公开(公告)号：US20240100047A1

公开(公告)日：2024-03-28

申请号：US18389272

申请日：2023-11-14

申请人： University of South Florida

发明人： Subhra Mohapatra ,  Shyam S. Mohapatra ,  Karthick Mayilsamy ,  Eleni Markoutsa ,  Andrew McGill

IPC分类号： A61K31/4985 ,  A61K9/127 ,  A61K9/51 ,  A61K31/155 ,  A61P31/14

CPC分类号： A61K31/4985 ,  A61K9/127 ,  A61K9/5123 ,  A61K31/155 ,  A61P31/14

摘要： A nanosystem and methods of treating, including prophylactically, coronavirus infections, such as those caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), by administering such nanosystem to a patient is presented. The nanosystem may be comprised of a single or a combination of therapeutic agents, optionally encapsulated in a nanoparticle having a targeting moiety directed to the particular coronavirus. For CoV-2 infections, at least one therapeutic agent, such as the dual DPP4/ACE2 inhibitor sitagliptin, may optionally be encapsulated within a nanoparticle having a fatty acid such as linoleic acid, as the targeting moiety. Administration can occur intranasally prior to infection for prophylactic treatment or post-infection for treatment of the viral infection.

公开(公告)号：US20240082261A1

公开(公告)日：2024-03-14

申请号：US18502589

申请日：2023-11-06

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： Charles Lockwood ,  Ozlem Guzeloglu-Kayisli ,  Umit Ali Kayisli ,  Frederick Schatz

IPC分类号： A61K31/557 ,  A61K31/201 ,  A61P15/06

CPC分类号： A61K31/557 ,  A61K31/201 ,  A61P15/06

摘要： Disclosed are compositions and methods for delaying or preventing idiopathic preterm

公开(公告)号：US20240069401A1

公开(公告)日：2024-02-29

申请号：US18502647

申请日：2023-11-06

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： Manoj Kumar Ram ,  Elias K. Stefanakos

IPC分类号： G02F1/1516 ,  C09K9/02 ,  G02F1/163

CPC分类号： G02F1/15165 ,  C09K9/02 ,  G02F1/163

摘要： In one embodiment, an electrochromic device includes a single active layer configured to be alternately placed in a light-transmitting state in which relatively large amounts of light can be transmitted through the active layer and a light-blocking state in which relatively small amounts of light can be transmitted through the active layer, where the device comprises no other layers of material that contribute to transitioning between the two states

公开(公告)号：US20240051959A1

公开(公告)日：2024-02-15

申请号：US18376525

申请日：2023-10-04

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： Yu CHEN ,  Michael SACCO ,  James LEAHY ,  Elena BRAY ,  Xingmin SUN ,  Xiujun ZHANG

IPC分类号： C07D471/08 ,  A61K45/06

CPC分类号： C07D471/08 ,  A61K45/06

摘要： Disclosed herein are compounds that can prevent and treat C. difficile by inhibiting sporulation. Also disclosed herein are compositions and formulations comprising the compound disclosed herein. Methods of preventing and treating C. difficile comprising administering the compounds described herein are also disclosed.

公开(公告)号：US20240043618A1

公开(公告)日：2024-02-08

申请号：US18380965

申请日：2023-10-17

申请人： University of South Florida

发明人： Ramesh Ayyala ,  Nurettin Sahiner

IPC分类号： C08G73/02 ,  A61P31/04 ,  A01P1/00

CPC分类号： C08G73/0273 ,  C08G73/0246 ,  A61P31/04 ,  A01P1/00

摘要： This disclosure relates to antimicrobial compositions, and more particularly to treatment of surfaces (e.g., face masks) for the reduction or prevention of transmission of microbes (e.g., bacteria, fungus, and/or viruses). In some embodiments, the compositions comprise a cationic polymer selected from the group consisting of: a polydiallyldimethylammonium salt, a polyethyleneimine salt, a polydiallyldimethylammonium with different counter ions, a chemically modified polyethyleneimine salt, or a combination thereof.

公开(公告)号：US20240039788A1

公开(公告)日：2024-02-01

申请号：US18479227

申请日：2023-10-02

申请人： University of South Florida

发明人： Almuthanna Nassar ,  Yasin Yilmaz

IPC分类号： H04L41/083 ,  H04L41/16

CPC分类号： H04L41/083 ,  H04L41/16 ,  H04L41/0886

摘要： Systems and methods for processing a service request within a network environment can include a first cluster of fog nodes that execute service tasks. The cluster can include a primary fog node and nearest neighbor fog nodes. The primary fog node can receive, from the network, a service request, determine service request resource data that includes a first time, quantity of resource blocks required to serve the request, and a hold time required to serve the request locally. An edge controller, connected to the network and the first cluster, can receive, from the primary fog node, the service request resource data, identify available resources at the nearest neighbor fog nodes and the primary fog node, and determine whether resource blocks are available to fulfill the service request using deep reinforcement learning algorithms. The edge controller can also refer a rejected service request to a cloud computing system for execution.

公开(公告)号：US20240017218A1

公开(公告)日：2024-01-18

申请号：US18473467

申请日：2023-09-25

申请人： University of South Florida

发明人： Clifford Ronald Merz

IPC分类号： B01D69/02 ,  C08J5/18 ,  B01D69/12

CPC分类号： B01D69/02 ,  C08J5/18 ,  B01D69/1216 ,  C08J2305/08 ,  B01D2325/022

摘要： Membranes comprising chitosan and re-acetylated chitosan for use in desalination and Salinity Gradient Power Vapor Pressure Desalination (SGP-VPD). A thin film composite (TFC) membrane comprising a minimally hydrophilic re-acetylated chitosan outer layer and a substantially hydrophilic chitosan porous support layer for performing desalination and a multi-layer membrane comprising substantially hydrophobic re-acetylated chitosan inner and outer layers surrounding a substantially hydrophilic chitosan porous support layer for performing SGP-VPD.

公开(公告)号：US20240007300A1

公开(公告)日：2024-01-04

申请号：US18341901

申请日：2023-06-27

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： Attila A. Yavuz ,  Saif Eddine Nouma

IPC分类号： H04L9/32

CPC分类号： H04L9/3247

摘要： A new series of secure logging schemes that are referred to as Optimal Signatures for secure Logging (OSLO) are created. OSLO schemes are the first AS-based secure logging schemes that achieve small-constant tag and public key sizes with near-optimal signing and batch verification via various granularities. These features make them ideal for IoT-STaaS applications, wherein efficient signing and batch verification are critical for the resource-limited IoTs and cold storage servers, respectively.

公开(公告)号：US11857679B2

公开(公告)日：2024-01-02

申请号：US17472819

申请日：2021-09-13

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： Edward Turos ,  Faeez Mahzamani

IPC分类号： A61K9/14 ,  A61K9/107 ,  A61P31/04 ,  A61K47/58 ,  A61K31/496 ,  A61K47/20 ,  A61K47/55 ,  A61K47/69

CPC分类号： A61K9/1075 ,  A61K31/496 ,  A61K47/20 ,  A61K47/552 ,  A61K47/58 ,  A61K47/6907 ,  A61P31/04

摘要： The subject invention pertains to polyacrylate homopolymers produced from acrylolated drug monomers. The homopolymers can be produced in the form of nanoparticles. The nanoparticles comprising the homopolymers can be produced via a free radical-induced emulsion polymerization of the acrylolated drug monomers to produce an aqueous emulsion of uniformly sized nanoparticles. The homopolymers of the invention containing acrylolated antibiotic monomers can be active against Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus and Escherichia coli. Accordingly, methods are provided of treating a disease, for example, an infection, by administering to a subject the homopolymers, homopolymeric nanoparticles, or emulsions containing homopolymeric nanoparticles of the invention.

公开(公告)号：US11857598B2

公开(公告)日：2024-01-02

申请号：US17400984

申请日：2021-08-12

申请人： University of South Florida

发明人： Hana Totary-Jain

IPC分类号： C07H21/04 ,  A61K38/17 ,  A61K31/7115 ,  A61K31/7088

CPC分类号： A61K38/1709 ,  A61K31/7088 ,  A61K31/7115 ,  C12Y207/07048 ,  C12N2310/113 ,  C12N2710/10343 ,  C12N2310/141 ,  C12N2330/10

摘要： Described herein are cell-selective mRNA constructs that can contain a RNA of interest and one or more miRNA targets. The cell-selective mRNA constructs described herein can be used to express an RNA of interest to a cell in a cell-selective manner.