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28 条记录 (耗时 0.024 秒)

    Substituted cyclic amidine derivatives as inhibitors of cell adhesion
    21.
    发明申请
    Substituted cyclic amidine derivatives as inhibitors of cell adhesion 失效
    取代的环脒衍生物作为细胞粘附的抑制剂

    公开(公告)号：US20020010199A1

    公开(公告)日：2002-01-24

    申请号：US09862194

    申请日：2001-05-21

    发明人： William K. Hagmann ,  George A. Doherty ,  Shrenik Shah

    IPC分类号： C07D211/72 ,  C07D27/14 ,  A61K031/4402 ,  A61K031/40

    CPC分类号： C07D211/72

    摘要： Compounds of Formula I are antagonists of VLA-4 and/or null4null7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of AIDS-related dementia, allergic conjunctivitis, allergic rhinitis, Alzheimer's disease, asthma, atherosclerosis, autologous bone marrow transplantation, certain types of toxic and immune-based nephritis, contact dermal hypersensitivity, inflammatory bowel disease including ulcerative colitis and Crohn's disease, inflammatory lung diseases, inflammatory sequelae of viral infections, meningitis, multiple sclerosis, multiple myeloma, myocarditis, organ transplantation, psoriasis, pulmonary fibrosis, restenosis, retinitis, rheumatoid arthritis, septic arthritis, stroke, tumor metastasis, uveititis, and type I diabetes.

    摘要翻译： 式I的化合物是VLA-4和/或α4β7的拮抗剂，因此可用于抑制或预防细胞粘附和细胞粘附介导的病理学。 这些化合物可以配制成药物组合物，适用于治疗AIDS相关的痴呆，过敏性结膜炎，过敏性鼻炎，阿尔茨海默病，哮喘，动脉粥样硬化，自体骨髓移植，某些类型的毒性和免疫性肾炎， 接触皮肤过敏，包括溃疡性结肠炎和克罗恩病的炎性肠病，炎症性肺病，病毒感染的炎症后遗症，脑膜炎，多发性硬化，多发性骨髓瘤，心肌炎，器官移植，牛皮癣，肺纤维化，再狭窄，视网膜炎，类风湿性关节炎，败血症 关节炎，中风，肿瘤转移，葡萄膜炎和I型糖尿病。

    Substituted-4-anilino pyrrolines
    25.
    发明授权
    Substituted-4-anilino pyrrolines 失效
    取代的4-苯胺基吡咯烷酮

    公开(公告)号：US3687973A

    公开(公告)日：1972-08-29

    申请号：US3687973D

    申请日：1969-10-30

    申请人： SANDOZ AG

    发明人： COOKE GEORGE A ,  GRIOT RUDOLF G

    IPC分类号： C07D207/22 ,  C07D27/14

    CPC分类号： C07D207/22 ,  Y10S514/96

    摘要： Substituted 4-anilino pyrrolines, e.g., 1-acetyl-4-(pnitroanilino) 3-pyrroline-3-carboxylic acid ethyl ester, are prepared by treating corresponding 4-oxo-pyrrolines with an appropriate aniline. The compounds are useful as central nervous system depressants.

    摘要翻译： 通过用合适的苯胺处理相应的4-氧代 - 吡咯烷来制备取代的4-苯胺基吡咯烷，例如1-乙酰基-4-（对硝基苯胺基）-3-吡咯啉-3-羧酸乙酯。 该化合物可用作中枢神经系统抑制剂。