公开(公告)号：US20210205398A1

公开(公告)日：2021-07-08

申请号：US15999722

申请日：2017-02-17

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jinhee KIM ,  Eun Sang CHO ,  No Soo KIM ,  Ok-Sun BANG ,  You Jin LEE ,  Young-Ah KIM ,  Eunna HUH

IPC: A61K36/899 ,  A61P7/06 ,  A23L33/105 ,  A23L33/00

Abstract: A composition contains Phragmitis Rhizoma extract as an active ingredient. As a result of treating mouse bone marrow cells with an extract of Phragmitis Rhizoma, it was confirmed to have an effect that a decrease in colony of hematopoietic cells, which is induced by an anticancer agent, is significantly recovered and bone marrow suppression caused by an anticancer agent is significantly recovered in an animal model which has been induced to have bone marrow suppression according to intraperitoneal injection of an anticancer agent. Thus, the Phragmitis Rhizoma extract can be advantageously used for a composition for prevention, amelioration, or treatment of a disorder caused by side effect of an anticancer agent, and there is a possibility of having the increased effect of an anticancer agent when it is used as an anticancer adjuvant in combination with an anticancer agent.

公开(公告)号：US20210113643A1

公开(公告)日：2021-04-22

申请号：US17040447

申请日：2018-12-11

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jin Sook KIM ,  Chan-Sik KIM ,  Ik Soo LEE ,  Gyu Hyung JO ,  Soo-Wang HYUN

IPC: A61K36/65 ,  A61K36/54 ,  A61P3/04 ,  A23L33/105 ,  A23L33/00

Abstract: Provided is a composition for preventing or treating obesity including a mixed extract of Cinnamomi twigs, and more particularly, a pharmaceutical composition for preventing or treating obesity including a mixed extract of Cinnamomi twigs and Moutan root bark, a health functional food composition of feed composition for preventing or alleviating obesity including the composition, and a method of preventing or treating obesity including administering the pharmaceutical composition to an individual having obesity or a risk of developing obesity. The mixed extract of Cinnamomi twigs and Moutan root bark may inhibit fat absorption in the intestinal tract and increases in body weight causing obesity by single-dose administration, reduce lipid content in the blood, decrease weight and size of adipocytes, effectively inhibit accumulation of fat in liver tissue, and inhibit diarrhea, a serious side effect of Xenical™, by long-term administration.

公开(公告)号：US20200268827A1

公开(公告)日：2020-08-27

申请号：US16646387

申请日：2018-09-12

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Dong Seon KIM ,  Yun Mi LEE ,  Eun Jung SON ,  Ji Youn KIM

IPC: A61K36/9062 ,  A61P19/02

Abstract: A method for treating osteoarthritis according to an embodiment of the present invention includes administering to a subject in need thereof a composition comprising an extract of Alpinia oxyphylla. The extract of Alpinia oxyphylla can reduce the expression of IL-1β, IL-6, TNF-α and COX-2 as an inflammatory factor and also the expression of MMP-9 as a cartilage degeneration-inducing factor, and can heal the cartilage damage, and thus it can be advantageously used as a functional health food composition for prevention or improvement of osteoarthritis or a therapeutic agent for osteoarthritis.

公开(公告)号：US10517913B2

公开(公告)日：2019-12-31

申请号：US15572062

申请日：2015-09-30

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： No Soo Kim ,  Jong-Shik Park ,  Jin-Mu Yi ,  You Jin Lee ,  Eun-Sang Cho ,  Jinhee Kim ,  Chae Jun Lim ,  Ok-Sun Bang ,  Youngah Kim

IPC: A61K36/30 ,  A61K31/282 ,  A61K31/337 ,  A61P25/02

Abstract: A composition comprising a Lithospermi Radix extract as an effective component prevents, alleviates, or treats peripheral neuropathy, in particular, peripheral neuropathy induced by an anti-cancer agent (i.e., chemotherapy-induced peripheral neuropathy). A method for preventing or treating peripheral neuropathy includes administering to a subject in need thereof the composition. The Lithospermi Radix extract can relieve the suppressed growth of neurites caused by an anti-cancer agent while neither inducing any cytotoxicity in normal cells nor changing the unique cytotoxic potential of an anti-cancer agent in human cancer cells. In addition, the Lithospermi Radix extract can efficiently lower the enhanced sensitivity to painful stimuli in peripheral neuropathic animals induced by an anti-cancer agent. Thus, the Lithospermi Radix extract can be advantageously used as an effective component of a composition for prevention, alleviation, or treatment of chemotherapy-induced peripheral neuropathy.

公开(公告)号：US20180264064A1

公开(公告)日：2018-09-20

申请号：US15742391

申请日：2016-07-08

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jin Yeul MA ,  Jung Hyun KIM ,  Jong Wook JEON ,  You Chang OH ,  Won Kyung CHO ,  Youn Hwan HWANG ,  Nam Hui YIM ,  Jae Myung YOO

IPC: A61K36/77 ,  A61K9/00 ,  A61P27/02

CPC classification number: A61K36/77 ,  A61K8/9789 ,  A61K9/0048 ,  A61K9/08 ,  A61K36/20 ,  A61K47/02 ,  A61K2800/84 ,  A61P27/02 ,  A61Q1/10 ,  A61Q19/005

Abstract: The present invention relates to a pharmaceutical composition for preventing and treating corneal diseases or conjunctival diseases, containing a maple leaf extract as an active ingredient. The maple leaf extract exhibits an effect of inhibiting hyperemia in the eyeball in which hyperemia has been induced and an effect of inhibiting angiogenesis in the eyeball in which corneal damage has been induced, thus being effectively used in a pharmaceutical composition for preventing and treating corneal diseases or conjunctival diseases.

公开(公告)号：US20170296607A1

公开(公告)日：2017-10-19

申请号：US15515896

申请日：2015-10-13

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Kwang-Hoon SONG ,  Yun Hee KIM ,  Hye Won LEE ,  A-Rang IM

IPC: A61K36/48

CPC classification number: A61K36/48 ,  A61K2236/331

Abstract: A health functional food composition and a pharmaceutical composition for preventing or ameliorating a non-alcoholic fatty liver disease include an extract of Dolichos lablab Linne as an active ingredient. The extract of Dolichos lablab Linne, being an active ingredient, effectively reduces accumulation of triglyceride in hepatocarcinoma cell line (HepG2). Therefore, the compositions are used for functional foods and medicines for the prevention or amelioration of non-alcoholic fatty liver.

公开(公告)号：US20170209510A1

公开(公告)日：2017-07-27

申请号：US15313654

申请日：2015-05-21

Applicant: Korea Institute of Oriental Medicine

Inventor： Jin Sook KIM ,  Junghyun KIM ,  Chan-Sik KIM ,  Eunjin SHON ,  Yun Mi LEE ,  Young Sook KIM ,  Sojin CHOI ,  Ik Soo LEE ,  Dong Ho JUNG ,  Bo-Jeong PYUN ,  Seung-Hyun JUNG

IPC: A61K36/65 ,  A61K36/484

CPC classification number: A61K36/65 ,  A61K36/484 ,  A61K2236/331 ,  A61K2236/333 ,  A61K2236/37 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating angioedema, containing as an active ingredient a peony root extract or an extract of a mixture of peony root and licorice. In particular, the extract of a mixture of peony root and licorice according to the present invention inhibits the excessive generation of advanced glycation end products, which may cause macular degeneration, inhibits blood-retinal barrier breakdown causing retinal edema in various animal models, protects or treats a subretinal region causing dry macular degeneration, inhibits angiogenesis causing wet macular degeneration, and thus can be usefully used as an active ingredient for the composition for preventing and treating angioedema including macular degeneration, macular edema, retinal edema, or varicose veins.

公开(公告)号：US20170000421A1

公开(公告)日：2017-01-05

申请号：US15125934

申请日：2014-10-31

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Young Min KIM ,  Chang Jin JUNG ,  Jae Uk KIM ,  Jong Yeol KIM

IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/107

CPC classification number: A61B5/702 ,  A61B5/0053 ,  A61B5/02 ,  A61B5/0205 ,  A61B5/02108 ,  A61B5/024 ,  A61B5/107 ,  A61B5/1072 ,  A61B5/4854 ,  A61B5/7203

Abstract: An arm-fastening device may comprise: a guide part for elastically fastening a first recessed point in the lower part of the radius of an arm of a user and a second recessed point in the lower part of the ulna of the arm of the user; a measurement part for, when the arm is fastened, measuring the length of the arm, the length being from a reference surface to the point where the guide part fastens the first recessed point and the second recessed point; and a determination part for determining whether the arm is fastened according to the result of a comparison of the measured length of the arm with a reference length used for determining whether the arm is fastened.

Abstract translation: 手臂固定装置可以包括：引导部分，用于弹性地固定使用者的手臂的半径的下部的第一凹陷点和使用者的手臂的尺骨的下部中的第二凹陷点; 测量部件，用于当所述臂被固定时，测量所述臂的长度，所述长度是从参考表面到所述引导部分固定所述第一凹陷点和所述第二凹陷点的点; 以及确定部，用于根据将所述臂的测量长度的比较结果与用于确定所述臂是否被固定的参考长度来确定所述臂是否紧固。

公开(公告)号：US20150328121A1

公开(公告)日：2015-11-19

申请号：US14651876

申请日：2013-10-18

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Sung Uk CHAE ,  Mi Young LEE

IPC: A61K8/63 ,  A61Q19/08 ,  A61Q19/00

CPC classification number: A61K8/63 ,  A61K8/60 ,  A61K8/97 ,  A61K31/7028 ,  A61K31/704 ,  A61K31/7048 ,  A61K36/8964 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08

Abstract: The present invention relates to a skin-moisturizing or wrinkle-improving external composition or cosmetic composition which contains, as an active ingredient, a compound represented by Formula 1, which can be extracted from Anemarrhena asphodeloides Bunge, or a pharmaceutically acceptable salt thereof. The composition prevents skin moisture loss and thus suppresses skin tissue damage induced by UV rays and so has a skin-wrinkle preventing or alleviating effect.

Abstract translation: 本发明涉及皮肤保湿或皱纹改善的外用组合物或化妆品组合物或其药学上可接受的盐，其含有作为活性成分的可由Anemarrhena asphodeloides Bunge提取的由式1表示的化合物或其药学上可接受的盐。 该组合物防止皮肤水分流失，从而抑制由紫外线引起的皮肤组织损伤，因此具有防止或减轻皮肤皱纹的作用。

公开(公告)号：US20150310262A1

公开(公告)日：2015-10-29

申请号：US14553972

申请日：2014-11-25

Applicant: KOREA INSTITUTE OF ORIENTAL MEDICINE

Inventor： Jun Hyeong DO ,  Ji Ho NAM ,  Jun Su JANG ,  Si Woo LEE ,  Ji Ho SO ,  Na Hye KIM ,  Jong Yeol KIM

IPC: G06K9/00

CPC classification number: G06K9/00308

Abstract: A method of determining a facial expression type may include extracting feature points representing facial characteristics from a facial image of a user; grouping the extracted feature points into a plurality of regions; and determining a facial expression type for each of a plurality of groups using feature points and a facial expression type function corresponding to each of the groups.

Abstract translation: 确定面部表情类型的方法可以包括从用户的面部图像提取表示面部特征的特征点; 将所提取的特征点分组成多个区域; 以及使用特征点和对应于每个组的面部表情类型函数来确定多个组中的每个组的面部表情类型。