公开(公告)号：US06805170B2

公开(公告)日：2004-10-19

申请号：US10694364

申请日：2003-10-27

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B304

CPC classification number: A61L2/081 ,  A61J1/1468 ,  A61J1/18 ,  A61L2202/121 ,  A61M2207/00 ,  B65B3/003 ,  B65D39/007 ,  B65D51/002

Abstract: A resealable cap for a medicament vial has a base portion formed of vulcanized rubber or like material known for providing a stable environment for the medicament contained within the vial, and a resealable portion overlying the base portion. The resealable portion is made of low-density polyethylene or like material, and can be punctured by a needle or like injection member for dispensing medicament into the vial. Prior to filling, the cap is assembled to the vial and the cap/vial assembly is sterilized. Then, a needle is inserted through the cap and medicament is introduced through the needle and into the vial. Upon withdrawal of the needle, the penetrated region of the cap is fused by laser or direct heat sealing to hermetically seal the needle hole in the cap.

Abstract translation: 用于药物小瓶的可重新密封的帽具有由硫化橡胶或类似材料形成的基部，其已知用于为容纳在小瓶内的药物提供稳定的环境，以及覆盖在基部上的可再密封部分。 可再密封部分由低密度聚乙烯或类似材料制成，并且可以用针或类似的注射构件刺穿以将药物分配到小瓶中。 在填充之前，将帽组装到小瓶中，并且帽/瓶组件被灭菌。 然后，将针插入帽中，并将药物通过针引入到小瓶中。 在取出针时，通过激光或直接热密封将盖的穿透区域熔合以密封盖中的针孔。

公开(公告)号：US06761286B2

公开(公告)日：2004-07-13

申请号：US10001745

申请日：2001-10-23

Applicant: Daniel Py ,  Joseph M. Ting

Inventor： Daniel Py ,  Joseph M. Ting

IPC: B65D3556

CPC classification number: B65D83/0055 ,  A61F9/0008 ,  B05B11/00412 ,  B05B11/0072 ,  B05B11/0097 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3092 ,  B05B11/3094 ,  B65D81/245

Abstract: A dispenser for dispensing a fluid includes a rigid vial that has a main fluid chamber containing a fluid, and a pump assembly that is in fluid communication with the main fluid chamber and is configured to dispense a predetermined quantity of fluid from the main fluid chamber. A flexible bladder is provided which is located within the main fluid chamber and is configured to expand to fill the ullage created within the main fluid chamber during dispensing of fluid by the pump assembly. The resilient bladder tends to force itself outwardly toward the rigid vial and, in turn, increases the pressure within the main fluid chamber in comparison to the interior of the bladder to thereby prevent the ingress of air or vapors through the bladder or otherwise into the main fluid chamber.

公开(公告)号：US06685109B2

公开(公告)日：2004-02-03

申请号：US09962949

申请日：2001-09-24

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B05B134

CPC classification number: B05B11/0067 ,  B05B1/3436 ,  B05B11/00412 ,  B05B11/007 ,  B05B11/0072 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3094

Abstract: An aerosol tip mechanism for an aerosol-type dispenser for dispensing liquid content has a flexible outer shell, a rigid cap portion composed of lower and upper portions, and a rigid nozzle portion having a rigid shaft received within the outlet portion of the flexible outer shell. The rigid shaft interfaces the outlet portion of the outer shell, forming a first normally-closed one-way valve. The lower and upper portions of the rigid cap portion form boots adapted to receive an outlet portion of the flexible outer shell, the boots thereby constraining a lateral motion of the outlet portion of the outer shell, and symmetrically centering the outlet portion around the rigid shaft of the nozzle. The rigid nozzle portion includes a plurality of liquid channels for delivering liquid from a reservoir to a swirling chamber defined within the rigid cap portion, which liquid channels are configured to minimize energy losses of the liquid and promote a more homogeneous fluid particle size in the dispensed aerosol. The aerosol tip mechanism provides for long-term sterility of the stored fluid, which in turn allows for preservation of the sterility of non-chemically preserved formulations, which may be in the form of suspension or liquid gels.

公开(公告)号：US5944702A

公开(公告)日：1999-08-31

申请号：US927873

申请日：1997-09-11

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61M11/00 ,  A61F9/00 ,  A61J1/05 ,  A61M35/00 ,  B05B11/00

CPC classification number: B05B11/307 ,  A61F9/0008 ,  A61M35/003 ,  B05B11/0072 ,  B05B11/3001 ,  B05B11/3074 ,  B05B11/3095

Abstract: An apparatus is used to apply medicament to an eye and stores the medicament in a medicament chamber. A nozzle is coupled in fluid communication with the medicament chamber and is formed by an outer nozzle portion and an inner nozzle portion received within the outer nozzle portion. A seam is formed by the interface of the inner nozzle portion and the outer nozzle portion and is normally in a closed position to prevent the passage of medicament through the nozzle. The seam opens in response to the flow of medicament of sufficient pressure into the seam to permit the passage of medicament through the nozzle for release into the eye.

Abstract translation: 使用一种装置将药物施用于眼睛并将药物储存在药物室中。 喷嘴与药物室流体连通地连接并由外部喷嘴部分和容纳在外部喷嘴部分内部的内部喷嘴部分形成。 接缝由内部喷嘴部分和外部喷嘴部分的界面形成，并且通常处于关闭位置以防止药物通过喷嘴。 响应于足够压力的药物流进入接缝以使药物通过喷嘴以释放到眼睛中，接缝开口。

公开(公告)号：US5855322A

公开(公告)日：1999-01-05

申请号：US927221

申请日：1997-09-10

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D83/14 ,  A61M11/00 ,  B05B1/34 ,  B05B11/00 ,  B05B17/04

CPC classification number: B05B11/007 ,  B05B1/341 ,  B05B1/3436 ,  B05B11/0072 ,  B05B11/0075

Abstract: A nozzle mechanism for generating an aerosol-type liquid discharge is provided, which nozzle mechanism ensures one-way movement of liquid during discharge and also has a substantially zero "dead volume" at the tip of the nozzle. The nozzle mechanism includes a flexible nozzle portion with an outlet and a fluid channel, a rigid shaft received within the flexible nozzle portion, and a rigid housing surrounding the flexible nozzle portion and exposing the outlet. The rigid shaft interfaces the outlet to form a first normally-closed, one-way valve, as well as to define a swirling chamber for collecting the liquid which has been channeled from the liquid reservoir, prior to being discharged via the outlet. The outlet has a tubular wall with thickness that decreases along the elongated axis of symmetry for the outlet toward the tip of the outlet. The fluid channel is circumferentially positioned within the flexible nozzle portion to create swirling action of the liquid delivered to the swirling chamber. Once the pressure on the swirling liquid reaches a threshold pressure sufficient to radially deform the portion of the outlet forming the first normally-closed valve, the liquid in the swirling chamber is discharged through the outlet. The nozzle mechanism is coupled to a flexible body portion which has a substantially tubular shape and a wall thickness which decreases from the bottom of the body portion toward the flexible nozzle portion. The rigid shaft received within the flexible nozzle portions extends down into the flexible body portion so that a second portion of the rigid shaft interfaces the flexible body portion to form a second normally-closed, one-way valve in the fluid communication path between the liquid reservoir and the swirling chamber.

Abstract translation: 提供了一种用于产生气溶胶型液体排出口的喷嘴机构，该喷嘴机构确保了排出期间液体的单向移动，并且在喷嘴的尖端处也具有基本为零的“死体积”。 喷嘴机构包括具有出口和流体通道的柔性喷嘴部分，容纳在柔性喷嘴部分内的刚性轴以及围绕柔性喷嘴部分并暴露出口的刚性壳体。 刚性轴将出口接合以形成第一常闭单向阀，并且在通过出口排出之前，限定用于收集已经从液体储存器引导的液体的旋转室。 出口具有管状壁，其厚度沿着用于出口朝向出口的尖端的细长对称轴线减小。 流体通道周向地定位在柔性喷嘴部分内，以产生输送到旋转室的液体的旋动作用。 一旦旋转液体上的压力达到足以使形成第一常闭阀的出口的部分径向变形的阈值压力，则旋转室中的液体通过出口排出。 喷嘴机构联接到柔性主体部分，其具有基本上管状的形状和从主体部分的底部向柔性喷嘴部分减小的壁厚。 容纳在柔性喷嘴部分内的刚性轴向下延伸到柔性主体部分中，使得刚性轴的第二部分接合柔性主体部分，以在液体之间的流体连通路径中形成第二常闭单向阀 水库和旋转室。

公开(公告)号：USD368774S

公开(公告)日：1996-04-09

申请号：US29948

申请日：1994-10-19

Applicant: Daniel Py

Designer： Daniel Py

公开(公告)号：US5133702A

公开(公告)日：1992-07-28

申请号：US635300

申请日：1990-12-28

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61F9/00 ,  B05B11/00

CPC classification number: A61F9/0026 ,  A61F9/0008 ,  B05B11/307

Abstract: An apparatus for applying medicament to an eye has an inner casing and an outer casing coupled to the inner casing and moveable relative thereto. An eyecup is supported on one end of the inner casing. The eyecup defines a surface shaped to conformably engage the facial tissue surrounding an eye. An ocular vial supported with the inner casing. The ocular vial holds medicament for release into an eye. An eyelid displacing member is coupled to the outer casing and slideably mounted through the inner casing. The eyelid displacing member includes a depresser tab adapted to engage the facial tissue below an eye. The depresser tab engages the facial tissue upon moving the outer casing toward the inner casing, thus displacing the lower eyelid to expose the ocular cul-de-sac. A dispensing member is supported by the outer casing. The dispensing member is adapted to actuate the ocular vial upon moving the outer casing toward the inner casing, to release medicament onto the exposed ocular cul-de-sac of the eye.

Abstract translation: 将药物施用于眼睛的装置具有内壳和外壳，所述内壳和外壳联接到所述内壳并且可相对于所述内壳移动。 内壳的一端支撑着眼罩。 眼罩定义了一个表面，其形状适合地与眼睛周围的面部组织接合。 用内壳支撑的眼部小瓶。 眼小瓶保持用于释放到眼睛中的药物。 眼睑移位构件联接到外壳并且可滑动地安装穿过内壳。 眼睑移位构件包括适于接合眼睛下方的面部组织的按压片。 当将外壳移动到内壳时，按压片接合面巾纸，从而使下眼皮移位以露出眼部凹陷。 分配构件由外壳支撑。 分配构件适于在将外壳移向内壳时致动眼小瓶，以将药剂释放到眼睛的暴露的眼睛凹陷上。

公开(公告)号：US5085651A

公开(公告)日：1992-02-04

申请号：US322761

申请日：1989-03-13

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61F9/00 ,  A61J1/00 ,  A61J1/20 ,  A61M11/00 ,  B65D25/08 ,  B65D81/32

CPC classification number: A61J1/2093 ,  A61F9/0008 ,  A61M11/00 ,  B65D25/08 ,  B65D81/3222 ,  A61J1/2027

Abstract: An ocular treatment apparatus for applying medicament into an eye has a vial defining a vial cavity for holding medicament. A nozzle is attached over an opening in the vial and is in fluid communication with the vial cavity for releasing drops of medicament. A piston member is suspended within the vial and slideably engaged within the vial cavity for displacing a substantially predetermined volume of medicament through the nozzle for release into the eye.

公开(公告)号：US4792334A

公开(公告)日：1988-12-20

申请号：US118388

申请日：1987-11-06

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61J1/05 ,  A61F9/00 ,  A61H33/04

CPC classification number: A61F9/0026

Abstract: An occular treatment apparatus for applying liquid medicament from a reservoir is provided. The apparatus includes a tubular housing with a first open end adapted to conform to the shape of the facial area surrounding the eye socket. The housing is constructed and arranged to receive, hold and position a reservoir containing the liquid medicament. A sighting opening is included on the housing to properly orient the eye and distract the user from the drops of liquid medicament to be introduced into the eye. An eyelid displacement mechanism is supported on the first open end of the housing at a position diametrically opposed to the sighting opening. The displacement mechanism is adapted to evert the lower eyelid and expose the cul de sac. This combination of an eye focused at the sighting hole and an everted lower eyelid exposes the cul de sac so that drops of medicament dispensed into the eye will more easily and directly be applied at or near the cul de sac where it is temporarily retained to increase the length of time the medicament will medicate the eyeball. In a further embodiment of the instant invention, the lower eyelid displacement mechanism will simultaneously cause drops of to be emitted from the reservoir as the cul de sac is everted to facilitate application of the drops of liquid medicament.

Abstract translation: 提供了一种用于从储存器施加液体药物的眼部治疗装置。 该装置包括管状壳体，其具有适于与围绕眼窝的面部区域的形状一致的第一开口端。 壳体被构造和布置成容纳，保持和定位包含液体药物的贮存器。 外壳上包含瞄准开口以适当地定向眼睛，并将使用者从用于引入眼睛的液体药剂滴分散。 眼皮置换机构在与瞄准开口直径相对的位置处支撑在壳体的第一开口端上。 移位机构适用于翻转下眼睑并露出骰子。 眼睛聚焦在瞄准孔和旋转的下眼睑上的这种组合暴露出死角，使得分配到眼睛中的药剂滴更容易并且直接地应用于临时保持的肠道或附近，以增加 药物将对眼球进行治疗的时间长短。 在本发明的另一个实施例中，下眼睑排出机构将同时导致由于肠胃脱出而从贮存器发射的液滴，以便于液滴药液的使用。

公开(公告)号：US10040619B2

公开(公告)日：2018-08-07

申请号：US13419352

申请日：2012-03-13

Applicant: Daniel Py ,  Benoit Adamo

Inventor： Daniel Py ,  Benoit Adamo

IPC: B65D37/00 ,  B65D83/00 ,  B65D47/18 ,  A61F9/00 ,  B05B11/00 ,  B05B15/50

CPC classification number: B65D83/0033 ,  A61F9/0008 ,  B05B11/0027 ,  B05B11/007 ,  B05B11/0097 ,  B05B11/3032 ,  B05B15/50 ,  B65D47/18

Abstract: A dispenser has a body with a variable-volume storage chamber for storing substance, and a dispensing portion defining a dosage chamber in fluid communication with the storage chamber. A first valve includes a valve seat and a flexible valve cover seated thereon defining a normally-closed fluid-tight seam therebetween. The valve cover relative to moves from the valve seat to allow substance through the seam and out of the dispenser. A second valve allows substance from the storage chamber into the dosage chamber and substantially prevents flow from the dosage chamber into the storage chamber. An actuator is manually movable between (i) a first non-actuated position, and (ii) a second actuated position extending into the dosage chamber for compressing a dose of substance therein, dispensing substance through the first valve. The elasticity of the actuator causes it to return to the first non-actuated position upon manually releasing the actuator.