公开(公告)号：US20250040849A1

公开(公告)日：2025-02-06

申请号：US18509415

申请日：2023-11-15

Applicant: Queensland University of Technology

Inventor： Anthony James SHIELD ,  David Andrew OPAR

IPC: A61B5/22 ,  A61B5/00 ,  A61B5/11 ,  A61B5/30 ,  A63B21/00 ,  A63B21/002 ,  A63B21/04 ,  A63B23/02 ,  A63B24/00 ,  A63B71/06

Abstract: An apparatus for use in assessing strength of at least one knee flexor muscle of a subject, the apparatus including a support, two securing members, each securing member securing a respective lower leg of the subject in a position that in use is substantially fixed relative to the support and at least one sensor, which in use senses a force indicative of the strength of the at least one knee flexor muscle in at least one leg of the subject while the subject performs an eccentric contraction of the at least one knee flexor muscle.

公开(公告)号：US11830377B2

公开(公告)日：2023-11-28

申请号：US16765239

申请日：2018-11-30

Applicant: QUEENSLAND UNIVERSITY OF TECHNOLOGY

Inventor： Dietmar Hutmacher ,  Nathan Castro ,  Onur Bas

IPC: G09B23/28 ,  A61B17/04 ,  A61B17/00

CPC classification number: G09B23/28 ,  A61B17/0401 ,  A61B2017/00716

Abstract: Disclosed is a suturing training device and a method of using the device. The device comprises a base having a first side and a second side, the base defining a plane. The device also comprises a first anchor and a second anchor positioned on the first side of the base. The first and second anchors are each connectable to a segment of tissue so that the tissue is suspended therebetween in use of the device. An actuator is associated with one or both of the first anchor and the second anchor. The actuator is actuatable to cause relative movement of the first and second anchors along the plane. A force gauge is configured to measure a force applied to the tissue when the first and second anchors are moved relative one another by the actuator.

公开(公告)号：US11752002B2

公开(公告)日：2023-09-12

申请号：US16636706

申请日：2018-08-13

Applicant: Griffith University ,  Queensland University of Technology ,  Gold Coast Hospital And Health Service

Inventor： Cedryck Vaquette ,  Hei Man Hayman Lui ,  Saso Ivanovski ,  Randy Bindra

IPC: A61F2/46 ,  A61F2/08 ,  A61F2/42 ,  B33Y80/00 ,  A61L27/22 ,  A61L27/24 ,  A61L27/38 ,  B33Y10/00 ,  A61F2/30

CPC classification number: A61F2/4261 ,  A61F2/08 ,  A61L27/222 ,  A61L27/225 ,  A61L27/227 ,  A61L27/24 ,  A61L27/386 ,  A61L27/3817 ,  A61L27/3821 ,  A61L27/3847 ,  A61L27/3886 ,  B33Y80/00 ,  A61F2002/30009 ,  A61F2002/30011 ,  A61F2002/30062 ,  A61F2002/30962 ,  A61F2002/30985 ,  A61F2002/4289 ,  A61F2002/4292 ,  B33Y10/00

Abstract: The present invention relates to a three-dimensional multiphasic synthetic tissue scaffold comprising first, second and third compartments, wherein: each said compartment comprises distinct microstructural, and/or chemical, and/or mechanical properties, and is connected with at least one other compartment of the scaffold via a continuous interface; the tissue scaffold is porous; and the external morphology of the tissue scaffold mimics that of a mammalian joint or a component thereof. The invention further relates to a method for producing the three dimensional multiphasic synthetic tissue scaffold using a polymeric material, the method comprising using a three-dimensional (3D) bioprinter to print the tissue scaffold by continuously deposit the polymeric material onto a platform until the tissue scaffold is produced in its entirety.

公开(公告)号：US20210254058A1

公开(公告)日：2021-08-19

申请号：US16971893

申请日：2019-02-22

Applicant: DOW AGROSCIENCES LLC ,  QUEENSLAND UNIVERSITY OF TECHNOLOGY

Inventor： Elane FISHILEVICH ,  Kenneth NARVA ,  Xiaozeng YANG ,  Meghan L. FREY ,  Murugesan RANGASAMY ,  Wendy LO ,  Premchand GANDRA ,  Peter Michael WATERHOUSE

IPC: C12N15/113 ,  C12N15/82 ,  A01N63/60

Abstract: This disclosure concerns compositions and methods for novel RNA inhibition molecules (e.g., small/short hairpin RNA (shRNA) molecules), polynucleotides encoding such molecules, use of such novel RNA inhibition molecules to inhibit a target gene by suppressing the expression of the mRNA of the target gene, and for application such as the of control insect pests, and transgenic plants that produce, and are protected, by these novel RNA inhibition molecules are described.

公开(公告)号：US10293042B2

公开(公告)日：2019-05-21

申请号：US15705059

申请日：2017-09-14

Applicant: Queensland University of Technology

Inventor： Robyn O'Hehir ,  Janet Davies ,  Jennifer Rolland

IPC: A61K39/35 ,  C07K14/415 ,  C07K16/16 ,  G01N33/577

Abstract: The present invention relates generally to novel recombinant polypeptides of Bahia grass pollen and to genetic sequences encoding same. More particularly, the present invention is directed to Pas n 1 polypeptides and derivatives, and fragments thereof and genetic sequences encoding same. The molecules of the present invention are useful in a range of therapeutic, prophylactic and diagnostic applications including, but not limited to, applications in the context of conditions characterized by an aberrant, inappropriate or otherwise unwanted immune response to the Bahia grass pollen.

公开(公告)号：US09452049B2

公开(公告)日：2016-09-27

申请号：US12625069

申请日：2009-11-24

Applicant: Robert E. Guldberg ,  Yash M. Kolambkar ,  Dietmar W. Hutmacher

Inventor： Robert E. Guldberg ,  Yash M. Kolambkar ,  Dietmar W. Hutmacher

IPC: A61F2/30 ,  A61F2/28 ,  A61L27/38 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L31/14 ,  A61L31/16 ,  A61F2/00

CPC classification number: A61F2/2846 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2002/0068 ,  A61F2002/2817 ,  A61F2002/2825 ,  A61F2002/285 ,  A61F2002/30028 ,  A61F2002/30075 ,  A61F2002/30235 ,  A61F2002/30838 ,  A61F2002/3084 ,  A61F2002/30914 ,  A61F2002/3092 ,  A61F2210/0061 ,  A61F2230/0069 ,  A61F2240/001 ,  A61F2310/00365 ,  A61L27/3804 ,  A61L27/3834 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/414 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/02

Abstract: Systems and method to affect anatomical structures is disclosed. The systems and method can be used to regenerate bone. The system can comprise a nanofiber mesh configured to substantially conform to an anatomical structure, wherein at least a portion of the nanofiber mesh defines a fillable space. The system can comprise a carrier substance comprising an active agent, such as a bone morphogenetic protein, The carrier substance can be disposed within the fillable space.

Abstract translation: 公开了影响解剖结构的系统和方法。 系统和方法可用于再生骨。 该系统可以包括被配置为基本上符合解剖结构的纳米纤维网，其中纳米纤维网的至少一部分限定了可填充空间。 该系统可以包含载体物质，其包含活性剂，例如骨形态发生蛋白。载体物质可以设置在可填充空间内。

公开(公告)号：US09434953B2

公开(公告)日：2016-09-06

申请号：US13978133

申请日：2011-12-15

Applicant: Manuel Benito Sainz ,  Mark David Kinkema

Inventor： Manuel Benito Sainz ,  Mark David Kinkema

IPC: C12N15/113 ,  C12N15/82

CPC classification number: C12N15/8238 ,  C12N15/113 ,  C12N15/8241

Abstract: The present invention provides nucleic acid molecules comprising one or more nucleotide sequences selected from the group consisting of the nucleotide sequence of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, and/or SEQ ID NO:10 that can be operably linked to a promoter, thereby making the promoter inducible by a chemical compound that can induce the expression of the alcohol dehydrogenase system of Aspergillus nidulans. Methods for making an inducible promoter and for making the expression of a nucleotide sequence of interest inducible are also provided. Further provided are plants, plant parts, and plant cells, comprising the compositions of the present invention.

Abstract translation: 本发明提供了包含一个或多个选自下组的核酸序列的核酸分子：SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：4，SEQ ID NO：5，SEQ ID NO： ：6，SEQ ID NO：7，SEQ ID NO：8和/或SEQ ID NO：10，其可以可操作地连接到启动子，从而使启动子可诱导可诱导醇脱氢酶表达的化学化合物 构巢曲霉系统。 还提供了制备诱导型启动子和用于诱导感兴趣的核苷酸序列的表达的方法。 还提供植物，植物部分和植物细胞，其包含本发明的组合物。

公开(公告)号：US20150297128A1

公开(公告)日：2015-10-22

申请号：US14424577

申请日：2012-09-03

Applicant: Anthony James SHIELD ,  David Andrew OPAR

Inventor： Anthony James SHIELD ,  David Andrew OPAR

IPC: A61B5/22 ,  A61B5/04 ,  A61B5/00

CPC classification number: A61B5/224 ,  A61B5/04004 ,  A61B5/1107 ,  A61B5/4528 ,  A61B5/4533 ,  A61B5/4585 ,  A61B5/6828 ,  A61B5/702 ,  A61B2503/10 ,  A61B2505/09 ,  A61B2562/14 ,  A63B21/00069 ,  A63B21/0023 ,  A63B21/0442 ,  A63B21/4013 ,  A63B21/4015 ,  A63B21/4029 ,  A63B21/4031 ,  A63B21/4037 ,  A63B23/0211 ,  A63B23/0238 ,  A63B24/0087 ,  A63B71/0619 ,  A63B2071/0625 ,  A63B2207/02 ,  A63B2208/0214 ,  A63B2208/0247 ,  A63B2208/0252 ,  A63B2208/0257 ,  A63B2208/0261 ,  A63B2209/10 ,  A63B2220/40 ,  A63B2220/51 ,  A63B2220/54 ,  A63B2220/58 ,  A63B2220/80 ,  A63B2220/803 ,  A63B2220/805 ,  A63B2220/833 ,  A63B2220/836 ,  A63B2225/09 ,  A63B2225/20 ,  A63B2225/50 ,  A63B2225/54

Abstract: An apparatus for use in assessing strength of at least one knee flexor muscle of a subject, the apparatus including a support, two securing members, each securing member securing a respective lower leg of the subject in a position that in use is substantially fixed relative to the support and at least one sensor, which in use senses a force indicative of the strength of the at least one knee flexor muscle in at least one leg of the subject while the subject performs an eccentric contraction of the at least one knee flexor muscle.

Abstract translation: 一种用于评估受试者的至少一个膝盖屈肌的强度的装置，所述装置包括支撑件，两个固定构件，每个固定构件将相对于所述受试者的相应小腿固定在相对于 所述支撑件和至少一个传感器，其在所述受试者执行所述至少一个膝盖屈肌的偏心收缩时，所述至少一个传感器在所述对象的至少一个腿部中感测到指示所述至少一个膝盖屈肌的强度的力。

公开(公告)号：US09090706B2

公开(公告)日：2015-07-28

申请号：US13511776

申请日：2010-11-30

Applicant: Zee Upton ,  Derek Van Lonkhuyzen

Inventor： Zee Upton ,  Derek Van Lonkhuyzen

IPC: A61K38/00 ,  C07K14/65 ,  C07K14/78 ,  A61K38/18 ,  A61K38/39

CPC classification number: C07K14/65 ,  A61K38/00 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/39 ,  C07K14/78 ,  C07K2319/00 ,  C07K2319/50

Abstract: Isolated protein complexes are provided comprising growth factors such as IGF-I, IGF-II, EGF, bFGF, or KGF and fibronectin, or at least domains thereof that enable binding to and activation of both a growth factor receptor, and an integrin receptor-binding domain of fibronectin. These protein complexes include synthetic proteins where the growth factor and fibronectin sequences are joined by a linker sequence. Also provided are uses of these protein complexes for stimulating or inducing cell migration and/or proliferation in wound healing, tissue engineering, cosmetic and therapeutic treatments such as skin replacement, skin replenishment and treatment of burns where epithelial cell migration is required. In other embodiments, the invention provides inhibition of cancer cell metastasis, particularly in relation to breast cancer.

Abstract translation: 提供了分离的蛋白质复合物，其包含生长因子如IGF-I，IGF-II，EGF，bFGF或KGF和纤连蛋白，或至少其结构域，其能够结合生长因子受体和整联蛋白受体 - 纤连蛋白的结合结构域。 这些蛋白质复合物包括其中生长因子和纤连蛋白序列通过接头序列连接的合成蛋白质。 还提供了这些蛋白质复合物用于刺激或诱导伤口愈合，组织工程，化妆品和治疗性处理如皮肤置换，皮肤补充和治疗需要上皮细胞迁移的灼伤的细胞迁移和/或增殖的用途。 在其它实施方案中，本发明提供对癌细胞转移的抑制，特别是与乳腺癌相关。

公开(公告)号：US20150036102A1

公开(公告)日：2015-02-05

申请号：US14380058

申请日：2013-02-21

Applicant: Queensland University of Technology

Inventor： Atanu Ghosh ,  Michael John Collins ,  Scott Andrew Read ,  Brett Ashley Davis

IPC: G02C7/02 ,  G02C7/06 ,  A61B3/10 ,  G02C7/14

CPC classification number: G02C7/02 ,  A61B3/10 ,  A61B3/1005 ,  G02C7/027 ,  G02C7/06 ,  G02C7/061 ,  G02C7/14 ,  G02C2202/24

Abstract: The invention provides an ophthalmic lens comprising one or more oblique prismatic component, wherein the lens slows myopia progression and/or treats or prevents myopia or a disease or condition associated with myopia. The one or more oblique prismatic components may be base-down or base-down and base-in or base up and base-in. The one or more oblique prismatic components may be central and/or in a distance and/or near zone of the ophthalmic lens. The invention also provides an ophthalmic lens comprising a central base-down prism in a distance zone wherein the lens slows myopia progression and/or treats or prevents myopia or a disease or condition associated with myopia. Also provided is an optical device comprising one or more ophthalmic lenses and a method of slowing myopia progression and/or treating or preventing myopia or a disease or condition associated with myopia including using one or more ophthalmic lenses.

Abstract translation: 本发明提供一种包括一个或多个倾斜棱镜部件的眼科镜片，其中镜片减慢近视进展和/或治疗或预防近视或与近视有关的疾病或病症。 一个或多个倾斜的棱柱部件可以是底部或底部的，并且基部或底部和底部。 一个或多个斜棱镜部件可以是眼镜片的中心和/或远离和/或近区域。 本发明还提供了一种眼镜片，其包括在距离区域中的中心底向下棱镜，其中镜片减缓近视进展和/或治疗或预防近视或与近视有关的疾病或病症。 还提供了包括一个或多个眼科镜片的光学装置和减轻近视进展和/或治疗或预防近视或与近视有关的疾病或病症的方法，包括使用一个或多个眼科镜片。