公开(公告)号：US07956183B2

公开(公告)日：2011-06-07

申请号：US12373216

申请日：2007-07-10

Applicant: Claude Michel Wischik ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

Inventor： Claude Michel Wischik ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

IPC: C07D279/28

CPC classification number: A61K31/5415 ,  C07D279/18 ,  C07D279/20

Abstract: A method for the synthesis of a diaminophenothiazinium compound of the following formula: comprising (a) purifying a corresponding reduced compound which is N-acylated at the heterocyclic nitrogen; (b) deacylating the purified compound to provide the corresponding reduced compound; and (c) oxidizing the reduced compound to provide the diaminophenothiazinium compound. Optional purification may performed, for example, after deacylating and after oxidizing. The method provides high purity diaminophenothiazinium compounds which are suitable for pharmaceutical and related therapeutic uses. Such uses include inactivating pathogens, the treatment of the infectious diseases, and for the treatment of diseases of protein aggregation, such as tauopathies, including Alzheimer's disease.

Abstract translation: 一种用于合成下式的二氨基吩噻嗪鎓化合物的方法：包括（a）在杂环氮中纯化相应的N-酰化的还原化合物; （b）将纯化的化合物去酰化以提供相应的还原化合物; 和（c）氧化还原的化合物以提供二氨基吩噻嗪鎓化合物。 任选的纯化可以例如在脱酰基后和氧化后进行。 该方法提供了适用于药物和相关治疗用途的高纯度二氨基吩噻嗪鎓化合物。 这样的用途包括灭活病原体，感染性疾病的治疗以及治疗蛋白质聚集的疾病，诸如包括阿尔茨海默病在内的tau蛋白病。

公开(公告)号：US20090259040A1

公开(公告)日：2009-10-15

申请号：US12373216

申请日：2007-07-10

Applicant: Claude Michel Wischik ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

Inventor： Claude Michel Wischik ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

IPC: C07D279/18

CPC classification number: A61K31/5415 ,  C07D279/18 ,  C07D279/20

Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesis and/or purification of certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment, prophylaxis, and diagnosis, etc., for example, a tauopathy; a disease of tau protein aggregation; Alzheimer's disease (AD); Pick's disease; Progressive Supranuclear Palsy (PSP); fronto temporal dementia (FTD); parkinsonism linked to chromosome 17 (FTDP-17); disinhibition-dementia-parkinsonism-amyotrophy complex (DDPAC); pallido-ponto-nigral degeneration (PPND); Guam-ALS syndrome; pallido-nigro-luysian degeneration (PNLD); cortico-basal degeneration (CBD); mild cognitive impairment (MCI); skin cancer; melanoma; methemoglobinemia; a viral infection; a bacterial infection; a protozoal infection; a parasitic infection; malaria; visceral leishmaniasis; African sleeping sickness; toxoplasmosis; giardiasis; Chagas' disease; Hepatitis C virus (HCV) infection; human immunodeficiency virus (HIV) infection; West Nile virus (WNV) infection; a synucleinopathy; Parkinson's disease (PD); dementia with Lewy bodies (DLB); multiple system atrophy (MSA); drug-induced parkinsonism; and pure autonomic failure (PAF).

Abstract translation: 本发明一般涉及化学合成和纯化领域，更具体地涉及合成和/或纯化某些3,7-二氨基吩噻嗪-5-肟化合物（本文称为“二氨基吩噻嗪鎓化合物”）的方法，包括甲基硫堇 （MTC）（也称为亚甲蓝）。 本发明还涉及所得的（高纯度）化合物，包含它们的组合物（例如片剂，胶囊）及其在灭活病原体的方法中的用途，以及医学治疗，预防和诊断等方法 ，tau病 tau蛋白聚集的疾病; 阿尔茨海默病（AD）; 皮克病 进行性核核麻痹（PSP） 颞痴呆（FTD）; 与17号染色​​体相关的帕金森综合征（FTDP-17）; 去抑痴呆 - 帕金森综合征 - 肌萎缩综合征（DDPAC）; 苍白球 - 黑质变性（PPND）; 关岛ALS综合征 苍白球黑素瘤变性（PNLD）; 皮质基底变性（CBD）; 轻度认知障碍（MCI）; 皮肤癌; 黑色素瘤 高铁血红蛋白血症; 病毒感染; 细菌感染; 原生动物感染; 寄生虫感染; 疟疾; 内脏利什曼病 非洲昏睡病 弓形体病 贾第虫病 恰加斯病 丙型肝炎病毒（HCV）感染; 人类免疫缺陷病毒（HIV）感染; 西尼罗病毒（WNV）感染; 突触核蛋白病 帕金森病（PD）; 路易体痴呆（DLB）; 多系统萎缩（MSA）; 药物引起的帕金森综合征 和纯自主神经衰竭（PAF）。

公开(公告)号：US20060124239A1

公开(公告)日：2006-06-15

申请号：US10544630

申请日：2004-02-09

Applicant: Colin Marshall ,  Darren Nash ,  Peter Mills

Inventor： Colin Marshall ,  Darren Nash ,  Peter Mills

IPC: B32B7/12

CPC classification number: G09F3/10 ,  C09J7/22 ,  C09J2203/334 ,  C09J2401/006 ,  C09J2467/006 ,  Y10T428/28

Abstract: There is described a method of applying a transparent label of polymeric film to an article to produce a labelled article having a substantial no-label appearance. Labelled articles and labels suitable for use in this method are also described. The labelling method comprises the steps of: (a) selecting films having the following properties (i) Cobb5min value (measured over 5 minutes) from 0.25 to 50 gm−2(min.)−1; and (ii) water vapour transmission rate under tropical conditions from 5 to 2000 gm−2(24 hr)−1, (b) selecting a liquid adhesive (such as a wet glue) having a viscosity from 1 to 500 Pa·s; and (c) applying the selected adhesive to fix the selected label film to the article where the thickness of the adhesive layer between the article and label on application thereof is from 25 to 150 microns. Preferred labels are clear or coloured laminated cellulose films selected to have Cobb5min from 1.25 to 15 gm−2(min.)−1 and WVTRtrop from 325 to 875 gm−2(24 hr)−1. Such films can be applied to a glass bottle using an optional transparent or white wet glue of viscosity from about 40 to about 150 Pa·s (such as starch glue, casein glue, EVA, PVA and/or non-casein based polymeric glue) to give the appearance of no label on the labelled bottle. The adhesive may be applied to give a solid content before drying from 40% to 60% by weight and a dry coat weight from 10 gm−2 to 125 gm−2. The preferred time for the label to be fixed in place is from 1 to 20 minutes with the label preferably dry after 5 minutes to 24 hours. This method may be used on a high speed labelling line where 300 to 1,000 labels are applied per minute.

Abstract translation: 描述了将一种聚合物膜的透明标签应用于制品以产生具有基本无标记外观的标记制品的方法。 还描述了适用于该方法的标签制品和标签。 标记方法包括以下步骤：（a）选择具有以下特性的膜（i）Cobb 5min值（在5分钟内测量）为0.25至50gm -2 / （分钟） ^{和（ii）热带条件下的水蒸汽透过率为5至2000gm -2（24hr）-1，（b）选择液体粘合剂（例如 湿胶），粘度为1〜500Pa·s; 和（c）施加所选择的粘合剂以将所选择的标签膜固定到制品上，其中在施加时，制品和标签之间的粘合剂层的厚度为25至150微米。 优选的标签是选择为具有1.25至15gm -2分钟（分钟）的Cobb 5分钟的透明或着色的层压纤维素膜-1和/或WVTR 从325至875gm -2（24小时）-1小时。 这种膜可以使用粘度为约40至约150Pa.s（例如淀粉胶，酪蛋白胶，EVA，PVA和/或非酪蛋白基聚合胶）的任选的透明或白色湿胶应用于玻璃瓶， 给标签瓶子上没有标签的外观。 可以施加粘合剂以在干燥之前将固体含量从40重量％至60重量％，干涂层重量从10g-2至125g /平方英尺。 将标签固定在适当位置的优选时间为1至20分钟，标签优选在5分钟至24小时后干燥。 该方法可用于每分钟应用300至1,000个标签的高速贴标线。}

公开(公告)号：US09242946B2

公开(公告)日：2016-01-26

申请号：US12875465

申请日：2010-09-03

Applicant: John Mervyn David Storey ,  James Peter Sinclair ,  Colin Marshall ,  Han Wan Tan ,  Claude Michel Wischik

Inventor： John Mervyn David Storey ,  James Peter Sinclair ,  Colin Marshall ,  Han Wan Tan ,  Claude Michel Wischik

IPC: C07D279/18 ,  C09B19/02

CPC classification number: A61K31/5415 ,  A61K9/0019 ,  A61K49/006 ,  C07D279/18 ,  C09B19/02 ,  G01N33/52 ,  Y02A50/393

Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiaziniumcompounds”) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt-formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases.

Abstract translation: 本发明一般涉及化学合成和纯化领域，更具体地涉及合成和纯化某些3,7-二氨基 - 吩噻嗪-5-鎓化合物（本文称为“二氨基吩噻嗪鎓化合物”）的方法，包括甲基氯化铑（MTC）（ 也称为亚甲基蓝）。 在一个实施方案中，该方法包括以下步骤：按顺序：亚硝基化（NOS）; 亚硝酰还原（NR）; 硫代磺酸形成（TSAF）; 氧化偶合（OC）; Cr（VI）还原（CR）; 两性离子中间体（IAPOZI）的分离和纯化; 闭环（RC）; 氯化物盐形成（CSF）; 一种：硫化物处理（ST）; 二甲基二硫代氨基甲酸酯处理（DT）; 碳酸盐处理（CT）; 乙二胺四乙酸处理（EDTAT）; 有机萃取（OE）; 和重结晶（RX）。 本发明还涉及所得的（高纯度）化合物，包含它们的组合物（例如片剂，胶囊）及其在灭活病原体的方法中的用途，以及治疗和诊断方法等，例如对于tau蛋白病 ，阿尔茨海默病（AD），皮肤癌，黑素瘤，病毒性疾病，细菌性疾病或原生动物疾病。

公开(公告)号：US08673415B2

公开(公告)日：2014-03-18

申请号：US13206232

申请日：2011-08-09

Applicant: Alastain Hugh Servante ,  Gary Power ,  Colin Marshall

Inventor： Alastain Hugh Servante ,  Gary Power ,  Colin Marshall

IPC: B32B27/36

CPC classification number: B41M5/52 ,  B41M5/504 ,  B41M5/506 ,  B41M5/508 ,  B41M5/5254 ,  B41M5/5281 ,  B41M7/0081 ,  C08J7/047 ,  C08J2451/00 ,  Y10T428/1352 ,  Y10T428/24802 ,  Y10T428/24851 ,  Y10T428/24893 ,  Y10T428/25 ,  Y10T428/254 ,  Y10T428/26 ,  Y10T428/265 ,  Y10T428/2848 ,  Y10T428/31551 ,  Y10T428/31573 ,  Y10T428/31667 ,  Y10T428/31678 ,  Y10T428/31699 ,  Y10T428/31725 ,  Y10T428/31786 ,  Y10T428/31797 ,  Y10T428/31855 ,  Y10T428/31906 ,  Y10T428/31913 ,  Y10T428/31928 ,  Y10T428/31935 ,  Y10T428/31938 ,  Y10T428/31993 ,  Y10T442/20

Abstract: The invention relates to printable films comprising a substrate and at least a surface layer, said layer covering at least one face of said substrate and comprising a water-dispersible polymer and an ethylenically unsaturated compound; to a process for the manufacture of such films; to printed films and especially to printed labels obtained from such printable films.

公开(公告)号：US20130192489A1

公开(公告)日：2013-08-01

申请号：US13805885

申请日：2011-06-21

Applicant: Martin Cockcroft ,  Colin Marshall

Inventor： Martin Cockcroft ,  Colin Marshall

IPC: C09D7/00

CPC classification number: C09D7/20 ,  B29C41/24 ,  B29K2001/00 ,  B29K2001/12 ,  C08B1/003 ,  C08J3/091 ,  C08J5/18 ,  C08J2301/02 ,  C08L1/02

Abstract: The present invention provides a process for producing a cellulose film in which a) cellulose is at least partly dissolved at a temperature of about 100° C. or lower in a dope comprising an ionic liquid and a cosolvent to form a cellulose solution, wherein said cosolvent comprises a polar aprotic component, and B) cellulose film is cast from the cellulose solution.

Abstract translation: 本发明提供一种纤维素膜的制造方法，其中a）在包含离子液体和共溶剂的涂料中，纤维素在约100℃以下的温度下至少部分溶解以形成纤维素溶液，其中所述 助溶剂包括极性非质子成分，B）纤维素膜从纤维素溶液中流出。

公开(公告)号：US20130154139A1

公开(公告)日：2013-06-20

申请号：US13805616

申请日：2011-06-21

Applicant: Martin Cockcroft ,  Colin Marshall

Inventor： Martin Cockcroft ,  Colin Marshall

IPC: B29D99/00

CPC classification number: B29D99/0078 ,  C08B1/003 ,  C08J3/091 ,  C08J2301/00 ,  D01F2/02 ,  Y02P20/542

Abstract: The present invention provides a process for producing cellulose shaped articles in which a) cellulose is at least partly dissolved at a temperature of about 100° C. or lower in a dope comprising an ionic liquid and a cosolvent to form a cellulose solution, wherein said cosolvent comprises a polar aprotic component, and b) cellulose shaped articles are cast from the cellulose solution.

Abstract translation: 本发明提供一种生产纤维素成型制品的方法，其中a）纤维素在包含离子液体和共溶剂的涂料中在约100℃或更低的温度下至少部分溶解以形成纤维素溶液，其中所述 共溶剂包括极性非质子组分，和b）纤维素成形制品从纤维素溶液中流出。

公开(公告)号：US20110201736A1

公开(公告)日：2011-08-18

申请号：US13029788

申请日：2011-02-17

Applicant: Alastair Hugh Servante ,  Gary Power ,  Colin Marshall

Inventor： Alastair Hugh Servante ,  Gary Power ,  Colin Marshall

IPC: C08L75/06 ,  C08K5/103 ,  C08K5/11

CPC classification number: B41M5/52 ,  B41M5/504 ,  B41M5/506 ,  B41M5/508 ,  B41M5/5254 ,  B41M5/5281 ,  B41M7/0081 ,  C08J7/047 ,  C08J2451/00 ,  Y10T428/1352 ,  Y10T428/24802 ,  Y10T428/24851 ,  Y10T428/24893 ,  Y10T428/25 ,  Y10T428/254 ,  Y10T428/26 ,  Y10T428/265 ,  Y10T428/2848 ,  Y10T428/31551 ,  Y10T428/31573 ,  Y10T428/31667 ,  Y10T428/31678 ,  Y10T428/31699 ,  Y10T428/31725 ,  Y10T428/31786 ,  Y10T428/31797 ,  Y10T428/31855 ,  Y10T428/31906 ,  Y10T428/31913 ,  Y10T428/31928 ,  Y10T428/31935 ,  Y10T428/31938 ,  Y10T428/31993 ,  Y10T442/20

Abstract: The invention relates to printable films comprising a substrate and at least a surface layer, said layer covering at least one face of said substrate and comprising a water-dispersible polymer and an ethylenically unsaturated compound; to a process for the manufacture of such films; to printed films and especially to printed labels obtained from such printable films.

Abstract translation: 本发明涉及包括基底和至少表面层的可印刷膜，所述层覆盖所述基底的至少一个表面并且包含水分散性聚合物和烯属不饱和化合物; 涉及制造这种膜的方法; 印刷膜，特别是从这种可印刷膜获得的印刷标签。

公开(公告)号：US20110094526A1

公开(公告)日：2011-04-28

申请号：US12893572

申请日：2010-09-29

Applicant: Colin MARSHALL ,  Jamie MOFFAT

Inventor： Colin MARSHALL ,  Jamie MOFFAT

IPC: A24D3/10 ,  D01D5/28

CPC classification number: A24D3/068 ,  A24D3/10 ,  B29C47/0014 ,  D01F2/00 ,  D01F2/02 ,  D01F2/28 ,  Y10T442/30

Abstract: The present invention concerns a biodegradable cigarette filter tow comprising composite filaments of cellulose and cellulose acetate, and a process for making such a filter tow comprising providing a solution dope comprising a blend of cellulose and cellulose acetate in an ionic liquid or in N-methylmorphilone-N-oxide (NMMO), and spinning casting the blend into a protic solvent to generate fibres or films, and converting the fibres or films into cigarette filter tow. The invention also concerns cigarette filters and cigarettes made from such a filter tow.

Abstract translation: 本发明涉及一种包括纤维素和乙酸纤维素的复合长丝的可生物降解的香烟过滤丝束，以及制备这种过滤丝束的方法，包括提供溶液涂料，该溶液涂料包含离子液体中的纤维素和乙酸纤维素的混合物或N-甲基吗啉酮 - N-氧化物（NMMO），并将共混物纺丝成质子溶剂以产生纤维或膜，并将纤维或膜转化为香烟过滤丝束。 本发明还涉及由这种过滤丝束制成的香烟过滤嘴和香烟。

公开(公告)号：US20110021510A1

公开(公告)日：2011-01-27

申请号：US12875465

申请日：2010-09-03

Applicant: John Mervyn David STOREY ,  James Peter SINCLAIR ,  Colin MARSHALL ,  Han Wan TAN ,  Claude Michel WISCHIK

Inventor： John Mervyn David STOREY ,  James Peter SINCLAIR ,  Colin MARSHALL ,  Han Wan TAN ,  Claude Michel WISCHIK

IPC: A61K31/5415 ,  C07D279/20 ,  A01N43/84 ,  A61P31/12 ,  A61P33/02 ,  A61P35/00 ,  A61P31/14 ,  A61P31/18 ,  A61P25/28 ,  A61P31/04

CPC classification number: A61K31/5415 ,  A61K9/0019 ,  A61K49/006 ,  C07D279/18 ,  C09B19/02 ,  G01N33/52 ,  Y02A50/393

Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiaziniumcompounds”) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt-formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases.

Abstract translation: 本发明一般涉及化学合成和纯化领域，更具体地涉及合成和纯化某些3,7-二氨基 - 吩噻嗪-5-鎓化合物（本文称为“二氨基吩噻嗪鎓化合物”）的方法，包括甲基氯化铑（MTC）（ 也称为亚甲基蓝）。 在一个实施方案中，该方法包括以下步骤：按顺序：亚硝基化（NOS）; 亚硝酰还原（NR）; 硫代磺酸形成（TSAF）; 氧化偶合（OC）; Cr（VI）还原（CR）; 两性离子中间体（IAPOZI）的分离和纯化; 闭环（RC）; 氯化物盐形成（CSF）; 一种：硫化物处理（ST）; 二甲基二硫代氨基甲酸酯处理（DT）; 碳酸盐处理（CT）; 乙二胺四乙酸处理（EDTAT）; 有机萃取（OE）; 和重结晶（RX）。 本发明还涉及所得的（高纯度）化合物，包含它们的组合物（例如片剂，胶囊）及其在灭活病原体的方法中的用途，以及治疗和诊断方法等，例如对于tau蛋白病 ，阿尔茨海默病（AD），皮肤癌，黑素瘤，病毒性疾病，细菌性疾病或原生动物疾病。