公开(公告)号：US20230332080A1

公开(公告)日：2023-10-19

申请号：US18336338

申请日：2023-06-16

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael E. GOODWIN ,  Nephi D. JONES

IPC: C12M1/00 ,  C12M3/00 ,  C12M1/06 ,  C12M1/34 ,  B01F27/61 ,  B01F27/07 ,  B01F27/113 ,  B01F27/213 ,  B01F27/2121 ,  B01F27/231 ,  B01F33/00 ,  B01F35/513 ,  B01F35/22

CPC classification number: C12M23/14 ,  C12M23/26 ,  C12M23/48 ,  C12M23/52 ,  C12M27/02 ,  C12M27/06 ,  C12M41/00 ,  B01F27/61 ,  B01F27/071 ,  B01F27/113 ,  B01F27/213 ,  B01F27/2121 ,  B01F27/2312 ,  B01F33/86 ,  B01F35/513 ,  B01F35/2209 ,  B01F35/715

Abstract: A fluid mixing system includes a support housing having an interior surface bounding a chamber. A flexible bag is disposed within the chamber of the support housing, the flexible bag having an interior surface bounding a compartment. An impeller is disposed within the chamber of the flexible bag. A drive shaft is coupled with the impeller such that rotation of the drive shaft facilitates rotation of the impeller. A drive motor assembly is coupled with the draft shaft and is adapted to rotate the drive shaft. An adjustable arm assembly is coupled with the drive motor assembly and is adapted to move the drive motor assembly which in turn moves the position of the drive shaft and impeller. An electrical controller can control movement of the adjustable arm.

公开(公告)号：US11786874B2

公开(公告)日：2023-10-17

申请号：US16715137

申请日：2019-12-16

Applicant: Life Technologies Corporation

Inventor： Michael E. Goodwin ,  Jacob D. Lee ,  Whitt F. Woods ,  Patrick L. Draper

IPC: B01F27/88 ,  C12M1/00 ,  C12M1/06 ,  B01F23/233 ,  B01F23/231 ,  B01F27/91 ,  B01F27/213 ,  B01F27/2121 ,  B01F33/00 ,  B01F33/501 ,  B01F35/41 ,  B01F35/45 ,  B01F35/513 ,  B65B1/02 ,  B65B3/04 ,  B01F27/00 ,  B01F27/053 ,  B01F27/091

CPC classification number: B01F27/88 ,  B01F23/233 ,  B01F23/23123 ,  B01F23/23124 ,  B01F27/213 ,  B01F27/2121 ,  B01F27/91 ,  B01F33/5013 ,  B01F33/86 ,  B01F35/413 ,  B01F35/451 ,  B01F35/513 ,  B65B1/02 ,  C12M23/26 ,  C12M27/02 ,  C12M29/06 ,  B01F27/00 ,  B01F27/053 ,  B01F27/091 ,  B01F2215/0431 ,  B65B3/045

Abstract: A method for processing a fluid includes removably securing a retention member to a vessel that bounds a chamber; inserting a collapsible bag within the chamber of the vessel; securing the bag to the retention member so that the bag is supported within the chamber of the vessel; and dispensing a fluid into a compartment of the collapsible bag supported within the chamber of the vessel. The fluid can be mixed within bag while the bag is disposed within the vessel.

公开(公告)号：US20230313109A1

公开(公告)日：2023-10-05

申请号：US18014567

申请日：2021-07-05

Applicant: Merck Patent GmbH

Inventor： Jochen Bastian SIECK ,  Christian SCHULTHEISS

IPC: C12M1/00 ,  C12M1/06 ,  C12M1/34

CPC classification number: C12M29/26 ,  C12M27/02 ,  C12M41/26

Abstract: The present invention relates to a device and processes for producing liquid media for cell cultures, whereby the liquid media are produced automatically by dissolving ingredients in water. The present invention also relates to a device for producing media used in cell cultures or a substance produced by cell cultures using a bioreactor process.

公开(公告)号：US20230313106A1

公开(公告)日：2023-10-05

申请号：US17921347

申请日：2021-03-18

Applicant: Xingyue PENG

Inventor： Xingyue PENG

IPC: C12M1/06 ,  C12M3/06

CPC classification number: C12M27/02 ,  C12M23/16

Abstract: A method for constructing a slow microcyclic artificial cell niche. A cell niche (62) which is isolated from a flow field is provided in the center of the flow field and the cell niche (62) is in communication with the flow field by means of an opening (61), wherein the opening (61) faces a wake (63) formed by means of the flow field flowing around the cell niche (62).

公开(公告)号：US11773358B2

公开(公告)日：2023-10-03

申请号：US16400008

申请日：2019-04-30

Applicant: Cytiva Sweden AB

Inventor： Klaus Gebauer ,  Eva Lindskog ,  Lars Magnusson

IPC: C12M1/00 ,  C12M1/06 ,  C12M1/36

CPC classification number: C12M23/14 ,  C12M27/02 ,  C12M41/48

Abstract: A method for controlling at least one culture parameter in a bioreactor bag (1; 31 a, 31 b) provided in a bioreactor system, the method comprising the steps of:

providing bioreactor information to a control unit (5; 35) controlling the bioreactor system;
controlling the at least one culture parameter in dependence of the bioreactor information.

公开(公告)号：US20230294020A1

公开(公告)日：2023-09-21

申请号：US18202208

申请日：2023-05-25

Applicant: Hoffmann-La Roche Inc.

Inventor： Oskar BRAUNERSREUTHER ,  Alexander JOCKWER ,  Torsten KLABUHN ,  Michael POHLSCHEIDT ,  Joerg THIELE

IPC: B01D21/00 ,  C12M1/26 ,  C12M1/00 ,  C12M1/06

CPC classification number: B01D21/0042 ,  B01D21/0045 ,  C12M33/22 ,  B01D21/0057 ,  C12M47/02 ,  C12M27/02 ,  C12M27/20 ,  B01D2221/06

Abstract: Separating apparatus, comprising a sedimentation settler and a collection vessel disposed underneath and being in fluid communication with the sedimentation settler, the collection vessel forming a receiving chamber having an outlet at or adjacent to the chamber bottom and having an inlet opening, wherein the collection vessel is arranged such the flow direction of the fluid in the area underneath the sedimentation settler is substantially in line with the direction of the channels of the sedimentation settler.

公开(公告)号：US20230293388A1

公开(公告)日：2023-09-21

申请号：US18303329

申请日：2023-04-19

Applicant: ALPHINITY USA, INC.

Inventor： Michael C. Gagne

IPC: A61J1/10 ,  C12M1/00 ,  C12M3/00 ,  C12M1/06 ,  F04D1/00 ,  F04D29/40 ,  B01F27/61 ,  B01F27/71 ,  B01F27/91 ,  B01F35/513 ,  B01F35/75

CPC classification number: A61J1/10 ,  B01F27/61 ,  B01F27/71 ,  B01F27/91 ,  B01F35/513 ,  B01F35/7544 ,  C12M23/14 ,  C12M23/46 ,  C12M27/02 ,  C12M29/10 ,  F04D1/00 ,  F04D29/40 ,  A61J1/1481

Abstract: A bioprocess vessel includes a flexible bag or substantially rigid container that defines an interior volume and having a bottom surface, the bottom surface being open or containing an aperture therein for the passage of fluid. A pump is secured to the bottom surface of the flexible bag or substantially rigid container. In some embodiments is secured directly to the flexible bag or substantially rigid container. In other embodiments, the pump is secured indirectly the flexible bag or substantially rigid container using, for example, a port that extends through the aperture on the bottom surface. The port or flanged surface may also be integrated into the pump, which is secured to the vessel. An optional mixing adaptor may be provided inside the interior volume of the flexible bag or substantially rigid container and at least partially covers the inlet that leads to the pump.

公开(公告)号：US11746317B2

公开(公告)日：2023-09-05

申请号：US17984151

申请日：2022-11-09

Applicant: VANDERBILT UNIVERSITY

Inventor： Ronald S. Reiserer ,  Gregory B. Gerken ,  David K. Schaffer ,  John P. Wikswo

IPC: C12M1/00 ,  C12M1/24 ,  C12M1/22 ,  C12M3/06 ,  C12M3/04 ,  C12M1/36 ,  C12M1/42 ,  C12M1/32 ,  C12M1/06 ,  F16K99/00

CPC classification number: C12M29/10 ,  C12M23/08 ,  C12M23/10 ,  C12M23/12 ,  C12M23/16 ,  C12M23/50 ,  C12M23/58 ,  C12M27/02 ,  C12M27/12 ,  C12M35/02 ,  C12M35/04 ,  C12M41/48 ,  F16K99/0013 ,  F16K99/0015 ,  F16K99/0023 ,  F16K99/0028

Abstract: A fluidic cartridge comprises a fluidic disk having a plurality of alignment openings; a fluidic chip comprising a body, one or more channels formed in the body in fluidic communications with input ports and output ports for transferring one or more fluids between the input ports and the output ports, and a plurality of protrusions formed on the body and received in the alignment openings of the fluidic disk for aligning the fluidic chip to the fluidic disk; an actuator operably engaging with the one or more channels for selectively and individually transferring the one or more fluids through the one or more channels from at least one of the input ports to at least one of the output ports at desired flow rates; and a tube member defining a cylindrical housing for accommodating the fluidic disk, the fluidic chip and the actuator therein.

公开(公告)号：US20230272494A1

公开(公告)日：2023-08-31

申请号：US18312218

申请日：2023-05-04

Applicant: Fluid Quip Technologies, LLC

Inventor： Neal Jakel ,  Albert Pollmeier

IPC: C13K1/08 ,  B01D61/14 ,  C07K1/14 ,  C11B3/00 ,  C12M1/00 ,  C12P7/06 ,  C12P7/16 ,  C12P19/02 ,  C12M1/06 ,  C12P7/649 ,  C13K1/06 ,  C12P19/14 ,  A23L7/104 ,  A23L29/30

CPC classification number: C13K1/08 ,  B01D61/145 ,  B01D61/147 ,  C07K1/14 ,  C11B3/00 ,  C12M21/12 ,  C12M29/04 ,  C12P7/06 ,  C12P7/16 ,  C12P19/02 ,  C12M27/02 ,  C12P7/649 ,  C13K1/06 ,  C12P19/14 ,  A23L7/104 ,  A23L29/35 ,  B01D61/146

Abstract: An improved dry grind system and method for producing a sugar stream from grains or similar carbohydrate sources and/or residues, such as for biofuel production, using membrane filtration. In particular, a sugar/carbohydrate stream, which includes a desired Dextrose Equivalent (DE) where DE describes the degree of conversion of starch to dextrose (aka glucose) and/or has had removed therefrom an undesirable amount of unfermentable components, can be produced after saccharification and prior to fermentation (or other sugar conversion process) using membrane filtration, with such sugar stream being available for biofuel production, e.g., alcohol production, or other processes. In addition, the systems and methods also can involve the removal of certain grain components, e.g., corn kernel components, including protein, oil and/or fiber, prior to fermentation or other conversion systems. In other words, sugar stream production and/or grain component separation occurs on the front end of the system and method.

公开(公告)号：US20230265376A1

公开(公告)日：2023-08-24

申请号：US18140181

申请日：2023-04-27

Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC

Inventor： COLIN R. TUOHEY

IPC: C12M1/00 ,  C12M1/06

CPC classification number: C12M23/14 ,  C12M27/02 ,  C12M29/26

Abstract: A flexible bioprocess bag comprising a number of flexible panels which are sealed to each other such that when the bag is filled they form at least a bottom of the bag and a side surface of the bag, wherein one of the flexible panels is called a bottom panel and when the bag is filled said bottom panel will constitute the bottom of the bag and parts of the side surface of the bag, said parts of the side surface being bent side parts of the bottom panel.