公开(公告)号：US20130136657A1

公开(公告)日：2013-05-30

申请号：US13747667

申请日：2013-01-23

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Wolfgang Hofmann ,  Taghi Noormofidi ,  Doris Zahrl

IPC: B05D5/00

CPC classification number: B05D5/00 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0627 ,  B01L2300/161 ,  G01N33/54393

Abstract: A method for at least partially applying a hydrophilic polymer to a measurement channel of a sensor cartridge is provided, which sensor cartridge can be replaceably inserted in an analyzer. The measurement channel comprises at least one sensor element. The method comprises inserting the sensor cartridge into the analyzer, introducing an aqueous solution containing chitosan or a chitosan derivative into the measurement channel of the sensor cartridge, and following a residence time replacing the aqueous chitosan solution with a gaseous or liquid medium, wherein residues of the chitosan or chitosan derivatives remain on the inside surface of the measurement channel and hydrophilize the surface.

Abstract translation: 提供了一种用于至少部分地将亲水性聚合物施加到传感器盒的测量通道的方法，该传感器盒可以可替换地插入到分析器中。 测量通道包括至少一个传感器元件。 该方法包括将传感器盒插入分析器中，将含有壳聚糖或壳聚糖衍生物的水溶液引入到传感器盒的测量通道中，并且在用气态或液体介质代替壳聚糖水溶液的停留时间之后， 壳聚糖或壳聚糖衍生物保留在测量通道的内表面上并使表面亲水化。

公开(公告)号：US20130131631A1

公开(公告)日：2013-05-23

申请号：US13741587

申请日：2013-01-15

Applicant: Roche Diagnostics Operations, Inc..

Inventor： Mark Nierzwick ,  Phillip E. Pash ,  James Duane Tenbarge

IPC: A61M5/172

CPC classification number: A61M5/1723 ,  G06F19/00 ,  G06F19/3468 ,  G16H40/63 ,  H04L63/061 ,  H04L63/0869 ,  H04W12/04 ,  H04W12/06

Abstract: A diabetes care kit for providing diagnostics and therapy that is preconfigured to reduce initial setup by a user. The kit can include a handheld diabetes managing device and insulin pump. The handheld diabetes managing device and insulin pump can each be preloaded with an encryption key such that the handheld diabetes managing device and the insulin pump are paired and a secure bidirectional communication link exists between the handheld diabetes managing device and the insulin pump.

Abstract translation: 一种用于提供诊断和治疗的糖尿病护理工具，预先配置以减少用户的初始设置。 该套件可以包括手持式糖尿病管理装置和胰岛素泵。 手持式糖尿病管理装置和胰岛素泵可以预先加载加密密钥，使得手持式糖尿病管理装置和胰岛素泵配对，并且在手持式糖尿病管理装置和胰岛素泵之间存在安全的双向通信链路。

公开(公告)号：US20130130215A1

公开(公告)日：2013-05-23

申请号：US13737268

申请日：2013-01-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Alain Bock ,  David L. Duke ,  Abhishek S. Soni

IPC: G09B23/28 ,  G09B19/00

CPC classification number: G09B23/28 ,  G09B19/00 ,  G16H50/50

Abstract: A system and method for considering the effects of aerobic exercise on blood glucose levels for individuals is described. In at least one embodiment of the system of the present disclosure, the system comprises a computing device for generating a prediction of future blood glucose levels for the individual at least partly based on an exercise model, wherein the exercise model is based on parameters that are independent of intensity of the aerobic exercise, and a means for taking an action at least based on the prediction from the exercise model.

Abstract translation: 描述了一种考虑有氧运动对个体血糖水平的影响的系统和方法。 在本公开的系统的至少一个实施例中，该系统包括计算装置，用于至少部分地基于运动模型生成针对个体的未来血糖水平的预测，其中运动模型基于 独立于有氧运动的强度，以及至少基于运动模型的预测采取行动的手段。

公开(公告)号：US20250155435A1

公开(公告)日：2025-05-15

申请号：US18506002

申请日：2023-11-09

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Simon Jochum ,  Matthias Hemann ,  Juliane Benz

IPC: G01N33/569 ,  C07K14/005 ,  C12N9/10 ,  G01N33/532

Abstract: Fusion polypeptides are disclosed which are substrates for Kutzneria albida transglutaminase. The fusion polypeptides comprise one or more FKBP chaperone(s) and a target polypeptide. Each of these elements is separated from the neighboring element by a linker amino acid sequence. It was found that inserting glutamic acid containing transglutaminase recognition motifs into the linker amino acid chains is advantageous. Subsequent labeling reactions catalyzed by the transglutaminase surprisingly provide labeled fusion polypeptides have superior properties when compared with chemically random-labeled fusion polypeptides of similar design. Assays and kits are provided for in vitro detection of target antibodies in samples.

公开(公告)号：US12296330B2

公开(公告)日：2025-05-13

申请号：US17099884

申请日：2020-11-17

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Ronald Egli ,  Mirko Klingauf ,  Daniel Ott ,  Jerome Wiss

IPC: B01L3/02 ,  G01N7/00 ,  G01N33/50 ,  G01N35/10

Abstract: An in-vitro diagnostic device including a pipetting unit and a pipetting method, which allow for a more reproducible and more precise pipetting of liquids, when piercing through a lid of a closed liquid container is required. The pipetting unit is controlled to repeat penetration of the lid of the closed liquid container if the pressure difference between the interior of the liquid container and the surrounding is outside an allowable predefined pressure range.

公开(公告)号：US12292454B2

公开(公告)日：2025-05-06

申请号：US17815585

申请日：2022-07-28

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Ole Lambaek ,  Dominik Schnarwiler ,  Bert Taeymans

IPC: G01N35/00

Abstract: A method for operating a laboratory automation system, having: a control device and a transport system with carriers and a first empty carrier queue provided with a first fixed number of queue spaces, each assignable an empty carrier; the method comprising: providing additional queue spaces, each assignable an empty carrier, assigning a first number of additional queue spaces from the additional queue spaces to the first empty carrier queue, operating the first empty carrier queue with the first fixed number of queue spaces plus the first number of additional queue spaces, assigning, in response to receiving operation data in the control device, a second number of additional queue spaces from the additional queue spaces to the first empty carrier queue and operating the first empty carrier queue with the first fixed number of queue spaces plus the second number of additional queue spaces. Further, a laboratory automation system is provided.

公开(公告)号：US20250138017A1

公开(公告)日：2025-05-01

申请号：US18930774

申请日：2024-10-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Vinzent Rolny ,  Holger Busskamp ,  Konstantin Kroeniger ,  Mahdokht Kohansal Nodehi ,  Magdalena Swiatek-de Lange ,  Gloria Tabares

IPC: G01N33/574 ,  G01N33/68

Abstract: The present invention relates to in vitro methods for aiding in the detection of hepatocellular carcinoma (HCC) in a subject. The method may comprise determining the amount of one or more N-glycan structure attached to haptoglobin (i.e. of the β-chain of haptoglobin having the sequence given in SEQ ID NO: 1) in a sample obtained from said subject and comparing the amount of said one or more glycan structure to a reference amount of said one or more glycan structure, wherein an altered amount of said one or more glycan structure in said patient sample relative to the reference amount of said one or more glycan structure is indicative for HCC. Further, the present invention relates to the use of one or more glycan structure attached to haptoglobinor of a glycopeptide derived from haptoglobin in combination with AFP and/or PIVKA-II in the detection of HCC.

公开(公告)号：US20250116670A1

公开(公告)日：2025-04-10

申请号：US18908787

申请日：2024-10-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christa Cobbaert ,  Konstantin Kroeniger ,  Guinevere Lageveen-Kammeijer ,  Jan Nouta ,  Vinzent Rolny ,  Renee Ruhaak ,  Magdalena Swiatek-de Lange ,  Gloria Tabares ,  Yuri van der Burgt ,  Manfred Wuhrer

IPC: G01N33/574 ,  G01N33/573

Abstract: The present invention relates to methods for assessing whether or not a patient has aggressive prostate cancer by determining the levels of particular glycoforms attached to prostate specific antigen (PSA) protein in a biofluid sample of a subject, and comparing the determined level or concentration to a reference. The methods are particularly useful for assessing subjects that have 2-10 ng/ml total PSA in the subject's serum.

公开(公告)号：US20250099000A1

公开(公告)日：2025-03-27

申请号：US18728195

申请日：2023-01-24

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Carsten DANZER ,  Martin Josef EMONS ,  Martin KLAMMER ,  Nicolas Seungoon SILLITOE ,  Riccardo TRIUNFO

IPC: A61B5/20 ,  A61B5/00 ,  G16H10/60 ,  G16H50/20

Abstract: A computer-implemented method is provided, which determines at a prediction time tp, a likelihood of kidney failure of a patient within an amount of time Δt. The method comprises receiving input data, the input data comprising a recent creatinine level cR or recent eGFR eGFRR, and one or more of the following: (a) an initial creatinine level c0 and either: a time t0 at which the initial creatinine level c0 was measured, or a time interval ΔT0=tp−t0; (b) an initial estimated glomerular filtration rate (eGFR) eGFR0 and either: a time t0 at which the initial eGFR was determined, or a time interval ΔT0=tp−t0; (c) for a plurality of past creatinine level measurements ci measured at a respective times ti, a statistical parameter derived from a linear regression of the plurality of past creatinine level measurements; and (d) for a plurality of past eGFR values eGFRi determined at respective times ti, a statistical parameter derived from a linear regression of the plurality of past eGFR values; and applying a machine-learning model to the input data to generate an output indicating the likelihood of kidney failure within the given amount of time Δt. Corresponding training methods and systems are also provided.

公开(公告)号：US20250069712A1

公开(公告)日：2025-02-27

申请号：US18726309

申请日：2022-12-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Ole Lambaek ,  Dominik Schnarwiler ,  Bert Taeymans

IPC: G16H10/40 ,  G06Q10/0631 ,  G06Q10/0639

Abstract: A method for operating a laboratory system having a plurality of sample containers; a plurality of laboratory devices to handle the sample containers, the sample containers being assigned for handling to the target device; and a control device configured to control assignment of the sample containers to the target devices; and assigning the sample containers. The assigning comprises: determining a target device workload state for each target device, the workload state being between a first range limit and a second range limit, and determined according to a metric being proportional to a resource target device state indicative of sample containers assigned to the target device, and a power of an output flow of the target device, assigning the sample containers to the target devices according to the target device workload states; and providing sample containers to the plurality of target devices. Furthermore, a laboratory system is provided.