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公开(公告)号：US20220348467A1
公开(公告)日：2022-11-03
申请号：US17620357
申请日：2020-06-17
Applicant: Kansas State University Research Foundation
Inventor： Stefan H. Bossmann , Christopher Sorensen , Jose Covarrubias , Madumali Kalubowilage , Arjun Nepal
IPC: C01B32/194 , C01B32/198 , C09D11/037 , C08K9/02 , C04B20/02
Abstract: Methods of preparing graphene/graphene oxide particulates under mild conditions, comprising reacting pristine graphene with hydrogen peroxide and a source of iron to oxidize the outer surface of the pristine graphene particulates in solution and yield graphene/graphene oxide particulates. Methods and articles incorporating the same are also disclosed.
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公开(公告)号：US10376599B2
公开(公告)日：2019-08-13
申请号：US15559543
申请日：2016-03-18
Applicant: Kansas State University Research Foundation
Inventor： Stefan H. Bossmann , Deryl L. Troyer , Aruni P. Malalasekera , Hongwang Wang , Sebastian O. Wendel , Gaohong Zhu
IPC: A61K38/00 , A61K49/00 , G01N33/573 , C12Q1/26 , C12Q1/34
Abstract: A nanoplatform assembly for detection of arginase, indoleamine 2,3-dioxygenase 1, and/or tryptophan 2,3-dioxygenase. The nanoplatform comprises an oligopeptide, which is used as a linker between two particles. More preferably, the linker is comprised of an oligopeptide containing a substrate for the target enzyme, where the substrate is chemically or physically modified by the target enzyme (but not cleaved). A central particle with a plurality of oligopeptide-tethered detectable particles and a plurality of directly attached detectable particles is described. Posttranslational modification of the oligopeptide leads to changes in the detectable signals from the first and/or second particles in the nanoplatform, which can be correlated to enzyme activity and concentration.
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公开(公告)号：US20240102995A1
公开(公告)日：2024-03-28
申请号：US18468020
申请日：2023-09-15
Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
Inventor： Bartosz Szczesny , Massoud Motamedi , Stefan H. Bossmann
IPC: G01N33/53
CPC classification number: G01N33/5308
Abstract: The present invention relates in general to the field of rapid detection and quantification of tissue/organ injury, and more particularly, to a novel platform for monitoring and quantification of circulating cell-free DNA including within extracellular vesicles, together with extracellular vesicles specific markers, and extracellular vesicles sizes also in combination with PCR-related technologies in biospecimens, and liquid biopsies for the assessment and prediction of severity of tissue/organ injury, monitoring of disease progression as well as the assessment of the response to therapeutic interventions.
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公开(公告)号：US11318470B2
公开(公告)日：2022-05-03
申请号：US16349700
申请日：2017-11-17
Applicant: Kansas State University Research Foundation
Inventor： Christopher T. Culbertson , Stefan H. Bossmann
Abstract: Microfluidic devices and nanobiosensors comprising a magnetic nanoparticle attached to a reporter molecule via a release unit for microfluidic-based detection of a target analyte in a biological sample. The nanobiosensors can be magnetically manipulated or guided through the microfluidics channels for incubation with the biological sample, concentration of the nanobiosensors, and detection of target analytes, without having to pump the entire initial sample through a microfluidic channel of the microfluidic device. The magnetic nanoparticles are separated from the reporter molecules before detection and can be re-used.
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公开(公告)号：US20150132230A1
公开(公告)日：2015-05-14
申请号：US14605083
申请日：2015-01-26
Applicant: Kansas State University Research Foundation
Inventor： Stefan H. Bossmann , Deryl L. Troyer , Matthew T. Basel
IPC: A61K49/00
CPC classification number: A61K49/0067 , A61K49/0036 , A61K49/0056 , A61K49/0065 , A61K49/0093 , B82Y15/00 , C07K5/1021 , C07K7/06 , C07K7/08 , C12Q1/37 , G01N33/588 , G01N2800/7028 , Y10S977/773 , Y10S977/774 , Y10S977/92
Abstract: The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell. The assays are comprised of two particles linked via an oligopeptide linkage that comprises a consensus sequence specific for the target protease. Cleavage of the sequence by the target protease can be detected visually or using various sensors, and the diagnostic results can be correlated with cancer prognosis.
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Patent Agency Ranking
公开(公告)号：US20240208811A1
公开(公告)日：2024-06-27
申请号：US18550752
申请日：2022-03-16
Inventor： Christopher M. Sorensen , Stefan H. Bossmann , Justin Wright , Shusil Sigdel , Jose Covarrubias , Arjun Nepal , Harold Charles Davidson
IPC: C01B3/36
CPC classification number: C01B3/36 , C01B2203/0255 , C01B2203/0405 , C01B2203/1217 , C01B2203/1235 , C01B2203/1276 , C01B2203/1614 , C01B2203/169
Abstract: Apparatus and processes for high-yield production of syngas components via combustion of a carbon-containing material and an oxygen-containing material are provided. Syngas components are generated in an exothermic, combustion reaction with only minor quantities of carbon dioxide, water, and elemental carbon produced.
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公开(公告)号：US11965881B2
公开(公告)日：2024-04-23
申请号：US16088407
申请日：2017-03-24
Applicant: The Board of Regents of The University of Texas System , Kansas State University Research Foundation
Inventor： Massoud Motamedi , Allan R. Brasier , Stefan H. Bossmann , Christopher T. Culbertson , Deryl Troyer
IPC: G01N33/543 , B01L3/00 , G01N33/574
CPC classification number: G01N33/54346 , B01L3/502715 , G01N33/574 , B01L2300/0636 , B01L2300/0816 , G01N2333/70596
Abstract: Methods and devices for microfluidic detection of a biological maker in a biospecimen collected from a subject are disclosed. The microfluidic devices include nanoparticle-based nanosensors comprising supramolecular recognition sequences, protease consensus sequences, post-translationally modifiable sequences, or sterically hindered benzylether bonds for specific interaction with a biological marker. Also disclosed are particular nanosensors for detecting cytokines, and other proteins based upon supramolecular recognition without chemical modification or enzymatic cleavage.
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公开(公告)号：US09731034B2
公开(公告)日：2017-08-15
申请号：US14605083
申请日：2015-01-26
Applicant: Kansas State University Research Foundation
Inventor： Stefan H. Bossmann , Deryl L. Troyer , Matthew T. Basel
CPC classification number: A61K49/0067 , A61K49/0036 , A61K49/0056 , A61K49/0065 , A61K49/0093 , B82Y15/00 , C07K5/1021 , C07K7/06 , C07K7/08 , C12Q1/37 , G01N33/588 , G01N2800/7028 , Y10S977/773 , Y10S977/774 , Y10S977/92
Abstract: The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell. The assays are comprised of two particles linked via an oligopeptide linkage that comprises a consensus sequence specific for the target protease. Cleavage of the sequence by the target protease can be detected visually or using various sensors, and the diagnostic results can be correlated with cancer prognosis.
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9.发明授权Nanoparticle catalyst capable of forming aromatic hydrocarbons from CO2 and H2 有权能够从CO 2和H 2形成芳族烃的纳米粒子催化剂公开(公告)号：US09555405B2
公开(公告)日：2017-01-31
申请号：US14603628
申请日：2015-01-23
Applicant: Kansas State University Research Foundation
Inventor： Hongwang Wang , Stefan H. Bossmann , Donghai Wang , Deryl L. Troyer , Tej Shrestha
IPC: C07C1/04 , C07C15/00 , B01J23/74 , B01J23/94 , B01J35/02 , B01J23/745 , C07C1/12 , B01J29/14 , B01J35/00 , B01J21/04 , B01J29/10 , C07C1/22 , C10L1/04 , B82Y40/00
CPC classification number: B01J35/026 , B01J21/04 , B01J23/745 , B01J29/106 , B01J29/146 , B01J35/0013 , B01J35/002 , B01J35/0033 , B01J35/0053 , B01J35/006 , B01J35/008 , B01J2229/186 , B82Y40/00 , C07C1/044 , C07C1/12 , C07C1/22 , C07C2523/745 , C10L1/04 , C10L2200/0469 , C10L2200/0492 , Y02P20/52 , C07C15/02
Abstract: Nanocatalysts and methods of using the same to obtain aromatic hydrocarbon compounds from a source of carbon atoms and a source of hydrogen atoms in a single reaction step is provided. The catalyst comprises an Fe/Fe3O4 nanocatalyst that may be supported on a non-reactive support material such as a zeolite or alumina CO2 and H2 are preferred sources of carbon and hydrogen atoms for the reaction. The aromatic hydrocarbon compounds produced are suitable for direct usage as fuel without need for further refining.
Abstract translation: 提供了纳米催化剂及其在单一反应步骤中由碳源和氢原子源获得芳族烃化合物的方法。 该催化剂包括Fe / Fe 3 O 4纳米催化剂，其可以负载在非反应性载体材料如沸石或氧化铝上，而H2和H2是用于反应的碳原子和氢原子的优选来源。 所生产的芳族烃化合物适合直接用作燃料，无需进一步精制。
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公开(公告)号：US20220024877A1
公开(公告)日：2022-01-27
申请号：US17277631
申请日：2019-09-20
Inventor： Stefan H. Bossmann , Madumali Kalubowilage , Man Zhang , Anjana Delpe-Acharige , Kayla Eschliman , Frank Wolschendorf , Olaf Kutsch , Alex Dalecki , Whitney Narmore
IPC: C07D231/42 , C07D231/22 , A61K45/06 , A61P31/04
Abstract: Heterocyclic compounds with a novel pyrazole thioamide-based NNSN structural motif, having highly effective zinc- or copper-activated toxicity against microbial infections at micromolar or nanomolar minimum inhibitory concentrations (MIC), and methods of making and using same.
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