公开(公告)号：US09125950B2

公开(公告)日：2015-09-08

申请号：US14486504

申请日：2014-09-15

Applicant: University of Florida Research Foundation, Inc.

Inventor： Raymond J. Bergeron, Jr.

IPC: A61K39/385 ,  A61K47/48 ,  A61K39/02 ,  C07K16/12 ,  A61K39/00

CPC classification number: A61K47/48276 ,  A61K39/107 ,  A61K39/385 ,  A61K47/6425 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/6031 ,  A61K2039/6068 ,  A61K2039/6081 ,  C07K16/1239 ,  Y02A50/472

Abstract: An immunogenic composition comprising a siderophore covalently linked to a pharmaceutically acceptable carrier molecule wherein the antigenicity of the siderophore moiety is sufficient to stimulate an immunologic response to the siderophore when the composition is circulating in the bloodstream of a human or non-human animal and vaccine.

Abstract translation: 包含与药学上可接受的载体分子共价连接的铁载体的免疫原性组合物，其中当组合物在人或非人动物和疫苗的血流中循环时，铁载体部分的抗原性足以刺激对铁载体的免疫应答。

公开(公告)号：US20150232406A1

公开(公告)日：2015-08-20

申请号：US14422740

申请日：2013-08-20

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Kenneth Boone Wagener ,  Michael Schulz

IPC: C07C51/60 ,  C08F236/02

CPC classification number: C07C51/60 ,  B01J31/2265 ,  B01J31/2273 ,  B01J31/2278 ,  B01J31/24 ,  B01J2231/54 ,  B01J2531/821 ,  C07C4/22 ,  C07C51/62 ,  C07C67/475 ,  C08F236/02 ,  C07C69/602 ,  C07C57/66 ,  C07C69/593

Abstract: Olefin metathesis between an acrylate monomer and a polyene comprising molecule or polymer is employed as a method of cross-metathesizing or depolymerizing the molecule. The metathesis reaction forms a telechelic acrylate molecule that is a monomer, oligomer or polymer. The telechelic acrylate molecule can be employed as a monomer for condensation polymerization.

Abstract translation: 使用丙烯酸酯单体和含多烯的分子或聚合物之间的烯烃复分解作为分子的交叉分解或解聚的方法。 复分解反应形成作为单体，低聚物或聚合物的遥爪丙烯酸酯分子。 丙烯酸遥爪分子可用作缩聚单体。

公开(公告)号：US20150202269A1

公开(公告)日：2015-07-23

申请号：US14413884

申请日：2013-01-23

Applicant: The Trustees of the University of Pennsylvania ,  University of Florida Research Foundation, Inc.

Inventor： William A Beltran ,  Gustavo D Aguirre ,  Samuel G Jacobson ,  Artur V Cideciyan ,  Alfred S Lewin ,  Sanford L Boye ,  William W Hauswirth ,  Wen-Tao Deng

IPC: A61K38/46 ,  A61K38/18 ,  C12N15/86

CPC classification number: A61K38/46 ,  A61K38/1709 ,  A61K38/185 ,  A61K48/00 ,  A61K48/005 ,  C07K14/4702 ,  C12N15/86 ,  C12N2750/14143 ,  C12N2830/008 ,  C12Y306/05

Abstract: Described herein are methods of preventing, arresting progression of or ameliorating vision loss and other conditions associated with retinitis pigmentosa and x-linked retinitis pigmentosa in a subject. The methods include administering to said subject an effective concentration of a composition comprising a recombinant adeno-associated virus (AAV) carrying a nucleic acid sequence encoding a normal retinitis pigmentosa GTPase regulator (RPGR gene), or fragment thereof, under the control of regulatory sequences which express the product of the gene in the photoreceptor cells of the subject, and a pharmaceutically acceptable carrier.

Abstract translation: 本文描述的是预防，阻止视力丧失进展或改善与受试者中色素性视网膜炎和色素连带性视网膜炎相关的其它病症的方法。 所述方法包括向所述受试者施用有效浓度的组合物，所述组合物包含携带编码正常视网膜色素变性GTP酶调节剂（RPGR基因）或其片段的核酸序列的重组腺相关病毒（AAV），其在调节序列的控制下 其表达该受试者的感光细胞中的基因的产物和药学上可接受的载体。

公开(公告)号：US09080011B2

公开(公告)日：2015-07-14

申请号：US13674561

申请日：2012-11-12

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Laurent Mialon ,  Stephen A. Miller

IPC: C08G63/66 ,  C08G63/06

CPC classification number: C08G63/00 ,  C08G63/065 ,  C08G63/66 ,  C08G63/83

Abstract: A biorenewable thermoplastic, poly(dihydroferulic acid) (PHFA), is an effective polyethylene terephthalate (PET) mimic that is prepared by a step-growth condensation polymerization of acetyldihydroferulic acid. Other biorenewable thermoplastic copolymers, poly(dihydroferulic acid-co-ferulic acid) are effective mimics of polystyrene and other thermoplastics. The PHFA copolymers can be prepared by the copolymerization of acetyldihydroferulic acid with acetylferulic acid, which are monomers that can be synthesized from starting materials isolated from lignin, rice bran, or other biorenewable sources.

Abstract translation: 生物可再生热塑性聚（二氢阿魏酸）（PHFA）是通过乙酰二氢阿魏酸的分步生长缩聚制备的有效的聚对苯二甲酸乙二醇酯（PET）模拟物。 其他生物可再生热塑性共聚物，聚（二氢阿魏酸 - 阿魏酸）是聚苯乙烯和其他热塑性塑料的有效模拟。 PHFA共聚物可以通过乙酰基二氢阿魏酸与乙酰基阿魏酸的共聚来制备，乙酰基阿魏酸是可从木质素，米糠或其他生物可再生来源分离的原料合成的单体。

公开(公告)号：US09075045B2

公开(公告)日：2015-07-07

申请号：US13911242

申请日：2013-06-06

Applicant: THE COMMONWEALTH MEDICAL COLLEGE ,  UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： David Alan Zacharias ,  Sonia Lobo Planey

IPC: C07K14/705 ,  G01N33/50 ,  C07K9/00 ,  C12Q1/68 ,  G01N33/68

CPC classification number: G01N33/5091 ,  C07K9/005 ,  C07K14/705 ,  C12Q1/6897 ,  G01N33/6893 ,  G01N2333/4728 ,  G01N2800/34 ,  Y10T436/110833 ,  Y10T436/112499

Abstract: An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is positive for the presence of APF in urine and diagnostic for IC. The diagnostic system is a significant and surprising advance in diagnosis of IC and has commercial applications relevant to women and men who suffer from symptoms consistent with IC.

公开(公告)号：US20150133316A1

公开(公告)日：2015-05-14

申请号：US14553053

申请日：2014-11-25

Applicant: University of Florida Research Foundation, Inc.

Inventor： Matias Kirst ,  Marcio Fernando Ribeiro De Resende, JR. ,  Leandro Gomide Neves ,  Christopher Dervinis ,  Kelly Mayrink Balmant

IPC: C12N15/10 ,  C12Q1/68

CPC classification number: C12N15/1065 ,  C12Q1/6806 ,  C12Q1/6853 ,  C12Q1/6874 ,  C12Q2521/301 ,  C12Q2525/155 ,  C12Q2525/161 ,  C12Q2525/179 ,  C12Q2535/122 ,  C12Q2537/159 ,  C12Q2563/179

Abstract: The present invention provides methods to produce a reduced representation of a genome for sequencing and DNA polymorphism detection. In particular, the invention provides PCR-based methods, with normalization of the amplified products using a duplex-specific nuclease, in order to reduce over-representation of PCR products. Oligonucleotides for use in the disclosed method are also provided.

Abstract translation: 本发明提供了用于产生用于测序和DNA多态性检测的基因组的减少表示的方法。 特别地，本发明提供基于PCR的方法，使用双链体特异性核酸酶使扩增产物正常化，以减少PCR产物的过度表达。 还提供了用于所公开的方法的寡核苷酸。

公开(公告)号：US09005540B2

公开(公告)日：2015-04-14

申请号：US14092409

申请日：2013-11-27

Applicant: University of Florida Research Foundation, Inc. ,  STC.UNM

Inventor： Kirk S. Schanze ,  Motokatsu Ogawa ,  Jonathan Robert Sommer ,  David G. Whitten ,  Thomas S. Corbitt

IPC: A61L2/00 ,  H01B1/04 ,  A01N25/28 ,  A01N25/00 ,  A01N25/10 ,  A01N25/34 ,  A01N43/90 ,  A61L2/23

CPC classification number: A01N25/28 ,  A01N25/00 ,  A01N25/10 ,  A01N25/34 ,  A01N43/90 ,  A61L2/23 ,  Y10S977/712 ,  Y10S977/903 ,  Y10T428/2982 ,  A01N41/04 ,  A01N2300/00

Abstract: Hollow conjugated polyelectrolyte (HCPE) microcapsules contain at least one conjugated polyelectrolyte and at least one other polyelectrolyte of complementary charge and the microcapsule has a hollow core. The conjugated polyelectrolyte is a polymer with a multiplicity of charged repeating units where a portion of the charged repeating units form a pi-conjugated sequence. The complementary polyelectrolyte is a polymer with a complementary charged repeating unit to the charged repeating units of the conjugated polyelectrolyte. The HCPE microcapsules can be formed by successively coating a sacrificial core with alternating layers of complementary polyelectrolytes, at least one of which is a conjugated polyelectrolyte. The sacrificial core can be removed to form the hollow center of a HCPE microcapsule. The HCPE microcapsules can be contacted with a medium containing microbes where the HCPE microcapsules associate with the microbes and efficiently kill the microbes when irradiated with light or other electromagnetic radiation.

Abstract translation: 中空共轭聚电解质（HCPE）微胶囊含有至少一种共轭聚电解质和至少一种其他互补电荷的聚电解质，微胶囊具有中空芯。 共轭聚电解质是具有多个带电重复单元的聚合物，其中一部分带电重复单元形成π-共轭序列。 互补聚电解质是与共轭聚电解质的带电重复单元具有互补的带电重复单元的聚合物。 HCPE微胶囊可以通过连续地涂覆具有互补聚电解质交替层的牺牲芯形成，其中至少一种是共轭聚电解质。 可以去除牺牲芯以形成HCPE微胶囊的中空中心。 HCPE微胶囊可以与含有微生物的培养基接触，其中HCPE微胶囊与微生物结合，并在用光或其他电磁辐射照射时有效杀死微生物。

公开(公告)号：US20150056259A1

公开(公告)日：2015-02-26

申请号：US14378864

申请日：2013-02-14

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Parvesh Sharma ,  Aarthi Narayanan ,  Hassan E. El-Shall ,  Brij M. Moudgil

IPC: A01N25/26 ,  A01N25/30 ,  A01N65/42

CPC classification number: A01N25/26 ,  A01N25/12 ,  A01N25/30 ,  A01N65/42

Abstract: Nanoengineered particulate coatings (NPCs) comprise a multiplicity of particulate hosts that are infused with a nanophase comprising a surfactant and at least one guest. The particulate hosts can be clay particles, the surfactant can be a cationic surfactant, and the guest can be an insect repellant. For example, montmorillonite particles infused with hexadecyl trimethyl ammonium bromide and garlic oil form NPCs that may be used to form an emulsion or suspension for spraying on citrus trees to repel Asian Citrus Psyllid.

Abstract translation: 纳米工程颗粒涂层（NPC）包含多个颗粒物质，其被纳入含有表面活性剂和至少一个客体的纳米相。 颗粒物可以是粘土颗粒，表面活性剂可以是阳离子表面活性剂，客体可以是驱虫剂。 例如，注入十六烷基三甲基溴化铵和大蒜油的蒙脱石颗粒形成NPC，其可以用于形成用于喷洒柑橘树上的乳液或悬浮液以排斥亚洲柑橘类Psyllid。

公开(公告)号：US20140355858A1

公开(公告)日：2014-12-04

申请号：US14294768

申请日：2014-06-03

Applicant: University of Florida Research Foundation, Inc.

Inventor： Walter Gene O'DELL

IPC: G06T7/00

CPC classification number: G06T7/0081 ,  G06T7/11 ,  G06T7/136 ,  G06T7/187 ,  G06T17/005 ,  G06T2207/10016 ,  G06T2207/10072 ,  G06T2207/20044 ,  G06T2207/30101 ,  G06T2207/30172

Abstract: Systems and methods to develop a vascular model of vascular trees that are captured with 3-Dimensional medical imaging data of a subject. Image processing iteratively traverses vessel image segments within the imaging data and creates a vessel model defined within a data structure that defines branch segments and bifurcation points where those branch segments split. The model generation algorithms incorporate strategies and parameters to identify and repair falsely identified bifurcations that reflect false inter-tree and intra-tree connections that can appear when processing images with complicated vessel trees. Accurate traversal of the vessel tree as portrayed in 3-Dimensional medical images is emphasized to correctly label branch generations and identify and repair erroneous interconnections between adjacent trees.

Abstract translation: 用于开发用受试者的三维医学成像数据捕获的血管树的血管模型的系统和方法。 图像处理迭代地遍历成像数据内的血管图像片段，并创建在数据结构内定义的血管模型，该血管模型定义了那些分支段分裂的分支段和分叉点。 模型生成算法包含策略和参数，用于识别和修复错误识别的分叉，这些分支反映了在使用复杂的血管树处理图像时可能出现的错误树间和树内连接。 强调在三维医学图像中描绘的血管树的精确遍历，以正确地标记分支代，并识别和修复相邻树之间的错误互连。

公开(公告)号：US20140346875A1

公开(公告)日：2014-11-27

申请号：US14368217

申请日：2012-12-24

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC.

Inventor： Raul Andres Chinga ,  Karl R. Zawoy ,  Subrata Roy ,  Jenshan Lin

IPC: H02M1/08 ,  H02M7/44 ,  H01J37/32

CPC classification number: H02M1/08 ,  H01J37/32348 ,  H02M7/44 ,  H02M7/53803 ,  H02M2001/0003 ,  H02M2007/4815 ,  H05H1/46 ,  H05H2001/4682 ,  Y02B70/1441 ,  Y10T307/406

Abstract: Embodiments of the subject invention are drawn to power supply units and systems for supplying power to loads. Specific embodiments relate to systems incorporating the loads. The power supply units and systems can include a feedback mechanism for monitoring the system and maintaining a parameter of interest at or near a desired value (e.g., for maintaining the frequency of operation at or near resonance). The feedback mechanism is configured such that, if the at least one parameter indicates that the frequency of operation is away from a resonant frequency of the power amplifier, the feedback mechanism adjusts the frequency of operation closer to the resonant frequency of the power amplifier. The at least one load can have a variable impedance, though embodiments are not limited thereto.

Abstract translation: 本发明的实施例涉及用于向负载供电的供电单元和系统。 具体实施例涉及包含负载的系统。 电源单元和系统可以包括用于监视系统并将感兴趣的参数维持在或接近期望值的反馈机制（例如，用于维持在或接近共振的操作频率）。 反馈机构被配置为使得如果至少一个参数指示操作频率远离功率放大器的谐振频率，则反馈机构调节操作频率更接近功率放大器的谐振频率。 至少一个负载可以具有可变阻抗，尽管实施例不限于此。