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    METHODS AND APPARATUS FOR POINT-OF-CARE NUCLEIC ACID AMPLIFICATION AND DETECTION
    1.
    发明申请
    METHODS AND APPARATUS FOR POINT-OF-CARE NUCLEIC ACID AMPLIFICATION AND DETECTION 有权
    点保护核酸放大和检测的方法和装置

    公开(公告)号：US20140356874A1

    公开(公告)日：2014-12-04

    申请号：US14262683

    申请日：2014-04-25

    申请人： Jane P. Bearinger ,  Scott Castanon ,  Kenneth J. Michlitsch

    发明人： Jane P. Bearinger ,  Scott Castanon ,  Kenneth J. Michlitsch

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6844 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502738 ,  B01L7/00 ,  B01L2300/0861 ,  B01L2300/18 ,  B01L2400/06 ,  C12Q1/6825 ,  C12Q1/6846 ,  C12Q2547/101 ,  C12Q2563/173 ,  C12Q2565/607 ,  C12Q2527/101 ,  C12Q2563/107 ,  C12Q2565/629

    摘要： Methods and apparatus are provided for point-of-care nucleic acid amplification and detection. One embodiment of the invention comprises a fully integrated, sample-to-answer molecular diagnostic instrument that optionally may be used in a multiplexed fashion to detect multiple target nucleic acid sequences of interest and that optionally may be configured for disposal after one-time use. The instrument preferable utilizes an isothermal nucleic acid amplification technique, such as loop-mediated isothermal amplification (LAMP), to reduce the instrumentation requirements associated with nucleic acid amplification. Detection of target amplification may be achieved, for example, via detection of a color shift or fluorescence in a dye added to the amplification reaction. Such detection may be performed visually by an operator or may be achieved utilizing an imaging technique, e.g., spectrophotometric imaging.

    摘要翻译： 提供了用于点对点核酸扩增和检测的方法和装置。 本发明的一个实施方案包括完全整合的样品至答复分子诊断仪器，其可任选地以多路复用方式使用以检测目标的多个靶核酸序列，并且可任选地配置为在一次使用后进行处置。 该仪器优选使用等温核酸扩增技术，例如环介导的等温扩增（LAMP），以减少与核酸扩增相关的仪器要求。 靶扩增的检测可以例如通过检测加入到扩增反应中的染料中的色移或荧光来实现。 这种检测可以由操作者视觉执行，或者可以使用成像技术（例如分光光度成像）来实现。

    Methods and apparatus for selective, oxidative patterning of a surface
    2.
    发明授权
    Methods and apparatus for selective, oxidative patterning of a surface 有权
    用于表面选择性，氧化图案化的方法和装置

    公开(公告)号：US08119335B2

    公开(公告)日：2012-02-21

    申请号：US11333090

    申请日：2006-01-17

    申请人： Jane P. Bearinger ,  Jeffrey A. Hubbell ,  Kenneth J. Michlitsch

    发明人： Jane P. Bearinger ,  Jeffrey A. Hubbell ,  Kenneth J. Michlitsch

    IPC分类号： C08F2/54 ,  C08F2/48 ,  G03F7/00

    CPC分类号： B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  G03F7/2014 ,  G03F7/2043 ,  Y10S430/143 ,  Y10T428/24802

    摘要： The present invention provides methods and apparatus for selectively patterning surfaces using radical species generated with a photocatalyst. The photocatalyst may comprise a photocatalytic semiconductor or a photosensitizer. The radical species are brought into contact with an oxidizable coating disposed on the surface, thereby locally oxidizing and selectively patterning the surface. The photocatalyst is preferably disposed on a delivery device, such as a stamp, mask, or scanning probe, that is brought into close proximity or contact with the coated surface. The photocatalyst is then excited in a manner capable of generating radical species, for example, oxygen-containing radical species, in appropriate media. It is expected that these radical species will be transferred to the coated surface along a substantially shortest distance path, thereby locally oxidizing and patterning the surface.

    摘要翻译： 本发明提供了使用由光催化剂生成的自由基物质来选择性地图案化表面的方法和装置。 光催化剂可以包含光催化半导体或光敏剂。 使自由基物质与设置在表面上的可氧化涂层接触，从而局部氧化并选择性地图案化该表面。 光催化剂优选地设置在与涂覆表面紧密接触或接触的输送装置，例如印模，掩模或扫描探针上。 然后在适当的介质中以能够产生自由基物质，例如含氧自由基物质的方式激发光催化剂。 预期这些自由基物质将沿着基本上最短的距离路径转移到涂覆的表面，从而局部氧化和图案化表面。

    METHODS AND APPARATUS FOR EAR PROTECTION
    3.
    发明申请
    METHODS AND APPARATUS FOR EAR PROTECTION 审中-公开
    保护方法和装置

    公开(公告)号：US20120124719A1

    公开(公告)日：2012-05-24

    申请号：US13168618

    申请日：2011-06-24

    申请人： Kenneth J. Michlitsch ,  Jane P. Bearinger

    发明人： Kenneth J. Michlitsch ,  Jane P. Bearinger

    IPC分类号： A41D13/05

    CPC分类号： A41D13/05 ,  A45D44/12 ,  A61F11/14

    摘要： Methods and apparatus are provided for protecting the external ear from the elements, heat, cold, wind, rain and/or snow. In some embodiments, an ear protector comprises a conforming anchor with an opening through which the external ear may be passed. The ear protector further comprises an insulating outer covering that, in combination with the anchor, forms the ear protector with a chamber positioned between the outer covering and the anchor. During use, the chamber is configured to receive the external ear, with the anchor's opening conformably positioned in proximity to at least a portion of the ear's root. The perimeter of the conforming anchor's opening resiliently deforms during passage of the external ear through the opening and into the chamber, and then conforms to the geometry of at least a portion of the ear root in order to securely and comfortably maintain the ear protector in position over the external ear without additional external support. The conforming anchor preferably is fabricated from a closed cell foamed elastomer.

    摘要翻译： 提供了用于保护外耳免受元件，热，冷，风，雨和/或雪的方法和装置。 在一些实施例中，耳朵保护器包括具有外耳道可穿过的开口的一致的锚。 耳朵保护器还包括绝缘外覆盖物，其与锚固件组合形成具有定位在外覆盖物和锚固件之间的腔室的护耳器。 在使用期间，腔室被构造成接收外耳，其中锚的开口顺应地定位在耳朵根部的至少一部分附近。 在外耳道通过开口并进入腔室时，适形锚的开口的周边弹性变形，然后符合耳根的至少一部分的几何形状，以便牢固和舒适地将耳朵保护器保持在适当位置 无需外部支持。 优选地，适形锚固件由闭孔发泡弹性体制成。

    Methods and apparatus for ear protection
    4.
    发明授权
    Methods and apparatus for ear protection 有权
    耳朵保护方法和装置

    公开(公告)号：US09591879B2

    公开(公告)日：2017-03-14

    申请号：US13168618

    申请日：2011-06-24

    申请人： Kenneth J. Michlitsch ,  Jane P. Bearinger

    发明人： Kenneth J. Michlitsch ,  Jane P. Bearinger

    IPC分类号： A61F11/06 ,  A41D13/05 ,  A61F11/14 ,  A45D44/12

    CPC分类号： A41D13/05 ,  A45D44/12 ,  A61F11/14

    摘要： Methods and apparatus are provided for protecting the external ear from the elements, heat, cold, wind, rain and/or snow. In some embodiments, an ear protector comprises a conforming anchor with an opening through which the external ear may be passed. The ear protector further comprises an insulating outer covering that, in combination with the anchor, forms the ear protector with a chamber positioned between the outer covering and the anchor. During use, the chamber is configured to receive the external ear, with the anchor's opening conformably positioned in proximity to at least a portion of the ear's root. The perimeter of the conforming anchor's opening resiliently deforms during passage of the external ear through the opening and into the chamber, and then conforms to the geometry of at least a portion of the ear root in order to securely and comfortably maintain the ear protector in position over the external ear without additional external support. The conforming anchor preferably is fabricated from a closed cell foamed elastomer.

    摘要翻译： 提供了用于保护外耳免受元件，热，冷，风，雨和/或雪的方法和装置。 在一些实施例中，耳朵保护器包括具有外耳道可穿过的开口的一致的锚。 耳朵保护器还包括绝缘外覆盖物，其与锚固件组合形成具有定位在外覆盖物和锚固件之间的腔室的护耳器。 在使用期间，腔室被构造成接收外耳，其中锚的开口顺应地定位在耳朵根部的至少一部分附近。 在外耳道通过开口并进入腔室时，适形锚的开口的周边弹性变形，然后符合耳根的至少一部分的几何形状，以便牢固和舒适地将耳朵保护器保持在适当位置 无需外部支持。 优选地，适形锚固件由闭孔发泡弹性体制成。

    METHODS AND APPARATUS FOR POINT-OF-CARE NUCLEIC ACID AMPLIFICATION AND DETECTION
    7.
    发明申请
    METHODS AND APPARATUS FOR POINT-OF-CARE NUCLEIC ACID AMPLIFICATION AND DETECTION 有权
    点保护核酸放大和检测的方法和装置

    公开(公告)号：US20120264116A1

    公开(公告)日：2012-10-18

    申请号：US13447218

    申请日：2012-04-14

    申请人： Kenneth J. Michlitsch

    发明人： Kenneth J. Michlitsch

    IPC分类号： C12M1/02 ,  C12Q1/68

    CPC分类号： C12Q1/6846 ,  C12Q2547/101 ,  C12Q2563/173 ,  C12Q2565/607

    摘要： Methods and apparatus are provided for point-of-care nucleic acid amplification and detection. One embodiment of the invention comprises a fully integrated, sample-to-answer molecular diagnostic instrument that optionally may be used in a multiplexed fashion to detect multiple target nucleic acid sequences of interest and that optionally may be configured for disposal after one-time use. Optionally, sample preparation is fully or partially achieved via heat treatment and/or using a filter paper, such as a chemically treated filter paper, e.g., an FTA card. The instrument preferable utilizes an isothermal nucleic acid amplification technique, such as loop-mediated isothermal amplification (LAMP), to reduce the instrumentation requirements associated with nucleic acid amplification. Detection of target amplification may be achieved, for example, via detection of a color shift or fluorescence in a dye added to the amplification reaction.

    摘要翻译： 提供了用于点对点核酸扩增和检测的方法和装置。 本发明的一个实施方案包括完全整合的样品至答复分子诊断仪器，其可任选地以多路复用方式使用以检测目标的多个靶核酸序列，并且可任选地配置为在一次使用后进行处置。 任选地，样品制备通过热处理和/或使用滤纸例如化学处理的滤纸例如FTA卡完全或部分实现。 该仪器优选使用等温核酸扩增技术，例如环介导的等温扩增（LAMP），以减少与核酸扩增相关的仪器要求。 靶扩增的检测可以例如通过检测添加到扩增反应中的染料中的色移或荧光来实现。

    Apparatus and methods for optimizing anchoring force
    8.
    发明授权
    Apparatus and methods for optimizing anchoring force 有权
    用于优化锚固力的装置和方法

    公开(公告)号：US08206417B2

    公开(公告)日：2012-06-26

    申请号：US10865243

    申请日：2004-06-09

    申请人： Tracy D. Maahs ,  Richard C. Ewers ,  Vahid Saadat ,  Alex Khairkhahan ,  Kenneth J. Michlitsch

    发明人： Tracy D. Maahs ,  Richard C. Ewers ,  Vahid Saadat ,  Alex Khairkhahan ,  Kenneth J. Michlitsch

    IPC分类号： A61B17/04

    CPC分类号： A61B17/0482 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0644 ,  A61B2017/00867 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2090/037

    摘要： Apparatus and methods for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.

    摘要翻译： 本文描述了用于优化锚固力的装置和方法。 在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。 当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。 可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。 此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。

    Autologous wound sealing apparatus
    10.
    发明授权
    Autologous wound sealing apparatus 有权
    自动伤口密封装置

    公开(公告)号：US07771454B2

    公开(公告)日：2010-08-10

    申请号：US10523219

    申请日：2003-07-25

    申请人： Kenneth J. Michlitsch

    发明人： Kenneth J. Michlitsch

    IPC分类号： A61B17/08

    CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00672

    摘要： Apparatus (10) is provided for sealing a vascular puncture tract by forming the autologous plug within the puncture tract, and extruding that plug into the puncture tract. The apparatus of the present invention forms an autologous blood plug by drawing blood into the apparatus from a vessel, mixing a blood congealing agent with the drawn blood, and ejecting a plug formed from the clotted blood within the puncture tract. Also provided are various closure elements (22) to isolate the drawn blood from the vessel during mixture with the blood congealing agent, and to facilitate placement of the apparatus relative to the vessel.

    摘要翻译： 设置装置（10），用于通过在穿刺道内形成自体塞子来密封血管穿刺管道，并将该塞子挤压到穿刺管道中。 本发明的装置通过从血管中将血液吸入装置，将血液凝固剂与抽取的血液混合，并在穿刺管内喷出由凝血血液形成的塞子，形成自体血栓。 还提供了各种封闭元件（22），以在与血液凝固剂混合期间将抽出的血液与血管隔离，并且便于相对于血管的装置放置。