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30 条记录 (耗时 0.03 秒)

    SYSTEM AND METHOD FOR DETECTING THERAPEUTIC AGENTS TO MONITOR ADHERENCE TO A TREATMENT REGIMEN
    24.
    发明申请
    SYSTEM AND METHOD FOR DETECTING THERAPEUTIC AGENTS TO MONITOR ADHERENCE TO A TREATMENT REGIMEN 有权

    公开(公告)号：US20220170949A1

    公开(公告)日：2022-06-02

    申请号：US17599892

    申请日：2020-03-31

    申请人： ORASURE TECHNOLOGIES, INC.

    发明人： Keith KARDOS ,  Giffin DAUGHTRIDGE

    IPC分类号： G01N33/94 ,  G01N33/569 ,  A61K31/685 ,  A61P31/18 ,  G01N30/72

    摘要： The disclosure provides methods, kits and systems for detecting a metabolite that is metabolized from a nucleotide in reverse transcriptase inhibitor in a biological sample obtained from a subject, and uses thereof in monitoring adherence to pre-exposure prophylaxis and counseling subjects who are engaged in or prescribed pre-exposure prophylaxis. The present disclosure also provides methods of preventing HIV infection in patients at risk of contracting infection by monitoring adherence to a regimen and adjusting or modifying the dosing schedule of the regimen accordingly. The metabolite may be detected using proteomic methods, including but not limited to antibody based methods, such as a lateral flow immunoassay or lab based assays such as semi-quantitative LC-MS/MS.

    CRYO-SURGICAL SYSTEMS AND METHODS OF USING THE SAME
    25.
    发明申请
    CRYO-SURGICAL SYSTEMS AND METHODS OF USING THE SAME 有权
    CRYO-SURGICAL系统及其使用方法

    公开(公告)号：US20150201989A1

    公开(公告)日：2015-07-23

    申请号：US14561335

    申请日：2014-12-05

    申请人： Philip Michael FORMICA

    发明人： Philip Michael FORMICA

    IPC分类号： A61B18/02

    CPC分类号： A61B18/0218 ,  A61B2018/0275

    摘要： A method of preparing a cryo-surgical system for treatment includes accessing a container containing a refrigerant, a delivery tube having a first end configured to be in flow communication with the container and a second end opposite the first end. The system further includes a plurality of flexible finger portions disposed proximate the second end of the delivery tube opposite the first end. A porous applicator bud is disposed proximate the second end of the delivery tube. The porous applicator bud includes a body portion disposed between the plurality of flexible finger portions and a contact surface extending from the plurality of flexible finger portions. An adjustment ring disposed along the delivery tube adjacent to the plurality of flexible finger portions can be used to adjust the size of the contact surface of the porous applicator bud.

    摘要翻译： 制备用于治疗的冷冻手术系统的方法包括进入容纳制冷剂的容器，具有构造成与容器流动连通的第一端和与第一端相对的第二端的输送管。 该系统还包括多个柔性指状部分，其设置在与第一端相对的输送管的第二端附近。 在输送管的第二端附近布置多孔施用器芽。 多孔施用器芽包括设置在多个柔性指状部分之间的主体部分和从多个柔性指状部分延伸的接触表面。 可以使用沿着与多个柔性指部分相邻的输送管设置的调节环来调节多孔施用器芽的接触表面的尺寸。

    Sample collector and test device
    26.
    发明授权
    Sample collector and test device 有权
    样品收集器和测试装置

    公开(公告)号：US08673239B2

    公开(公告)日：2014-03-18

    申请号：US13017324

    申请日：2011-01-31

    申请人： R. Sam Niedbala ,  John W. Scott ,  Peter A. Bourdelle ,  Hans H. Feindt

    发明人： R. Sam Niedbala ,  John W. Scott ,  Peter A. Bourdelle ,  Hans H. Feindt

    IPC分类号： G01N33/48

    CPC分类号： B01L3/5029 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/007 ,  B01L3/5023 ,  B01L2300/0663 ,  B01L2300/0835 ,  B01L2400/0481 ,  Y10T436/2575

    摘要： A sample collector and test device is disclosed. The sample collector and test device may be used together as a diagnostic tool for collecting and assay of analytes contained in a sample. A sample collector is also disclosed which may be used with existing sample containers and or test devices. The sample collector may indicate sample adequacy when a sufficient volume of sample has been collected for assay and may also include a sample retaining feature which retains a portion of expressed sample for confirmatory testing, if desirable. The sample collector may also include a mechanism for expressing sample in a sample collector and/or test device. A test device is also disclosed for retaining and assay of an expressed sample. The disclosed test device may be used with existing sample collectors. In a preferred embodiment, test device is used with a preferred sample collector. Test device may include a locking feature for locking a sample retained on a sample collector or test device may be used to receive expressed sample collected from a syringe or another suitable sample delivery device.

    摘要翻译： 公开了一种样品收集器和测试装置。 样品收集器和测试装置可以一起用作用于收集和测定样品中包含的分析物的诊断工具。 还公开了可以与现有样品容器和/或测试装置一起使用的样品收集器。 当已经收集足够体积的样品用于测定时，样品收集器可以指示样品充分性，并且如果需要，还可以包括保留一部分表达样品用于确认测试的样品保留特征。 样品收集器还可以包括用于在样品收集器和/或测试装置中表达样品的机制。 还公开了用于保留和测定表达样品的测试装置。 所公开的测试装置可以与现有的样品收集器一起使用。 在一个优选实施例中，测试装置与优选的样品收集器一起使用。 测试装置可以包括用于锁定保持在样品收集器上的样品的锁定特征，或者测试装置可用于接收从注射器或另一合适的样品输送装置收集的表达样品。

    Device for collection and assay of oral fluids
    30.
    发明授权
    Device for collection and assay of oral fluids 有权

    公开(公告)号：US07192555B2

    公开(公告)日：2007-03-20

    申请号：US09973956

    申请日：2001-10-11

    申请人： Ronald W. Mink ,  Andrew S. Goldstein ,  Robert C. Bohannon

    发明人： Ronald W. Mink ,  Andrew S. Goldstein ,  Robert C. Bohannon

    IPC分类号： G01N33/558

    CPC分类号： A61B10/0051 ,  A61B2010/0006 ,  G01N30/90 ,  Y10S435/974 ,  Y10S436/81 ,  Y10T436/25

    摘要： A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to enable inspection of selected sites on the lateral chromatographic strip for test results. A porous wick material protrudes from the housing to a collection site exterior of the housing at one end and communicates to the lateral chromatographic strip at the other end. The porous wick material has particulate construction, the particles adsorbing aqueous oral fluid to transport the fluid from the mouth to the lateral chromatographic strip without substantial absorption. The particles of the porous wick material are bound together to define a continuous interstitial volume for the flow of oral fluid to be transported and are treated to be hydrophilic to the adsorbed oral fluids. The porous wick material readily releases oral fluid to the lateral chromatographic strip. Prevention of reverse flow to the oral cavity from the lateral chromatographic strip naturally occurs due to the circuitous flow path of the porous wick material. A bite plate is coupled to the housing and insertable between the teeth of the patient to position the porous wick in the oral cavity for collecting the oral fluid. The bite plate is typically held in place by the occlusal force of the teeth, preferably the molars and/or the bicuspids, to position the porous wick in the buccal space. By observing the lateral chromatographic strip while the test device is in the mouth immediate test results are obtained.