公开(公告)号：US10444225B2

公开(公告)日：2019-10-15

申请号：US14418645

申请日：2013-08-02

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Nadège Lachmann ,  Joachim Fluhr

IPC: G01N33/50

Abstract: The present invention relates to a method for determining the isotropy of the skin surface of a subject, and hence the degree of maturation of the said skin surface, by examining various parameters reflecting the cell organization. Methods for identifying active agents, raw materials and formulation are also provided.

公开(公告)号：US20190000902A1

公开(公告)日：2019-01-03

申请号：US16064312

申请日：2016-12-21

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Sophie LECLERE-BIENFAIT ,  Stéphanie BREDIF

IPC: A61K36/185 ,  A61K8/9789 ,  A61K8/49 ,  A61K8/368 ,  A61Q19/08 ,  A61Q17/04 ,  A61P17/16 ,  A61P29/00 ,  A61K31/353 ,  A61K31/192

Abstract: The invention relates to a polyphenolic extract of passion flower seeds, in particular Passiflora incarnata or Passiflora edulis seeds, comprising at least 30 percent by weight polyphenols, expressed as gallic acid equivalent, relative to the weight of the dry extract. The invention also relates to a method for preparing an extract of said type, a composition containing same, and the cosmetic, dermatological or therapeutic use thereof.

公开(公告)号：US20180369193A1

公开(公告)日：2018-12-27

申请号：US16117511

申请日：2018-08-30

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Alex SAUNOIS ,  Caroline BAUDOUIN ,  Sophie LECLERE-BIENFAIT ,  Sebastien GARNIER ,  Philippe MSIKA

IPC: A61K31/353 ,  A23L33/105 ,  A61Q19/00 ,  A23L19/00 ,  A61K9/00 ,  A61K8/49 ,  A61Q19/08 ,  A61Q19/02 ,  A61Q17/00 ,  A61K36/54 ,  A61K8/97 ,  A61Q17/04 ,  A61Q5/12 ,  A61K45/06

Abstract: The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which consists in administering such a composition or such an extract.

公开(公告)号：US10143648B2

公开(公告)日：2018-12-04

申请号：US15529694

申请日：2015-11-26

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Caroline Baudouin ,  Stéphanie Bredif

IPC: A61K36/79 ,  A61K8/97 ,  A61Q19/00 ,  A61Q7/00 ,  A61Q17/04 ,  A61Q19/08 ,  A61K36/00

Abstract: The present invention relates to the use of a peptide and glycoside extract of Schizandra fruit as a cutaneous neurosensory agent, for improving the response of the cutaneous neurosensory system, in particular for: —improving cutaneous innervation in the basal state, —combatting age-related loss of cutaneous innervation in the basal state, advantageously for preventing loss of the cutaneous sensitivity and/or combatting thinning of the epidermis, and/or —improving cutaneous perception of the environment, more particularly for combatting burns, extreme cold and/or pain.

公开(公告)号：US20170241989A1

公开(公告)日：2017-08-24

申请号：US15128717

申请日：2015-03-31

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Caroline Baudouin

IPC: G01N33/50 ,  G01N33/68 ,  C12Q1/68

CPC classification number: G01N33/5088 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N33/6881 ,  G01N2500/04 ,  G01N2500/10

Abstract: The invention relates to biomarkers of the skin of children and, in particular, that of infants, having altered expression in the presence of urine. Such markers are particularly advantageous as they allow the skin's response to urine to be monitored. The inventors have developed methods for evaluating the efficacy in vitro of formulations in preventing the harmful effects of urine on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.

公开(公告)号：US09616009B2

公开(公告)日：2017-04-11

申请号：US14514646

申请日：2014-10-15

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Caroline Baudouin ,  Philippe Msika

IPC: A61K8/60 ,  A61K8/97 ,  A61K9/48 ,  A61K31/70 ,  A61K31/7004 ,  A61K36/54 ,  A61K45/06 ,  A61Q3/00 ,  A61Q7/00 ,  A23L2/52 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A23L7/126 ,  A61Q5/00

CPC classification number: A61K8/60 ,  A23L2/52 ,  A23L7/126 ,  A23V2002/00 ,  A61K8/97 ,  A61K9/4858 ,  A61K31/70 ,  A61K31/7004 ,  A61K36/54 ,  A61K45/06 ,  A61K2800/5922 ,  A61K2800/92 ,  A61Q3/00 ,  A61Q5/00 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q7/00 ,  A61K2300/00

Abstract: The present invention relates to a composition including at least one C7 sugar, or derivative from esterification of said sugar, and a pharmaceutically acceptable carrier for treating alopecia. The present invention also relates to a method for cosmetically treating hair and nails, said method being intended to stimulate the growth thereof and/or slow the loss thereof. According to said method, a cosmetic composition including at least one C7 sugar, or derivative from esterification of said sugar, is administered. The present invention finally relates to a method for cosmetic care of hair and/or eyelashes and/or nails.

公开(公告)号：US09422504B2

公开(公告)日：2016-08-23

申请号：US14368895

申请日：2012-12-26

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Jacques Legrand

IPC: C11B1/00 ,  C11B1/06 ,  A23L1/30 ,  A61K36/54 ,  C11B1/04 ,  C11B1/10 ,  C11B1/08 ,  A23L1/212

CPC classification number: C11B1/06 ,  A23L19/00 ,  A23L33/105 ,  A23L33/115 ,  A61K36/54 ,  C11B1/04 ,  C11B1/08 ,  C11B1/10 ,  C11B1/102

Abstract: The present invention relates to the use of whole soft avocados to obtain an avocado oil rich in unsaponifiable, said unsaponifiable containing aliphatic acetogenins and/or their derivatives. Advantageously, the oil has an acid value less than or equal to 3 mgKOH/g. The invention also relates to a process for obtaining an avocado oil rich in unsaponifiable from whole soft avocados. said unsaponifiable containing aliphatic acetogenins and/or their derivatives. The invention also relates to an avocado oil rich in unsaponifiable obtainable by this process. The invention also relates to the use of the avocado oil to prepare a concentrate of avocado oil enriched in unsaponifiable or an avocado unsaponifiable rich in aliphatic furans. Finally, the invention relates to an avocado unsaponifiable rich in aliphatic furans or a concentrate of avocado oil enriched in unsaponifiable, obtainable from said avocado oil, for its use as a drug, advantageously in the prevention and/or the treatment of connective tissue disorders such as arthrosis, articular pathologies such as rhumatisms, or parodontal disorders, such as gingivitis or parodontitis.

Abstract translation: 本发明涉及使用整个软的鳄梨来获得富含不皂化的所述不皂化的含脂肪酸乙偶姻和/或其衍生物的鳄梨油。 有利地，油的酸值小于或等于3mgKOH / g。 本发明还涉及一种从整个软鳄梨中获得不可皂化的鳄梨油的方法。 所述不可皂化的含脂肪族乙酰胆酸和/或其衍生物。 本发明还涉及一种富含不可皂化的鳄梨油，可通过该方法获得。 本发明还涉及鳄梨油用于制备富含不可皂化的鳄梨油的浓缩物或不可皂化的富含脂肪族呋喃的鳄梨油。 最后，本发明涉及不可皂化的富含脂肪呋喃的鳄梨或富含不皂化油的鳄梨油浓缩物，可从所述鳄梨油获得，用于药物，有利地用于预防和/或治疗结缔组织疾病，例如 作为关节病，关节病变如眩晕症或传染疾病，例如牙龈炎或牙菌斑。

公开(公告)号：US08957232B2

公开(公告)日：2015-02-17

申请号：US13575402

申请日：2011-01-31

Applicant: Alex Saunois ,  Jacques Legrand ,  Eglantine Mercier

Inventor： Alex Saunois ,  Jacques Legrand ,  Eglantine Mercier

IPC: C07C51/48 ,  C07D307/00 ,  B01D11/04 ,  A23L1/30 ,  C11B1/10 ,  C11C1/02 ,  C11C3/00

CPC classification number: B01D11/0492 ,  A23L33/10 ,  A23L33/105 ,  A23L33/115 ,  C11B1/10 ,  C11C1/025 ,  C11C3/003

Abstract: The invention relates to a method for the extraction of all unsaponifiable fraction contained in a vegetable oil, an oil originating from a micro-organism or a vegetable butter or in a co-product from the vegetable oil refining industry, such as deodorization discharge. The method includes at least: A) a step comprising the transformation of the aforementioned oils, butter or co-product from the vegetable oil refining industry or oils originating from micro-organisms into a hydro-alcoholic solution by means of, in particular, a step selected from saponification and esterification steps; B) a step comprising the extraction of the hydro-alcoholic solution in which the fatty fraction is separated from the unsaponifiable fraction by means of liquid/liquid extraction; and C) an optional step comprising the purification of the unsaponifiable fraction, selected from the group containing crystallization and liquid/liquid extraction steps. According to the invention, at least one step from the liquid/liquid extraction steps in step B, the crystallization steps in step C and the liquid/liquid extraction steps in step C is performed using a first solvent system containing a concentration of solvent selected from among: fluorinated aromatic solvents, particularly trifluorotoluene (BTF) and hexafluorobenzene (BHF); tert-butyl ethers, particularly 2-ethoxy-2-methylpropane, also known as ethyl-tert-butyl-ether (ETBE); solvents comprising at least one silicon atom, particularly hexamethyldisiloxane (HMDS) and tetramethylsilane (TMS); methyl-tetrahydrofuran (MeTHF); and mixtures thereof, representing at least 50 vol.-% in relation to the total volume of the solvent system. The invention also relates to the fractions obtained using this method and to compositions containing said fractions.

Abstract translation: 本发明涉及一种用于提取植物油，来自微生物或植物黄油的油或植物油精制工业的共同产品中所含的所有不皂化成分的方法，例如除臭排放物。 该方法至少包括：A）包括将来自植物油精炼工业的前述油，黄油或副产物或由微生物产生的油转化成水醇溶液的步骤，特别是通过 从皂化和酯化步骤中选择的步骤; B）包括通过液/液萃取提取其中脂肪级分与不皂化部分分离的水醇溶液的步骤; 和C）任选步骤，其包括纯化非皂化部分，其选自含有结晶和液/液萃取步骤的组。 根据本发明，从步骤B中的液/液萃取步骤，步骤C中的结晶步骤和步骤C中的液/液萃取步骤至少一步是使用含有浓度为 其中：氟化芳族溶剂，特别是三氟甲苯（BTF）和六氟苯（BHF）; 叔丁基醚，特别是2-乙氧基-2-甲基丙烷，也称为乙基叔丁基醚（ETBE）; 包含至少一个硅原子，特别是六甲基二硅氧烷（HMDS）和四甲基硅烷（TMS）的溶剂; 甲基 - 四氢呋喃（MeTHF）; 和其混合物，相对于溶剂系统的总体积代表至少50vol。％。 本发明还涉及使用该方法获得的级分和含有所述级分的组合物。

公开(公告)号：US08747815B2

公开(公告)日：2014-06-10

申请号：US10564785

申请日：2004-07-19

Applicant: Philippe Msika ,  Antoine Piccirilli ,  Nathalie Piccardi

Inventor： Philippe Msika ,  Antoine Piccirilli ,  Nathalie Piccardi

IPC: A61K8/97 ,  A61K36/48 ,  A61K31/045 ,  A61Q19/00 ,  A61Q11/00

CPC classification number: A61K8/97 ,  A61K31/045 ,  A61K36/48 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/08

Abstract: The present invention relates to the use of a lupeol-rich extract for the production of a cosmetic or pharmaceutical composition for treating and/or preventing a connective tissue degeneration. Said invention also relates to the use of a lupeol-rich extract for the production of a pharmaceutical composition for preventing and/or treating non-inflammatory articular pathologies, periodontal diseases and stretch marks. The invention also relates to the use of a lupeol-rich extract for the production of a cosmetic composition as a cicatrizing agent, a restructuring agent and an anti-sagging agent for skin and/or mucosae.

Abstract translation: 本发明涉及富含富勒索的提取物用于生产用于治疗和/或预防结缔组织变性的化妆品或药物组合物的用途。 所述发明还涉及富含富勒酸的提取物用于制备用于预防和/或治疗非炎性关节病变，牙周疾病和妊娠纹的药物组合物的用途。 本发明还涉及富含富勒酸的提取物用于生产化妆品组合物作为痤疮剂，重组剂和用于皮肤和/或粘膜的抗流挂剂的用途。

公开(公告)号：US08734865B2

公开(公告)日：2014-05-27

申请号：US11547031

申请日：2005-04-04

Applicant: Jean-Christophe Choulot ,  Antoine Piccirilli ,  Nathalie Piccardi ,  Philippe Msika ,  François Paul

Inventor： Jean-Christophe Choulot ,  Antoine Piccirilli ,  Nathalie Piccardi ,  Philippe Msika ,  François Paul

IPC: A61K36/48 ,  A61Q5/02 ,  A61K31/715 ,  A61K8/97 ,  A61K36/00

CPC classification number: A61K8/645 ,  A61K8/64 ,  A61K8/73 ,  A61K8/97 ,  A61K36/48 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/08

Abstract: The invention relates to a composition comprising a lupin total extract consisting of a lupin sugar extract, comprising at least 50% galactooligosaccharides by weight, in relation to the weight of dry matter, and a lupin peptide extract. The composition can also contain a chromane derivative or a chromene derivative. The invention also relates to a pharmaceutical and/or cosmetic composition comprising said lupin total extract, used advantageously as an anti-inflammatory agent, which repairs the cutaneous barrier and heals, used particularly in the prevention and/or treatment of erythemas.

Abstract translation: 本发明涉及包含由羽扇豆糖提取物组成的羽扇豆总提取物的组合物，所述羽扇蛋白提取物包含相对于干物质重量的至少50重量％的低聚半乳寡糖和羽扇豆肽提取物。 该组合物还可以含有色度衍生物或色烯衍生物。 本发明还涉及一种药物和/或化妆品组合物，其包含有利地作为抗炎剂的所述羽扇豆总提取物，其修复特别用于预防和/或治疗红斑的皮肤屏障和愈合。