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公开(公告)号：US09452267B2
公开(公告)日：2016-09-27
申请号：US13261424
申请日：2011-02-28
CPC分类号： A61M5/3202 , A61M5/2466 , A61M5/326 , A61M5/3272 , A61M5/3287 , A61M5/3293 , A61M2005/2414 , A61M2005/247 , A61M2005/3267 , A61M2005/3289
摘要： An injection device (10) comprising a housing (12), a needle hub (38) slidable within the housing (12), a needle (40) having a distal end piercing tip (42) and a proximal end piercing tip (44), the needle hub being moveable from a first position wherein the distal end piercing tip (42) is within the housing to a second position wherein the distal end piercing tip (42) extends outwardly of the housing (12), a spring (23) biasing the needle hub (38) towards the first position, and a cartridge receiving member (48) mounted within the housing (12), and a plunger rod assembly (66) for exerting pressure on the cartridge receiving member (48) to move the cartridge (26) and the needle hub (38) from the first position to the second position, the plunger rod assembly (66) and the cartridge receiving member (48) being arranged such that when the cartridge rod assembly is pushed, a rotational movement is imparted to the cartridge receiving member (48) to thereby prevent access to the cartridge after injection.
摘要翻译： 一种注射装置（10），包括壳体（12），可在所述壳体（12）内滑动的针座（38），具有远端刺穿尖端（42）和近端刺穿尖端（44）的针（40） 所述针毂可从第一位置移动，其中所述远端刺穿末端（42）处于所述壳体内至第二位置，其中所述远端刺穿末端（42）从所述壳体（12）向外延伸，弹簧（23） 将针座（38）偏置到第一位置，以及安装在壳体（12）内的盒容纳构件（48），以及用于在盒容纳构件（48）上施加压力以移动 盒（26）和针座（38）从第一位置到第二位置，柱塞杆组件（66）和盒接收构件（48）被布置成使得当推动盒式杆组件时，旋转运动 被施加到盒接收构件（48），从而防止盒后部进入 呃注射。
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公开(公告)号：US09381135B2
公开(公告)日：2016-07-05
申请号：US13261729
申请日：2012-03-05
IPC分类号： A61J1/20
CPC分类号： A61J1/20 , A61J1/201 , A61J1/2096 , Y10T137/9029
摘要： A transfer device for pharmaceuticals comprising a housing which has an open bottom permitting insertion of a vial within the housing, a piercing member mounted within the housing and having an interior passageway formed therein, a connector for a syringe located on top of the housing, and a moveable member mounted within the housing, the moveable member being moveable from a first position preventing access to the piercing member and a second position permitting access to the piercing member when the vial is inserted in the housing.
摘要翻译： 一种用于药物的转移装置，包括：外壳，其具有敞开的底部，允许小瓶在壳体内插入;刺穿构件，其安装在壳体内并具有形成在其中的内部通道;位于壳体顶部的注射器连接器;以及 安装在所述壳体内的可移动构件，所述可移动构件可从第一位置移动，从而防止进入所述穿孔构件;以及当所述小瓶插入所述壳体中时允许进入所述刺穿构件的第二位置。
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公开(公告)号：US09119770B2
公开(公告)日：2015-09-01
申请号：US13261792
申请日：2012-07-05
IPC分类号： A61J1/20 , A61K31/137 , A61K31/5575 , B65D81/32
CPC分类号： A61J1/2093 , A61J1/2031 , A61J1/2051 , A61J2200/40 , A61J2200/72 , A61K31/137 , A61K31/5575 , B65D81/3211
摘要： A reconstitution device (10) for mixing a first component (70) with a second component (72) wherein there are provided first and seconds housings (12, 14) which are engageable together, a conduit (28) having an internal passageway (30) having a dispensing end and an inlet end, first, second and third plungers (52, 54) mounted in said internal passageway (30), first and second compartments (70, 72) being defined by the plungers, a shearing channel (32) formed in a side wall of conduit (28) to permit mixing of contents located in the first and second compartments (74, 76), a plunger rod (58) to cause initial mixing of the first and second components (70, 72), and a spring member (48) biasing against the moveable member (42).
摘要翻译： 一种用于将第一部件（70）与第二部件（72）混合的重构装置（10），其中设置有可接合在一起的第一和第二壳体（12,14），具有内部通道（30）的导管（28） ）具有分配端和入口端，安装在所述内部通道（30）中的第一和第二柱塞（52,54），由所述柱塞限定的第一和第二隔室（70,72），剪切通道（32） ）形成在导管（28）的侧壁中以允许混合位于第一和第二隔室（74,76）中的内容物，柱塞杆（58）以使第一和第二部件（70,72）初始混合， ，以及弹簧构件（48），其抵靠所述可移动构件（42）。
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公开(公告)号：US08998880B2
公开(公告)日：2015-04-07
申请号：US13507273
申请日：2012-06-18
CPC分类号： A61M5/385 , A61J1/201 , A61J1/2055 , A61J1/2096
摘要： A method for transferring and mixing a pharmaceutical mixture utilizing a by-pass cartridge and a syringe. After mixing the dry component and the diluent in the by-pass cartridge, the mixture can be passed to a syringe which includes a syringe plunger having a fluid passageway therein with a hydrophobic membrane covering the passageway. The mixture can be transferred back and forth between the by-pass cartridge and the syringe through a small bore to achieve mixing, particularly in the case of microspheres held in suspension.
摘要翻译： 一种利用旁路药筒和注射器转运和混合药物混合物的方法。 在旁路盒中混合干燥组分和稀释剂之后，可以将混合物送入注射器，该注射器包括其中具有流体通道的注射器柱塞，其中覆盖通道的疏水膜。 混合物可以通过小孔在旁路筒和注射器之间来回传递以实现混合，特别是在保持悬浮的微球的情况下。
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5.发明授权Reconstitution system for mixing the contents of a vial containing a first substance with a second substance stored in a cartridge 有权用于将容纳第一物质的小瓶的内容物与存储在筒中的第二物质混合的重构系统公开(公告)号：US08100154B2
公开(公告)日：2012-01-24
申请号：US11974737
申请日：2007-10-16
IPC分类号： B65B1/04
CPC分类号： A61J1/2089 , A61J1/062 , A61J1/201 , A61J1/2013 , A61J1/2051 , A61J1/2055 , A61J1/2065
摘要： A transfer assembly for transfering a fluid to a vial, admixing the same and then returning the fluid to a cartridge, the transfer assembly having a vial gripper located at a first end and a cartridge holder at the second end of an elongated outer housing, a fluid passageway extending between the vial gripper and the cartridge holder with piercing elements being located at respective ends of the fluid passageway. In a preferred embodiment, an adaptor is mounted on the end of the outer housing where the cartridge holder is situated. The adaptor may move from a retracted to an extended position wherein it will surround the needle.
摘要翻译： 一种转移组件，用于将流体转移到小瓶中，将其混合，然后将流体返回到药筒，转移组件具有位于第一端的小瓶夹持器和位于细长外壳体的第二端处的药筒保持器， 流体通道在小瓶夹持器和药筒保持器之间延伸，穿刺元件位于流体通道的相应端部处。 在优选实施例中，适配器安装在外壳的其中盒保持器所在的端部。 适配器可以从缩回移动到延伸位置，其中它将围绕针。
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公开(公告)号：US07736353B2
公开(公告)日：2010-06-15
申请号：US10540230
申请日：2004-01-22
申请人： David L. Reynolds
发明人： David L. Reynolds
IPC分类号： A61M5/32
CPC分类号： A61J1/2089 , A61J1/201 , A61J1/2013 , A61J1/2051 , A61J1/2055 , A61J1/2096 , A61M5/002 , A61M5/1782 , A61M5/31511 , A61M5/31596 , A61M2005/3139
摘要： An assembly for transferring a fluid between a vessel having a body with an open end and a slidable piston positioned within the body and a vial having a penetrable seal. The assembly includes a housing having first and second open ends, and a bore extending between the first and second open ends. The housing is removably connectable to the piston. The assembly also includes a conduit having first and second ends and first and second apertures adjacent to the first and second ends, respectively. The present invention provides for an assembly for transferring a fluid between a vessel having a body with an open end and a slidable piston positioned within the body and a vial having a penetrable seal. The assembly includes a housing having first and second open ends, and a bore extending between the first and second open ends. The housing is removably connectable to the piston. The assembly also includes a conduit having first and second ends and first and second apertures adjacent to the first and second ends, respectively.
摘要翻译： 用于在具有开口端的容器和位于主体内的可滑动活塞的容器之间传送流体的组件和具有可穿透密封件的小瓶。 组件包括具有第一和第二开口端的壳体以及在第一和第二开口端之间延伸的孔。 壳体可拆卸地连接到活塞。 组件还包括分别具有第一和第二端以及与第一和第二端相邻的第一和第二孔的管道。 本发明提供一种用于在具有开口端的主体和位于主体内的可滑动活塞的容器和具有可穿透密封件的小瓶之间传送流体的组件。 组件包括具有第一和第二开口端的壳体以及在第一和第二开口端之间延伸的孔。 壳体可拆卸地连接到活塞。 组件还包括分别具有第一和第二端以及与第一和第二端相邻的第一和第二孔的管道。
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7.发明授权Fluid transfer assembly for pharmaceutical delivery system and method for using same 失效用于药物输送系统的流体输送组件及其使用方法公开(公告)号：US07678333B2
公开(公告)日：2010-03-16
申请号：US11197439
申请日：2005-08-05
CPC分类号： A61J1/2096 , A61J1/201 , A61J1/2013 , A61J1/2051 , A61J1/2055
摘要： The present invention provides a transfer assembly for transferring a fluid between a vessel and a vial and a method for using same. The vial may be a maximum recovery vial. The vessel has a body with an open end and a slidable piston positioned within the body through the open end. The maximum recovery vial has an inner chamber with an open end and a closed end and a penetrable seal covering the open end of the inner chamber. The transfer assembly includes a housing having first and second open ends and a bore extending between the first and second open ends. The housing is connectable to the piston. The transfer assembly also includes a conduit having first and second ends and first and second apertures adjacent to the first and second ends, respectively. The conduit is longitudinally slidable within the bore between a retracted position in which the first aperture is positioned within at least one of the housing and the piston when the housing is connected to the piston, and an activated position in which the first aperture protrudes through the piston into the body of the vessel when the housing is connected to the piston. The transfer assembly also includes a vial socket assembly having a vial socket and a hollow piercing member. The vial socket is sized and shaped for receiving and engaging at least a portion of the maximum recovery vial including the penetrable seal. The hollow piercing member has a first open end in fluid communication with the conduit and a second open end for piercing the penetrable seal of the maximum recovery vial. The hollow piercing member is sized to extend substantially the full length of the inner chamber of the maximum recovery vial when the maximum recovery vial is fully engaged in the vial socket. The vial socket assembly is moveable longitudinally relative to the housing in concert with the conduit.
摘要翻译： 本发明提供一种用于在容器和小瓶之间传送流体的转移组件及其使用方法。 小瓶可以是最大回收小瓶。 容器具有开口端的本体和通过开口端定位在体内的可滑动活塞。 最大回收小瓶具有内室，其具有开口端和封闭端以及覆盖内室开口端的可穿透密封件。 传送组件包括具有第一和第二开口端的壳体和在第一和第二开口端之间延伸的孔。 外壳可连接到活塞。 传送组件还包括分别具有第一和第二端以及与第一和第二端相邻的第一和第二孔的导管。 所述管道可在所述孔内在缩回位置之间纵向滑动，在所述缩回位置中，当所述壳体连接到所述活塞时，所述第一孔被定位在所述壳体和所述活塞中的至少一个中;以及启动位置， 当壳体连接到活塞时，活塞进入容器的主体。 传送组件还包括具有小瓶插座和中空穿刺构件的小瓶插座组件。 小瓶插座的尺寸和形状适于接收和接合包括可穿透密封件的最大回收小瓶的至少一部分。 空心刺穿构件具有与导管流体连通的第一开口端和用于刺穿最大回收小瓶的可穿透密封件的第二开口端。 当最大回收小瓶完全接合在小瓶插座中时，中空穿刺构件的尺寸被设计成基本上延伸最大回收小瓶的内室的整个长度。 小瓶插座组件可以与导管一致地相对于壳体纵向移动。
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公开(公告)号：US20090308895A1
公开(公告)日：2009-12-17
申请号：US12157866
申请日：2008-06-13
CPC分类号： B01F15/0201 , A61M5/2448 , A61M2005/3152 , B01F13/002 , B01F13/0023 , B01F15/0087 , B01F15/0237
摘要： A device for mixing a substance comprised of two constituents contained in a cartridge and having a cartridge holder thereabout, the device comprising a plunger rod for pushing the closure member to permit the transfer of a diluent in a first chamber through a by-pass channel to mix with a constituent in a first chamber, the plunger rod being driven by means of a rack and a pinion gear arrangement to prevent overly rapid movement of the plunger rod.
摘要翻译： 一种用于混合包含在盒中的两个组分并且在其周围具有盒保持器的物质的装置，该装置包括用于推动封闭构件的柱塞杆，以允许通过旁通通道将第一室中的稀释剂转移到 与第一室中的组分混合，柱塞杆通过齿条和小齿轮装置驱动，以防止柱塞杆的过度快速运动。
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公开(公告)号：US20080023683A1
公开(公告)日：2008-01-31
申请号：US11495350
申请日：2006-07-28
申请人： David L. Reynolds , Steven R. Smith
发明人： David L. Reynolds , Steven R. Smith
IPC分类号： B66F7/12
CPC分类号： B66F7/10
摘要： A lifting mechanism for track-type vehicles has a rectangular, elongated base skid onto which at least three separately adjustable lifts are positioned. A first lift is positioned at the forward end of the skid and includes a crossbar extending between the elongated sides of the skid. A telescoping, hydraulic jack is positioned at each end of the crossbar, which jacks can be extended to lift the crossbar into engagement with the lower side of a vehicle. Positionable lifting devices are also located along opposing, elongated sides of the skid. Each lifting device is a telescoping hydraulic jack carried at one end of a telescoping arm. The arm is pivotally mounted to the skid at the other end of the arm. The arm's telescopic length and rotational position can be adjusted as necessary to position the lifting device attached thereto as desired under a vehicle.
摘要翻译： 用于轨道式车辆的提升机构具有长方形的细长的基座滑道，至少三个分开调节的升降机位于该基座上。 第一升降机位于滑板的前端，并且包括在滑板的细长侧面之间延伸的横杆。 伸缩式液压千斤顶定位在横梁的每个端部处，该千斤顶可以延伸以提升横杆与车辆的下侧接合。 可定位的提升装置也位于滑板的相对的细长侧面。 每个提升装置是在伸缩臂的一端承载的伸缩式液压千斤顶。 手臂可枢转地安装在手臂另一端的滑轨上。 臂的伸缩长度和旋转位置可以根据需要进行调整，以根据需要在车辆下方安装附接的提升装置。
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公开(公告)号：US06802828B2
公开(公告)日：2004-10-12
申请号：US09993299
申请日：2001-11-23
申请人： David L. Reynolds
发明人： David L. Reynolds
IPC分类号： A61M532
CPC分类号： A61J1/2089 , A61J1/062 , A61J1/201 , A61J1/2013 , A61L2/07 , A61L2/20 , A61L2/206 , A61M2005/31506 , A61M2207/00 , A61M2209/045 , B65B3/003 , B65B7/2821 , Y10T29/49826 , Y10T29/53339
摘要： A system is provided which permits syringe barrels of prefilled disposable syringes to be filled and capped on standard vial filling equipment, and which permits the syringe body and piston comprising the barrel to be simultaneously sterilized by a sterilizing gas. The system provides means for stabilizing syringe barrels so they can be conveyed upright on their bases without tipping through vial filling and capping equipment. Preferably, the stabilizing means comprises a cylindrical sleeve into which the lower end of the syringe body is inserted, thereby stably supporting it against tipping. The system also provides means by which the piston is retained in close proximity to the lower end of the syringe body, but slightly separated therefrom to permit access to all surfaces of the piston by a sterilizing gas. Preferably, the piston is retained directly below the lower end of the syringe body, and substantially centred therewith, to permit the piston to be inserted into the lower end of the body merely by pushing the body and piston together.
摘要翻译： 提供了一种系统，其允许预充式一次性注射器的注射器筒在标准瓶灌装设备上填充和封盖，并且其允许注射器主体和包括筒的活塞通过灭菌气体同时灭菌。 该系统提供用于稳定注射器筒的装置，使得它们可以在其基座上直立地输送，而不会通过小瓶灌装和封盖设备倾倒。 优选地，稳定装置包括圆柱形套筒，注射器主体的下端插入其中，从而稳定地支撑注射器本体以防止倾翻。 该系统还提供了一种装置，通过该装置，活塞被保持在紧邻注射器主体的下端，但是稍微分开，以允许通过灭菌气体进入活塞的所有表面。 优选地，活塞直接保持在注射器主体的下端并且基本上位于其中心，以便仅通过将主体和活塞推入到主体和活塞中才能将活塞插入到主体的下端。
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