公开(公告)号：US10702832B2

公开(公告)日：2020-07-07

申请号：US15770893

申请日：2016-09-12

Applicant: EMD Millipore Corporation

Inventor： Salvatore Giglia ,  David Nhiem

IPC: B01D65/10 ,  G01N15/08

Abstract: A method of integrity testing porous materials that is non-destructive to the material being tested. The method includes humidifying the inlet gas stream to minimize or prevent the porous material from drying out. The inlet gas stream includes at least two gases, wherein one of the gases has a different permeability in liquid than the other, such as oxygen and nitrogen. The permeate gas stream may be subjected to a driving force such as reduced pressure to increase the flow of gases and reduce test time. Multiple porous materials can be integrity tested at the same time, such as by manifolding a plurality of them together. The integrity test is capable of detecting the presence of oversized pores or defects that can compromise the retention capability of the porous material.

公开(公告)号：US20200206655A1

公开(公告)日：2020-07-02

申请号：US16734641

申请日：2020-01-06

Applicant: EMD Millipore Corporation

Inventor： Stephane Olivier ,  Didier Metz

IPC: B01D27/04 ,  G01N1/40

Abstract: The invention relates to the filtering of liquid samples, preferably in a laboratory environment, for example for collecting micro organisms from the liquid sample for subsequent testing. The invention provides a method for filtering a liquid sample which comprises providing a blank of a deformable sheet material and a filtration medium, deforming the blank to form a funnel extending above and about the filtration medium, introducing the liquid sample to be filtered into the so formed funnel, and filtering the liquid sample from the funnel through the filtration medium, for example to a downstream receptacle. The method is accordingly based on the concept that the funnel is not or at least not completely preformed but provided in a form of a blank of a deformable material sheet which is deformed so as to form the funnel at the point and time of use during filtration.

公开(公告)号：US20200182387A1

公开(公告)日：2020-06-11

申请号：US16315045

申请日：2017-05-23

Applicant: EMD Millipore Corporation

Inventor： Martin Morrissey

IPC: F16L33/22

Abstract: A clamp device for a barb member having a barbed region for disposing within an end of a flexible tube having an outer surface. The clamp device includes a flexible member including a body having a plurality of finger members compressible between a first resting position and a second clamping position; at least one of the flexible finger members having a radially inwardly extending tooth; the body having a through bore and an outer surface comprising threads; the flexible member being slidable over the barbed region and the outer surface of the flexible tube; a compression member having a body having a through bore and an inner surface including threads; the compression member being slidable over the flexible member; wherein upon threadingly engaging the compression member with the flexible member, the compression member compresses the finger member against the barb member.

公开(公告)号：US10675454B2

公开(公告)日：2020-06-09

申请号：US15867915

申请日：2018-01-11

Applicant: EMD Millipore Corporation

Inventor： James Vigna ,  Joseph Muldoon ,  John Cieciuch ,  Robert Langlois

IPC: A61M39/18 ,  F16L37/36 ,  F16L37/367 ,  F16L55/07

Abstract: Fluid transfer device and method that allows for sterile wet connections, allows the connection to be reversed, and allows the connection to be reconnected, while leaving the connectors sterile and reusable under pressure. In certain embodiments, the device includes a first member and a second member, the latter adapted to receive the former in locking engagement upon actuation of the device to create fluid communication between the two in a sterile manner. Each of the members include a door that when opened, allows the first member to be linearly displaced into the second member to allow fluid to be transferred. When fluid transfer is complete, the first member can be retracted from the second member, and the doors closed.

公开(公告)号：US10656046B2

公开(公告)日：2020-05-19

申请号：US15520082

申请日：2015-12-17

Applicant: EMD Millipore Corporation

Inventor： Stephen G. Hunt ,  Nicholas Landry ,  Martin Szyk

IPC: G01M3/28 ,  B01D65/10 ,  B01D65/02 ,  B01D61/24 ,  F16J15/00 ,  F16K1/46

Abstract: The present disclosure relates to a filter capsule that supports direct integrity testing of an internal filter element. The filter capsule includes a filter housing having an inlet port, an outlet port, a passage running longitudinally between the inlet port and outlet port and holding a filter element, and an aseptic vent assembly. The filter housing also includes an integrity test assembly that can be used as a direct connection for integrity testing hardware, as opposed to upstream of the filter capsule. In one embodiment, the integrity test assembly comprises a body having a bore formed through its interior and a movable plunger within the bore. The plunger includes a handle to move the plunger between a closed position and an open position. Various seals between the plunger and the bore form a fluid tight seal between various portions of the plunger and the bore.

公开(公告)号：US10550148B2

公开(公告)日：2020-02-04

申请号：US14736596

申请日：2015-06-11

Applicant: EMD Millipore Corporation

Inventor： Venkatesh Natarajan ,  Herbert Lutz ,  Bala Raghunath

IPC: C07K1/34 ,  C07K1/18 ,  C07K16/00 ,  C07K1/22 ,  B01D15/08 ,  B01D61/14 ,  C07K16/06 ,  C07K1/36 ,  B01D15/12 ,  A61L2/00

Abstract: In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device.

公开(公告)号：US20190282963A1

公开(公告)日：2019-09-19

申请号：US16428189

申请日：2019-05-31

Applicant: EMD Millipore Corporation

Inventor： Jonathan Steen

IPC: B01D63/12 ,  B01D61/14 ,  C02F1/44 ,  D06C15/02 ,  B01D61/02 ,  B01D63/10

Abstract: The present invention provides compact spiral-wound filter elements having cassette-like performance. The invention further provides filtration systems (e.g., TFF systems) and processes (e.g., SPTFF processes) employing compact spiral-wound filter elements having cassette-like performance.

公开(公告)号：US20190277744A1

公开(公告)日：2019-09-12

申请号：US16349855

申请日：2017-11-20

Applicant: EMD Millipore Corporation

Inventor： Salvatore Giglia

IPC: G01N15/08 ,  B01D65/10 ,  G01N33/00

Abstract: A method of integrity testing porous materials that is non-destructive to the material being tested. The inlet gas stream includes at least two gases, wherein one of the gases has a different permeability in liquid than the other, such as oxygen and nitrogen in water. The relative permeability of the gases is measured in the retentate stream, thereby avoiding accessing the permeate stream and potentially introducing contaminants to the material being tested. The integrity test is capable of detecting the presence of oversized pores or defects that can compromise the retention capability of the porous material.

公开(公告)号：USD857839S1

公开(公告)日：2019-08-27

申请号：US29633223

申请日：2018-01-12

Applicant: EMD Millipore Corporation

Designer： Matthew Natale ,  Brian Hillier

公开(公告)号：US20190224600A1

公开(公告)日：2019-07-25

申请号：US16316890

申请日：2017-10-23

Applicant: EMD Millipore Corporation

Inventor： Akshat Gupta ,  Dana Kinzlmaier ,  Kara Pizzelli ,  Elizabeth Goodrich

IPC: B01D39/18 ,  D21C9/00 ,  B01D37/02

Abstract: Treatment methods for reduction of (1→3)-β-D-glucan leachables from cellulose-containing filter materials are described.