain demonstrated approximately 10-fold greater resistance to ethanol and resistance to the protein misfolding agent AZC. Expression of HpETT1 also increased ethanol tolerance in Saccharomyces cerevisiae. HpEtt1 has 39% sequence identity to a previously identified protein from S. cerevisiae denoted MPE1, however, the MPE1 gene does not confer ethanol resistance to the 7E mutant. Another gene from the yeast Pichia stipitis was identified that encodes an orthologue protein having 37% identity to HpETT1 herein designated PsETT1 and also confers ethanol resistance to the 7E mutant.

    Abstract translation: 描述赋予酵母中乙醇耐受性的基因，赋予乙醇耐性的基因和用于鉴定这些基因的突变菌株的方法。 本文命名为HpETT1的基因从酵母多形汉逊酵母中分离。 HpETT1在乙醇敏感突变体多形汉逊酵母菌株中的表达命名为7E，突变体的乙醇敏感性。 当HpETT1的多个拷贝整合到基因组中并过表达时，转化的菌株表现出比乙醇大约10倍的抗性和对蛋白质错误折叠剂AZC的抗性。 HpETT1的表达也增加了酿酒酵母中的乙醇耐受性。 HpEtt1与来自酿酒酵母的先前鉴定的蛋白质具有39％的序列同一性，表示MPE1，然而，MPE1基因不赋予7E突变体的乙醇抗性。 鉴定了来自酵母毕赤酵母属的另一种基因，其编码与本文命名为PsETT1的HpETT1具有37％同一性的直向同源蛋白，并且还赋予对7E突变体的乙醇抗性。

    Development of strains of the thermotolerant yeast Hansenula polymorpha capable of alcoholic fermentation of starch and xylan by expression of starch and xylan degrading enzymes
    30.
    发明授权
    Development of strains of the thermotolerant yeast Hansenula polymorpha capable of alcoholic fermentation of starch and xylan by expression of starch and xylan degrading enzymes 有权
    通过淀粉和木聚糖降解酶的表达开发能够通过淀粉和木聚糖进行酒精发酵的耐热酵母汉逊氏酵母菌株

    公开(公告)号：US09388399B2

    公开(公告)日：2016-07-12

    申请号：US12989735

    申请日：2009-05-06

    Applicant: Charles Abbas ,  Andriy Sibirny ,  Andriy Y. Voronovsky

    Inventor： Charles Abbas ,  Andriy Sibirny ,  Andriy Y. Voronovsky

    IPC: C12N9/34 ,  C12N9/28 ,  C12P7/06 ,  C12N9/30 ,  C12N9/26

    CPC classification number: C12N9/2428 ,  C12N9/2414 ,  C12N9/242 ,  C12P7/06 ,  C12Y302/01001 ,  C12Y302/01003 ,  C12Y302/01008 ,  C12Y302/01037 ,  C12Y401/01001 ,  Y02E50/17 ,  Y02P20/52

    Abstract: Genes SWA2 and GAM1 from the yeast, Schwanniomyces occidentalis, encoding α-amylase and glucoamylase, respectively, were cloned and expressed in H. polymorpha. The expression was achieved by integration of the SWA2 and GAM1 genes into the chromosome of H. polymorpha under operably linked to a strong constitutive promoter of the H. polymorpha-glyceraldehyde-3-phosphate dehydrogenase gene (HpGAP. Resulting transformants acquired the ability to grow on a minimal medium containing soluble starch as a sole carbon source and can produce Ethanol at high-temperature fermentation from starch up to 10 g/L. A XYN2 gene encoding endoxylanase was obtained from the fungus Trichoderma resee, and a xlnD gene coding for β-xylosidase was obtained from the fungus Aspergillus niger. Co-expression of these genes was also achieved by integration into the H. polymorpha chromosome under control of the HpGAP promoter. The resulting transformants were capable of growth on a minimal medium supplemented with birchwood xylan as a sole carbon source. Successful expression of xylanolytic enzymes resulted in a recipient strain capable of fermentation of birchwood xylan to ethanol at 48° C. Further with co expression of the forgoing genes in a H. polymorpha strain that overexpresses a pyruvate decarboxylase gene further improved ethanol production.

    Abstract translation: 来自酵母的SWA2和GAM1基因分别编码α-淀粉酶和葡糖淀粉酶，分别在多形汉逊酵母中表达。 该表达是通过将SWA2和GAM1基因整合到多形汉逊酵母的染色体中而实现的，其可操作地连接于多形汉逊酵母 - 甘油醛-3-磷酸脱氢酶基因（HpGAP）的强组成型启动子。得到的转化体获得了生长能力 在含有可溶性淀粉作为唯一碳源的基本培养基上，可以从高达10g / L的淀粉高温发酵生产乙醇，从真菌木霉菌获得编码内切木聚糖酶的XYN2基因，并获得编码＆bgr的xlnD基因 来自真菌黑曲霉的α-脱氧核苷酸酶，这些基因的共表达也通过在HpGAP启动子控制下整合入多形汉逊酵母染色体而实现，所得转化体能够在补充有桦木木聚糖的基本培养基上生长 作为唯一的碳源，木聚糖酶的成功表达导致能够发酵桦木木聚糖的受体菌株 到48℃的乙醇。此外，在多克隆多因子菌株中共表达过去基因，其过表达丙酮酸脱羧酶基因进一步改善乙醇生产。

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