公开(公告)号：US20200347087A1

公开(公告)日：2020-11-05

申请号：US16724654

申请日：2019-12-23

Applicant: President and Fellows of Harvard College

Inventor： Andrew G. Myers ,  Ziyang Zhang

IPC: C07H15/12 ,  C07H17/02 ,  C07H11/02 ,  C07H15/18 ,  C07C201/12 ,  C07C201/14 ,  C07H1/00

Abstract: The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A′) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D′) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.

公开(公告)号：US20200239404A1

公开(公告)日：2020-07-30

申请号：US16844077

申请日：2020-04-09

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE NANTES ,  UNIVERSITE D'ANGERS ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALT

Inventor： François GUERARD ,  Jean-François GESTIN ,  Martin W. BRECHBIEL ,  Yong-Sok LEE

IPC: C07C201/12 ,  C07C253/30 ,  C07D207/46 ,  C07C247/16 ,  C07C247/10 ,  C07B59/00 ,  C07C41/18 ,  C07C67/307 ,  C07C33/46 ,  C07C29/58 ,  C07C29/10 ,  C07C29/62 ,  C07C43/225 ,  C07C17/361 ,  C07C25/24

Abstract: The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and diaryliodonium compound as such. The invention also concerns a method of synthesizing a iodo- or astatolabelled biomolecule and/or vector using said iodo- or astatoarene.

公开(公告)号：US20200239390A1

公开(公告)日：2020-07-30

申请号：US16847193

申请日：2020-04-13

Applicant: DOW GLOBAL TECHNOLOGIES LLC ,  REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Melanie S. SANFORD ,  Douglas BLAND ,  Patrick S. HANLEY ,  Megan A. CISMESIA ,  Sydonie D. SCHIMLER

IPC: C07C17/02 ,  C07C317/14 ,  C07C25/13 ,  C07D215/18 ,  C07D209/88 ,  C07C253/30 ,  C07D279/16 ,  C07J21/00 ,  C07D213/75 ,  C07C67/307 ,  C07C201/12 ,  C07D213/57 ,  C07C45/63 ,  C07C41/22 ,  C07C231/12 ,  C07D213/61 ,  C07D213/79 ,  C07D209/08 ,  C07C17/093 ,  C07D311/16 ,  C07D453/02

Abstract: Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species.Also disclosed is a fluorination method comprising providing , a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species.Further disclosed a fluorination method comprising providing a compound having the structure Ar-OH to a reaction mixture; where Ar is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar-OH to provide a fluorinated aryl species having the structure Ar-F.

公开(公告)号：US10703708B2

公开(公告)日：2020-07-07

申请号：US15777828

申请日：2016-11-24

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE NANTES ,  UNIVERSITE D'ANGERS ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： François Guerard ,  Jean-François Gestin ,  Martin W. Brechbiel ,  Yong-Sok Lee

IPC: C07C201/12 ,  C07C67/307 ,  C07C41/18 ,  C07B59/00 ,  C07C247/10 ,  C07C247/16 ,  C07D207/46 ,  C07C253/30 ,  C07C25/24 ,  C07C17/361 ,  C07C43/225 ,  C07C29/62 ,  C07C29/10 ,  C07C29/58 ,  C07C33/46

Abstract: The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and diaryliodonium compound as such. The invention also concerns a method of synthesizing a iodo- or astatolabelled biomolecule and/or vector using said iodo- or astatoarene.

公开(公告)号：US10689325B2

公开(公告)日：2020-06-23

申请号：US16415612

申请日：2019-05-17

Applicant: Genentech, Inc.

Inventor： Stephan Bachmann ,  Serena Maria Fantasia ,  Michael Jansen ,  Stefan Koenig ,  Xin Linghu ,  Sebastian Rieth ,  Nathaniel L. Segraves ,  Andreas Zogg

IPC: C07D498/22 ,  C07C213/00 ,  C07C201/12 ,  C07C213/02 ,  C07K16/12 ,  C07D498/04 ,  A61K47/68 ,  C07D498/18 ,  A61K39/00

Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.

公开(公告)号：US10550056B2

公开(公告)日：2020-02-04

申请号：US15558978

申请日：2016-03-18

Applicant: Board of Regents of the Nevada System of Higher Education, on Behalf of the University of Nevada, Reno

Inventor： Wesley A. Chalifoux ,  Kyle C. Sproul ,  Wenlong Yang

IPC: C07C43/205 ,  C07C22/08 ,  C07C25/24 ,  C07C15/38 ,  C07C201/12 ,  C07C205/06 ,  C07C209/68 ,  C07C211/50 ,  C07C5/09 ,  C07C17/354 ,  C07C25/22 ,  C07C41/20 ,  C07C303/30 ,  C07C309/68 ,  C07D333/08 ,  C07F7/08 ,  C08G61/10

Abstract: Disclosed herein are embodiments of aryl compounds and polymers thereof that are made using methods that do not require harsh conditions or expensive reagents. The methods disclosed herein utilize precursor compounds that can be polymerized to form polycyclic aromatic hydrocarbons and polymers, such as carbon-based polymers like nanostructures (e.g., graphene or graphene-like nanoribbons).

公开(公告)号：US20190315768A1

公开(公告)日：2019-10-17

申请号：US16451509

申请日：2019-06-25

Applicant: Angus Chemical Company

Inventor： Daniel M. Trauth ,  George D. Green ,  Raymond J. Swedo ,  Richard L. James ,  Ian A. Tomlinson

IPC: C07D498/10 ,  C07D498/04 ,  A01N43/90 ,  C07C201/08 ,  C07C201/12 ,  C07C205/02 ,  C07C215/28 ,  C07C205/04 ,  C07C205/05 ,  C07C205/15 ,  C07C205/16 ,  C07C215/20 ,  C08G18/32 ,  A01N43/76 ,  C07D263/52 ,  C07D263/04 ,  C07C239/10 ,  C07C215/42 ,  C07C215/08 ,  C07C205/18 ,  C07C205/06

Abstract: Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

公开(公告)号：US20190217275A1

公开(公告)日：2019-07-18

申请号：US16249730

申请日：2019-01-16

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： Chao Wang ,  Michael J. Manto ,  Pengfei Xie

IPC: B01J23/10 ,  C01F17/00 ,  B01J23/92 ,  B01J35/00 ,  B01J38/68 ,  C07C201/12

CPC classification number: B01J23/10 ,  B01J23/92 ,  B01J35/0013 ,  B01J38/68 ,  C01F17/0043 ,  C01P2002/60 ,  C01P2002/72 ,  C01P2002/84 ,  C01P2002/85 ,  C01P2004/04 ,  C07C201/12

Abstract: Described are methods of dephosphorylation. Methods of dephosphorylation include contacting a phosphate containing substrate with one or more CeO2 nanocrystal. Also described is modifying the pH of the dephosphorylation reaction to affect the amount and rate of dephosphorylation. Further described are methods of making CeO2 nanocrystals of the present disclosure.

公开(公告)号：US10336683B2

公开(公告)日：2019-07-02

申请号：US15448894

申请日：2017-03-03

Applicant: Genentech, Inc.

Inventor： Stephan Bachmann ,  Serena Maria Fantasia ,  Michael Jansen ,  Stefan Koenig ,  Xin Linghu ,  Sebastian Rieth ,  Nathaniel L. Segraves ,  Andreas Zogg

IPC: C07D498/22 ,  C07C213/00 ,  C07D498/18 ,  C07K16/12 ,  C07C201/12 ,  C07C213/02 ,  C07D498/04 ,  A61K47/68 ,  A61K39/00

Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.

公开(公告)号：US10294201B2

公开(公告)日：2019-05-21

申请号：US15895685

申请日：2018-02-13

Applicant: Dermira, Inc.

Inventor： Anthony Adrian Shaw ,  Enrico Vigano ,  Renato Molteni

IPC: C07D207/12 ,  C07C309/73 ,  C07C303/22 ,  C07C201/12 ,  C07C309/30 ,  B01D9/00 ,  C07C63/24 ,  C07C67/08 ,  C07C69/608 ,  C07F11/00

Abstract: Provided herein are methods for the production of glycopyrronium tosylate and glycopyrronium tosylate compositions. Also provided herein are compositions useful in the production of glycopyrronium tosylate. Additionally provided herein are glycopyrronium tosylate compositions. Glycopyrronium tosylate is useful for the treatment of, among other conditions, hyperhidrosis.