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    NANOPATTERNED SURFACES AND METHODS FOR ACCELERATED FREEZING AND LIQUID RECOVERY
    34.
    发明申请
    NANOPATTERNED SURFACES AND METHODS FOR ACCELERATED FREEZING AND LIQUID RECOVERY 审中-公开

    公开(公告)号：US20190292754A1

    公开(公告)日：2019-09-26

    申请号：US16301236

    申请日：2017-05-12

    Applicant: Kansas State University Research Foundation

    Inventor： Amy Betz ,  Melanie Derby

    IPC: E03B3/28 ,  F25B39/02 ,  F28F13/18

    Abstract: Inventive surfaces, and methods of using the same, are provided that exhibit improved water collection and frost formation properties over prior art surfaces. The inventive surfaces have a plurality of nanosized recessed areas formed therein. The geometries and patterns of the recessed areas are particularly designed to discourage water droplet coalescence on the surfaces. Due to these designs, the surfaces are capable of forming and maintaining smaller, as well as asymmetrical, droplets on the surfaces. As a result, a greater surface area of the inventive surfaces can be covered by water droplets, thereby increasing water recovery. In addition, the smaller, asymmetrical droplets lead to desirable frost layer characteristics under non-cryogenic freezing conditions.

    Nanosensors for detecting enzymatic activity in dairy production
    35.
    发明授权
    Nanosensors for detecting enzymatic activity in dairy production 有权

    公开(公告)号：US10416144B2

    公开(公告)日：2019-09-17

    申请号：US15329395

    申请日：2015-07-27

    Applicant: Kansas State University Research Foundation

    Inventor： Deryl L. Troyer ,  Stefan H. Bossmann ,  Aruni P. Malalasekera ,  Thilani N. Samarakoon ,  Hongwang Wang ,  Madumali Kalubowilage

    IPC: G01N33/04 ,  C12Q1/04 ,  C12Q1/37 ,  C12Q1/44

    Abstract: Methods for detecting biomarkers of inflammation, infection, and/or bacterial activity in dairy production, which indicate issues with the milk itself or issues related to the health of the cow. The methods generally comprise contacting a milk sample with a nanoplatform assembly to create an assay solution, and detecting spectral changes in the assay solution that are triggered by enzymatic activity (when present) in the sample. The nanoplatform assembly comprises a first particle, a second particle, and a linkage therebetween, wherein the linkage comprises a protease consensus sequence (the sequence of amino acids cleaved by the protease), or an ester linkage (cleaved by a protease or lipase). A plurality of second particles can also be linked to the first particle. Test strips are also described, which undergo a visual color change in the presence of the target enzyme in the milk sample.

    Non-invasive monitoring cancer using integrated microfluidic profiling of circulating microvesicles
    36.
    发明授权
    Non-invasive monitoring cancer using integrated microfluidic profiling of circulating microvesicles 有权

    公开(公告)号：US10350599B2

    公开(公告)日：2019-07-16

    申请号：US15357231

    申请日：2016-11-21

    Applicant: University of Kansas ,  Kansas State University Research Foundation

    Inventor： Zheng Zhao ,  Mei He ,  Yong Zeng

    IPC: B01F5/06 ,  G01N33/574 ,  B01L3/00 ,  B01F13/00

    Abstract: A microfluidic exosome profiling platform integrating exosome isolation and targeted proteomic analysis is disclosed. This platform is capable of quantitative exosomal biomarker profiling directly from plasma samples with markedly enhanced sensitivity and specificity. Identification of distinct subpopulation of patient-derived exosomes is demonstrated by probing surface proteins and multiparameter analyzes of intravesicular biomarkers in the selected subpopulation. The expression of IGF-1R and its phosphorylation level in non-small cell lung cancer (NSCLC) patient plasma is assessed as a non-invasive alternative to the conventional biopsy and immunohistochemistry. Detection of ovarian cancer also is assessed. The microfluidic chip, which may be fabricated of a glass substrate and a layer of poly(dimethylsiloxane), includes a serpentine microchannel to mix a fluid and a microchamber for the collection and detection of exosomes.

    SYSTEM FOR DELIVERING HYPERTHERMIA TREATMENTS
    38.
    发明申请
    SYSTEM FOR DELIVERING HYPERTHERMIA TREATMENTS 审中-公开

    公开(公告)号：US20190125443A1

    公开(公告)日：2019-05-02

    申请号：US16093774

    申请日：2017-04-17

    Applicant: Kansas State University Research Foundation

    Inventor： Punit Prakash ,  Stefan H. Bossmann ,  Sergio Curto

    IPC: A61B18/18 ,  G01R33/48 ,  G01R33/30 ,  G01R33/28

    Abstract: Apparatus for delivering in vivo hyperthermia treatments to a subject and methods of performing such treatments are provided. The apparatus comprises an imaging device, such as an MRI scanner, a microwave applicator, and a controller to target particular tissues within the subjects body for hyperthermia treatment. The microwave applicator emits microwave energy toward the target tissue and the imaging device provides real-time feedback as to the position of the applicator relative to the target tissues and thermometry data so as to permit real-time adjustment of the applicators operating parameters.

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