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1066 条记录 (耗时 0.028 秒)

    Extended Release Dosage Form
    31.
    发明申请
    Extended Release Dosage Form 有权
    延长释放剂型

    公开(公告)号：US20070128279A1

    公开(公告)日：2007-06-07

    申请号：US11673066

    申请日：2007-02-09

    申请人： David Edgren ,  Patrick Wong ,  Gurdish Bhatti ,  Shu Li ,  Robert Skluzacek

    发明人： David Edgren ,  Patrick Wong ,  Gurdish Bhatti ,  Shu Li ,  Robert Skluzacek

    IPC分类号： A61K31/485 ,  A61K9/24 ,  A61K31/16

    CPC分类号： A61K9/0004 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2866 ,  A61K9/2886

    摘要： A membrane system comprising an interior wall, a fluid-permeable exterior wall surrounding the interior wall and an internal compartment defined by the membrane system, wherein fluid permeability of the interior wall is responsive to osmolarity of an osmotic core within the internal compartment are disclosed. A controlled release dosage form comprising the membrane system and a process for delivering an osmotically active formulation from an osmotic pump over an extended period of time are also disclosed.

    摘要翻译： 公开了一种膜系统，其包括内壁，围绕内壁的流体可渗透的外壁和由膜系统限定的内部隔室，其中内壁的流体渗透性响应于内部隔室内的渗透性芯的渗透压。 还公开了一种包含膜系统的控释剂型，以及用于在延长的时间段内从渗透泵输送渗透活性制剂的方法。

    Electrotransport agent delivery method and apparatus
    32.
    发明授权
    Electrotransport agent delivery method and apparatus 失效
    电子输送剂输送方法和装置

    公开(公告)号：US07212853B1

    公开(公告)日：2007-05-01

    申请号：US08952368

    申请日：1996-06-07

    申请人： J. Bradley Phipps ,  Gary A. Lattin ,  Ronald P. Haak ,  Felix Theeuwes ,  Suneel K. Gupta

    发明人： J. Bradley Phipps ,  Gary A. Lattin ,  Ronald P. Haak ,  Felix Theeuwes ,  Suneel K. Gupta

    IPC分类号： A61N1/30

    CPC分类号： A61N1/325 ,  A61N1/044 ,  A61N1/0448

    摘要： An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein current pulses have a magnitude above a critical level (Ic) at which the skin is transformed into a higher electrotransport delivery efficiency (E) state. Most preferably the length of the applied current pulses is at least 5 msec and preferably at least 10 msec.

    摘要翻译： 提供了一种用于通过完整皮肤递送治疗剂的电转运剂递送装置（10）及其操作方法。 该装置施加脉冲电输送电流，其中电流脉冲具有高于皮肤转化为更高的电转运递送效率（E）状态的临界水平（I C）以上的幅度。 最优选地，施加的电流脉冲的长度为至少5毫秒，优选至少10毫秒。

    Dosage form comprising liquid formulation
    35.
    发明申请
    Dosage form comprising liquid formulation 失效
    包含液体制剂的剂型

    公开(公告)号：US20070048368A1

    公开(公告)日：2007-03-01

    申请号：US11589558

    申请日：2006-10-30

    申请人： Liang-Chang Dong ,  Steven Espinal ,  Patrick Wong

    发明人： Liang-Chang Dong ,  Steven Espinal ,  Patrick Wong

    IPC分类号： A61K9/52

    CPC分类号： A61K9/4858 ,  A61K9/0004 ,  A61K9/1075 ,  A61K9/4866

    摘要： A sustained release dosage form includes a capsule made of a thermoplastic polymer having a softening point below 200° C. and an orifice formed or formable within the capsule, an emulsion formulation contained within the capsule, and an expandable composition within the capsule remote from the orifice. The emulsion formulation comprises a drug, an emulsifying surfactant, and an oil. The expandable composition is configured to expand and expel the emulsion formulation through the orifice.

    摘要翻译： 持续释放剂型包括由软化点低于200℃的热塑性聚合物制成的胶囊，以及在胶囊内形成或可形成的孔，包含在胶囊内的乳剂，以及远离胶囊内的胶囊内的可膨胀组合物 孔。 乳液制剂包含药物，乳化表面活性剂和油。 可膨胀组合物构造成通过孔膨胀和排出乳液制剂。

    Method for preventing crystal formation in a dispersion of a liquid in a matrix
    38.
    发明授权
    Method for preventing crystal formation in a dispersion of a liquid in a matrix 有权
    防止液体在基质中分散液中晶体形成的方法

    公开(公告)号：US07169409B2

    公开(公告)日：2007-01-30

    申请号：US10658247

    申请日：2003-09-08

    申请人： John W. Dohner ,  Scott A. Bura

    发明人： John W. Dohner ,  Scott A. Bura

    IPC分类号： A61K9/70

    CPC分类号： A61K9/7053 ,  A61F2013/0296 ,  A61K9/7084

    摘要： An improved method for the manufacture of transdermal drug delivery devices comprising liquid dispersions of a liquid in an aqueous or nonaqueous matrix is disclosed. More particularly, the invention relates to preventing the formation of a crystalline structure in such liquid dispersions by annealing films and laminates in-line immediately following film formation and/or lamination during the manufacture of these devices.

    摘要翻译： 公开了一种用于制造透皮药物递送装置的改进方法，其包括在水性或非水性基质中液体的液体分散体。 更具体地说，本发明涉及通过在制造这些装置的膜形成和/或层压之间立即退火膜和层压体来防止在这种液体分散体中形成结晶结构。

    Minimally compliant, volume-efficient piston for osmotic drug delivery systems
    39.
    发明授权
    Minimally compliant, volume-efficient piston for osmotic drug delivery systems 有权
    适用于渗透药物输送系统的容积效率活塞

    公开(公告)号：US07112335B2

    公开(公告)日：2006-09-26

    申请号：US11219960

    申请日：2005-09-06

    申请人： Scott D. Lautenbach

    发明人： Scott D. Lautenbach

    IPC分类号： A61F2/00 ,  A61K9/22

    CPC分类号： A61K9/48 ,  A61K9/0004 ,  A61M31/002 ,  A61M2005/14513

    摘要： An osmotic pump having a minimally compliant, volume-efficient piston positioned within a capsule is provided. The capsule has an interior surface, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a length-to-total-diameter ratio of about 1.1:1 and a core-diameter-to-total-diameter ratio of about 0.9:1. The piston enables greater beneficial agent and/or osmotic agent payload without increasing the size of the capsule. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and, in turn, cause delivery of the beneficial agent from the capsule.

    摘要翻译： 提供了一种具有位于胶囊内的最小顺应性体积效率的活塞的渗透泵。 胶囊具有内表面，有益剂和渗透剂。 活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。 可移动密封件将渗透剂与有益剂分离。 活塞具有约1.1:1的长度与总直径之比和约0.9:1的芯直径与总直径之比。 该活塞能够增加更大的有益剂和/或渗透剂有效载荷，而不增加胶囊的尺寸。 渗透剂通过半渗透体吸收来自周围环境的液体，引起活塞移动，从而使有益剂从胶囊输送。