公开(公告)号：US10525433B2

公开(公告)日：2020-01-07

申请号：US12518743

申请日：2007-12-12

Applicant: Ofer Toledano ,  Hanan Sertchook ,  Raed Abu-Reziq ,  Haim Bar-Simantov ,  Leora Shapiro

Inventor： Ofer Toledano ,  Hanan Sertchook ,  Raed Abu-Reziq ,  Haim Bar-Simantov ,  Leora Shapiro

IPC: A61K9/66 ,  A61K8/06 ,  A61K8/18 ,  A61Q11/00 ,  A61Q17/04 ,  B01J13/14

Abstract: A process for preparing nanocapsules having a core-shell structure, comprising:(a) preparing an oil-in-water emulsion by emulsification of an oily phase that comprises a core material, in an aqueous phase, under high shear forces, wherein one or both of the oily phase, and the aqueous phase comprises a sol-gel precursor; (b) subjecting the emulsion obtained in (a) to a high pressure homogenization to obtain a nano-emulsion; and (c) applying conditions for hydrolyzing and polycondensing the sol-gel precursor to obtain nanocapsules having a metal oxide shell encapsulating the core material, said nanocapsules have a particle size distribution of: d10=10-80 nm, d50=30-200 nm, and d90=70-500 nm, in diameter. The invention also relate to nanocapsules having the above particle size distribution and to composition comprising the nanocapsules.

公开(公告)号：US10512796B2

公开(公告)日：2019-12-24

申请号：US13500937

申请日：2010-12-30

Applicant: Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco-Dagan

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco-Dagan

IPC: A01N25/28 ,  A61Q19/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/26 ,  A61K8/38 ,  A61K8/67 ,  A61K9/00 ,  A61K9/51 ,  B01J13/14

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US10420743B2

公开(公告)日：2019-09-24

申请号：US16033257

申请日：2018-07-12

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Ori Nov

IPC: A61K9/50 ,  A61K31/203 ,  A61K31/327 ,  A61P17/10 ,  A61K9/00

Abstract: The present application is directed to regimens, methods of treatment, and compositions for the treatment of acne in a subject suffering therefrom.

公开(公告)号：US20180235924A1

公开(公告)日：2018-08-23

申请号：US15753397

申请日：2016-08-17

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer TOLEDANO ,  Alon SERI-LEVY ,  Karine NEIMANN ,  Ori NOV

IPC: A61K31/327 ,  A61K9/00 ,  A61K9/16 ,  A61P17/06 ,  A61P17/04 ,  A61P17/10

CPC classification number: A61K31/327 ,  A61K9/0014 ,  A61K9/16 ,  A61K9/501 ,  A61K9/5089 ,  A61K31/192 ,  A61K2300/00 ,  A61P17/04 ,  A61P17/06 ,  A61P17/10

Abstract: The invention provides compositions comprising as active agents benzoyl peroxide (BPO), adapalene and optionally clindamycin phosphate, kits and uses thereof in methods for treating skin surface condition in a subject in need thereof.

公开(公告)号：US20180117369A1

公开(公告)日：2018-05-03

申请号：US15834805

申请日：2017-12-07

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A61Q19/00 ,  B01J13/14 ,  A61K9/51 ,  A61K8/11 ,  A61K8/67 ,  A61K8/38 ,  A61K8/26 ,  A61K8/25 ,  A61K9/00

CPC classification number: A61Q19/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/26 ,  A61K8/38 ,  A61K8/671 ,  A61K9/0014 ,  A61K9/5115 ,  A61K9/5192 ,  A61K2800/412 ,  B01J13/14

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US20120269874A1

公开(公告)日：2012-10-25

申请号：US13495701

申请日：2012-06-13

Applicant: Ofer TOLEDANO ,  Hanan SERTCHOOK ,  Natalia LOBODA ,  Haim BAR-SIMANTOV ,  Leora SHAPIRO ,  Raed ABU-REZIQ

Inventor： Ofer TOLEDANO ,  Hanan SERTCHOOK ,  Natalia LOBODA ,  Haim BAR-SIMANTOV ,  Leora SHAPIRO ,  Raed ABU-REZIQ

IPC: A61K9/14 ,  A61K31/192 ,  A61K31/4436 ,  A61K31/327 ,  A61P17/10 ,  A61P17/06 ,  A61Q19/08 ,  A61Q19/02 ,  A61P31/00 ,  A61P17/00 ,  A61K8/38 ,  A61K8/49 ,  A61K8/02 ,  B05D7/24 ,  A61K31/203

CPC classification number: A61K9/0014 ,  A61K9/28 ,  A61K47/34

Abstract: The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.

Abstract translation: 本发明涉及用于局部应用的组合物，其包含作为活性成分的过氧化物和类视色素，其中所述过氧化物和类视色素之一为第一微粒的形式，其包含由金属氧化物层包被的活性成分的固体颗粒物质， 所述过氧化物和类视色素中的另一种以未包衣的游离形式或活性成分的包衣形式存在。 本发明还涉及使用所述组合物治疗受试者的表面状况的方法，制备显示出改善的稳定性的组合物的方法，以及试剂盒，其包含：（a）第一组合物，其包含作为第一活性成分的过氧化物; 和（b）第二组合物，其包含类视黄醇作为第二活性成分; 所述第一和第二活性成分中的至少一个被金属氧化物层包覆。

公开(公告)号：US20120015014A1

公开(公告)日：2012-01-19

申请号：US13243189

申请日：2011-09-23

Applicant: Noa LAPIDOT ,  Shlomo Magdassi ,  David Avnir ,  Claudi Rottman ,  Orit Gans ,  Alon Seri-Levy

Inventor： Noa LAPIDOT ,  Shlomo Magdassi ,  David Avnir ,  Claudi Rottman ,  Orit Gans ,  Alon Seri-Levy

IPC: A61K9/50 ,  A61K31/327 ,  A61P3/02 ,  A61Q19/00 ,  A61K31/07 ,  A61K8/67 ,  A61K8/38 ,  A61K8/11 ,  A61P17/10

CPC classification number: A61K8/042 ,  A61K8/11 ,  A61K8/25 ,  A61K8/37 ,  A61K8/38 ,  A61K8/602 ,  A61K8/671 ,  A61K9/501 ,  A61K9/5031 ,  A61K9/5115 ,  A61K9/5138 ,  A61K2800/412 ,  A61K2800/75 ,  A61Q1/00 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/937 ,  Y10S514/944 ,  Y10S514/945

Abstract: A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.

Abstract translation: 一种用于局部施用的治疗性，化妆品或药妆组合物，其能够稳定活性成分并递送活性成分，其包含多个具有核 - 壳结构的微胶囊。 微胶囊的直径约为0.1至100微米。 每个微胶囊的核心包含至少一种活性成分，并被包封在微胶囊壳内。 壳由至少一种通过溶胶 - 凝胶法获得的无机聚合物组成，并且外壳在局部施用之前保护活性成分，并被设计成在施用后从微胶囊中释放活性成分。 该组合物可用于包封在其它制剂中不稳定或对皮肤有刺激性的活性成分，例如过氧化苯甲酰。

公开(公告)号：US20110262506A1

公开(公告)日：2011-10-27

申请号：US13126288

申请日：2010-01-05

Applicant: Ofer Toledano ,  Daniela Mavor ,  Eli Drori ,  Maya Erlich ,  Sharon Hershkovitch

Inventor： Ofer Toledano ,  Daniela Mavor ,  Eli Drori ,  Maya Erlich ,  Sharon Hershkovitch

IPC: A61K8/02 ,  A61P17/10 ,  A61P31/00 ,  A61P29/00 ,  A61P17/04 ,  A61B19/02 ,  A61P17/08 ,  A61P17/00 ,  A61P35/00 ,  A61P17/16 ,  A61Q19/02 ,  A61Q19/00 ,  A61K9/00 ,  A61P17/06

CPC classification number: A61K8/38 ,  A61K8/11 ,  A61K8/25 ,  A61K8/26 ,  A61K8/27 ,  A61K8/28 ,  A61K8/29 ,  A61K2800/88 ,  A61Q19/00 ,  A61Q19/008 ,  A61Q19/08

Abstract: Provided is a multi component topical system including at least one component including at least one first active agent coated by metal oxide; and at least one skin treating component free of the active agent. Further provided are methods of using the multi component topical system and kits including them.

Abstract translation: 提供了一种多组分局部系统，其包括至少一种包含至少一种被金属氧化物涂覆的第一活性剂的组分; 和至少一种不含活性剂的皮肤处理组分。 还提供了使用多组分局部系统和包括它们的试剂盒的方法。

公开(公告)号：US12295935B2

公开(公告)日：2025-05-13

申请号：US18123702

申请日：2023-03-20

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Ori Nov

IPC: A61K31/327 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61K9/107 ,  A61K9/50 ,  A61P17/00 ,  A61P17/10

Abstract: A regimen and a pharmaceutical composition for the treatment of a skin condition and/or skin affliction are described. The regimen includes topically applying to the skin of a subject in need of such treatment a pharmaceutical composition comprising about 2.5% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient.

公开(公告)号：US12070629B2

公开(公告)日：2024-08-27

申请号：US17340334

申请日：2021-06-07

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A61Q19/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/26 ,  A61K8/38 ,  A61K8/67 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61K9/50 ,  A61K9/51 ,  B01J13/14 ,  B01J13/18 ,  F28D20/02 ,  A61K47/32 ,  A61K47/38

CPC classification number: A61Q19/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/26 ,  A61K8/38 ,  A61K8/671 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/10 ,  A61K9/501 ,  A61K9/5115 ,  A61K9/5192 ,  B01J13/14 ,  B01J13/18 ,  F28D20/023 ,  A61K9/5026 ,  A61K47/32 ,  A61K47/38 ,  A61K2800/412

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.