公开(公告)号：US20040055211A1

公开(公告)日：2004-03-25

申请号：US10296499

申请日：2003-07-15

Inventor： Torbjorn Lestander ,  Per Oden

IPC: A01C001/00

CPC classification number: A01C1/025 ,  G01N21/359 ,  G01N2201/129

Abstract: A method to determine viability or non-viability of seeds is disclosed, wherein individual seeds or seed populations are analysed by a spectrometric method to provide spectral data; and said spectral data are compared with reference spectral data obtained for a reference seed or reference seed population by means of said spectrometric method and calibrated with reference to viability or non-viability of said reference seed or seed population by means of a calibrating method based on pattern recognition. Suitable calibrating methods are based on multivariate or megavariate analysis, neural network systems and regression analysis.

Abstract translation: 公开了一种确定种子生存力或不可行性的方法，其中通过光谱法分析个体种子或种子种群以提供光谱数据; 并且将所述光谱数据与通过所述光谱测定法获得的参考种子或参考种子群体的参考光谱数据进行比较，并通过基于以下的校准方法参照所述参考种子或种子群体的生存力或不可行性进行校准 模式识别。 合适的校准方法基于多变量或巨变分析，神经网络系统和回归分析。

公开(公告)号：US6111255A

公开(公告)日：2000-08-29

申请号：US338843

申请日：1999-06-23

Applicant: Donald C. Malins

Inventor： Donald C. Malins

IPC: C12N15/09 ,  C12Q1/68 ,  G01J3/45 ,  G01N21/35 ,  G01N33/15 ,  G01N33/566 ,  A61B6/00

CPC classification number: G01N21/35 ,  G01J3/45 ,  C12Q1/6886 ,  C12Q2600/112 ,  G01N2021/3595 ,  G01N2201/129 ,  G06F19/24

Abstract: Methods of screening for a tumor or tumor progression to the metastatic state are provided. The screening methods are based on the characterization of DNA by principal components analysis of spectral data yielded by Fourier transform-infrared spectroscopy of DNA samples. The methods are applicable to a wide variety of DNA samples and cancer types.

Abstract translation: 提供筛选肿瘤或肿瘤进展至转移状态的方法。 筛选方法基于通过DNA样品的傅立叶变换红外光谱产生的光谱数据的主成分分析对DNA的表征。 该方法适用于各种DNA样品和癌症类型。

公开(公告)号：US6015667A

公开(公告)日：2000-01-18

申请号：US659115

申请日：1996-06-03

Applicant: Muhammad A. Sharaf

Inventor： Muhammad A. Sharaf

IPC: C12N15/09 ,  C12Q1/68 ,  G01N21/27 ,  G01N21/64 ,  G01N27/416 ,  G01N27/42 ,  G01N27/447 ,  G01N30/74 ,  G01N30/86 ,  G01N33/50 ,  G06F17/00 ,  C12P19/34

CPC classification number: G01N30/8665 ,  G01N2201/129

Abstract: A signal processing method in a processor is provided for performing a multicomponent analysis of a signal resulting from a spectral response of a mixture comprising a plurality of spectrally resolvable molecular species. The method provides both a determination of a concentration estimate and a statistical confidence interval for each species. In the method, a data vector d is received from a multichannel detector, data vector d having a length n.sub.c, n.sub.c being the number of detector channels being monitored. A calibration matrix K having n.sub.c rows and n.sub.p columns is provided wherein n.sub.c is larger than n.sub.p, n.sub.p being the number of spectrally resolvable molecular species. Next, a concentration estimate vector c having length n.sub.p is determined. Finally, a confidence interval CI.sub.i for each of the elements of the concentration estimate vector is determined according to the expressionCI.sub.i =c.sub.i .+-.(varcovar(c.sub.ii)).sup.1/2 Q.sub.(cl,nf)where Q is the critical value of a statistical distribution for a given level of confidence, cl, and a given number of degrees of freedom n.sub.f where n.sub.f =n.sub.c -n.sub.p. The invention further includes a program storage device embodying the method; a DNA sequencing process employing the method; and, an apparatus for carrying out the method.

Abstract translation: 提供了一种处理器中的信号处理方法，用于对包含多个可光谱解析的分子物质的混合物的光谱响应产生的信号进行多组分分析。 该方法提供了每种物种的浓度估计和统计置信区间的确定。 在该方法中，从多通道检测器接收数据矢量d，数据矢量d的长度为nc，nc为被监视的检测器通道的数量。 提供了具有nc行和np列的校准矩阵K，其中nc大于np，np是可光谱解析的分子种类的数量。 接下来，确定长度为np的浓度估计矢量c。 最后，根据表达式Cii = ci +/-（varcovar（cii））+ E，fra 1/2 + EE Q（cl，nf）确定浓度估计向量的每个元素的置信区间CIi，其中Q是 nf = nc-np给定给定的置信度cl和给定数量的自由度nf的统计分布的临界值。 本发明还包括体现该方法的程序存储装置; 采用该方法的DNA测序方法; 以及用于执行该方法的装置。

公开(公告)号：US5910655A

公开(公告)日：1999-06-08

申请号：US913012

申请日：1997-09-04

Applicant: John Skilling

Inventor： John Skilling

IPC: G01N27/62 ,  G06F17/00 ,  H01J49/02 ,  H01J49/26 ,  H01J49/00 ,  B01D59/44

CPC classification number: H01J49/0027 ,  G01N2201/129

Abstract: The accuracy of the elemental analysis of a sample by mass spectrometry is enhanced by providing plural estimates of the likely mass spectrum of the sample. These estimates are compared with experimentally obtained spectra to generate trial sets of possible compositions of the sample. The generated trial sets are subsequently employed to obtain mean values for the amount of each constituent of the sample.

Abstract translation: PCT No.PCT / GB97 / 00016 371日期：1997年9月4日 102（e）1997年9月4日PCT PCT 1997年1月3日PCT公布。 出版物WO97 / 25736 日期1997年7月17日通过提供样品的可能质谱的多个估计值，增强了通过质谱法对样品进行元素分析的准确度。 将这些估计与实验获得的光谱进行比较以产生样品的可能组合的试验组。 随后使用生成的试验组来获得样品的每个组分的量的平均值。

公开(公告)号：US5880830A

公开(公告)日：1999-03-09

申请号：US790696

申请日：1997-01-29

Applicant: Israel Schechter

Inventor： Israel Schechter

IPC: G01N21/64 ,  G01N21/65 ,  G01N21/71

CPC classification number: G01N21/6456 ,  G01N2021/6421 ,  G01N2201/129

Abstract: A method for on-line analysis of polycyclic aromatic hydrocarbons (PAH) in aerosols. The aerosols are collected on non-fluorescing filter paper, excited to fluorescence and imaged spectrally. The images are compared with spectra in a database to determine and quantify the PAH species present. The scope of the invention is broader than fluorescence, and includes excitation analysis of particulate matter generally.

Abstract translation: 一种在气溶胶中多环芳烃（PAH）的在线分析方法。 将气溶胶收集在非荧光滤纸上，激发荧光并成像。 将图像与数据库中的光谱进行比较，以确定和量化存在的PAH种类。 本发明的范围比荧光宽，并且包括通常的颗粒物质的激发分析。

公开(公告)号：US5699269A

公开(公告)日：1997-12-16

申请号：US494203

申请日：1995-06-23

Applicant: Terrence Rodney Ashe ,  Stilianos George Roussis ,  James Wade Fedora ,  Gerald Felsky ,  William Patrick Fitzgerald

Inventor： Terrence Rodney Ashe ,  Stilianos George Roussis ,  James Wade Fedora ,  Gerald Felsky ,  William Patrick Fitzgerald

IPC: G01N30/02 ,  G01N30/62 ,  G01N30/72 ,  G01N30/86 ,  G01N30/88 ,  G01N33/28 ,  G01J3/42

CPC classification number: G01N33/2823 ,  G01N2030/626 ,  G01N2030/8854 ,  G01N2201/129 ,  G01N30/7206 ,  G01N30/8668 ,  G01N30/8693

Abstract: A method for predicting the properties of crude oils or their boiling fractions which comprises selecting a chemical or perceptual or physical or performance property or groups of properties of the crude oil or its boiling fractions and creating a training set from reference samples which contain characteristic molecular species present in the crude oil or its boiling fractions. The reference samples are subjected to GC/MS analysis wherein the often collinear data generated is treated by multivariate correlation methods. The training set produces coefficients which are multiplied by the matrix generated from a GC/MS analysis of an unknown sample to produce a predicted value of the chemical, performance, perceptual or physical property or groups of properties selected.

Abstract translation: 一种用于预测原油或其沸腾馏分的性质的方法，其包括选择原油或其沸点馏分的化学或感知或物理或性能特性或性质组合，并从包含特征分子种类的参考样品产生训练集 存在于原油或其沸腾馏分中。 参考样品进行GC / MS分析，其中生成的常数共线数据通过多变量相关方法进行处理。 训练集产生系数，乘以由未知样本的GC / MS分析产生的矩阵，以产生所选择的化学，性能，知觉或物理属性或属性组的预测值。

公开(公告)号：US5641966A

公开(公告)日：1997-06-24

申请号：US578693

申请日：1995-12-27

Applicant: Bo Karlberg ,  Mikael Karlsson

Inventor： Bo Karlberg ,  Mikael Karlsson

IPC: G01N21/27 ,  G01N21/31 ,  G01N33/18 ,  G01J3/00

CPC classification number: G01N33/182 ,  G01N21/31 ,  G01N33/1806 ,  G01N33/1813 ,  G01N2201/129

Abstract: The present invention relates to a method of determining physical and/or chemical properties in water samples containing suspended substances and/or particles, the physical and/or chemical properties being singly or jointly determined as amount of nitrate, iron, ammonium, phosphate, total nitrogen or total phosphorous; turbidity, chemical oxygen demand (COD) and/or biological oxygen demand (BOD).

Abstract translation: PCT No.PCT / SE94 / 00605 Sec。 371 1995年12月27日第 102（e）日期1995年12月27日PCT提交1994年6月28日PCT公布。 出版物WO95 / 01560 PCT 日期1995年1月12日本发明涉及一种确定含有悬浮物和/或颗粒的水样中物理和/或化学性质的方法，其物理和/或化学性质单独或联合确定为硝酸盐，铁， 铵，磷酸盐，总氮或总磷; 浊度，化学需氧量（COD）和/或生物需氧量（BOD）。

公开(公告)号：US5605838A

公开(公告)日：1997-02-25

申请号：US307415

申请日：1994-09-19

Applicant: Juergen Backhaus ,  Reinhold Mischler

Inventor： Juergen Backhaus ,  Reinhold Mischler

IPC: G01J3/42 ,  B01L3/00 ,  G01N1/28 ,  G01N1/40 ,  G01N21/01 ,  G01N21/31 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/47 ,  G01N33/52 ,  G01N21/00

CPC classification number: B01L3/5085 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/47 ,  G01N2001/4027 ,  G01N2201/129 ,  Y10T436/112499 ,  Y10T436/25375

Abstract: The invention concerns a method for the quantitative analysis of sample liquids. A sample is dried and irradiated with visible and/or infrared light. Light that is diffusely or specularly reflected from the sample and sample carrier is detected and analysed. Furthermore the invention concerns a system for carrying out the method according to the invention and a sample carrier having a diffusely or specularly reflecting surface.

Abstract translation: 本发明涉及用于定量分析样品液体的方法。 将样品干燥并用可见光和/或红外光照射。 检测并分析从样品和样品载体扩散或镜面反射的光。 此外，本发明涉及用于实施根据本发明的方法的系统和具有漫反射或镜面反射表面的样品载体。

公开(公告)号：US5592402A

公开(公告)日：1997-01-07

申请号：US430093

申请日：1995-04-26

Applicant: Kenneth R. Beebe ,  Glen H. Hughes ,  Harry D. Ruhl ,  Richard C. Winterton

Inventor： Kenneth R. Beebe ,  Glen H. Hughes ,  Harry D. Ruhl ,  Richard C. Winterton

IPC: G01N30/86 ,  G06F17/00 ,  G06G7/48 ,  G01N31/00 ,  G06G7/58

CPC classification number: G06K9/00503 ,  G01N30/8641 ,  G01N2201/129 ,  G01N30/8637

Abstract: An improved method is provided for determining when a set of multivariate data (such as a chromatogram or a spectrum) is an outlier. The method involves using a procedure such as Principal Component Analysis to create a model describing a calibration set of spectra or chromatograms which is known to be normal, and to create residuals describing the portion of a particular spectrum or chromatogram which is not described by the model. The improvement comprises using an average residual spectrum calculated for the calibration set, rather than the origin of the model as a reference point for comparing a spectrum or chromatogram obtained from an unknown sample. The present invention also includes separating a complex set of data into various sub-parts such as sub-chromatograms or sub-spectra, so that outliers in any sub-part can be more readily detected. In one particular embodiment, the invention is directed towards a method for dividing a chromatogram into the sub-parts of peak information, baseline shape, baseline offset, and noise.

Abstract translation: 提供了一种改进的方法来确定何时一组多变量数据（如色谱图或光谱）是异常值。 该方法包括使用诸如主成分分析的过程来创建描述已知是正常的光谱或色谱图的校准集的模型，并且产生描述特定光谱或色谱图部分的残差，该模型未被模型描述 。 改进之处在于使用为校准集计算的平均残留光谱，而不是将模型的来源作为比较从未知样品获得的光谱或色谱图的参考点。 本发明还包括将复杂的数据集合分离成各种子部分，例如亚色谱图或子光谱，使得可以更容易地检测任何子部分中的异常值。 在一个具体实施方案中，本发明涉及将色谱图分成峰信息，基线形状，基线偏移和噪声的子部分的方法。

公开(公告)号：US5453619A

公开(公告)日：1995-09-26

申请号：US150192

申请日：1993-12-08

Applicant: Marc Asselain ,  Daniel Manifacier ,  Yves Agnet

Inventor： Marc Asselain ,  Daniel Manifacier ,  Yves Agnet

IPC: G01N21/03 ,  G01N21/35 ,  G01N21/25

CPC classification number: G01N21/3577 ,  G01N21/0332 ,  G01N2201/0231 ,  G01N2201/129 ,  Y10S250/91

Abstract: Method and apparatus for the spectrophotometric assay of aqueous liquids are provided with a pump for aspirating liquids, a filter with two outlets for filling a cell in which the interferometric measurements are made at a temperature between 35 and 50.degree. C. at a maximum fluctuation of 0.2.degree. C., and with a maximum relative humidity of 0.2%. Absorption curves A(f) are determined with respect to a matrix and the concentrations of components to be assayed are calculated by the use of standard equations.

Abstract translation: 提供了含水液体分光光度法测定方法和装置，其具有抽吸液体的泵，具有两个出口的过滤器，用于填充细胞，其中在35至50℃的温度下进行干涉测量，其最大波动 0.2℃，最大相对湿度为0.2％。 吸收曲线A（f）是相对于基质确定的，并且通过使用标准方程式来计算要测定的组分的浓度。