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公开(公告)号：US11318169B2
公开(公告)日：2022-05-03
申请号：US16421191
申请日：2019-05-23
申请人： TissueTech, Inc.
发明人： Scheffer Tseng , Ek Kia Tan , Hua He
摘要： Compositions and preparations of fetal support tissue that prevent or reduce the proliferation and epithelial-mesenchymal transition (EMT) of epithelial cells, wherein the epithelial cells may be human epithelial cells and the human epithelial cells may be conjunctival, retinal, corneal, limbal, or renal epithelial cells. Methods of preventing or reducing the proliferation, cell migration, and EMT of epithelial cells in an individual in need thereof, wherein the epithelial cells may be human epithelial cells and the human epithelial cells may be conjunctival, retinal, corneal, limbal, or renal epithelial cells. Methods of preventing or treating proliferative vitreoretinopathy in an individual in need thereof.
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公开(公告)号：US20220118026A1
公开(公告)日：2022-04-21
申请号：US17556380
申请日：2021-12-20
IPC分类号： A61K35/50 , A61K35/545 , A61K38/13 , A61K45/06 , C12N5/074 , A61K31/4353 , A61K31/436 , A61K31/485 , A61K31/52 , A61K31/661 , A61K35/12 , A61K35/28 , A61K35/30 , A61K35/407 , A61K35/44 , A61K35/48 , A61K35/51
摘要： The invention relates to the treatment of various injuries, disorders, dysfunctions, diseases, and the like of the brain with MAPCs, particularly in some aspects, to the treatment of the same resulting from hypoxia, including that caused by systemic hypoxia and that caused by insufficient blood supply. In some further particulars the invention relates, for example, to the treatment of hypoxic ischemic brain injury with MPACs, in children, for example, and to the treatment of cortical infarcts and stroke with MAPCs in adults, for example.
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公开(公告)号：US20220080080A1
公开(公告)日：2022-03-17
申请号：US17486638
申请日：2021-09-27
申请人： StimLabs LLC
发明人： John Daniel , Sarah Griffiths , Annelise Mowry Roy
摘要： Compositions comprising translucent, dehydrated placental tissue and methods of preparing and using those tissues are provided. Repeated dehydration techniques may produce translucent, dehydrated placental tissues, including translucent, dehydrated placental membrane and umbilical cord, with improved visualization and/or handling characteristics. The present invention also includes methods of healing a wound of the skin, eye, nerve, tendon, muscle, dental region, or dura, including burns, comprising applying the translucent, dehydrated placental tissues of the invention to the wound.
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公开(公告)号：US11261426B2
公开(公告)日：2022-03-01
申请号：US15189215
申请日：2016-06-22
摘要： Objects of the present invention are to provide a method for directly obtaining pluripotent stem cells which do not have tumorigenic property from body tissue and the thus obtained pluripotent stem cells. The present invention relates to SSEA-3 (+) pluripotent stem cells that can be isolated from body tissue.
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公开(公告)号：US11241454B2
公开(公告)日：2022-02-08
申请号：US15592375
申请日：2017-05-11
发明人： Louis M. Pelus , Jonathan Hoggatt , Pratibha Singh
IPC分类号： A61K48/00 , C12N5/00 , C12N5/071 , A61K35/14 , A61K31/00 , C12N5/0789 , A61K31/395 , A61K31/405 , A61K31/5415 , A61K35/28 , A61K35/50 , A61K35/51 , A61K38/19 , C12N9/02 , A61K31/4035 , A61K31/4196 , C12N5/16 , C12N15/63 , C12N15/86 , A61K35/12
摘要： This disclosure is directed to the methods of enhancing hematopoietic stem cells (HSPC) and progenitor cell (HSPC) engraftment procedure. Treatment in vivo of a HSPC donor with compounds that reduce PGE2 biosynthesis or PGE2 receptor antagonists alone, or in combination with other hematopoietic mobilization agents such as AMD3100 and G-CSF, increases the circulation of available HSPCs. Compounds that reduce the cellular synthesis of PGE2 include non-steroidal anti-inflammatory compounds such as indomethacin. Treatment ex vivo of HSPC with an effective amount of PGE2 or at least one of its derivatives such as 16,16-dimethyl prostaglandin E2 (dmPGE2), promotes HSPC engraftment. Similar methods may also be used to increase viral-mediated gene transduction efficacy into HSPC.
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公开(公告)号：US20220031761A1
公开(公告)日：2022-02-03
申请号：US17275946
申请日：2019-09-11
申请人： Harry Thomas Temple , Wendy Weston
发明人： Harry Thomas Temple , Wendy Weston
IPC分类号： A61K35/50 , A61K38/18 , A61K36/886 , A61K31/4166 , A61P31/04 , A61P31/02
摘要： Compositions for promoting skin regeneration, skin rejuvenation, and wound healing that include tissues derived from the human placenta, such as the amniotic membrane, chorionic membrane, and umbilical cord. The placental tissues can be combined or compounded with aloe or allantoin or both to form topical treatment creams. Additionally, these compositions have therapeutic and cosmetic uses.
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公开(公告)号：US20220030851A1
公开(公告)日：2022-02-03
申请号：US17494690
申请日：2021-10-05
摘要： The invention is directed to methods of modulating ischemic injury in tissues and organs, including donor tissue and organs and intact tissue and organs. The invention is further directed to methods of increasing time to ischemic injury in such tissues and organs. The invention is further directed to storing and preserving donor tissues and organs. Such methods utilize compositions comprising Amnion-derived Cellular Cytokine Solution (herein referred to as ACCS). The ACCS compositions may be formulated for sustained-release, targeted-release, timed-release, extended-release, etc. and may be used alone or in combination with various suitable active agents.
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公开(公告)号：US20220016179A1
公开(公告)日：2022-01-20
申请号：US17186278
申请日：2021-02-26
IPC分类号： A61K35/50 , C12N5/00 , A61L27/36 , A61L27/34 , A61L27/48 , A61L27/52 , A61L15/40 , A61L26/00 , A61K47/36 , A61K47/42
摘要： The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta. In certain embodiments, the composition comprises amniotic membrane powder or solubilized amniotic membrane (SAM). In some aspects, the composition is cell-free and rich in cytokines, extracellular matrix proteins, and other components that improve tissue regeneration. In one aspect, the composition is a hydrogel scaffold that comprises amniotic membrane. The present invention reduces contraction and improves blood vessel development in regenerating tissue.
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公开(公告)号：US11224616B1
公开(公告)日：2022-01-18
申请号：US16007246
申请日：2018-06-13
申请人： BioDlogics LLC
发明人： Timothy R. Brahm
摘要： A wound or tissue healing composition and related treatment methods are provided. The wound or tissue healing composition includes an effective amount of a platelet-rich plasma aseptically recovered from umbilical cord and an effective amount of a human birth tissue material composition.
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公开(公告)号：US11179422B2
公开(公告)日：2021-11-23
申请号：US11315969
申请日：2005-12-22
申请人： Laura Brown , Sridevi Dhanaraj , Agnieszka Seyda
发明人： Laura Brown , Sridevi Dhanaraj , Agnieszka Seyda
IPC分类号： A61K48/00 , A61K35/51 , C12N5/074 , C12N5/073 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/27 , C12N5/0735 , A61K35/50 , A61K35/12
摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products such as lysates related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions such as osteoarthritis.
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