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21.发明申请公开(公告)号：US20090258932A1
公开(公告)日：2009-10-15
申请号：US12421425
申请日：2009-04-09
申请人： JONG-MOOK KIM , SUJEONG KIM , WOONG HAHN , WONSUN YOO
发明人： JONG-MOOK KIM , SUJEONG KIM , WOONG HAHN , WONSUN YOO
IPC分类号： A61K31/7088
CPC分类号： C07K14/4753
摘要： The present invention provides for a method of treating or preventing ischemic or liver disease in a subject by administering a composition reconstituted from a lyophilized hepatocyte growth factor (HGF) DNA formulation, where the DNA formulation comprises an HGF plasmid DNA, salt and a carbohydrate. The invention further provides for a method of making such a lyophilized DNA formulation that preserves or enhances gene expression both in vitro and in vivo, thus maintaining or stimulating the biological activity of the expressed protein. The invention also provides for the DNA formulation, or the lyophilized DNA formulation according to the methods disclosed.
摘要翻译： 本发明提供了通过施用从冻干的肝细胞生长因子（HGF）DNA制剂重组的组合物来治疗或预防受试者的缺血性或肝脏疾病的方法，其中所述DNA制剂包含HGF质粒DNA，盐和碳水化合物。 本发明进一步提供了制备这样的冻干DNA制剂的方法，其在体外和体内保留或增强基因表达，从而维持或刺激所表达的蛋白质的生物学活性。 本发明还提供了根据所公开的方法的DNA制剂或冻干的DNA制剂。
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公开(公告)号：US07585943B2
公开(公告)日：2009-09-08
申请号：US11407336
申请日：2006-04-20
申请人： Sujeong Kim , Jong-Mook Kim , Song Shan Xu
发明人： Sujeong Kim , Jong-Mook Kim , Song Shan Xu
IPC分类号： C07K5/00 , C07K14/00 , C12N9/00 , C07K14/52 , C07K16/00 , C07K2/00 , C07K4/00 , C07K14/54 , C07K14/555 , C07K14/575 , C07K14/705
CPC分类号： C12N15/62 , C07K7/06 , C07K7/08 , C07K14/5412 , C07K14/5431 , C07K14/57581 , C07K14/705 , C07K2319/00 , C07K2319/01
摘要： The present invention relates to compositions and methods for fusion protein separation utilizing a peptide linker comprising a novel thrombin cleavage site.
摘要翻译： 本发明涉及使用包含新型凝血酶切割位点的肽接头的融合蛋白分离的组合物和方法。
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公开(公告)号：US20080171852A9
公开(公告)日：2008-07-17
申请号：US11407336
申请日：2006-04-20
申请人： Sujeong Kim , Jong-Mook Kim , Song Shan Xu
发明人： Sujeong Kim , Jong-Mook Kim , Song Shan Xu
CPC分类号： C12N15/62 , C07K7/06 , C07K7/08 , C07K14/5412 , C07K14/5431 , C07K14/57581 , C07K14/705 , C07K2319/00 , C07K2319/01
摘要： The present invention relates to compositions and methods for fusion protein separation utilizing a peptide linker comprising a novel thrombin cleavage site.
摘要翻译： 本发明涉及使用包含新型凝血酶切割位点的肽接头的融合蛋白分离的组合物和方法。
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公开(公告)号：US20080153770A1
公开(公告)日：2008-06-26
申请号：US11870361
申请日：2007-10-10
申请人： Sunyoung KIM , Sujeong KIM , Jun-Tae LEE
发明人： Sunyoung KIM , Sujeong KIM , Jun-Tae LEE
CPC分类号： C12N15/86 , C12N2740/13043 , C12N2830/00
摘要： The present invention relates to the use of internal promoters in mammalian expression vectors including plasmid vectors and enhancer-deleted retroviral vectors. The retroviral vectors have improved safety and optimal levels of transgene expression and vector titers.
摘要翻译： 本发明涉及内源启动子在哺乳动物表达载体中的应用，包括质粒载体和增强子缺失的逆转录病毒载体。 逆转录病毒载体改善了转基因表达和载体滴度的安全性和最佳水平。
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公开(公告)号：US20190085092A1
公开(公告)日：2019-03-21
申请号：US15755819
申请日：2016-08-30
发明人： Richard MORGAN , Kevin FRIEDMAN , Seung Shin YU , Jae-Gyun JEONG , Jin-A CHAE
IPC分类号： C07K16/30 , C07K14/705 , A61P35/00
摘要： The invention provides improved compositions for adoptive cell therapies for cancers that express the glycoepitope STn on TAG-72.
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公开(公告)号：US10058583B2
公开(公告)日：2018-08-28
申请号：US14007095
申请日：2012-03-29
申请人： Doo Suk Lee , Dong Sik Kim , Seon Hee Kim
发明人： Doo Suk Lee , Dong Sik Kim , Seon Hee Kim
IPC分类号： A61K36/9066 , A61K36/77 , A61K36/8988 , A61K36/537 , A61K36/88 , A61K45/06
CPC分类号： A61K36/9066 , A61K36/537 , A61K36/77 , A61K36/88 , A61K36/8988 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a composition for preventing or treating neurological diseases including an extract of Euphoria longan fruit, red sage and Gastrodia elata as an active ingredient. The composition of the present disclosure has a superior effect of inhibiting the activity of acetylcholinesterase (AChE), which hydrolyzes the neurotransmitter acetylcholine directly involved in impairment of cognitive function. In addition, the composition of the present disclosure is safe for the human body since the biologically safe extract of Euphoria longan fruit, red sage and Gastrodia elata is used as the active ingredient.
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27.发明授权Composition comprising the extract of Actinidia arguta and related species for the prevention and treatment of allergic disease and non-allergic inflammatory disease 有权包含猕猴桃提取物和相关物种的组合物，用于预防和治疗过敏性疾病和非过敏性炎性疾病公开(公告)号：US09131722B2
公开(公告)日：2015-09-15
申请号：US10646145
申请日：2003-08-22
申请人： Bong Cheol Kim , Mi Rim Jin , Eun Jin Park , Hyung Jin Jung , Sung Seup Shin , Jin Hwan Oh , Hwa Jun Lee , Sun Young Kim , Hyang Jeon
发明人： Bong Cheol Kim , Mi Rim Jin , Eun Jin Park , Hyung Jin Jung , Sung Seup Shin , Jin Hwan Oh , Hwa Jun Lee , Sun Young Kim , Hyang Jeon
IPC分类号： A01N65/00 , A61K36/00 , A23L1/30 , A61K36/185
CPC分类号： A23L1/3002 , A23L33/105 , A23V2002/00 , A61K36/185 , A23V2250/70 , A23V2250/21 , A23V2250/72 , A23V2250/7056 , A23V2250/705 , A23V2250/156 , A23V2250/032 , A23V2250/28 , A23V2250/0644
摘要： The present invention provides a pharmaceutical composition comprising the extract of hardy kiwifruit as an active ingredient in an effective amount to treat and prevent allergic disease and non-allergic inflammatory disease by reducing inflammation action, by inhibiting histamine release from mast cell, and by increasing the level of Th1 cytokines, IgG2a in serum and reducing the level of Th2 cytokines and IgE in serum. The present invention also provides a use of above extract for the preparation of pharmaceutical composition. The present invention also provides a health food or food additives, a cosmetic composition, a feed or feed additives comprising above extract for prevention or alleviation of allergic disease and non-allergic inflammatory disease by reducing inflammation action, by inhibiting histamine release from mast cell, and by increasing the level of Th1 cytokines, IgG2a in serum, and reducing the level of Th2 cytokines and IgE in serum.
摘要翻译： 本发明提供一种药物组合物，其含有作为有效成分的强力猕猴桃提取物，通过抑制组织胺从肥大细胞释放而通过减少炎症作用，以及通过增加免疫反应来治疗和预防过敏性疾病和非变应性炎性疾病 血清中Th1细胞因子水平，IgG2a水平，降低血清中Th2细胞因子和IgE水平。 本发明还提供了上述提取物用于制备药物组合物的用途。 本发明还提供一种保健食品或食品添加剂，化妆品组合物，饲料或饲料添加剂，其包含通过抑制组织胺从肥大细胞释放而防止或减轻过敏性疾病和非变应性炎性疾病的上述提取物， 并通过增加血清中Th1细胞因子，IgG2a的水平，降低血清中Th2细胞因子和IgE的水平。
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公开(公告)号：US20140296142A1
公开(公告)日：2014-10-02
申请号：US14355792
申请日：2012-03-27
申请人： Jong Mook Kim , Jae Gyun Jeong
发明人： Jong Mook Kim , Jae Gyun Jeong
IPC分类号： C07K14/475
CPC分类号： C07K14/4753 , A61K31/711 , A61K38/1833 , A61K48/005
摘要： The present invention relates to a pharmaceutical composition for the prevention or treatment of diabetic neuropathy, wherein the pharmaceutical composition comprises, as active ingredients, different types of isoforms of HGF or a polynucleotide encoding the isoforms. The present invention is the first invention demonstrating that diabetic neuropathy can be prevented and treated using different types of isoforms of HGF. According to the present invention, it is possible to very effectively treat diabetic neuropathy.
摘要翻译： 本发明涉及用于预防或治疗糖尿病性神经病的药物组合物，其中该药物组合物包含作为活性成分的不同类型的HGF同种型或编码同种型的多核苷酸。 本发明是第一个发现，可以使用不同类型的HGF异构体来预防和治疗糖尿病性神经病变。 根据本发明，可以非常有效地治疗糖尿病性神经病变。
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公开(公告)号：US08716446B2
公开(公告)日：2014-05-06
申请号：US12589511
申请日：2009-08-21
申请人： Yuni Jung , Seong-Hyun Ho , Myung-Ok Park , Myoung-Suk Kim
发明人： Yuni Jung , Seong-Hyun Ho , Myung-Ok Park , Myoung-Suk Kim
CPC分类号： C07K14/5431 , A61K38/00 , A61K47/10 , C07K2319/31
摘要： The present invention provides for biopolymer conjugates of an IL-11 analog (mIL-11) and a biocompatible polymer. The mIL-11 of the invention displays an enhanced resistance to acidolysis and shows increased stability as compared to rhIL-11. The conjugates of the present invention are characterized by a longer serum half-life and exhibit essentially no loss of activity as compared to the corresponding unconjugated mIL-11.
摘要翻译： 本发明提供了IL-11类似物（mIL-11）和生物相容性聚合物的生物聚合物缀合物。 与rhIL-11相比，本发明的mIL-11显示出增强的酸解耐性并且显示增加的稳定性。 本发明的缀合物的特征在于较长的血清半衰期，与相应的未结合的mIL-11相比基本上没有活性损失。
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公开(公告)号：US08445268B2
公开(公告)日：2013-05-21
申请号：US12705516
申请日：2010-02-12
申请人： Joon Youb Lee , Dong-Hyeon Kim , Yeonseok Chung , Sun-Young Chang , Kyung-Chul Lee , Chang-Yuil Kang
发明人： Joon Youb Lee , Dong-Hyeon Kim , Yeonseok Chung , Sun-Young Chang , Kyung-Chul Lee , Chang-Yuil Kang
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/55522 , C07K2319/02 , C12N2840/203
摘要： The present invention relates to human Her-2/neu expressing plasmid constructs having anti-cancer activity and a DNA vaccine comprising same for preventing and/or treating cancer. The Her-2/neu DNA vaccines of the present invention can be effectively used as a therapeutic vaccine in reducing metastasis after tumor surgery or as a prophylactic vaccine for people with genetic high risk.
摘要翻译： 本发明涉及具有抗癌活性的人Her-2 / neu表达质粒构建体和包含其的用于预防和/或治疗癌症的DNA疫苗。 本发明的Her-2 / neu DNA疫苗可以有效地用作减少肿瘤手术后转移的治疗性疫苗，或作为遗传高风险人群的预防性疫苗。
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