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1.发明授权Nanoparticle catalyst capable of forming aromatic hydrocarbons from CO2 and H2 有权能够从CO 2和H 2形成芳族烃的纳米粒子催化剂公开(公告)号：US09555405B2
公开(公告)日：2017-01-31
申请号：US14603628
申请日：2015-01-23
Applicant: Kansas State University Research Foundation
Inventor： Hongwang Wang , Stefan H. Bossmann , Donghai Wang , Deryl L. Troyer , Tej Shrestha
IPC: C07C1/04 , C07C15/00 , B01J23/74 , B01J23/94 , B01J35/02 , B01J23/745 , C07C1/12 , B01J29/14 , B01J35/00 , B01J21/04 , B01J29/10 , C07C1/22 , C10L1/04 , B82Y40/00
CPC classification number: B01J35/026 , B01J21/04 , B01J23/745 , B01J29/106 , B01J29/146 , B01J35/0013 , B01J35/002 , B01J35/0033 , B01J35/0053 , B01J35/006 , B01J35/008 , B01J2229/186 , B82Y40/00 , C07C1/044 , C07C1/12 , C07C1/22 , C07C2523/745 , C10L1/04 , C10L2200/0469 , C10L2200/0492 , Y02P20/52 , C07C15/02
Abstract: Nanocatalysts and methods of using the same to obtain aromatic hydrocarbon compounds from a source of carbon atoms and a source of hydrogen atoms in a single reaction step is provided. The catalyst comprises an Fe/Fe3O4 nanocatalyst that may be supported on a non-reactive support material such as a zeolite or alumina CO2 and H2 are preferred sources of carbon and hydrogen atoms for the reaction. The aromatic hydrocarbon compounds produced are suitable for direct usage as fuel without need for further refining.
Abstract translation: 提供了纳米催化剂及其在单一反应步骤中由碳源和氢原子源获得芳族烃化合物的方法。 该催化剂包括Fe / Fe 3 O 4纳米催化剂，其可以负载在非反应性载体材料如沸石或氧化铝上，而H2和H2是用于反应的碳原子和氢原子的优选来源。 所生产的芳族烃化合物适合直接用作燃料，无需进一步精制。
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公开(公告)号：US10376599B2
公开(公告)日：2019-08-13
申请号：US15559543
申请日：2016-03-18
Applicant: Kansas State University Research Foundation
Inventor： Stefan H. Bossmann , Deryl L. Troyer , Aruni P. Malalasekera , Hongwang Wang , Sebastian O. Wendel , Gaohong Zhu
IPC: A61K38/00 , A61K49/00 , G01N33/573 , C12Q1/26 , C12Q1/34
Abstract: A nanoplatform assembly for detection of arginase, indoleamine 2,3-dioxygenase 1, and/or tryptophan 2,3-dioxygenase. The nanoplatform comprises an oligopeptide, which is used as a linker between two particles. More preferably, the linker is comprised of an oligopeptide containing a substrate for the target enzyme, where the substrate is chemically or physically modified by the target enzyme (but not cleaved). A central particle with a plurality of oligopeptide-tethered detectable particles and a plurality of directly attached detectable particles is described. Posttranslational modification of the oligopeptide leads to changes in the detectable signals from the first and/or second particles in the nanoplatform, which can be correlated to enzyme activity and concentration.
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公开(公告)号：US10416144B2
公开(公告)日：2019-09-17
申请号：US15329395
申请日：2015-07-27
Applicant: Kansas State University Research Foundation
Inventor： Deryl L. Troyer , Stefan H. Bossmann , Aruni P. Malalasekera , Thilani N. Samarakoon , Hongwang Wang , Madumali Kalubowilage
Abstract: Methods for detecting biomarkers of inflammation, infection, and/or bacterial activity in dairy production, which indicate issues with the milk itself or issues related to the health of the cow. The methods generally comprise contacting a milk sample with a nanoplatform assembly to create an assay solution, and detecting spectral changes in the assay solution that are triggered by enzymatic activity (when present) in the sample. The nanoplatform assembly comprises a first particle, a second particle, and a linkage therebetween, wherein the linkage comprises a protease consensus sequence (the sequence of amino acids cleaved by the protease), or an ester linkage (cleaved by a protease or lipase). A plurality of second particles can also be linked to the first particle. Test strips are also described, which undergo a visual color change in the presence of the target enzyme in the milk sample.
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4.发明申请NANOPARTICLE CATALYST CAPABLE OF FORMING AROMATIC HYDROCARBONS FROM CO2 AND H2 有权从CO2和H2形成芳香烃的纳米催化剂公开(公告)号：US20150141238A1
公开(公告)日：2015-05-21
申请号：US14603628
申请日：2015-01-23
Applicant: Kansas State University Research Foundation
Inventor： Hongwang Wang , Stefan H. Bossmann , Donghai Wang , Deryl L. Troyer , Tej Shrestha
CPC classification number: B01J35/026 , B01J21/04 , B01J23/745 , B01J29/106 , B01J29/146 , B01J35/0013 , B01J35/002 , B01J35/0033 , B01J35/0053 , B01J35/006 , B01J35/008 , B01J2229/186 , B82Y40/00 , C07C1/044 , C07C1/12 , C07C1/22 , C07C2523/745 , C10L1/04 , C10L2200/0469 , C10L2200/0492 , Y02P20/52 , C07C15/02
Abstract: Nanocatalysts and methods of using the same to obtain aromatic hydrocarbon compounds from a source of carbon atoms and a source of hydrogen atoms in a single reaction step is provided. The catalyst comprises an Fe/Fe3O4 nanocatalyst that may be supported on a non-reactive support material such as a zeolite or alumina CO2 and H2 are preferred sources of carbon and hydrogen atoms for the reaction. The aromatic hydrocarbon compounds produced are suitable for direct usage as fuel without need for further refining.
Abstract translation: 提供了纳米催化剂及其在单一反应步骤中由碳源和氢原子源获得芳族烃化合物的方法。 该催化剂包括Fe / Fe 3 O 4纳米催化剂，其可以负载在非反应性载体材料如沸石或氧化铝上，而H2和H2是用于反应的碳原子和氢原子的优选来源。 所生产的芳族烃化合物适合直接用作燃料，无需进一步精制。
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5.发明授权Acid-functionalized nanoparticle catalyst and catalyzed reactions using the same 有权酸官能化的纳米颗粒催化剂和使用其的催化反应公开(公告)号：US08877951B2
公开(公告)日：2014-11-04
申请号：US14351786
申请日：2012-10-24
Applicant: Kansas State University Research Foundation
Inventor： Hongwang Wang , Stefan Bossmann , Byungjun Kollbe Ahn , Xiuzhi Susan Sun
IPC: B01J31/28 , C07D307/48
CPC classification number: B01J31/28 , B01J23/745 , B01J23/8986 , B01J23/94 , B01J23/96 , B01J31/08 , B01J31/10 , B01J35/0006 , B01J35/0013 , B01J35/002 , B01J35/0033 , B01J35/008 , B01J35/08 , B01J35/1014 , B01J35/1019 , B01J37/0209 , B01J37/031 , B01J37/343 , B01J38/72 , C07C67/343 , C07D307/48 , Y02P20/584 , Y10T428/2995 , C07C69/58
Abstract: Superparmagnetic acid-functionalized nanoparticle catalysts are provided along with methods of using the same to protonate an oxygen atom of a carbon-oxygen bond. Particularly, the catalysts comprise a nanoparticle having a ferromagnetic core surrounded by a metal oxide shell. The nanoparticle is at least partially coated with an acid-functionalized siloxane compound. The acid-functionalized nanoparticles may be used to catalyze any number of reactions that can be catalyzed in the presence of protons. The ferromagnetic core permits the nanoparticle catalyst material to be separated from the reaction medium through application of a magnetic field and reused.
Abstract translation: 提供了超磁性酸官能化纳米颗粒催化剂及其使用方法来质子化氧 - 氧键的氧原子。 特别地，催化剂包括具有被金属氧化物壳包围的铁磁性核的纳米颗粒。 纳米颗粒至少部分地涂覆有酸官能化的硅氧烷化合物。 酸官能化的纳米颗粒可用于催化任何数量的可在质子存在下催化的反应。 铁磁芯允许通过施加磁场将纳米颗粒催化剂材料与反应介质分离并重复使用。
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Patent Agency Ranking
公开(公告)号：US20130183702A1
公开(公告)日：2013-07-18
申请号：US13800456
申请日：2013-03-13
Applicant: Kansas State University Research Foundation
Inventor： Stefan H. Bossmann , Deryl L. Troyer , Matthew T. Basel , Tej B. Shrestha , Hongwang Wang
CPC classification number: A61K9/127 , A61K47/48238 , A61K47/48815 , A61K47/62 , A61K47/6911
Abstract: Supramolecular assemblies for delivering active agents to cancerous or precancerous tissues in a subject are provided. These supramolecular assemblies are also useful in assays for detecting and imaging of cancerous and precancerous cells. The assemblies are protease-sensitive and comprise a peptide linkage containing a protease consensus sequence. The assemblies can be selectively targeted to cancerous tissue where the protease enzymes degrade the peptide linkage thereby releasing the active agents which were physically or mechanically contained in or retained by the supramolecular assembly.
Abstract translation: 提供了用于将活性剂递送至受试者中的癌性或癌前组织的超分子组装体。 这些超分子组装也可用于癌和癌前细胞的检测和成像检测。 组装体是蛋白酶敏感的并且包含含有蛋白酶共有序列的肽键。 组装可以选择性地靶向癌组织，其中蛋白酶降解肽键，从而释放在超分子组装中物理或机械包含或保留的活性剂。
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公开(公告)号：US20180099057A1
公开(公告)日：2018-04-12
申请号：US15559543
申请日：2016-03-18
Applicant: Kansas State University Research Foundation
Inventor： Stefan H. Bossmann , Deryl L. Troyer , Aruni P. Malalasekera , Hongwang Wang , Sebastian O. Wendel , Gaohong Zhu
CPC classification number: A61K49/0093 , A61K49/0032 , A61K49/0036 , A61K49/0056 , C12Q1/26 , C12Q1/34 , C12Y113/11011 , C12Y113/11052 , C12Y305/03001 , G01N33/573
Abstract: A nanoplatform assembly for detection of arginase, indoleamine 2,3-dioxygenase 1, and/or tryptophan 2,3-dioxygenase. The nanoplatform comprises an oligopeptide, which is used as a linker between two particles. More preferably, the linker is comprised of an oligopeptide containing a substrate for the target enzyme, where the substrate is chemically or physically modified by the target enzyme (but not cleaved). A central particle with a plurality of oligopeptide-tethered detectable particles and a plurality of directly attached detectable particles is described. Posttranslational modification of the oligopeptide leads to changes in the detectable signals from the first and/or second particles in the nanoplatform, which can be correlated to enzyme activity and concentration.
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公开(公告)号：US20170219548A1
公开(公告)日：2017-08-03
申请号：US15329395
申请日：2015-07-27
Applicant: Kansas State University Research Foundation
Inventor： Deryl L. Troyer , Stefan H. Bossmann , Aruni P. Malalasekera , Thilani N. Samarakoon , Hongwang Wang , Madumali Kalubowilage
CPC classification number: G01N33/04 , C12Q1/04 , C12Q1/37 , C12Q1/44 , G01N2333/952
Abstract: Methods for detecting biomarkers of inflammation, infection, and/or bacterial activity in dairy production, which indicate issues with the milk itself or issues related to the health of the cow. The methods generally comprise contacting a milk sample with a nanoplatform assembly to create an assay solution, and detecting spectral changes in the assay solution that are triggered by enzymatic activity (when present) in the sample. The nanoplatform assembly comprises a first particle, a second particle, and a linkage therebetween, wherein the linkage comprises a protease consensus sequence (the sequence of amino acids cleaved by the protease), or an ester linkage (cleaved by a protease or lipase). A plurality of second particles can also be linked to the first particle. Test strips are also described, which undergo a visual color change in the presence of the target enzyme in the milk sample.
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公开(公告)号：US09216154B2
公开(公告)日：2015-12-22
申请号：US13800456
申请日：2013-03-13
Applicant: Kansas State University Research Foundation
Inventor： Stefan H. Bossmann , Deryl L. Troyer , Matthew T. Basel , Tej B. Shrestha , Hongwang Wang
CPC classification number: A61K9/127 , A61K47/48238 , A61K47/48815 , A61K47/62 , A61K47/6911
Abstract: Supramolecular assemblies for delivering active agents to cancerous or precancerous tissues in a subject are provided. These supramolecular assemblies are also useful in assays for detecting and imaging of cancerous and precancerous cells. The assemblies are protease-sensitive and comprise a peptide linkage containing a protease consensus sequence. The assemblies can be selectively targeted to cancerous tissue where the protease enzymes degrade the peptide linkage thereby releasing the active agents which were physically or mechanically contained in or retained by the supramolecular assembly.
Abstract translation: 提供了用于将活性剂递送至受试者中的癌性或癌前组织的超分子组装体。 这些超分子组装也可用于癌和癌前细胞的检测和成像检测。 组装体是蛋白酶敏感的并且包含含有蛋白酶共有序列的肽键。 组装可以选择性地靶向癌组织，其中蛋白酶降解肽键，从而释放在超分子组装中物理或机械包含或保留的活性剂。
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10.发明申请公开(公告)号：US20140275583A1
公开(公告)日：2014-09-18
申请号：US14351786
申请日：2012-10-24
Applicant: Kansas State University Research Foundation
Inventor： Hongwang Wang , Stefan Bossmann , Byungjun Kollbe Ahn , Xiuzhi Susan Sun
IPC: B01J31/28 , C07D307/48
CPC classification number: B01J31/28 , B01J23/745 , B01J23/8986 , B01J23/94 , B01J23/96 , B01J31/08 , B01J31/10 , B01J35/0006 , B01J35/0013 , B01J35/002 , B01J35/0033 , B01J35/008 , B01J35/08 , B01J35/1014 , B01J35/1019 , B01J37/0209 , B01J37/031 , B01J37/343 , B01J38/72 , C07C67/343 , C07D307/48 , Y02P20/584 , Y10T428/2995 , C07C69/58
Abstract: Superparmagnetic acid-functionalized nanoparticle catalysts are provided along with methods of using the same to protonate an oxygen atom of a carbon-oxygen bond. Particularly, the catalysts comprise a nanoparticle having a ferromagentic core surrounded by a metal oxide shell. The nanoparticle is at least partially coated with an acid-functionalized siloxane compound. The acid-functionalized nanoparticles may be used to catalyze any number of reactions that can be catalyzed in the presence of protons. The ferromagnetic core permits the nanoparticle catalyst material to be separated from the reaction medium through application of a magnetic field and reused.
Abstract translation: 提供了超磁性酸官能化纳米颗粒催化剂及其使用方法来质子化氧 - 氧键的氧原子。 特别地，催化剂包含具有由金属氧化物壳包围的铁心的纳米颗粒。 纳米颗粒至少部分地涂覆有酸官能化的硅氧烷化合物。 酸官能化的纳米颗粒可用于催化任何数量的可在质子存在下催化的反应。 铁磁芯允许通过施加磁场将纳米颗粒催化剂材料与反应介质分离并重复使用。
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