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公开(公告)号：US06638244B1
公开(公告)日：2003-10-28
申请号：US09668159
申请日：2000-09-25
申请人： David L. Reynolds
发明人： David L. Reynolds
IPC分类号： A61M3700
CPC分类号： A61J1/2096 , A61F13/0203 , A61J1/10 , A61J1/1475 , A61J1/201 , A61J1/2013 , A61J1/2051 , A61J1/2058 , A61J1/2065 , A61J1/2086 , A61J1/2089 , A61L15/225 , C08L89/06
摘要： A system is provided for providing syringes filled with pharmaceuticals whose components must be stored separately, using a liquid such as water in a pharmaceutical vial, an active ingredient in a protosyringe such as a bottomless vial or a cartridge, and a combiner assembly which enables the content of the pharmaceutical vial to be transferred into the protosyringe and converts it into a ready-to-use syringe on activation. The combined assembly includes a tubular body having recesses at opposite ends for receiving capped ends of the vial and the protosyringe, and a hub and needle assembly between penetrable sheaths or shields which acts on activation of the assembly to enable the transfer and conversion referred to above. Components of the system may also be used to convert protosyringes and pharmaceutical vials containing pharmaceuticals into delivery systems.
摘要翻译： 提供一种系统，用于提供填充有药物的注射器，其组件必须分开储存，使用液体如药物小瓶中的水，前列腺素如无底瓶或药筒中的活性成分，以及组合器组件， 将药物小瓶的内容物转移到前列腺素中并在活化时将其转化成即用型注射器。 组合的组件包括管状体，其具有在相对端处的凹部，用于接收小瓶和前列腺体的封端，以及在可穿透护套或屏蔽之间的毂和针组件，其作用于组件的启动以实现上述转移和转换 。 该系统的组分也可用于将含有药物的衍生物和药物瓶转化成递送系统。
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公开(公告)号：US5709666A
公开(公告)日：1998-01-20
申请号：US338843
申请日：1994-11-14
申请人： David L. Reynolds
发明人： David L. Reynolds
CPC分类号： A61J1/2096 , A61J1/2089 , A61M5/28 , A61M5/284 , A61J1/10 , A61J1/1475 , A61J1/201 , A61J1/2013 , A61J1/2044 , A61J1/2075 , A61M2005/3139 , A61M5/1452
摘要： A prefilled syringe system is provided for two component pharmaceuticals, which is a combination of a first subassembly consisting of a capped bottomless pharmaceutical vial containing a first component and closed at its bottom end by a piston which can be connected to a plunger and a second subassembly consisting of a shell containing a second component and closed by a further piston and located in telescopable relationship with the plunger, a cap which can be forced onto the cap of the bottomless vial, and a double ended needle or a functionally equivalent cannula assembly which is caused to pierce both pistons as the assemblies are connected by forcing the cap onto the bottomless vial, thus placing the vials in communication. The shell vial is pressed towards the bottomless vial to express its contents into the latter, and the plunger and shell vial are then removed so that the cap and needle are left connected to the bottomless vial and the plunger may be connected to the piston of the bottomless vial to convert it into a syringe. The shell vial may telescope either over or within the plunger. In the first case, the plunger acts to operate the piston of the shell vial during expression of its contents, whereas in the latter case a separate component is required for this purpose.
摘要翻译： 为双组分药物提供预充式注射器系统，其是由包含第一组分的封盖无底药物小瓶组成的第一子组件的组合，并且在其底端由可以连接到柱塞的活塞和第二子组件 由包含第二部件并由另一个活塞封闭并与柱塞可伸缩关系定位的壳体组成，可以将盖子压在无底瓶的盖上，以及双端针或功能上相当的插管组件 当组件通过将盖子迫使到无底瓶上而连接两个活塞，从而将小瓶连通。 将外壳小瓶压向无底小瓶以将其内容物表达到后者中，然后移除柱塞和壳小瓶，使得帽和针保持连接到无底瓶，并且柱塞可以连接到活塞的活塞 无底瓶，将其转换成注射器。 外壳小瓶可以在柱塞之上或之内望远镜。 在第一种情况下，柱塞用于在其内容物表达期间操作壳小瓶的活塞，而在后一种情况下，需要单独的部件用于此目的。
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公开(公告)号：US3993556A
公开(公告)日：1976-11-23
申请号：US526868
申请日：1974-11-25
摘要： In a fluid catalytic cracking unit utilizing a zeolite cracking catalyst and employing a multiplicity of elongated reaction zones or risers, significant improvements are obtained by introducing a light gas oil to at least one elongated reaction zone and a heavier gas oil to at least one other elongated reaction zone. Optionally, the vaporous effluent from either or both elongated reaction zones may be subjected to further cracking in the dense phase of catalyst in the reactor vessel. Operating conditions within the elongated reaction zones are established to permit the conversion of the heavier gas oil to be 0-30 volume percent lower than the light gas oil. Higher yields of higher octane gasoline are obtained where the unit is operated in the disclosed manner.
摘要翻译： 在使用沸石裂化催化剂并使用多个细长反应区或立管的流化催化裂化装置中，通过将轻瓦斯油引入至少一个细长的反应区和较重的瓦斯油至少一个其它细长的 反应区。 任选地，来自任一或两个细长反应区的气态流出物可能在反应器容器中的催化剂密相中进一步裂化。 建立细长反应区域内的操作条件，以使重质瓦斯油的转化率比轻质瓦斯油低0.03％。 获得更高产率的较高辛烷值汽油，其中该单元以所公开的方式操作。
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公开(公告)号：US08915902B2
公开(公告)日：2014-12-23
申请号：US12925924
申请日：2010-11-01
IPC分类号： A61J1/20
CPC分类号： A61J1/2089 , A61J1/1406 , A61J1/2013 , A61J1/2055 , A61J1/2096 , B65B3/003
摘要： A transfer system suitable for medicaments comprising a vial socket, a housing having first and second open ends with the first open end being releasably connected to the vial socket, a needle hub mounted within the housing, a needle having first and second piercing ends mounted in the needle hub, a vial having a neck and a body, the vial being inserted in the vial socket and being non removably retained therein, a cartridge having a plunger sealing an open end thereof and a septum located at an opposite end of the cartridge, and an activation cap for causing the needle to penetrate a septum of the vial and the septum of the cartridge to permit transfer of components therebetween.
摘要翻译： 一种适用于药物的转运系统，包括小瓶插座，具有第一开口端和第二开口端的壳体，第一开口端可拆卸地连接到小瓶插座;安装在壳体内的针座;具有安装在第一和第二穿刺端 针座，具有颈部和主体的小瓶，小瓶插入小瓶插座中并且不可移除地保持在其中;具有密封其开口端的柱塞的盒和位于盒的相对端的隔膜， 以及激活帽，用于使针穿透小瓶的隔膜和药筒的隔膜，以允许其间的部件传递。
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公开(公告)号：US20120152039A1
公开(公告)日：2012-06-21
申请号：US13261191
申请日：2010-09-08
IPC分类号： G01N1/14
CPC分类号： A61J1/2096 , A61J1/1425 , A61J1/201 , A61J1/2051 , B01F13/002 , B01F13/0022 , B01F15/0212 , B01F15/0223
摘要： A transfer device (10) which comprises an outer housing (24), an inner body (26) formed within the housing (24), the inner body (26) having a conduit (66) extending therethrough to provide fluid communication between upper and lower chambers, the conduit (66) having a piercing tip (68) at a lower end, a cap (54)having a top wall and a downwardly extending wall (58), the cap being retained in position such that access cannot be had to the inner body (26), and a pushing member (44) which has at least one leg (48) extending upwardly, the pushing member having an activated position where the leg (48) will extend upwardly to the upper chamber and move the cap (54) such that access may be had to the inner body (26).
摘要翻译： 一种转移装置（10），包括外壳体（24），形成在壳体（24）内部的内部主体（26），内部主体（26）具有延伸穿过其中的导管（66），以提供上部和 所述导管（66）在下端具有穿刺尖端（68），具有顶壁和向下延伸的壁（58）的帽（54），所述帽保持在适当的位置，使得不能进入 以及具有向上延伸的至少一个腿部（48）的推动构件（44），所述推动构件具有启动位置，其中所述腿部（48）将向上延伸到所述上部腔室并且使所述推动构件 帽（54），使得可能对内部主体（26）进行接近。
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公开(公告)号：US20110068124A1
公开(公告)日：2011-03-24
申请号：US12737013
申请日：2009-06-10
IPC分类号： B67D7/06
CPC分类号： B01F15/0201 , A61M5/2448 , A61M2005/3152 , B01F13/002 , B01F13/0023 , B01F15/0087 , B01F15/0237
摘要： A device for mixing a substance comprised of two constituents contained in a cartridge (12) and having a cartridge holder (32) thereabout, the device comprising a plunger rod (46) for pushing a closure member (20) to permit the transfer of a diluent in a second chamber (28) through a by-pass channel (24) to mix with a constituent in a first chamber (26), the plunger rod (48) being driven by means of a rack (48) and a pinion gear (50) arrangement to prevent overly rapid movement of the plunger rod (46).
摘要翻译： 一种用于混合包含在盒（12）中的两个组分并且在其周围具有盒保持器（32）的物质的装置，该装置包括用于推动封闭构件（20）以允许传送一个 稀释剂通过旁通通道（24）在第二腔室（28）中与第一腔室（26）中的组分混合，柱塞杆（48）通过齿条（48）和小齿轮 （50）布置以防止柱塞杆（46）的过度快速移动。
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公开(公告)号：US20100042071A1
公开(公告)日：2010-02-18
申请号：US12462696
申请日：2009-08-06
IPC分类号： A61M5/32
CPC分类号： A61M5/385 , A61J1/201 , A61J1/2055 , A61J1/2096
摘要： A method for transferring and mixing a pharmaceutical mixture utilizing a by-pass cartridge and a syringe. After mixing the dry component and the diluent in the by-pass cartridge, the mixture can be passed to a syringe which includes a syringe plunger having a fluid passageway therein with a hydrophobic membrane covering the passageway. The mixture can be transferred back and forth between the by-pass cartridge and the syringe through a small bore to achieve mixing, particularly in the case of microspheres held in suspension.
摘要翻译： 一种利用旁路药筒和注射器转运和混合药物混合物的方法。 在旁路盒中混合干燥组分和稀释剂之后，可以将混合物送入注射器，该注射器包括其中具有流体通道的注射器柱塞，其中覆盖通道的疏水膜。 混合物可以通过小孔在旁路筒和注射器之间来回传递以实现混合，特别是在保持悬浮的微球的情况下。
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公开(公告)号：US20090082751A1
公开(公告)日：2009-03-26
申请号：US12157867
申请日：2008-06-13
IPC分类号： A61J1/20
CPC分类号： A61J1/2089 , A61J1/062 , A61J1/201 , A61J1/2013 , A61J1/2051
摘要： A system and method for transferring a fluid from a first container to a second container, the system comprising a first container (112) having a fluid (126) therein, the first container being sealed by a septum (124) and a piston (122), the second container being sealed at its mouth by a pierceable septum (132) and having a plunger (130) at the opposite end, a moveable needle shuttle (116) having first (144) and second (146) piercing ends, the arrangement being such that upon advancement of the first container with respect to the second container, a second one of the piercing ends (144) is adapted to pierce plunger (130) of the second container and a first piercing end (146) being designed to pierce the septum (124) of the first container.
摘要翻译： 一种用于将流体从第一容器传送到第二容器的系统和方法，所述系统包括其中具有流体（126）的第一容器（112），所述第一容器由隔膜（124）和活塞（122）密封 ），第二容器在其口部由可刺破的隔膜（132）密封并且在相对端具有柱塞（130），具有第一（144）和第二（146）穿刺端部的可移动的针梭（116） 布置使得在相对于第二容器推进第一容器时，穿刺端（144）中的第二个适于刺穿第二容器的柱塞（130），并且第一刺穿端（146）设计成 刺穿第一个容器的隔膜（124）。
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公开(公告)号：US6123685A
公开(公告)日：2000-09-26
申请号：US917128
申请日：1997-08-25
申请人： David L. Reynolds
发明人： David L. Reynolds
CPC分类号： A61M5/155 , A61M2005/14204
摘要： A syringe is modified to permit gradual administration of its contents with reduced problems due to seizing or stiction of its piston by dividing its piston axially into two parts, a front detached part and rear part which is the only part having provision for attachment to a syringe actuator. The rear part has a passage through which fluid can be gradually introduced from an actuator into a chamber between the parts so as to force the front part forward while the rear part is restrained against rearward movement. The passage may be initially closed by a septum which is penetrated by a cannula on the actuator. If the syringe actuator is a plunger, the syringe can be used conventionally.
摘要翻译： 注射器被修改为允许逐渐地管理其内容物，由于其活塞的卡住或固定而将其活塞轴向分成两部分，即前部分离部分和后部部分，其仅仅是提供用于连接到注射器的唯一部分 执行器。 后部具有通道，通过该通道，流体可以从致动器逐渐地引入到部件之间的室中，以便在后部被约束以防止向后移动的同时迫使前部部分向前。 通道可以最初由隔膜穿过致动器上的插管来封闭。 如果注射器致动器是柱塞，则可以常规使用注射器。
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公开(公告)号：US5978547A
公开(公告)日：1999-11-02
申请号：US63236
申请日：1998-04-20
申请人： David L. Reynolds , James T. Foley
发明人： David L. Reynolds , James T. Foley
CPC分类号： H02P7/295 , H02M7/219 , H02P7/2913
摘要： A hybrid DC motor controller is provided for driving a DC motor. A switch is connected in series with the DC motor, and a capacitor is coupled in parallel with the DC motor and the switch. The speed of the DC motor is controlled by the capacitor voltage and the duty cycle of a pulse-width modulated (PWM) signal supplied to the switch. The hybrid controller combines a motor speed control loop with a PWM optimization loop. The motor speed control loop generates a PWM signal in response to the speed of the DC motor and conducts that PWM signal to the switch to control the DC motor. The PWM optimization loop includes a controller that is responsive to the PWM signal and an AC voltage signal. This controller compares the PWM signal with a PWM signal setpoint, and drives the PWM signal toward the PWM signal setpoint by adjusting the capacitor voltage in response to the comparison between the PWM signal and the PWM signal setpoint. The speed of the DC motor changes in response to the adjusted capacitor voltage, and the motor speed control loop changes the PWM signal in response to the changed motor speed. These adjustments have the cumulative effect of driving the PWM signal toward the PWM signal setpoint. The controller included in the PWM optimization loop controls a rectifier for selectively supplying a rectified voltage to the capacitor.
摘要翻译： 提供用于驱动DC电动机的混合DC电动机控制器。 开关与直流电动机串联连接，电容器与直流电动机和开关并联。 直流电机的速度由电容器电压和提供给开关的脉宽调制（PWM）信号的占空比控制。 混合控制器将电机速度控制回路与PWM优化回路相结合。 电机速度控制回路根据直流电机的转速产生PWM信号，并将该PWM信号传送到开关以控制直流电动机。 PWM优化环路包括响应于PWM信号和AC电压信号的控制器。 该控制器将PWM信号与PWM信号设定值进行比较，并根据PWM信号和PWM信号设定值之间的比较调整电容电压，将PWM信号驱动到PWM信号设定值。 直流电机的速度响应于调整后的电容器电压而变化，电机速度控制环路根据电机转速变化来改变PWM信号。 这些调整具有驱动PWM信号朝向PWM信号设定点的累积效应。 包括在PWM优化环路中的控制器控制整流器，用于选择性地向电容器提供整流电压。
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