公开(公告)号：US12144191B2

公开(公告)日：2024-11-12

申请号：US17352622

申请日：2021-06-21

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Dion Khodagholy ,  Georgios Spyropoulos

IPC: H10K10/46 ,  G01N27/414 ,  H10K77/10

Abstract: An internal-ion gated electrochemical transistor is provided. In some embodiments, the internal-ion gated electrochemical transistor comprises: a gate electrode, a source electrode, and a drain electrode; a channel formed between the source electrode and the drain electrode, wherein the channel comprises a conducting polymer, wherein the channel serves as a reservoir of positively charged mobile ions; and an ion membrane between the channel and the gate electrode, wherein: in an off state, at least a subset of the positively charged mobile ions are ionically bonded to negatively charged ions of the conducting polymer, and wherein in an on state, at least a subset of the positively charged mobile ions are unbonded from the negatively charged ions of the conducting polymer to induce a current within the channel, and wherein at least one of the off state and the on state is actuated by application of a voltage to the gate electrode.

公开(公告)号：US20240371540A1

公开(公告)日：2024-11-07

申请号：US18556743

申请日：2022-04-22

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education ,  THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Hrvoje Petek ,  Yanan Dai ,  Chen-Bin Huang ,  Atreyie Ghosh ,  Zhikang Zhou

IPC: G21K1/00 ,  G21K1/06

Abstract: Described herein are systems and methods for assembling electron spin and charge to possess one or more properties of a magnetic monopole. Example systems can include a laser configured to generate a light beam with a first spin and/or a first orbital angular momentum, and a surface including a coupling structure having a geometrical charge. When exposed to the light beam, the surface is configured to enable excitations of surface plasmon polariton field waves at metal-dielectric interfaces of the coupling structure to generate a plasmonic field. The surface can be configured to focus the plasmonic field to form a plasmonic vortex, in which plasmonic spin-orbit coupling between a total spin and a total orbital angular momentum forms a topological spin texture that is homotopic to that of a magnetic monopole.

公开(公告)号：US20240351928A1

公开(公告)日：2024-10-24

申请号：US18637984

申请日：2024-04-17

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Julian John Alexander VAN DER MADE ,  Kartik CHANDRAN ,  Elizabetth Amy LANDIS ,  Ruby LAI

IPC: C02F3/34 ,  C02F1/467 ,  C02F1/72 ,  C02F101/34 ,  C02F101/36 ,  C02F103/34 ,  C12M1/00 ,  C12M1/06 ,  C12M1/12 ,  C12M1/42 ,  C12N1/14

CPC classification number: C02F3/347 ,  C02F1/4672 ,  C02F1/722 ,  C12M25/02 ,  C12M27/06 ,  C12M29/06 ,  C12M35/02 ,  C12N1/14 ,  C02F2101/34 ,  C02F2101/36 ,  C02F2103/34 ,  C02F2305/026

Abstract: A fungal culture is provided that incorporates concentrations of Fenton reactants and white rot fungi biomass. These components synergize to degrade recalcitrant organic compounds such as lignins, perfluorochemicals including PFOA, plastics, and related compounds, particularly with 1.5 mM H2O2, 1 mM Fe2+, and Phanerochaete chrysosporium exhibiting lignin degrading capabilities comparable to cultures of Fenton-only reaction mediums with significantly higher concentrations of hydrogen peroxide. Both the fungi and the Fenton reactants work to degrade the organic compounds. Additionally, the Fenton reactants impose oxidative stress on fast-growing microbial competitors such as E. coli, selectively inhibiting the competing bacteria and their disadvantageous effects on white rot fungi activity. The white rot fungi recycle Fe(II) ions to reduce Fenton reactant input burden. An electro-Fenton reaction process can further reduce this burden by replenishing H2O2. The resulting systems and methods demonstrate more economical and sustainable treatment of recalcitrant organic compounds.

公开(公告)号：US12125593B2

公开(公告)日：2024-10-22

申请号：US17494562

申请日：2021-10-05

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Paul Sajda ,  Xueqing Liu

IPC: G16H50/20 ,  G06T7/00 ,  G06T9/00

CPC classification number: G16H50/20 ,  G06T7/0012 ,  G06T9/002 ,  G06T2207/10088

Abstract: The present subject matter relates to techniques for hierarchical deep transcoding. The disclosed system can include a processor that can be configured to receive a functional magnetic resonance imaging (fMRI) data and/or an extracranial electroencephalogram (EEG) data and reconstruct a latent source space from the fMRI data and/or the EEG data by decoding the EEG data and/or the fMRI data to a latent source space. The fMRI data and the EEG data can be simultaneously acquired.

公开(公告)号：US12123005B2

公开(公告)日：2024-10-22

申请号：US16508021

申请日：2019-07-10

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Antonio Iavarone ,  Anna Lasorella ,  Raul Rabadan

IPC: C12Q1/6886 ,  C07K14/47 ,  C07K14/71 ,  C07K14/82 ,  C07K16/18 ,  C07K16/28 ,  C12N9/12 ,  C12N15/62 ,  G01N33/574

CPC classification number: C12N15/62 ,  C07K14/47 ,  C07K14/71 ,  C07K14/82 ,  C07K16/18 ,  C07K16/2863 ,  C12N9/12 ,  C12Q1/6886 ,  G01N33/57492 ,  C07K2319/00 ,  C07K2319/73 ,  C12Q2600/158 ,  G01N2333/91205

Abstract: The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.

公开(公告)号：US12121850B2

公开(公告)日：2024-10-22

申请号：US17595572

申请日：2020-05-22

Applicant: Carbfix ,  UNIVERSITY OF ICELAND ,  THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK ,  BARNARD COLLEGE

Inventor： Bergur Sigfússon ,  Edda Sif Pind Aradóttir ,  Ingvi Gunnarsson ,  Magnus pór Arnarson ,  Einar Gunnlaugsson ,  Hólmfriður Sigurdardóttir ,  Húni Sighvatsson ,  Sigurður Reynir Gíslason ,  Eric H. Oelkers ,  Kiflom G. Mesfin ,  Sandra Ósk Snæbjörnsdóttir ,  Iwona M. Galeczka ,  Domenik Wolff-Boenisch ,  Helgi A. Alfredsson ,  Porsteinn Jónsson ,  Andri Stefánsson ,  Jürg Matter ,  Martin Stute ,  Deirdre Elizabeth Clark ,  Martin Johannes Voigt

IPC: E21B41/00 ,  B01D53/14 ,  B65G5/00 ,  E21B47/11

CPC classification number: B01D53/1475 ,  B01D53/1412 ,  B01D53/1468 ,  B65G5/00 ,  E21B41/0064 ,  E21B47/11 ,  B01D2252/103 ,  Y02C20/40

Abstract: This invention relates to a method and a system of abating carbon dioxide (CO2) and/or hydrogen sulfide (H2S) in a geological reservoir. Water is pumped or transferred from a water source to an injection well. The gasses are merged with the water under conditions where the hydraulic pressure of the water is less than the pressure of CO2 and/or H2S gas at the merging point. The water with CO2 and/or H2S gas bubbles is transferred further downwardly at a certain velocity higher than the upward flow velocity of said CO2 and/or H2S gas bubbles ensuring downward movement of gas bubbles resulting in full dissolution of said CO2 and/or H2S in the water due to elevating pressure. The complete dissolution ensures a lowered pH of the water entering a geological (e.g. geothermal) reservoir which is needed to promote mineral reactions leading to CO2 and H2S abatement This abatement may be quantified by dissolving a tracer substance in a predetermined molar ratio to said dissolved CO2 and/or H2S and monitored in a monitoring well.

公开(公告)号：US20240348172A1

公开(公告)日：2024-10-17

申请号：US18292315

申请日：2022-07-27

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Matthias Preindl ,  Liwei Zhou ,  William-Michael Eull ,  Matthew Jahnes

IPC: H02M3/335 ,  H02M1/00 ,  H02M1/12 ,  H02M1/14 ,  H02M1/44 ,  H02M3/00 ,  H02M7/797

CPC classification number: H02M3/33571 ,  H02M1/0058 ,  H02M1/126 ,  H02M1/14 ,  H02M3/01 ,  H02M7/797 ,  H02M1/009 ,  H02M1/44 ,  H02M3/33584

Abstract: Systems and methods for a high-efficiency power converter incorporating a half-bridge topology with one or more an additional upper capacitor and a drain-source capacitor. The converter includes DC voltage terminals and a DC link capacitor coupled across a positive and negative DC terminal of the DC voltage terminals. The converter further includes a power switching element pair including a high side switch and a low side switch coupled together at a midpoint node. The converter further includes an LC filter having a switch-side inductor, a lower capacitor coupled between a second end of switch-side inductor and the negative DC terminal; and an upper capacitor coupled between the second end of the switch-side inductor and the positive DC terminal. The converter may further include drain-source capacitors coupled across the drain and source terminals of the switches.

公开(公告)号：US20240343781A1

公开(公告)日：2024-10-17

申请号：US18291530

申请日：2022-07-22

Applicant: The Trustees of Columbia University in the City of New York

Inventor： David D. HO ,  Yaoxing HUANG ,  Lihong LIU ,  Manoj S. NAIR ,  Jian YU ,  Sho IKETANI

IPC: C07K16/10 ,  A61P31/20

CPC classification number: C07K16/1003 ,  A61P31/20 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The subject matter described herein relates to engineered monoclonal antibodies, derived from antibodies isolated from human patients, neutralizing a SARS-CoV-2 virus, its variants, or related coronaviruses.

公开(公告)号：US12115140B2

公开(公告)日：2024-10-15

申请号：US17391853

申请日：2021-08-02

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Piero D. Dalerba ,  Sara Viragova

IPC: A61K31/192 ,  A61K31/203

CPC classification number: A61K31/192 ,  A61K31/203

Abstract: The method of treating adenoid cystic carcinoma or other cancer tumors includes the administration of an effective dosage of an inverse agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling to a patient in need thereof, alone or in combination with other cancer treatment. Non-limiting examples of an inverse agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling include 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid (commonly referred to as “BMS493”) and 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl] ethynyl]benzoic acid (commonly referred to as “AGN193109”). Alternatively, prior to administration of the inverse agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling, a direct agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling may be administered to the patient. Non-limiting examples of a direct agonist of retinoic acid receptor (RAR) or retinoid x receptor (RXR) signaling include all-trans retinoic acid (ATRA), isotretinoin, alitretinoin, and bexarotene.

公开(公告)号：US20240337825A1

公开(公告)日：2024-10-10

申请号：US18435404

申请日：2024-02-07

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK CITY

Inventor： Jyotirmoy MANDAL ,  Yuan YANG ,  Nanfang YU

IPC: G02B26/00 ,  C08J9/28 ,  C08K5/00 ,  C09D5/33 ,  E04D7/00 ,  E04D13/00 ,  E04F13/08 ,  E06B9/24 ,  G02B1/14 ,  G02B5/20

CPC classification number: G02B26/004 ,  C08J9/286 ,  C08K5/0041 ,  C09D5/004 ,  E04D7/00 ,  E04D13/00 ,  E04F13/08 ,  E06B9/24 ,  G02B1/14 ,  G02B5/208 ,  B32B2305/026 ,  C08J2301/12 ,  C08J2301/28 ,  C08J2325/06 ,  C08J2327/06 ,  C08J2327/14 ,  C08J2327/20 ,  C08J2383/04 ,  E06B2009/2411 ,  E06B2009/2417

Abstract: A switchable light transmission module is disclosed that includes a substrate having a first surface defining at least part of an enclosed volume, a porous layer disposed on the first surface and in fluid communication with the enclosed volume, and a reservoir in fluid communication with the enclosed volume. The reservoir is configured to supply a fluid to the sealed volume such that the fluid contacts the porous layer. The fluid has a refractive index that is close to the refractive index of the porous layer, has a high wettability for the porous layer, and does not dissolve the porous layer. When in a dry state, voids in the porous layer are filled with air which has a much different refractive index than the porous layer itself, resulting in a surface that is reflective and not very transmissive. During wetting of the porous layer by the fluid, however, those voids are filled with the fluid, reducing the difference in refractive index across the polymer-fluid interfaces such that light scattering is negligible and the surface becomes light permeable.