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175 条记录 (耗时 0.015 秒)

    Process for producing interferon
    21.
    发明授权
    Process for producing interferon 失效
    生产干扰素的方法

    公开(公告)号：US4216203A

    公开(公告)日：1980-08-05

    申请号：US924703

    申请日：1978-07-14

    申请人： Michael D. Johnston

    发明人： Michael D. Johnston

    IPC分类号： C12P21/00 ,  A61K38/21 ,  C07K14/555 ,  A61K45/02

    CPC分类号： C07K14/555 ,  Y10S514/889

    摘要： Interferon is produced by incubating cells, which are susceptible to producing interferon, prior to induction by an inducer, in a medium containing an effective non-toxic amount of a straight chain, saturated carboxylic acid or a salt thereof.

    摘要翻译： 干扰素通过在含有有效无毒量的直链，饱和羧酸或其盐的培养基中培养易于产生干扰素的细胞产生，在诱导剂诱导之前。

    Quinone derivatives useful as medicaments
    24.
    发明授权
    Quinone derivatives useful as medicaments 失效
    喹诺酮衍生物作为药物有用

    公开(公告)号：US4139637A

    公开(公告)日：1979-02-13

    申请号：US694491

    申请日：1976-06-09

    申请人： Maurice Rouchy

    发明人： Maurice Rouchy

    IPC分类号： C07C281/18 ,  A61K31/175 ,  A61K31/445 ,  A61K31/535 ,  A61K31/555

    CPC分类号： C07C281/18 ,  Y10S514/889

    摘要： The present invention relates to new chemical compounds which are useful in particular as medicaments. The compounds are derivatives of a quinone endowed with physiological and particularly vitamin activity and of a substituted hydrazine; they correspond to the following general formulas: ##STR1## R.sub.1 and R.sub.2 are identical or different and correspond to the general formula: ##STR2## X represents S, Se, O or NH; R.sub.a, R.sub.b are identical or different and are either H, or a branched or unbranched alkyl radical, or the radical --CH.sub.2 NR.sub.4 R.sub.5 ; in this case R.sub.4 and R.sub.5 are lower alkyl radicals or else form either a morpholine ring or a methylated piperazine ring,R.sub.6 and R.sub.7 may be hydrogen, methyl, allyl, phytyl, farnesyl, geranyl, linayl. R.sub.6 is different from R.sub.7 and one of the two is either hydrogen, methyl or allyl,R.sub.8 and R.sub.9 are identical or different and are --H, --CH.sub.3 or --OCH.sub.3, or form the two together a benzene ring.The compounds in accordance with the invention are endowed with antiviral and vitamin properties and can be administered in therapeutically active doses intravenously, intramuscularly or orally.

    摘要翻译： 本发明涉及特别用作药物的新化合物。 所述化合物是具有生理特别是维生素活性的醌的取代的肼的衍生物; 它们对应于以下通式： R 1和R 2相同或不同，并且对应于通式：其中X表示S，Se，O或NH; R a，R b相同或不同，为H或支链或非支链烷基，或基团-CH 2 NR 4 R 5; 在这种情况下，R4和R5是低级烷基，或者形成吗啉环或甲基化哌嗪环，R6和R7可以是氢，甲基，烯丙基，植酰基，法呢基，香叶基，亚麻基。 R6不同于R7，二者之一是氢，甲基或烯丙基，R8和R9相同或不同，为-H，-CH3或-OCH3，或两者一起形成苯环。

    3,6-Bis-(heterocyclic aminoacyl-amino)-acridines and salts thereof
    26.
    发明授权
    3,6-Bis-(heterocyclic aminoacyl-amino)-acridines and salts thereof 失效
    3,6-双 - （杂环氨酰基 - 氨基） - 吖啶及其盐

    公开(公告)号：US4021551A

    公开(公告)日：1977-05-03

    申请号：US600434

    申请日：1975-07-30

    申请人： Ernest Cullen ,  Peter Meindl ,  Hans Tuppy ,  Gerhard Bodo

    发明人： Ernest Cullen ,  Peter Meindl ,  Hans Tuppy ,  Gerhard Bodo

    IPC分类号： C07D219/08 ,  C07D401/12 ,  A61K31/54 ,  C07D413/12 ,  C07D417/12

    CPC分类号： C07D219/08 ,  Y10S514/889

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl,R.sub.2 and R.sub.3, together with each other and the nitrogen atom to which they are attached, form a saturated or unsaturated heterocyclic ring system which may optionally contain one or more additional heteroatoms, andA is lower alkylene or aryl-lower alkylene, and nontoxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as inducers of the formation of interferon.

    摘要翻译： 其中R 1是氢或甲基，R 2和R 3彼此以及与它们相连的氮原子形成饱和或不饱和杂环体系，其可以任选地含有一个或多个 另外的杂原子，和A是低级亚烷基或芳基 - 低级亚烷基，和无毒的药学上可接受的酸加成盐; 化合物及其盐可用作干扰素形成的诱导剂。

    6-Substituted purine 3',5'-cyclic nucleotides
    27.
    发明授权
    6-Substituted purine 3',5'-cyclic nucleotides 失效
    6-取代嘌呤3 {40,5 {40-环核苷酸

    公开(公告)号：US3948886A

    公开(公告)日：1976-04-06

    申请号：US368323

    申请日：1973-06-08

    申请人： Dennis A. Shuman ,  Rich B. Meyer, Jr. ,  Roland K. Robins

    发明人： Dennis A. Shuman ,  Rich B. Meyer, Jr. ,  Roland K. Robins

    IPC分类号： C07H19/20

    CPC分类号： C07H19/20 ,  Y10S514/889 ,  Y10S526/923

    摘要： Described herein are novel 6-alkylthio and 6-arylalkylthio purine 3',5' cyclic nucleotides variously exhibiting adenyl cyclase and (in animal studies) tumor inhibitory properties, interferon potentiation, antiviral activity, and the ability to activate adenosine 3',5'-cyclic phosphate-dependent protein kinase while enjoying resistance to phosphodiesterase hydrolysis superior to that of its naturally occuring analog. The compounds are obtained by alkylation of the corresponding 6-thio nucleotide, which is in turn provided by a novel synthetic route.

    摘要翻译： 本文描述了新颖的6-烷硫基和6-芳基烷硫基嘌呤3'，5'环核苷酸，其各不相同地显示腺苷酸环化酶和（在动物研究中）肿瘤抑制性质，干扰素增强，抗病毒活性和激活腺苷3'，5' 环磷酸依赖性蛋白激酶，同时享受抗磷酸二酯酶水解优于其天然存在的类似物。 通过相应的6-硫代核苷酸的烷基化获得化合物，其又由新的合成途径提供。

    Complexs of polyriboinosinic acid and polyribo-2-thiocytidylic acid
    28.
    发明授权
    Complexs of polyriboinosinic acid and polyribo-2-thiocytidylic acid 失效
    聚氨基磷酸和聚二氧杂环戊二烯酸的复合物

    公开(公告)号：US3843629A

    公开(公告)日：1974-10-22

    申请号：US26367772

    申请日：1972-06-16

    申请人： MERCK PATENT GMBH

    发明人： SCHEIT K ,  SAIKO O ,  FAERBER P ,  REUSS K

    IPC分类号： C07H21/00 ,  C07D51/52 ,  C07D51/54

    CPC分类号： C07H21/00 ,  Y10S514/889

    摘要： Two-component complexes consisting of a polyriboinosinic acid of the formula
    WHEREIN M IS AN INTEGER FROM 1 TO 3, INCLUSIVE; AND N IS AN INTEGER FROM 1 TO 2,000, INCLUSIVE; AND THE METAL AND AMMONIUM SALTS THEREOF, EXHIBIT ANTIMICROBIAL, IN PARTICULAR ANTIVIRAL, ACTIVITY.

    WHEREIN K IS AN INTEGER FROM 1 TO 3, INCLUSIVE; AND B IS AN INTEGER FROM 1 TO 2,000, INCLUSIVE; AND THE METAL AND AMMONIUM SALTS THEREOF, AND A POLYRIBO-2-THIOCYTIDYLIC ACID OF THE FORMULA

    Method of preparing high yields of double-stranded ribonucleic acid
    29.
    发明授权
    Method of preparing high yields of double-stranded ribonucleic acid 失效
    制备双链抗坏血酸的方法

    公开(公告)号：US3819482A

    公开(公告)日：1974-06-25

    申请号：US25125772

    申请日：1972-05-08

    申请人： SEMANCIK J ,  ETTEN J VAN ,  VIDAVER A

    发明人： VIDAVER A ,  VAN ETTEN J ,  SEMANCIK J

    IPC分类号： C07H21/00 ,  C12N7/00 ,  C12P19/34 ,  C12D13/06

    CPC分类号： C07H21/00 ,  C12N7/00 ,  C12N2795/14251 ,  C12P19/34 ,  Y10S435/803 ,  Y10S435/874 ,  Y10S514/889

    摘要： An unusual bacteriophage phi 6, ATCC No. 21781-B, containing a lipid coat and double-stranded ribonucleic acid has been isolated for the plant pathogenic bacterium Pseudomonas phaseolicola ATCC No. 21781. High yields of double-stranded ribonucleic acid may be obtained rapidly and expediently by cultivating a host bacterium for the bacteriophage, infecting the host bacteria with the bacteriophage to provide a lysate and recovering double-stranded ribonucleic acid from the separated bacteriophage. The intact or whole bacteriophage, the bacteriophage with its lipid coat removed, and the isolated nucleic acid have all been found to be effective interferon inducers.

    摘要翻译： 已经分离了含有脂质外壳和双链核糖核酸的不寻常的噬菌体phi 6，ATCC 21781-B，用于植物致病菌Pseudomonas phaseolicola ATCC No.21781。可以快速获得高产量的双链核糖核酸 通过培养用于噬菌体的宿主细菌，用噬菌体感染宿主细菌以提供裂解物并从分离的噬菌体中回收双链核糖核酸。