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公开(公告)号:US20240330451A1
公开(公告)日:2024-10-03
申请号:US18742266
申请日:2024-06-13
发明人: Aaron Costin , Janise McNair
IPC分类号: G06F21/55
CPC分类号: G06F21/554 , G06F2221/034
摘要: The present disclosure provide multi-access edge computing systems and methods. One such system comprises a plurality of sensor devices that are configured to collect construction site sensor data and transmit the sensor data to a local computing system that is configured to combine the sensor data with user feedback data and transmit the combined data to an edge computing system. The edge computing system is configured to process the combined data and transmit the combined data to a cloud computing system, where the cloud computing system that is configured to process the transmitted data from the edge computing system. The edge computing system or the cloud computing system is configured to execute a site risk prediction application and predict a hazard within a construction site based on the collected construction site sensor data and generate an output signal to equipment operating at the construction site.
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公开(公告)号:US20240299382A1
公开(公告)日:2024-09-12
申请号:US18572491
申请日:2022-06-27
发明人: Daiqing LIAO
IPC分类号: A61K31/505 , A61K31/166 , A61K31/24 , A61P35/00
CPC分类号: A61K31/505 , A61K31/166 , A61K31/24 , A61P35/00
摘要: Described herein are compounds methods for reducing the amount of rest compressor 1 (RCOR1, also known as CoREST1), lysine-specific histone demethylase 1A (LSD1, also known as KDM1A), histone deacetylase 1 (HDAC1), histone deacetylase 2 (HDAC2) or any combination thereof in a subject. These proteins are core subunits of the CoREST complex that has both lysine deacetylase and lysine demethylase activity. By reducing the amount of RCOR1, LSD1, HDAC1 and/or HDAC2, cancer cell proliferation and tumor growth are impaired. In one aspect, the compounds useful herein have the formula I or the pharmaceutically acceptable salt thereof.
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公开(公告)号:US20240246883A1
公开(公告)日:2024-07-25
申请号:US18422115
申请日:2024-01-25
发明人: Mica F. MCMILLAN
摘要: In one aspect, the disclosure relates to slow-release fertilizers including a peat and an optional filler material such as, for example sand, methods of making the same, methods of improving the growth of plants including using the same, and plants grown using the disclosed methods. The slow-release fertilizers are environmentally safe and conducive to the establishment of various plants, including ground cover plants. In some aspects, the slow-release fertilizers induce soil-water repellency in systems in which they are applied and can be useful for research as well as horticultural purposes. In another aspect, the slow-release fertilizers provide increased levels of ammonia, amino acids, and other nutrients relative to conventional fertilizers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号:US20240238418A1
公开(公告)日:2024-07-18
申请号:US18289705
申请日:2022-05-06
发明人: Elias Sayour , Jianping Huang , Hector Ruben Mendez-Gomez , Paul Antonio Castillo Caro , Ruixuan Liu
CPC分类号: A61K39/4611 , A61K9/1272 , A61K39/4631 , A61K39/464429 , A61P35/00 , A61K2239/39
摘要: The disclosure provides a method of preconditioning a subject for chimeric antigen receptor (CAR) T cell therapy. The method comprises administering to the subject a composition comprising a nanoparticle comprising a positively-charged surface and an interior comprising (i) a core and (ii) at least two nucleic acid layers, wherein each nucleic acid layer is positioned between a cationic lipid bilayer, at least one day prior to administering CAR T cell therapy to the subject. The disclosure also provides a method of treating a solid tumor in a subject, the method comprising administering to a subject comprising a surface antigen negative solid tumor a first composition comprising the nanoparticle, wherein the nucleic acid within the nanoparticle encodes the surface antigen, and a second composition comprising a CAR T cell that targets the surface antigen.
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公开(公告)号:US20240237951A1
公开(公告)日:2024-07-18
申请号:US18608281
申请日:2024-03-18
IPC分类号: A61B5/00 , A61B5/0205 , A61B5/024 , A61B5/08 , A61B5/113 , G01S7/41 , G01S13/536 , G01S13/88
CPC分类号: A61B5/725 , A61B5/0205 , A61B5/024 , A61B5/0816 , A61B5/1135 , A61B5/4839 , A61B5/7246 , G01S7/415 , G01S13/536 , G01S13/88
摘要: Various examples are provided for accurate heart rate measurement. In one example, a method includes determining respiration displacement from radar-measured cardiorespiratory motion data; adjusting notch depths of a data filter based upon the respiration displacement; and identifying a heart rate from data filtered by the data filter. In another example, a system includes a computing device that can determine a respiration displacement from radar-measured cardiorespiratory motion data; wherein the computing device can adjust a data filter based upon the respiration displacement; and can identify a heart rate based on data filtered by the data filter.
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公开(公告)号:US20240228292A1
公开(公告)日:2024-07-11
申请号:US18243866
申请日:2023-09-08
IPC分类号: C01B32/162
CPC分类号: C01B32/162 , C01B2202/02 , C01P2002/82
摘要: Various examples are provided related to synthesis of single wall carbon nanotubes (SWNTs). In one example, a method includes providing a vapor including a metal catalyst, silicon at a level of about 10 at % of the metal catalyst with balance carbon; synthesizing single wall carbon nanotubes (SWNTs) from the vapor; and collecting the synthesized SWNTs. The vapor including the metal catalyst, silicon and carbon can be provided in a variety of ways. Synthesis of the SWNTs can be an oxygen free synthesis.
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公开(公告)号:US20240203118A1
公开(公告)日:2024-06-20
申请号:US18544015
申请日:2023-12-18
发明人: Sabrina A. Dugan , Nawari O. Nawari
CPC分类号: G06V20/176 , G06T7/73 , G06V20/17 , G06T2207/10028
摘要: The present disclosure presents systems and methods for automatically performing an accessibility audit using Artificial Intelligence (AI) techniques. One such method, among others, comprises acquiring geospatial imaging data of a location site; identifying, using artificial intelligence, accessible features of the location site that are determined to be accessible to a person having a physical disability; identifying, using artificial intelligence, inaccessible features of the location site that are determined to be inaccessible to a person having a physical disability; and/or generating, using Global Information System mapping processes, an aerial map of a location site using the geospatial imaging data, wherein the aerial map comprises a first layer denoting the accessible features of the location site using specific colors, wherein the aerial map comprises a second layer denoting the inaccessible features of the location site using different specific colors.
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公开(公告)号:US20240158450A1
公开(公告)日:2024-05-16
申请号:US18488604
申请日:2023-10-17
申请人: The University of North Carolina at Chapel Hill , University of Florida Research Foundation, Inc.
IPC分类号: C07K14/005 , C07K16/08 , C12N15/86
CPC分类号: C07K14/005 , C07K16/081 , C12N15/86 , A61K2039/507 , C07K2317/34 , C12N2750/14122
摘要: The present invention provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo.
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公开(公告)号:US11964075B2
公开(公告)日:2024-04-23
申请号:US17150038
申请日:2021-01-15
发明人: Yong Huang , Kaidong Song , Ashley M. Compaan , Wenxuan Chai
CPC分类号: A61L27/52 , A61L27/222 , A61L27/3687 , A61L2400/06
摘要: Described herein are injectable composite inks composed of a hydrogel continuous phase with a plurality of microgels present within the hydrogel continuous phase. The inks described herein have unique chemical and physical properties that enable them to be printed into a number of different types of articles. The articles produced by the injectable composite inks have numerous medical applications.
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公开(公告)号:US20240127050A1
公开(公告)日:2024-04-18
申请号:US18267184
申请日:2021-12-08
发明人: Qing LU , Xiaoxi SHEN , Tingting HOU
摘要: Various examples are provided related to the application of a kernel neural network (KNN) to the analysis of high dimensional and ultrahigh dimensional data for, e.g., risk prediction. In one embodiment, a method includes training a KNN with a training set to produce a trained KNN model, determining a likelihood of a condition based at least in part upon an output indication of the trained KNN corresponding to one or more phenotypes, identifying treatment or prevention strategy for an individual based at least in part upon the likelihood of the condition. The KNN model includes a plurality of kernels as a plurality of layers to capture complexity between the data with disease phenotypes. The training set of data includes genetic information applied as inputs to the KNN and the phenotype(s), and the output indication is based upon analysis of data comprising genetic information from the individual by the trained KNN.
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