公开(公告)号：US11912823B2

公开(公告)日：2024-02-27

申请号：US17319886

申请日：2021-05-13

Applicant: Genentech, Inc.

Inventor： Ganesh Prasadh Vissvesvaran ,  Robert David Kiss ,  Steven J. Meier ,  Inchan Kwon ,  Kara Calhoun ,  Kate Winchester ,  Amelia Adams ,  Marion Glenn ,  Stefan Koenig ,  Alan Deese

IPC: C08G65/30 ,  C12N5/00 ,  C07K16/00

CPC classification number: C08G65/30 ,  C07K16/00 ,  C12N5/0018 ,  C07K2317/14 ,  C08G2650/50 ,  C12N2500/50

Abstract: Provided herein are methods of preparing a poloxamer for use in a cell culture medium. Also provided herein are cell culture media containing the poloxamer prepared by the methods herein, as well as methods of using the media for cell culturing and polypeptide production from cells.

公开(公告)号：US11034793B2

公开(公告)日：2021-06-15

申请号：US15273155

申请日：2016-09-22

Applicant: Genentech, Inc.

Inventor： Ganesh Prasadh Vissvesvaran ,  Robert David Kiss ,  Steven J. Meier ,  Inchan Kwon ,  Kara Calhoun ,  Kate Winchester ,  Amelia Adams ,  Marion Glenn ,  Stefan Koenig ,  Alan Deese

IPC: C08G65/30 ,  C12N5/00 ,  C07K16/00

Abstract: Provided herein are methods of preparing a poloxamer for use in a cell culture medium. Also provided herein are cell culture media containing the poloxamer prepared by the methods herein, as well as methods of using the media for cell culturing and polypeptide production from cells.

公开(公告)号：US20190270695A1

公开(公告)日：2019-09-05

申请号：US16415612

申请日：2019-05-17

Applicant: Genentech, Inc.

Inventor： Stephan Bachmann ,  Serena Maria Fantasia ,  Michael Jansen ,  Stefan Koenig ,  Xin Linghu ,  Sebastian Rieth ,  Nathaniel L. Segraves ,  Andreas Zogg

IPC: C07C213/00 ,  A61K47/68 ,  C07D498/04 ,  C07D498/18 ,  C07K16/12 ,  C07C213/02 ,  C07C201/12

Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.

公开(公告)号：US10689325B2

公开(公告)日：2020-06-23

申请号：US16415612

申请日：2019-05-17

Applicant: Genentech, Inc.

Inventor： Stephan Bachmann ,  Serena Maria Fantasia ,  Michael Jansen ,  Stefan Koenig ,  Xin Linghu ,  Sebastian Rieth ,  Nathaniel L. Segraves ,  Andreas Zogg

IPC: C07D498/22 ,  C07C213/00 ,  C07C201/12 ,  C07C213/02 ,  C07K16/12 ,  C07D498/04 ,  A61K47/68 ,  C07D498/18 ,  A61K39/00

Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.

公开(公告)号：US10336683B2

公开(公告)日：2019-07-02

申请号：US15448894

申请日：2017-03-03

Applicant: Genentech, Inc.

Inventor： Stephan Bachmann ,  Serena Maria Fantasia ,  Michael Jansen ,  Stefan Koenig ,  Xin Linghu ,  Sebastian Rieth ,  Nathaniel L. Segraves ,  Andreas Zogg

IPC: C07D498/22 ,  C07C213/00 ,  C07D498/18 ,  C07K16/12 ,  C07C201/12 ,  C07C213/02 ,  C07D498/04 ,  A61K47/68 ,  A61K39/00

Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.

公开(公告)号：US20170252457A1

公开(公告)日：2017-09-07

申请号：US15448894

申请日：2017-03-03

Applicant: Genentech, Inc.

Inventor： Stephan Bachmann ,  Serena Maria Fantasia ,  Michael Jansen ,  Stefan Koenig ,  Xin Linghu ,  Sebastian Rieth ,  Nathaniel L. Segraves ,  Andreas Zogg

IPC: A61K47/48 ,  C07K16/12 ,  C07D498/18 ,  C07C213/00 ,  C07K19/00

CPC classification number: C07C213/00 ,  A61K47/6803 ,  A61K47/6835 ,  A61K2039/505 ,  C07C201/12 ,  C07C213/02 ,  C07D498/04 ,  C07D498/18 ,  C07K16/1267 ,  C07K16/1271 ,  C07K2317/77 ,  C07C205/37 ,  C07C215/78

Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.