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    Methods and apparatus for point-of-care nucleic acid amplification and detection
    32.
    发明授权
    Methods and apparatus for point-of-care nucleic acid amplification and detection 有权
    点对点核酸扩增和检测的方法和装置

    公开(公告)号：US08911941B2

    公开(公告)日：2014-12-16

    申请号：US13447218

    申请日：2012-04-14

    Applicant: Kenneth J. Michlitsch

    Inventor： Kenneth J. Michlitsch

    IPC: C12Q1/68 ,  C12P19/34 ,  C12M1/36

    CPC classification number: C12Q1/6846 ,  C12Q2547/101 ,  C12Q2563/173 ,  C12Q2565/607

    Abstract: Methods and apparatus are provided for point-of-care nucleic acid amplification and detection. One embodiment of the invention comprises a fully integrated, sample-to-answer molecular diagnostic instrument that optionally may be used in a multiplexed fashion to detect multiple target nucleic acid sequences of interest and that optionally may be configured for disposal after one-time use. Optionally, sample preparation is fully or partially achieved via heat treatment and/or using a filter paper, such as a chemically treated filter paper, e.g., an FTA card. The instrument preferable utilizes an isothermal nucleic acid amplification technique, such as loop-mediated isothermal amplification (LAMP), to reduce the instrumentation requirements associated with nucleic acid amplification. Detection of target amplification may be achieved, for example, via detection of a color shift or fluorescence in a dye added to the amplification reaction.

    Abstract translation: 提供了用于点对点核酸扩增和检测的方法和装置。 本发明的一个实施方案包括完全整合的样品至答复分子诊断仪器，其可任选地以多路复用方式使用以检测目标的多个靶核酸序列，并且可任选地配置为在一次使用后进行处置。 任选地，样品制备通过热处理和/或使用滤纸例如化学处理的滤纸例如FTA卡完全或部分实现。 该仪器优选使用等温核酸扩增技术，例如环介导的等温扩增（LAMP），以减少与核酸扩增相关的仪器要求。 靶扩增的检测可以例如通过检测添加到扩增反应中的染料中的色移或荧光来实现。

    METHODS AND APPARATUS FOR POINT-OF-CARE NUCLEIC ACID AMPLIFICATION AND DETECTION
    33.
    发明申请
    METHODS AND APPARATUS FOR POINT-OF-CARE NUCLEIC ACID AMPLIFICATION AND DETECTION 有权
    点保护核酸放大和检测的方法和装置

    公开(公告)号：US20140356874A1

    公开(公告)日：2014-12-04

    申请号：US14262683

    申请日：2014-04-25

    Applicant: Jane P. Bearinger ,  Scott Castanon ,  Kenneth J. Michlitsch

    Inventor： Jane P. Bearinger ,  Scott Castanon ,  Kenneth J. Michlitsch

    IPC: C12Q1/68

    CPC classification number: C12Q1/6844 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502738 ,  B01L7/00 ,  B01L2300/0861 ,  B01L2300/18 ,  B01L2400/06 ,  C12Q1/6825 ,  C12Q1/6846 ,  C12Q2547/101 ,  C12Q2563/173 ,  C12Q2565/607 ,  C12Q2527/101 ,  C12Q2563/107 ,  C12Q2565/629

    Abstract: Methods and apparatus are provided for point-of-care nucleic acid amplification and detection. One embodiment of the invention comprises a fully integrated, sample-to-answer molecular diagnostic instrument that optionally may be used in a multiplexed fashion to detect multiple target nucleic acid sequences of interest and that optionally may be configured for disposal after one-time use. The instrument preferable utilizes an isothermal nucleic acid amplification technique, such as loop-mediated isothermal amplification (LAMP), to reduce the instrumentation requirements associated with nucleic acid amplification. Detection of target amplification may be achieved, for example, via detection of a color shift or fluorescence in a dye added to the amplification reaction. Such detection may be performed visually by an operator or may be achieved utilizing an imaging technique, e.g., spectrophotometric imaging.

    Abstract translation: 提供了用于点对点核酸扩增和检测的方法和装置。 本发明的一个实施方案包括完全整合的样品至答复分子诊断仪器，其可任选地以多路复用方式使用以检测目标的多个靶核酸序列，并且可任选地配置为在一次使用后进行处置。 该仪器优选使用等温核酸扩增技术，例如环介导的等温扩增（LAMP），以减少与核酸扩增相关的仪器要求。 靶扩增的检测可以例如通过检测加入到扩增反应中的染料中的色移或荧光来实现。 这种检测可以由操作者视觉执行，或者可以使用成像技术（例如分光光度成像）来实现。

    Handle assemblies for intravascular treatment devices and associated systems and methods
    34.
    发明授权
    Handle assemblies for intravascular treatment devices and associated systems and methods 有权
    手术组件用于血管内治疗装置及相关系统和方法

    公开(公告)号：US08808345B2

    公开(公告)日：2014-08-19

    申请号：US12759641

    申请日：2010-04-13

    Applicant: Benjamin J. Clark ,  William R. George ,  Kenneth J. Michlitsch ,  John Paul Sam ,  Erik Thai ,  Andrew Wu

    Inventor： Benjamin J. Clark ,  William R. George ,  Kenneth J. Michlitsch ,  John Paul Sam ,  Erik Thai ,  Andrew Wu

    IPC: A61B18/08 ,  A61B19/00 ,  A61B17/00 ,  A61B18/00

    CPC classification number: A61B18/08 ,  A61B34/74 ,  A61B2017/003 ,  A61B2018/00916

    Abstract: The present disclosure comprises handle assemblies for intravascular treatment devices. In one embodiment, a handle assembly comprises an actuator for deflecting a distal region of an intravascular treatment device. In one embodiment, a handle assembly comprises a rotator for rotating an intravascular treatment device independently of the handle assembly. In one embodiment, a handle assembly comprises a rotation limiting element for limiting independent rotation of an intravascular treatment device relative to the handle assembly. Methods and systems for intravascular delivery, deflection and placement of an intravascular treatment device via a handle assembly of the present invention are also provided.

    Abstract translation: 本公开包括用于血管内治疗装置的手柄组件。 在一个实施例中，手柄组件包括用于偏转血管内治疗装置的远侧区域的致动器。 在一个实施例中，手柄组件包括用于独立于手柄组件旋转血管内治疗装置的旋转器。 在一个实施例中，手柄组件包括用于限制血管内治疗装置相对于手柄组件的独立旋转的旋转限制元件。 还提供了通过本发明的手柄组件进行血管内递送，偏转和放置血管内治疗装置的方法和系统。

    AUTOLOGOUS WOUND SEALING APPARATUS
    36.
    发明申请
    AUTOLOGOUS WOUND SEALING APPARATUS 有权
    自动封口机

    公开(公告)号：US20130006300A1

    公开(公告)日：2013-01-03

    申请号：US13615551

    申请日：2012-09-13

    Applicant: Kenneth J. Michlitsch

    Inventor： Kenneth J. Michlitsch

    IPC: A61B17/03

    CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00672

    Abstract: The apparatus is provided for sealing a vascular puncture tract by forming the autologous plug within the puncture tract, and extruding that plug into the puncture tract. The apparatus of the present invention forms an autologous blood plug by drawing blood into the apparatus from a vessel, mixing a blood congealing agent with the drawn blood, and ejecting a plug formed from the clotted blood within the puncture tract. Also provided are various closure elements to isolate the drawn blood from the vessel during mixture with the blood congealing agent, and to facilitate placement of the apparatus relative to the vessel.

    Abstract translation: 该装置用于通过在穿刺管内形成自体塞子并将该塞子挤压到穿刺管中来密封血管穿刺道。 本发明的装置通过从血管中将血液吸入装置，将血液凝固剂与抽取的血液混合，并在穿刺管内喷出由凝血血液形成的塞子，形成自体血栓。 还提供了各种封闭元件，以在与血液凝结剂混合期间将抽取的血液与血管隔离，并且便于相对于血管的装置放置。

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