In vitro test system to evaluate xenobiotics as immune-modulators of drug transport and metabolism in human hepatocytes
    34.
    发明授权
    In vitro test system to evaluate xenobiotics as immune-modulators of drug transport and metabolism in human hepatocytes 有权
    体外测试系统评估异种生物作为人肝细胞中药物转运和代谢的免疫调节剂

    公开(公告)号:US08846576B2

    公开(公告)日:2014-09-30

    申请号:US13481295

    申请日:2012-05-25

    CPC classification number: G01N33/5067 G01N33/5014 G01N33/5023 G01N2500/10

    Abstract: A method of evaluating the effect of a xenobiotic on biomarkers, such as drug transporters and drug-metabolizing enzymes in hepatocytes is provided. The method comprises the formation of a xenobiotic-stimulated biological sample, such as whole blood, which contains a plurality of cytokines. A portion of xenobiotic-stimulated biological sample is cultured with hepatocytes. The hepatocytes are then analyzed to evaluate the activity of drug transporters and/or drug-metabolizing enzymes, or other biomarkers to determine the effect of the xenobiotic on drug metabolism in the hepatocytes.

    Abstract translation: 提供了一种评估异生素对肝细胞中生物标志物如药物转运蛋白和药物代谢酶的影响的方法。 该方法包括形成含有多种细胞因子的异生素刺激的生物样品,例如全血。 一部分异生素刺激的生物样品与肝细胞一起培养。 然后分析肝细胞以评估药物转运蛋白和/或药物代谢酶或其他生物标志物的活性,以确定异种生物对肝细胞中药物代谢的影响。

    Processing contact information
    35.
    发明授权
    Processing contact information 有权
    处理联系信息

    公开(公告)号:US08812515B1

    公开(公告)日:2014-08-19

    申请号:US11961922

    申请日:2007-12-20

    CPC classification number: G06F17/30958 Y10S707/99933 Y10S707/99934

    Abstract: Systems and methods for processing contact information are described. In one embodiment, an entity name is identified from an event associated with an article, wherein the entity name is associated with an entity and the event is associated with a user, contact information associated with the entity name is identified, the entity name and at least some of the contact information is indexed, and the entity name and at least some of the contact information is stored.

    Abstract translation: 描述用于处理联系人信息的系统和方法。 在一个实施例中,从与物品相关联的事件识别实体名称,其中实体名称与实体相关联,并且事件与用户相关联,识别与实体名称相关联的联系人信息,实体名称和在 索引最少的一些联系人信息,并存储实体名称和至少一些联系人信息。

    Covered, enclosed, collapsible, shippable, disposable animal litter box
    36.
    发明授权
    Covered, enclosed, collapsible, shippable, disposable animal litter box 有权
    覆盖,封闭,可折叠,可运输,一次性动物垃圾箱

    公开(公告)号:US08794186B2

    公开(公告)日:2014-08-05

    申请号:US13087200

    申请日:2011-04-14

    CPC classification number: A01K1/0125

    Abstract: Enclosed, collapsible and shippable disposable animal litter box which can be shipped without loss of animal litter pre-filled in the litter box, and which can be collapsed by the user for disposal after use, thus resealing the box so that used litter and animal waste are prevented from escaping the box. Litter box includes a top, bottom, left side, right side, front, and rear of sheet material with a litter tray for holding animal litter. Various sides are hingedly attached to each other for shipping, opening up by the user into an enclosed use position for the animal, and then for being closed into a disposal position after use. An animal entryway is provided. Entryway includes a removable seal for sealing entry for preventing litter from escaping when litter box is in collapsed position during both shipping of clean litter and discarding of used litter.

    Abstract translation: 封闭,可折叠和可运输的一次性动物垃圾箱,可以运输而不丢失预先装入垃圾箱的动物垃圾,用户可以在使用后倒塌处理,从而将盒子重新密封,使用废弃物和动物废物 被阻止逃离箱子。 垃圾箱包括片材的顶部,底部,左侧,右侧,前部和后部以及用于保持动物垃圾的垃圾盘。 各个侧面铰接地相互连接,用于运输,使用者打开到动物的封闭使用位置,然后在使用后关闭到处置位置。 提供动物入口。 入口处包括一个可拆卸密封件,用于密封进入,以防止在垃圾箱处于折叠位置时,在清洁垃圾的运输和废弃废弃物的丢弃期间垃圾不会逸出。

    Asymmetric multi-channel GRIN optical connector
    37.
    发明授权
    Asymmetric multi-channel GRIN optical connector 有权
    不对称多通道GRIN光连接器

    公开(公告)号:US08774579B2

    公开(公告)日:2014-07-08

    申请号:US13624427

    申请日:2012-09-21

    CPC classification number: G02B6/322 G02B3/0087 G02B6/3821 G02B6/3853

    Abstract: A gradient-index (GRIN) optical connector is disclosed that includes a GRIN lens having a central optical axis and front and back opposite endfaces. A plurality of optical fibers are optically coupled to the back endface of the GRIN lens and defines a first optical fiber bundle having an asymmetric arrangement relative to the central optical axis of the GRIN lens. The GRIN lens has a refractive index profile generally defined by an alpha profile having an alpha parameter α in a range 1.92≦α≦1.98. An optical fiber connector assembly formed by interfacing two of the GRIN optical connectors is also disclosed.

    Abstract translation: 公开了一种梯度折射率(GRIN)光学连接器,其包括具有中心光轴和前后相对端面的GRIN透镜。 多个光纤光学耦合到GRIN透镜的后端面,并且限定了相对于GRIN透镜的中心光轴具有不对称布置的第一光纤束。 GRIN透镜的折射率分布通常由具有α参数α在1.92和n1E;α≦̸ 1.98范围内的α分布限定。 还公开了通过接合两个GRIN光连接器而形成的光纤连接器组件。

    MECHANICAL POSITION INDICATOR
    38.
    发明申请
    MECHANICAL POSITION INDICATOR 有权
    机械位置指示器

    公开(公告)号:US20140026808A1

    公开(公告)日:2014-01-30

    申请号:US13989597

    申请日:2011-11-09

    CPC classification number: B64D45/0005 B64C25/00 B64D2045/008

    Abstract: A mechanical position indicator for providing a visual indication that a first part of an aircraft landing gear has assumed a predetermined position relative to a second part, the position indicator being arranged to be coupled to a first one of the first and second parts and in a first state arranged to hold an indicator element in a deployed position, the position indicator being arranged such that upon the first part assuming the predetermined position relative to the second part, a second one of the first and second parts changes the position indicator from the first state to a second state in which the indicator element is displaced from the deployed position, the position indicator being arranged to inhibit the indicator element thereafter returning to the deployed position.

    Abstract translation: 一种用于提供飞行器起落架的第一部分相对于第二部分已经具有预定位置的视觉指示的机械位置指示器,所述位置指示器布置成联接到所述第一和第二部分中的第一部分,并且以 第一状态被布置成将指示器元件保持在展开位置,位置指示器布置成使得在第一部分相对于第二部分呈现预定位置时,第一部分和第二部分中的第二部分将位置指示器从第一部分 状态到第二状态,其中指示元件从展开位置移位,位置指示器布置成阻止指示元件返回到展开位置。

    Non-Dispersive Infrared Sensor with a Reflective Diffuser
    39.
    发明申请
    Non-Dispersive Infrared Sensor with a Reflective Diffuser 有权
    具有反射扩散器的非分散红外传感器

    公开(公告)号:US20130334423A1

    公开(公告)日:2013-12-19

    申请号:US13526589

    申请日:2012-06-19

    CPC classification number: G01N21/3504 G01N21/61 G01N2201/0634 G01N2201/0696

    Abstract: The present application provides a non-dispersive infrared gas sensor. The non-dispersive infrared gas sensor may include an infrared source, an infrared detector, and a waveguide extending about the infrared source and the infrared detector. The waveguide may include a reflective diffuser thereon.

    Abstract translation: 本申请提供了一种非分散红外气体传感器。 非分散红外气体传感器可以包括红外源,红外检测器和围绕红外源和红外检测器延伸的波导。 波导可以在其上包括反射扩散器。

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