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21.发明申请公开(公告)号：US20050064046A1
公开(公告)日：2005-03-24
申请号：US10940589
申请日：2004-09-14
申请人： Joseph DiTrolio
发明人： Joseph DiTrolio
CPC分类号： A61K9/0024 , A61K33/14 , A61M37/0069 , Y10S514/951 , Y10S514/955 , Y10S514/966 , Y10S514/968
摘要： Novel methods for the chemical ablation of tissue (e.g. prostatic tissue) are described. These methods include the steps of: (a) providing one or more solid salt dosage form comprising 50-100% w/w salt; and (b) inserting one or more of such solid salt dosage forms into the tissue. The solid salt dosage form is optionally inserted into the tissue under real-time ultrasonic observation. An advantage of the present invention is its ability to eliminate toxic byproducts. For example, where NaCl-based solid salt dosage forms are used to effect localized chemical ablation, the concentration is ultimately reduced to the level of normal saline (i.e., about 0.9%) upon absorption by the body of the subject being treated.
摘要翻译： 描述了用于组织（例如前列腺组织）的化学消融的新方法。 这些方法包括以下步骤：（a）提供一种或多种包含50-100％w / w盐的固体盐剂型; 和（b）将一种或多种这样的固体盐剂型插入组织中。 在实时超声波观察下，将固体盐剂型任选地插入组织。 本发明的优点是其消除有毒副产物的能力。 例如，当使用基于NaCl的固体盐剂型来实现局部化学消融时，在被被治疗的受试者的身体吸收时，浓度最终降低到生理盐水的水平（即约0.9％）。
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22.发明授权Biodegradable porous polymer scaffolds for tissue engineering prepared from an effervescent mixture and its preparation 失效由泡腾混合物制备的用于组织工程的可生物降解的多孔聚合物支架及其制备公开(公告)号：US06562374B1
公开(公告)日：2003-05-13
申请号：US09699213
申请日：2000-10-27
申请人： Dong Keun Han , Kwang-Duk Ahn , Jong-Man Kim , Young Min Ju
发明人： Dong Keun Han , Kwang-Duk Ahn , Jong-Man Kim , Young Min Ju
IPC分类号： C08J900
CPC分类号： C08J9/08 , A61L27/18 , A61L27/56 , A61L27/58 , C08J9/28 , C08J2201/048 , C08J2367/04 , Y10S514/802 , Y10S514/945 , Y10S514/955 , C08L67/04
摘要： The present invention provides a method for preparing biodegradable porous polymer scaffolds for tissue engineering, comprising: a) fabricating a polymer sample from a polymer solution containing at least one biodegradable polymer and an effervescent mixture; b) effervescing the polymer sample in the presence of an effervescent medium such as an aqueous alcohol solution; and c) drying. The method for preparing biodegradable polymer scaffolds of the present invention has the advantages that the process is simple, that pore size can be easily controlled, that the problem caused by the secretion and existence of the toxic substance can be avoid by using a material harmless to human body, and that high efficiency can be achieved. In addition, biodegradable porous polymer scaffolds prepared by above method have the advantages that high porosity can be achieved and an open cell structure in which pores are interconnected is obtained.
摘要翻译： 本发明提供了一种制备用于组织工程的可生物降解的多孔聚合物支架的方法，包括：a）从含有至少一种可生物降解的聚合物和泡腾混合物的聚合物溶液制备聚合物样品; b）在存在聚合物样品的情况下， 泡腾介质如醇水溶液; 和.c）干燥。本发明的可生物降解的聚合物支架的制备方法具有以下优点：该方法简单，可以容易地控制孔径，通过使用可以避免由分解和存在的有毒物质引起的问题 对人体无害的物质，可以实现高效率。 此外，通过上述方法制备的可生物降解的多孔聚合物支架具有能够获得高孔隙率并且获得孔互连的开孔结构的优点。
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23.发明申请公开(公告)号：US20020028243A1
公开(公告)日：2002-03-07
申请号：US09796170
申请日：2001-02-28
发明人： David B. Masters
IPC分类号： A61K009/14
CPC分类号： A61K9/0024 , A61K9/0085 , A61K9/7007 , A61K47/42 , A61L27/227 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/602 , A61L2300/606 , A61L2300/622 , Y10S514/95 , Y10S514/953 , Y10S514/955 , Y10S514/964 , Y10S623/915 , C08L89/00
摘要： The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin/bone/tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices. Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents. The film is then partially dried, rolled or otherwise shaped, and then compressed to form the desired protein matrix device.
摘要翻译： 本发明涉及蛋白质基质材料和装置，以及制备和使用蛋白质基质材料和装置的方法。 更具体地，本发明涉及可用于各种医学应用的蛋白质基质材料和装置，包括但不限于用于药理学活性剂的控制释放的药物递送装置，包封的或涂覆的支架装置，血管，管状移植物， 血管移植物，伤口愈合装置，包括蛋白质基质缝合材料和网眼，皮肤/骨/组织移植物，生物相容导电基质，透明蛋白质基质，蛋白质基质粘附防止屏障，细胞支架和其他生物相容性蛋白质基质装置。 此外，本发明涉及通过形成包含一种或多种可生物降解的蛋白质材料，一种或多种生物相容性溶剂和任选的一种或多种药理学活性剂的膜制备的蛋白质基质材料和装置。 然后将膜部分干燥，滚动或以其他方式成形，然后压缩以形成所需的蛋白质基质装置。
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公开(公告)号：US5980928A
公开(公告)日：1999-11-09
申请号：US902113
申请日：1997-07-29
申请人： Paul B. Terry
发明人： Paul B. Terry
CPC分类号： A61M37/0069 , A61F9/0017 , A61K9/0051 , A61F2250/0067 , A61K9/0024 , Y10S514/914 , Y10S514/954 , Y10S514/955
摘要： A method to reduce the likelihood of conjunctivitis in farm animals, especially cattle, includes the step of injecting an implant containing an antibiotic effective against the microbes associated with conjunctivitis subcutaneously into the animal in close proximity to the eye. Preferably the implant includes a matrix to allow time release of the antibiotic and the implant is placed in the animal near the first part of July. Also preferably the antibiotic is tetracycline.
摘要翻译： 一种降低农场动物，特别是牛的结膜炎可能性的方法包括将含有抗生素的植入物注射到与结膜炎相关的微生物皮下注射到紧邻眼睛的动物中的步骤。 优选地，植入物包括允许抗生素释放时间的基质，并且在7月的第一部分附近将植入物置于动物体内。 还优选地，抗生素是四环素。
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25.发明授权
公开(公告)号：US5486362A
公开(公告)日：1996-01-23
申请号：US140280
申请日：1993-10-21
CPC分类号： A61K31/445 , A61K9/1647 , A61K9/7023 , A61K9/009 , Y10S514/81 , Y10S514/811 , Y10S514/812 , Y10S514/813 , Y10S514/953 , Y10S514/955 , Y10S514/963 , Y10S514/965
摘要： A drug delivery system useful in treating an individual for a drug dependence is described. One embodiment of the system is useful for aiding individuals in the cessation of smoking or chewing nicotine containing products is described. The delivery system includes a physical constraint modulation system (PCMS.TM.) containing lobeline. The drug delivery system is capable of delivering lobeline to an individual in a controlled, sustained release manner and providing long-term therapeutic levels of lobeline to the individual. The delivery of lobeline in such a manner reduces or eliminates the individual's smoking or chewing habit. The PCMS may be a biodegradable polymer containing the lobeline capable of subcutaneous or intramuscular injection or implantation into the individual or may be part of a transdermal patch containing lobeline. Also described are methods of using the drug delivery systems in treating other drug dependencies and kits containing the drug delivery systems.
摘要翻译： 描述了可用于治疗个体药物依赖性的药物递送系统。 该系统的一个实施方案可用于帮助个体停止吸烟或咀嚼含有尼古丁的产品。 递送系统包括包含小叶的物理约束调制系统（PCMS TM）。 药物递送系统能够以受控的，持续释放的方式向个体递送小叶，并向个体提供长期治疗水平的叶片。 以这种方式递送小叶减少或消除个体的吸烟或咀嚼习惯。 PCMS可以是包含能够皮下或肌内注射或植入个体的小叶的可生物降解的聚合物，或者可以是含有叶的透皮贴片的一部分。 还描述了使用药物递送系统来治疗其它药物依赖性的方法和含有药物递送系统的试剂盒。
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公开(公告)号：US5286490A
公开(公告)日：1994-02-15
申请号：US518905
申请日：1990-05-04
申请人： Marcus G. Grodberg
发明人： Marcus G. Grodberg
CPC分类号： A61K9/7084 , A61K33/42 , Y10S514/946 , Y10S514/947 , Y10S514/955 , Y10S514/964
摘要： A transdermal fluoride medication for providing fluoride ion for the prevention and treatment of bone loss disease, which may have an estrogen-containing substance for not only treating hormonal imbalance but to obtain more advantageous use of the fluoride ion within the body. A transdermal enhancer is present. The preferred form is a transdermal patch containing sodium monofluorophosphate and further optionally including an estrogen-containing substance and a transdermal enhancer, which is adhesively attached on the skin of the patient for slow release of fluoride ion and, optionally, estrogen to the bloodstream of the patient. Up to ten percent of sodium fluoride and/or calcium can be added.
摘要翻译： 用于提供用于预防和治疗骨丢失疾病的氟离子的透皮氟化物药物，其可以具有含雌激素的物质，用于不仅治疗激素失衡，而且可以更有利地使用体内的氟离子。 存在透皮增强剂。 优选的形式是含有单氟磷酸钠的透皮贴剂，并且进一步任选地包括含雌激素的物质和经皮增强剂，其粘附在患者皮肤上用于缓慢释放氟离子和任选的雌激素至血液中的 患者。 高达10％的氟化钠和/或钙可以加入。
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公开(公告)号：US5094856A
公开(公告)日：1992-03-10
申请号：US611339
申请日：1990-11-09
申请人： Svyatoplay N. Fyodorov , Sergey N. Bagrov , Fatyana S. Amstislavskaya , Irina A. Maklakova , Sergey V. Maslenkov
发明人： Svyatoplay N. Fyodorov , Sergey N. Bagrov , Fatyana S. Amstislavskaya , Irina A. Maklakova , Sergey V. Maslenkov
IPC分类号： A61L27/36
CPC分类号： A61L27/3604 , A61L27/3641 , A61L27/3683 , A61L2430/16 , Y10S128/08 , Y10S514/912 , Y10S514/955
摘要： Ophthalmologic collagen coverings derived from animal eyes and a process preparing such coverings comprising treatment of a fibrous tunic of an animal eye with an alkali metal hydroxide in a saturated solution of a salt of an alkali metal, followed by neutralization, dissolution in an aqueous solution of an organic acid, purification of the resulting solution of collagen by dialysis against a buffer solution while bringing the solution of collagen to a pH of 4.5 to 7.5 and drying the thus-obtained solution of collagen simultaneously with shaping spherical coverings therefrom.
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28.发明授权公开(公告)号：US08057827B2
公开(公告)日：2011-11-15
申请号：US11810075
申请日：2007-06-04
申请人： Joseph V. DiTrolio
发明人： Joseph V. DiTrolio
CPC分类号： A61K9/0024 , A61K33/14 , A61M37/0069 , Y10S514/951 , Y10S514/955 , Y10S514/966 , Y10S514/968
摘要： Novel methods for the chemical ablation of tissue (e.g. prostatic tissue) are described. These methods include the steps of: (a) providing one or more solid salt dosage forms comprising 50-100% w/w salt; and (b) inserting one or more of such solid salt dosage forms into the tissue. The solid salt dosage forms is optionally inserted into the tissue under real-time ultrasonic observation. An advantage of the present invention is its ability to eliminate toxic byproducts. For example, where NaCl-based solid salt dosage forms are used to effect localized chemical ablation, the concentration is ultimately reduced to the level of normal saline (i.e., about 0.9%) upon absorption by the body of the subject being treated.
摘要翻译： 描述了用于组织（例如前列腺组织）的化学消融的新方法。 这些方法包括以下步骤：（a）提供一种或多种包含50-100％w / w盐的固体盐剂型; 和（b）将一种或多种这样的固体盐剂型插入组织中。 在实时超声波观察下，将固体盐剂量形式任选地插入到组织中。 本发明的优点是其消除有毒副产物的能力。 例如，当使用基于NaCl的固体盐剂型来实现局部化学消融时，在被被治疗的受试者的身体吸收时，浓度最终降低到生理盐水的水平（即约0.9％）。
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29.发明授权公开(公告)号：US07662409B2
公开(公告)日：2010-02-16
申请号：US09796170
申请日：2001-02-28
申请人： David B. Masters
发明人： David B. Masters
CPC分类号： A61K9/0024 , A61K9/0085 , A61K9/7007 , A61K47/42 , A61L27/227 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/602 , A61L2300/606 , A61L2300/622 , Y10S514/95 , Y10S514/953 , Y10S514/955 , Y10S514/964 , Y10S623/915 , C08L89/00
摘要： The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin/bone/tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices. Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents. The film is then partially dried, rolled or otherwise shaped, and then compressed to form the desired protein matrix device.
摘要翻译： 本发明涉及蛋白质基质材料和装置，以及制备和使用蛋白质基质材料和装置的方法。 更具体地，本发明涉及可用于各种医学应用的蛋白质基质材料和装置，包括但不限于用于药理学活性剂的控制释放的药物递送装置，包封的或涂覆的支架装置，血管，管状移植物， 血管移植物，伤口愈合装置，包括蛋白质基质缝合材料和网眼，皮肤/骨/组织移植物，生物相容导电基质，透明蛋白质基质，蛋白质基质粘附防止屏障，细胞支架和其他生物相容性蛋白质基质装置。 此外，本发明涉及通过形成包含一种或多种可生物降解的蛋白质材料，一种或多种生物相容性溶剂和任选的一种或多种药理学活性剂的膜制备的蛋白质基质材料和装置。 然后将膜部分干燥，滚动或以其他方式成形，然后压缩以形成所需的蛋白质基质装置。
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公开(公告)号：US20070237801A1
公开(公告)日：2007-10-11
申请号：US11810075
申请日：2007-06-04
申请人： Joseph DiTrolio
发明人： Joseph DiTrolio
CPC分类号： A61K9/0024 , A61K33/14 , A61M37/0069 , Y10S514/951 , Y10S514/955 , Y10S514/966 , Y10S514/968
摘要： Novel methods for the chemical ablation of tissue (e.g. prostatic tissue) are described. These methods include the steps of: (a) providing one or more solid salt dosage form comprising 50-100% w/w salt; and (b) inserting one or more of such solid salt dosage forms into the tissue. The solid salt dosage form is optionally inserted into the tissue under real-time ultrasonic observation. An advantage of the present invention is its ability to eliminate toxic byproducts. For example, where NaCl-based solid salt dosage forms are used to effect localized chemical ablation, the concentration is ultimately reduced to the level of normal saline (i.e., about 0.9%) upon absorption by the body of the subject being treated.
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