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公开(公告)号:US11858888B2
公开(公告)日:2024-01-02
申请号:US16859791
申请日:2020-04-27
申请人: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College , University of Southern California
发明人: Nicolas G. Bazan , Nicos A. Petasis
IPC分类号: C07C57/03 , C07C59/42 , C07F9/10 , C07C69/587 , C07C69/732 , A61K31/232 , A61K31/202 , A61P25/28 , A61P29/00
CPC分类号: C07C57/03 , A61K31/202 , A61K31/232 , A61P25/28 , A61P29/00 , C07C59/42 , C07C69/587 , C07C69/732 , C07F9/10 , C07F9/106
摘要: This disclosure provides compounds, pharmaceutical compositions, and methods of use for the prevention and treatment of inflammatory diseases or degenerative diseases including neurodegenerative diseases. Embodiments of the present disclosure provide compounds related to very long chain polyunsaturated fatty acids, pharmaceutical compositions containing the provided compounds, and methods of treating a subject with a condition or disease using provided compounds or pharmaceutical compositions.
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公开(公告)号:US11840549B2
公开(公告)日:2023-12-12
申请号:US17118795
申请日:2020-12-11
发明人: Frank H. Ebetino , Shuting Sun , Mark W. Lundy , Charles E. McKenna , Eric Richard , Parish Sedghizadeh , Keivan Sadrerafi , Philip T. Cherian
IPC分类号: C07F9/6558 , C07F9/6561 , A61P31/04 , A61P19/10 , A61K47/55 , A61K47/54
CPC分类号: C07F9/65583 , A61K47/548 , A61K47/55 , A61K47/552 , A61P19/10 , A61P31/04 , C07F9/6561
摘要: Described herein are bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof that can include a bisphosphonate and a quinolone, where the quinolone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof.
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公开(公告)号:US20230394516A1
公开(公告)日:2023-12-07
申请号:US18132021
申请日:2023-04-07
IPC分类号: G06Q30/0207 , G06N3/098
CPC分类号: G06Q30/0215 , G06N3/098
摘要: A federated learning environment includes a central coordinator that is responsible to orchestrate execution of the federated learning environment, and a plurality of clients jointly that trains machine learning and deep learning models on client computing devices without sharing their local private datasets. The clients only share their locally trained model parameters with the central coordinator. Model parameters are encrypted before sharing with the controller. The central coordinator aggregates local models and computes a new global model in encrypted space. This process repeats for a number of synchronization periods or asynchronously until specific convergence criteria are met. A federated learning marketplace is established to incentivize data providers to join federations through a revenue-sharing model, and to facilitate the use of machine-learning models to organizations outside of the federation.
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公开(公告)号:US20230389850A1
公开(公告)日:2023-12-07
申请号:US18249667
申请日:2021-10-21
CPC分类号: A61B5/363 , A61B5/02438 , A61B5/7267 , G16H50/20
摘要: The present application relates to using noninvasive techniques to determine whether a patient has experienced a cardiac event. The present application also relates to using noninvasive techniques to determine a size of a myocardial infarction experienced by a patient. In some embodiments, arterial pressure waveforms may be obtained, and from the arterial pressure waveform, a set of cardiac parameters may be extracted. The extracted cardiac parameters may be provided, as input, to the trained machine learning model, which may output a result indicating whether the patient experienced a cardiac event, a size of a myocardial infarction experience by a patient, or other information about the patient's cardiac health.
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公开(公告)号:US11825839B2
公开(公告)日:2023-11-28
申请号:US16557897
申请日:2019-08-30
发明人: Britney O. Pennington , Jeffrey K. Bailey , Mohamed A. Faynus , Cassidy Arnold , Lincoln V. Johnson , Dennis O. Clegg , Mark S. Humayun , David R. Hinton , Danhong Zhu , Debbie Mitra
CPC分类号: A01N1/021 , C12N5/0621 , C08G61/025
摘要: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
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公开(公告)号:US20230366117A1
公开(公告)日:2023-11-16
申请号:US18180112
申请日:2023-03-07
发明人: David Alvin TYVOLL , Nan CHEN , Bharat Kumar MENON , Heather Michelle GRANDIN , Jenna Brynne LUBET
CPC分类号: C25D11/26 , C25D21/02 , C25D11/024
摘要: Embodiments of methods and apparatuses for forming the metal oxide nanostructure on surfaces are disclosed. In certain embodiments, the nanostructures can be formed on a substrate made of a nickel titanium alloy, resulting in a nanostructure that can include both titanium oxide and nickel oxide. The nanostructure can be formed on the surface(s) of an implantable medical device, such as a stent.
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公开(公告)号:US11812624B2
公开(公告)日:2023-11-07
申请号:US16262460
申请日:2019-01-30
发明人: Mark E. Thompson , Abegail Tadle , Karim El Roz , Peter Ivan Djurovich , Daniel Sylvinson Muthiah Ravinson , Jessica H. Golden , Stuart W. Sawyer
IPC分类号: H01L51/00 , H10K85/60 , C07F5/02 , C07D471/14 , C09K11/02 , C09K11/06 , H10K85/40 , H10K50/11 , H10K50/18 , H10K101/10
CPC分类号: H10K85/654 , C07D471/14 , C07F5/02 , C07F5/022 , C09K11/025 , C09K11/06 , H10K85/40 , H10K85/6572 , H10K85/6576 , C09K2211/1018 , H10K50/11 , H10K50/18 , H10K2101/10
摘要: A compound of Formula X
wherein
ring A is absent, or present and selected from a 5-membered or 6-membered, carbocyclic or heterocyclic ring, which is optionally substituted; ring B is absent, or present and selected from a 5-membered or 6-membered, carbocyclic or heterocyclic ring, which is optionally substituted; and at least one of ring A or ring B is present, and the hash line represents ring A fused to ring N—W1—W2 and ring B fused to ring N—W3—W4;
W1, W2, W3, W4, W5, and W6 are independently selected from CR1 or N;
Z is selected from CRZ or N; and
Y is selected from a group consisting of C(R2)2, B(R2)2, Al(R2)2, Si(R2)2, and Ge(R2)2.
An optoelectronic device selected from the group consisting of a photovoltaic device, a photodetector device, a photosensitive device, and an OLED, the optoelectronic device including an organic layer that comprises a compound of Formula X. A consumer product that includes the optoelectronic device.-
38.
公开(公告)号:US20230345016A1
公开(公告)日:2023-10-26
申请号:US18134110
申请日:2023-04-13
发明人: Shashank Nelamangala SRIDHARA , Eduardo Hernan Pavez CARVELLI , Antonio ORTEGA , Ryousuke WATANABE , Keisuke NONAKA , Kyouhei UNNO
IPC分类号: H04N19/186
CPC分类号: H04N19/186
摘要: Encoding efficiency for attribute information in point cloud information is improved.
A point cloud encoding device includes a subsampling unit configured to preserve chroma signals of some points in a point cloud to be encoded and discard chroma signals of remaining points other than those points, and an attribute information encoding unit configured to encode the chroma signals of those points in the point cloud to be encoded and luma signals of all points.-
39.
公开(公告)号:US20230339185A1
公开(公告)日:2023-10-26
申请号:US18028946
申请日:2021-09-27
发明人: Qiang HUANG
IPC分类号: B29C64/386 , G05B19/4099
CPC分类号: B29C64/386 , G05B19/4099 , B33Y50/00
摘要: A system, method, and computer-readable medium having machine instructions provides for predicting geometric shape accuracy of 3D printed products. Such a prediction may involve developing a model of an object and determining ways in which an actually-manufactured 3D object corresponding to the model differs in real life. These differences correspond to shape deviations. Shape deviations may be process dependent and/or path dependent, and different layers of the object as well as the manufacturing process to make the different layers may introduce shape deviations in layers of the object. By developing a transfer functions of the manufacturing process and associated interlayer effects of the layers and then appropriately offsetting inputs to the manufacturing process, the shape deviations may be ameliorated.
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公开(公告)号:US11786521B2
公开(公告)日:2023-10-17
申请号:US17503760
申请日:2021-10-18
发明人: Thomas Chen
IPC分类号: A61K31/495 , C07D231/12 , A61K31/4188 , A61K47/54 , C07B59/00 , A61K31/4015 , A61K9/00 , A61K31/045 , A61K31/415 , C07D207/26 , C07C33/14 , C07D487/04 , A61K45/06 , A61N5/10 , A61K31/635 , A61K47/55 , A61K31/366
CPC分类号: A61K31/495 , A61K9/0043 , A61K31/045 , A61K31/366 , A61K31/4015 , A61K31/415 , A61K31/4188 , A61K31/635 , A61K45/06 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/55 , A61N5/10 , C07B59/00 , C07C33/14 , C07D207/26 , C07D231/12 , C07D487/04 , C07B2200/05 , C07C2601/16
摘要: The present methods treat neurofibromatosis by a administering to a subject perillyl alcohol or iso-perillyl alcohol. The present methods also treat neurofibromatosis by administering to a subject a carbamate of perillyl alcohol, or a carbamate of iso-perillyl alcohol. The perillyl alcohol carbamate may comprise perillyl alcohol conjugated with rolipram or temozolomide.
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