公开(公告)号：US10851059B2

公开(公告)日：2020-12-01

申请号：US16325880

申请日：2017-08-16

Applicant: Novartis AG

Inventor： Florian Karl Kleinbeck-Riniker ,  Ives Mafli ,  Benjamin Martin ,  Gerhard Penn ,  Gottfried Sedelmeier ,  Joerg Sedelmeier ,  Francesco Venturoni

IPC: C07C271/22 ,  C07D213/16 ,  C07C201/12 ,  C07C251/38 ,  C07C201/16 ,  C07C205/53 ,  C07C249/08 ,  C07D213/36 ,  C07C205/51 ,  C07C67/347 ,  C07C231/02 ,  C07C269/00 ,  C07C201/06 ,  C07C227/18 ,  C07C45/49 ,  C07C229/06 ,  C07C249/02 ,  C07D207/267 ,  C07D207/12

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

公开(公告)号：US10675607B2

公开(公告)日：2020-06-09

申请号：US15880201

申请日：2018-01-25

Applicant: Arkema France ,  IFP Energies Nouvelles

Inventor： Catherine Laroche ,  Philibert Leflaive ,  Ludivine Bouvier ,  Serge Nicolas ,  Cecile Lutz ,  Marie-Laurence Labede

IPC: B01D53/02 ,  B01D53/08 ,  B01J20/12 ,  B01J20/18 ,  B01J20/28 ,  B01J20/30 ,  C07C15/02 ,  C07C15/08 ,  C07C201/16 ,  C07C205/06 ,  C07C209/86 ,  C07C211/50 ,  C07C29/76 ,  C07C37/82 ,  C07C39/07 ,  C07C7/13

Abstract: The present invention relates to zeolitic adsorbents based on agglomerated crystals of FAU zeolite containing barium and/or potassium, with large external surface area, combining optimum properties in terms of selectivity and mechanical strength. These adsorbents find applications in the separation of cuts of C8-aromatic isomers and notably of xylenes, in the separation of isomers of substituted toluene such as nitrotoluene, diethyltoluene, toluenediamine, in the separation of cresols, and in the separation of polyhydric alcohols such as sugars.

公开(公告)号：US10513487B2

公开(公告)日：2019-12-24

申请号：US15320807

申请日：2015-06-22

Applicant: Covestro Deutschland AG

Inventor： Thomas Knauf ,  Peter Drinda ,  Stefan Wershofen ,  Klaus-Gerd Gruner ,  Volker Hartjes

IPC: C07C201/08 ,  C07C205/06 ,  B01J19/24 ,  C07C201/16

Abstract: This invention relates to methods for producing chemical products, wherein the one or more feed materials are reacted to form a chemical product or a chemical composition. The invention further relates to plants for performing such methods, said plants being designed in such a way that, during an interruption of the methods, no input of at least one feed material into the reaction occurs and the plant parts not affected by a revision measure, maintenance measure, repair measure, or cleaning measure are operated in so-called re-circulation mode. It is thereby achieved, among other things, that only the affected plant part needs to be shut down for the time of the measure, which can be advantageous with regard to the productivity and economy of the method and the quality of the produced products. Finally, the invention relates to methods for operating plants in the event that individual plant parts are taken out of service.

公开(公告)号：US10023524B2

公开(公告)日：2018-07-17

申请号：US15320804

申请日：2015-06-22

Applicant: Covestro Deutschland AG

Inventor： Thomas Knauf ,  Peter Drinda

IPC: C07C201/08 ,  C07C201/16 ,  B01J19/24

Abstract: The present invention relates to a process for the continuous production of nitrobenzene by the nitration of benzene with nitric acid and sulphuric acid under adiabatic conditions, not the entire production plant being shut down during a production stop, but the production plant being entirely or at least partly operated in recirculation mode. The invention further relates to a plant for producing nitrobenzene and to a method for operating a plant for producing nitrobenzene.

公开(公告)号：US20180155269A1

公开(公告)日：2018-06-07

申请号：US15735014

申请日：2015-06-12

Applicant: Steven D. BUCHI ,  Alfred A. GUENKEL ,  NORAM International Limited

Inventor： Steven D. Buchi ,  Alfred A. Guenkel

IPC: C07C201/16 ,  C07C205/06 ,  C07C205/17 ,  C01C1/10 ,  C02F1/20

CPC classification number: C07C201/16 ,  C01C1/10 ,  C02F1/20 ,  C02F3/02 ,  C02F2101/345 ,  C02F2101/38 ,  C02F2103/36 ,  C07C205/06 ,  C07C205/17 ,  Y02W10/15

Abstract: A process for removing impurities from crude nitrated aromatic products obtained during the nitration of aromatic compounds. The nitrated aromatic products are purified by treatment with ammonia washing followed by caustic washing. The nitrophenolic-containing wash waters are treated to recover dissolved organics and ammonia, and the stripped ammonia-wash effluent is incinerated. Carbon dioxide, which can accumulate in the process, is purged to the caustic washer.

公开(公告)号：US09771290B2

公开(公告)日：2017-09-26

申请号：US14784443

申请日：2014-04-15

Applicant: BAYER MATERIALSCIENCE AG

Inventor： Thomas Knauf ,  Antoni Mairata ,  Erik Sluyts ,  Jan Van Tricht

IPC: C02F9/00 ,  C02F1/02 ,  C02F1/20 ,  C02F1/66 ,  C07C201/16 ,  C07C201/08 ,  C02F101/32 ,  C02F101/38 ,  C02F103/18 ,  C02F101/16 ,  C02F103/36

CPC classification number: C02F9/00 ,  C02F1/025 ,  C02F1/20 ,  C02F1/66 ,  C02F2101/16 ,  C02F2101/322 ,  C02F2101/38 ,  C02F2103/18 ,  C02F2103/36 ,  C02F2301/066 ,  C07C201/08 ,  C07C201/16 ,  C07C205/06

Abstract: The present invention provides a process for working up alkaline waste water which is formed during washing of crude nitrobenzene obtained by nitration of benzene, wherein (i) the alkaline waste water is heated to a temperature of from 150° C. to 500° C. under an increased pressure with respect to atmospheric pressure with exclusion of oxygen; (ii) a base is added to the waste water obtained in (i); and (iii) the waste water obtained in (ii) is purified further by stripping with a stripping gas and the stripping gas stream loaded with impurities is then cooled to a temperature of from 10° C. to 60° C.

公开(公告)号：US09687833B2

公开(公告)日：2017-06-27

申请号：US14777649

申请日：2014-06-03

Applicant: DEXERIALS CORPORATION

Inventor： Hiroki Kanaya ,  Mamiko Nomura

IPC: C07C201/12 ,  B01J31/00 ,  B01J31/06 ,  B01J37/00 ,  C07C205/48 ,  C07B53/00 ,  C07C201/16 ,  B01J8/02

CPC classification number: B01J31/062 ,  B01J8/02 ,  B01J31/06 ,  B01J37/00 ,  B01J2208/02 ,  C07B53/00 ,  C07B2200/07 ,  C07C201/12 ,  C07C201/16 ,  C07C205/48 ,  C07C2601/10 ,  C07C2601/14 ,  C07C205/19

Abstract: An optically active compound production method using a column reactor, a column for column reactor is charged with asymmetric catalyst particles to produce the column reactor, and reaction compound is introduced into column reactor to bring reaction compound into contact with asymmetric catalyst particles, whereby reaction compound is converted to optically active compound. Asymmetric catalyst particles are preferably resin particles that are prepared from a monomer composition containing a proline derivative monomer having unsaturated bond and radical polymerization initiator and serve as catalyst for enamine mechanism reaction. Asymmetric catalyst particles are preferably resin particles prepared by micro-channel method including injecting monomer composition into continuous phase to thereby form droplets of monomer composition in continuous phase and then heating droplets to cause proline derivative monomer having an unsaturated bond to undergo radical polymerization.

公开(公告)号：US20170174612A1

公开(公告)日：2017-06-22

申请号：US15320804

申请日：2015-06-22

Applicant: Covestro Deutschland AG

Inventor： Thomas Knauf ,  Peter Drinda

IPC: C07C201/08 ,  B01J19/24 ,  C07C201/16

CPC classification number: C07C201/08 ,  B01J19/0006 ,  B01J19/002 ,  B01J19/1881 ,  B01J19/24 ,  B01J19/2465 ,  B01J2219/00006 ,  B01J2219/0004 ,  B01J2219/00268 ,  C07C201/16 ,  C07C205/06

Abstract: The present invention relates to a process for the continuous production of nitrobenzene by the nitration of benzene with nitric acid and sulphuric acid under adiabatic conditions, not the entire production plant being shut down during a production stop, but the production plant being entirely or at least partly operated in recirculation mode. The invention further relates to a plant for producing nitrobenzene and to a method for operating a plant for producing nitrobenzene.

公开(公告)号：US09469623B2

公开(公告)日：2016-10-18

申请号：US14615972

申请日：2015-02-06

Applicant: DAIICHI SANKYO COMPANY, LIMITED

Inventor： Yoshitaka Nakamura ,  Kazutoshi Ukai ,  Takafumi Kitawaki ,  Takumi Nakajima ,  Yutaka Kitagawa ,  Yukito Furuya ,  Makoto Imai ,  Eiji Numagami ,  Masakazu Wakayama ,  Ayako Saito

IPC: C07C67/343 ,  C07C211/27 ,  C07C201/16 ,  C07C253/34 ,  C07C253/30 ,  C07C227/42 ,  C07C253/10 ,  C07D319/06 ,  C07C255/47 ,  C07C201/12 ,  C07C205/50 ,  C07C229/32 ,  C07C227/04 ,  C07C67/00 ,  C07C69/608 ,  C07C253/00

CPC classification number: C07D319/06 ,  C07B2200/07 ,  C07C67/00 ,  C07C67/343 ,  C07C69/608 ,  C07C201/12 ,  C07C201/16 ,  C07C205/50 ,  C07C211/27 ,  C07C227/04 ,  C07C227/42 ,  C07C229/32 ,  C07C253/00 ,  C07C253/10 ,  C07C253/30 ,  C07C253/34 ,  C07C255/47 ,  C07C2602/20

Abstract: An object of the present invention is to provide an optically active bicyclic γ-amino acid derivative in a high purity. The object can be attained by a mixture of compounds represented by the general formulas (I) and (I′), or a method for producing a compound represented by the general formula (VII) or a salt thereof via the compound (I): wherein R1 and R2 each represent a C1-6 alkyl group or the like; and R3 represents a cyano group or the like,

公开(公告)号：US20160060152A1

公开(公告)日：2016-03-03

申请号：US14784699

申请日：2014-04-14

Applicant: BAYER MATERIALSCIENCE AG

Inventor： Thomas Knauf ,  Antoni Mairata ,  Erik Sluyts ,  Jan Van Tricht

IPC: C02F9/00 ,  C07C209/36 ,  C07C201/16 ,  C02F1/02 ,  C02F1/20

CPC classification number: C02F9/00 ,  C02F1/025 ,  C02F1/04 ,  C02F1/20 ,  C02F2101/322 ,  C02F2101/38 ,  C02F2103/18 ,  C02F2209/06 ,  C02F2301/046 ,  C07C201/08 ,  C07C201/16 ,  C07C209/36 ,  C07C205/06

Abstract: The invention relates to a process for working up alkaline waste water which is formed during washing of crude nitrobenzene obtained by nitration of benzene, wherein (i) the alkaline waste water is heated under an increased pressure with respect to atmospheric pressure with exclusion of oxygen and is then cooled and expanded; (ii) the waste water obtained in (i) is purified further by stripping with a stripping gas and the stripping gas stream loaded with impurities is then cooled to a temperature of from 10° C. to 60° C.; and (iii) the liquid process product obtained in (ii) by cooling the stripping gas stream loaded with impurities is separated into an aqueous and an organic phase and the organic phase is used further in an aniline production process.

Abstract translation: 本发明涉及一种处理在通过硝化苯得到的粗硝基苯洗涤过程中形成的碱性废水的方法，其中（i）碱性废水在相对于大气压的增压下被加热而排除氧气， 然后冷却和膨胀; （ii）（i）中获得的废水通过汽提气体进一步纯化，然后将装有杂质的汽提气流冷却至10℃至60℃的温度; 和（iii）通过将负载有杂质的汽提气体冷却而获得的（ii）中获得的液体处理产物分离成水相和有机相，有机相进一步用于苯胺生产过程。