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71 条记录 (耗时 0.047 秒)

    SINGLE CHAIN FC, METHODS OF MAKING AND METHODS OF TREATMENT
    33.
    发明申请
    SINGLE CHAIN FC, METHODS OF MAKING AND METHODS OF TREATMENT 审中-公开
    单链FC，制备方法和治疗方法

    公开(公告)号：US20080260738A1

    公开(公告)日：2008-10-23

    申请号：US12106081

    申请日：2008-04-18

    申请人： Margaret D. Moore ,  Marshall D. Snavely ,  Brian A. Fox ,  Gabriela H. Hoyos

    发明人： Margaret D. Moore ,  Marshall D. Snavely ,  Brian A. Fox ,  Gabriela H. Hoyos

    IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  A61P43/00 ,  C12N1/14 ,  C12N5/06 ,  C12P21/04

    CPC分类号： C07K16/32 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/734

    摘要： The present invention relates generally to scFc molecules. The scFc molecules comprise at least two Fc regions and at least one linker, and can be produced in a variety of single chain configurations. The scFc molecules can further comprise at least one binding entity and/or at least one functional molecule. Binding entities can be fused to the scFc molecule in a variety of configurations. The present invention also relates generally to methods for making such molecules and methods for their use. The scFc molecules provided herein can be recombinantly produced. Also provided are monovalent forms of the scFc molecules that have an equivalent or superior ADCC and/or CDC response than do bivalent molecules targeting the same antigens. Provided herein are improved antigen binding compositions. Methods for using the scFc molecules of the present inventions are provided

    摘要翻译： 本发明一般涉及scFc分子。 scFc分子包含至少两个Fc区和至少一个接头，并且可以以多种单链构型生产。 scFc分子可进一步包含至少一个结合实体和/或至少一个功能性分子。 结合实体可以以各种配置融合到scFc分子。 本发明一般还涉及制备这种分子的方法及其使用方法。 本文提供的scFc分子可以重组生产。 还提供了与靶向相同抗原的二价分子相比，具有等同或优异的ADCC和/或CDC响应的scFc分子的单价形式。 本文提供了改进的抗原结合组合物。 提供了使用本发明的scFc分子的方法

    Kunitz domain polypeptide zkun10
    36.
    发明授权
    Kunitz domain polypeptide zkun10 失效
    Kunitz结构域多肽zkun10

    公开(公告)号：US07183391B2

    公开(公告)日：2007-02-27

    申请号：US11082148

    申请日：2005-03-16

    申请人： Paul O. Sheppard ,  Brian A. Fox

    发明人： Paul O. Sheppard ,  Brian A. Fox

    IPC分类号： C07K14/81 ,  C12Q1/25

    CPC分类号： C07K14/8114 ,  A61K38/00

    摘要： We claim the proteinase inhibitors comprising a Kunitz domain, wherein the Kunitz domain comprises amino acid residues 57–107 of SEQ ID NO: 2. We also claim a fusion protein comprising said Kunitz domain. In addition, we claim a method of inhibiting protease degradation or protease activity in a composition which contains plasma proteins and proteases. The proteinase inhibitors is used as components of cell culture media in cell culture process, and as inhibitors of protease-mediated degradation of plasma proteins in protein purification.

    摘要翻译： 我们要求包含Kunitz结构域的蛋白酶抑制剂，其中Kunitz结构域包含SEQ ID NO：2的氨基酸残基57-107。我们还要求包含所述Kunitz结构域的融合蛋白。 此外，我们提出了在含有血浆蛋白和蛋白酶的组合物中抑制蛋白酶降解或蛋白酶活性的方法。 蛋白酶抑制剂在细胞培养过程中用作细胞培养基的组分，并且作为蛋白质介导的蛋白质纯化中血浆蛋白质降解的抑制剂。

    Dimerized PDGF-D and materials and methods for producing it
    37.
    发明授权
    Dimerized PDGF-D and materials and methods for producing it 失效
    二聚PDGF-D及其制备方法

    公开(公告)号：US07122351B2

    公开(公告)日：2006-10-17

    申请号：US10274638

    申请日：2002-10-18

    申请人： Margaret Dow Moore ,  Brian A. Fox

    发明人： Margaret Dow Moore ,  Brian A. Fox

    IPC分类号： C12N5/10 ,  C12N15/16 ,  C12N15/63

    CPC分类号： C07K14/49 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026

    摘要： Proteins consisting of two PDGF-D polypeptide chains, polynucleotides encoding the polypeptides, and materials and methods for making the proteins are disclosed. Each of the polypeptide chains consists of, from amino terminus to carboxyl terminus, the following operably linked segments: P1-P2-h-CH2-CH3; P1-P2-CH2-CH3; h-CH2-CH3-P2-P1; or CH2-CH3-P2-P1. Within these polypeptide chains, P1 is a first polypeptide segment as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365–370, inclusive; P2 is a second polypeptide segment consisting of from 4 to 20 amino acid residues; h is an immunoglobulin hinge region or portion thereof; and CH2 and CH3 are CH2 and CH3 domains of an immunoglobulin heavy chain, respectively. Within the protein, the two polypeptide chains are joined by one or more disulfide bonds, each of the chains is optionally glycosylated, and the protein binds to and activates cell-surface PDGF receptors.

    摘要翻译： 公开了由两个PDGF-D多肽链组成的蛋白质，编码多肽的多核苷酸，以及用于制备蛋白质的材料和方法。 每个多肽链由氨基末端至羧基末端组成以下可操作连接的片段：P1-P2-h-C H-2-C 3 H 3; P1-P2-C H-2-C H 3; H-C H-2-C 3-P2-P1; 或C H 2 -C 3 -PO-P-2。 在这些多肽链中，P1是从氨基酸x至氨基酸y的SEQ ID NO：2或SEQ ID NO：4所示的第一个多肽区段，其中x是246至258的整数，包括端值，y是 整数为365-370，含 P2是由4至20个氨基酸残基组成的第二多肽区段; h是免疫球蛋白铰链区域或其部分; 和C H 2和C H 3是免疫球蛋白重链的C H 2 H 2和C 3 H 3结构域 ， 分别。 在蛋白质内，两条多肽链通过一个或多个二硫键连接，每个链任选被糖基化，并且蛋白质结合并激活细胞表面PDGF受体。

    Cytokine Protein Family
    40.
    发明授权
    Cytokine Protein Family 有权
    细胞因子蛋白家族

    公开(公告)号：US08124065B2

    公开(公告)日：2012-02-28

    申请号：US13028101

    申请日：2011-02-15

    申请人： Paul O. Sheppard ,  Brian A. Fox ,  Kevin M. Klucher ,  David W. Taft ,  Wayne Kindsvogel

    发明人： Paul O. Sheppard ,  Brian A. Fox ,  Kevin M. Klucher ,  David W. Taft ,  Wayne Kindsvogel

    IPC分类号： A61K38/00 ,  A61K45/00 ,  C07K14/00

    CPC分类号： C07K14/56 ,  C12Q2600/158

    摘要： The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.

    摘要翻译： 本发明涉及与氨基酸序列水平上与干扰素-α最密切相关的zcyto20，zcyto21，zcyto22，zycto24和zcyto25蛋白的多核苷酸和多肽分子。 该蛋白家族的受体是II类细胞因子受体。 本发明包括减少病毒感染和增加单核细胞计数的方法。 本发明还包括针对zcyto20多肽的抗体，以及产生多核苷酸和多肽的方法。