公开(公告)号：US20110238137A1

公开(公告)日：2011-09-29

申请号：US12929475

申请日：2011-01-27

申请人： Kazuhiro Tsujita

发明人： Kazuhiro Tsujita

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61N2005/0626 ,  A61N2005/067

摘要： A laser source irradiates a tumor site, permeated with photosensitizer, using pulse laser for PAI. The photosensitizer absorbs the pulse laser for PAI to generate ultrasonic waves. An ultrasonic wave detection device detects the ultrasonic waves to output an ultrasonic signal. A processor device performs various processes to the ultrasonic signal to generate image data. Based on the image data, a photosensitizer concentration calculator calculates concentration distribution of the photosensitizer at a specific depth in the tumor site. Based the obtained concentration distribution, an irradiation condition of CW laser for photodynamic therapy (PDT) is set or changed. Based on the irradiation condition, the CW laser for PDT is irradiated to the tumor site.

摘要翻译： 激光源照射肿瘤部位，用光敏剂渗透脉冲激光用于PAI。 光敏剂吸收PAI的脉冲激光产生超声波。 超声波检测装置检测超声波以输出超声波信号。 处理器设备对超声信号执行各种处理以产生图像数据。 基于图像数据，光敏剂浓度计算器计算光敏剂在肿瘤部位的特定深度的浓度分布。 基于获得的浓度分布，设定或改变了用于光动力疗法（PDT）的CW激光的照射条件。 基于照射条件，将PDT的CW激光照射到肿瘤部位。

公开(公告)号：US07331234B2

公开(公告)日：2008-02-19

申请号：US10701555

申请日：2003-11-06

申请人： Kazuhiro Tsujita ,  Tomoo Satoh

发明人： Kazuhiro Tsujita ,  Tomoo Satoh

IPC分类号： G01N29/00

CPC分类号： G01N29/075 ,  A61B8/483 ,  G01N29/0609 ,  G01N29/262 ,  G01N2291/106 ,  G01S7/5209 ,  G01S15/8915

摘要： An ultrasonic imaging method and apparatus capable of obtaining image information at a high volume rate and improving resolution. The ultrasonic imaging apparatus has an ultrasonic transducer array including plural ultrasonic transducers for transmitting ultrasonic waves in accordance with drive signals and receiving ultrasonic waves to output detection signals; pulsers for supplying the drive signals; an ignition timing controller for controlling the pulsers to respectively transmit plural ultrasonic beams toward plural directions within a predetermined period so that adjacent two ultrasonic beams are separated by 20° or more from each other; receivers for processing the plural detection signals; and plural phase matching units, provided in correspondence with a number of the ultrasonic beams to be transmitted, for performing phase matching on the basis of the processed detection signals so that plural receiving focal points are formed for each of the transmitted plural ultrasonic beams.

摘要翻译： 一种能够以高体积率获得图像信息并提高分辨率的超声成像方法和装置。 超声波成像装置具有包括多个用于根据驱动信号发送超声波并接收超声波以输出检测信号的超声波换能器的超声波换能器阵列; 用于提供驱动信号的脉冲发生器; 点火正时控制器，用于控制脉冲发生器在预定时间段内分别向多个方向发送多个超声波束，使得相邻的两个超声波束彼此分离20°以上; 用于处理多个检测信号的接收器; 以及与要发送的多个超声波束相对应地设置的多个相位匹配单元，用于基于处理的检测信号进行相位匹配，从而为发送的多个超声波束中的每一个形成多个接收焦点。

公开(公告)号：US20070282169A1

公开(公告)日：2007-12-06

申请号：US11806539

申请日：2007-06-01

申请人： Kazuhiro Tsujita

发明人： Kazuhiro Tsujita

IPC分类号： A61B1/06 ,  A61B1/04

CPC分类号： A61B1/041 ,  A61B1/00009 ,  A61B1/00016 ,  A61B1/0005 ,  A61B1/045 ,  A61B5/0031 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/073

摘要： A capsule endoscope for endoscopic imaging is swallowable in a body, for image pickup of an object. In a capsule endoscopic system, a receiver receives image data in a form of a radio signal from the capsule endoscope, and for storing the image data. A computer as image processor produces an object image according to the image data from the receiver. A spectral image generator produces data of a spectral image having a wavelength band by arithmetic operation according to the image data. To this end, the spectral image generator arithmetically operates with a coefficient matrix to form the spectral image. Furthermore, capsule type information, assigned to the capsule endoscope discretely, is retrieved. The capsule type information is stored in a data storage medium, and read by the spectral image generator to determine the coefficient matrix.

摘要翻译： 用于内窥镜成像的胶囊型内窥镜在身体中吞噬，用于物体的图像拾取。 在胶囊内窥镜系统中，接收器以胶囊型内窥镜的无线信号的形式接收图像数据，并存储图像数据。 作为图像处理器的计算机根据来自接收器的图像数据产生对象图像。 光谱图像生成器根据图像数据通过算术运算产生具有波长带的光谱图像的数据。 为此，光谱图像发生器用系数矩阵算术运算以形成光谱图像。 此外，检索分配给胶囊型内窥镜的胶囊型信息。 胶囊类型信息存储在数据存储介质中，并由光谱图像发生器读取以确定系数矩阵。

公开(公告)号：US20070019208A1

公开(公告)日：2007-01-25

申请号：US11535361

申请日：2006-09-26

申请人： Masahiro Toida ,  Yoshikatsu Morishima ,  Kazuhiro Tsujita ,  Hiroshi Fujita

发明人： Masahiro Toida ,  Yoshikatsu Morishima ,  Kazuhiro Tsujita ,  Hiroshi Fujita

IPC分类号： G01B9/02 ,  G01B11/02

CPC分类号： G01B9/02004 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0084 ,  A61B5/0086 ,  G01B9/02003 ,  G01B9/02014 ,  G01B9/02044 ,  G01B9/02091 ,  G01J3/10 ,  G01N21/4795

摘要： Low coherence light having a central wavelength λc of 1.1 μm and a full width at half maximum spectrum Δλ of 90 nm is emitted. The low coherence light has wavelength properties suited for the light absorbing properties, the diffusion properties, and the dispersion properties of living tissue. A light dividing means divides the low coherence light into a measuring light beam, which is irradiated onto a measurement target via an optical probe, and a reference light beam that propagates toward an optical path length adjusting means. A multiplexing means multiplexes a reflected light beam, which is the measuring light beam reflected at a predetermined depth of the measurement target, and the reference light beam, to form coherent light. A coherent light detecting means detects the optical intensity of the multiplexed coherent light. An image obtaining means performs image processes, and displays an optical tomographic image on a display apparatus.

摘要翻译： 发射具有1.1μm的中心波长lambdac和半峰全宽度的低相干光，发射90nm的Deltalambda。 低相干光具有适合于吸光性能，扩散性能和生物体组织的分散性能的波长特性。 光分割装置将低相干光分成通过光学探针照射到测量对象上的测量光束和朝向光程长度调节装置传播的参考光束。 多路复用装置将作为在测量对象的预定深度处反射的测量光束的反射光和参考光束进行多路复用，以形成相干光。 相干光检测装置检测多路复用相干光的光强度。 图像获取装置执行图像处理，并在显示装置上显示光学断层图像。

公开(公告)号：US20060074317A1

公开(公告)日：2006-04-06

申请号：US11244297

申请日：2005-10-06

申请人： Yoshiaki Satou ,  Tomoo Sato ,  Hiroyuki Karasawa ,  Kazuhiro Tsujita

发明人： Yoshiaki Satou ,  Tomoo Sato ,  Hiroyuki Karasawa ,  Kazuhiro Tsujita

IPC分类号： A61B8/14

CPC分类号： A61B8/4438 ,  A61B8/12 ,  A61B8/4411 ,  A61B8/4488 ,  B06B1/0633 ,  G10K11/341

摘要： An ultrasonic probe of a radial scan type mountable on an ultrasonic observation apparatus, which inputs and outputs M numbers of signals in parallel, comprises the following: N (N>M) numbers of ultrasonic transducers disposed on an outer periphery of a tip, and grouped into plural sensor element groups activated in sequence, each of which has M numbers of ultrasonic transducers; N numbers of first signal lines respectively connected to the N numbers of ultrasonic transducers for transmitting a drive signal for driving the ultrasonic transducers and an echo signal from within a living organism; M numbers of second signal lines connected to the ultrasonic observation apparatus; and a multiplexer disposed between the first signal lines and the second signal lines, which selectively switches M numbers of the first signal lines for respectively connecting to the second signal lines according to the sensor element group to be activated.

摘要翻译： 可安装在超声波观察装置上的径向扫描型超声波探头，其并联输入和输出M个信号，包括：设置在尖端外周的超声波换能器的N（N> M）个数，以及 被分组成依次激活的多个传感器元件组，每个具有M个超声波换能器; 分别连接到N个超声波换能器的N个第一信号线，用于传输用于驱动超声波换能器的驱动信号和来自活体内的回波信号; 连接到超声波观察装置的M个第二信号线; 以及多路复用器，设置在第一信号线和第二信号线之间，根据要被激活的传感器元件组，选择性地切换M个第一信号线以分别连接到第二信号线。

公开(公告)号：US06955417B2

公开(公告)日：2005-10-18

申请号：US10400910

申请日：2003-03-28

申请人： Tsutomu Yokouchi ,  Kazuo Sanada ,  Kazuhiro Tsujita

发明人： Tsutomu Yokouchi ,  Kazuo Sanada ,  Kazuhiro Tsujita

IPC分类号： B41J2/14 ,  B41J2/16

CPC分类号： B41J2/1433 ,  B41J2002/14475

摘要： An inkjet recording head includes nozzles arrayed in one direction and ink droplet ejecting devices formed in the respective nozzles. Each nozzle has a height difference in a depthwise direction on a side on which ink droplets are ejected and an ink liquid surface is formed between both edges forming the height difference. An inkjet printer uses this inkjet recording head. The inkjet recording head can eject ink obliquely to the ejection surface for correcting recording pitches at joining portions and preventing the periphery of the nozzles from being contaminated by the ink splashed back from image receiving paper. The ejection angle and the ejecting direction can also be suitably selected and adjusted.

摘要翻译： 喷墨记录头包括沿一个方向排列的喷嘴和形成在各个喷嘴中的墨滴喷射装置。 每个喷嘴在其上喷射墨滴的一侧上的深度方向上具有高度差，并且在形成高度差的两个边缘之间形成油墨表面。 喷墨打印机使用该喷墨记录头。 喷墨记录头可以将喷墨墨水倾斜地喷射到喷射表面，用于校正接合部分处的记录间距，并且防止喷嘴的周边被从图像接收纸溅出的墨水污染。 也可以适当地选择和调整喷射角度和喷射方向。

公开(公告)号：US20050070796A1

公开(公告)日：2005-03-31

申请号：US10947301

申请日：2004-09-23

申请人： Kazuhiro Tsujita

发明人： Kazuhiro Tsujita

IPC分类号： A61B8/08 ,  A61B8/15 ,  G01S7/52 ,  A61B8/00

CPC分类号： A61B8/483 ,  A61B8/0858 ,  A61B8/0875 ,  A61B8/15 ,  G01S7/52026 ,  G01S7/52046

摘要： An ultrasonic diagnosing apparatus capable of obtaining more image information on living tissues by utilizing attenuation information of ultrasonic waves at plural frequencies as information on tissues within an object to be inspected. The ultrasonic diagnosing apparatus includes: a separating unit for separating a frequency component of a signal obtained by transmitting ultrasonic waves to the object and receiving the ultrasonic waves reflected from the object or transmitted through the object, into frequency components at different frequencies or in different frequency bands to obtain plural frequency components; a computing unit for obtaining relative relationships between intensity of the plural frequency components obtained by the separating unit at different points of time to obtain changes in the relative relationships between the intensity; and an image data generating unit for generating image data on the object based on the changes in the relative relationships between the intensity obtained by the computing unit.

摘要翻译： 能够通过利用多个频率的超声波的衰减信息获得更多的生物体组织的图像信息的超声波诊断装置，作为被检查对象内的组织的信息。 超声波诊断装置包括：分离单元，用于将通过向对象发送超声波获得的信号的频率分量和从对象反射的或通过对象发送的超声波分离成不同频率或不同频率的频率分量 频带获得多个频率分量; 计算单元，用于获得由所述分离单元在不同时间点获得的多个频率分量的强度之间的相对关系，以获得所述强度之间的相对关系的变化; 以及图像数据生成单元，用于基于由计算单元获得的强度之间的相对关系的变化来生成对象上的图像数据。

公开(公告)号：US06747281B2

公开(公告)日：2004-06-08

申请号：US09919853

申请日：2001-08-02

申请人： Tomonari Sendai ,  Kazuhiro Tsujita ,  Yukihiko Nakajima

发明人： Tomonari Sendai ,  Kazuhiro Tsujita ,  Yukihiko Nakajima

IPC分类号： G01N2164

CPC分类号： A61B1/0646 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/045 ,  A61B1/0638 ,  A61B5/0071 ,  A61B5/0084

摘要： According to a method of and apparatus for displaying as an autofluorescent-light image emitted from a target subject upon the irradiation thereof by a excitation light, even for cases in which a malfunction of the apparatus occurs that prevents an operator from obtaining a desired image, a standard-image is displayed so as to enable an operator to safely and expediently remove the insertion portion of the endoscope from the body of a patient, whereby the safety of the patient can be ensured. When an irregularity in the temperature of one of the light sources, the operation of one of the drive apparatus, or other cause of an operational irregularity occurring in of one of the light sources is detected by the semiconductor-laser temperature detecting means, the reference-light source temperature detecting means, or the emission-output detecting means, in response to a detection signal thereof, the standard-image display mode is switched to automatically.

摘要翻译： 根据用于通过激发光照射从目标对象发射的自发荧光图像的方法和装置，即使发生防止操作者获得期望图像的设备故障的情况， 显示标准图像，以使操作者能够从患者的身体安全且方便地将内窥镜的插入部分去除，由此可以确保患者的安全性。 当半导体激光温度检测装置检测到光源中的一个的温度不均匀，其中一个驱动装置的操作或其中一个光源中发生的操作不规则的其他原因时，参考 光源温度检测装置或发射输出检测装置，响应于其检测信号，标准图像显示模式被自动切换。

公开(公告)号：US06694176B1

公开(公告)日：2004-02-17

申请号：US09672766

申请日：2000-09-29

申请人： Kazuhiro Tsujita ,  Katsumi Hayashi

发明人： Kazuhiro Tsujita ,  Katsumi Hayashi

IPC分类号： A61B600

CPC分类号： A61B5/0084 ,  A61B5/0071

摘要： A method and an apparatus for detecting fluorescence to distinguish between a sub mucosa and a mucosa immediately and easily. The sub mucosa of organic tissue is distinguished from and the mucosa thereof based on autofluorescence emitted from the organic tissue in response to stimulating light projected thereon. The distinction between the sub mucosa and the mucosa is made based on normalized intensity of the autofluorescence emitted from the organic tissue utilizing the fact that the spectrum of autofluorescence emitted from the sub mucosa is different from the spectrum of autofluorescence emitted from the mucosa.

摘要翻译： 用于检测荧光以便立即且容易地区分子粘膜和粘膜的方法和装置。 基于从投射在其上的刺激光从有机组织发射的自发荧光，有机组织的子粘膜与其粘膜区分开。 基于从有机组织发出的自发荧光的归一化强度，使用从粘膜发出的自发荧光的光谱与从粘膜发出的自发荧光的光谱不同的事实，进行子粘膜和粘膜之间的区别。

公开(公告)号：US06687534B2

公开(公告)日：2004-02-03

申请号：US09919613

申请日：2001-08-01

申请人： Kazuhiro Tsujita

发明人： Kazuhiro Tsujita

IPC分类号： A61B600

CPC分类号： A61N1/08

摘要： A fluorescent-light image display apparatus for displaying on a monitor a fluorescent-light image emitted from a target area irradiated by a excitation light. A photo-detector inputs the output value of the excitation light into an irregularity controller, which determines whether or not the output of the excitation light is smaller than a set value. If the output of the excitation light is determined to be larger than the set value, an irregularity detection signal is output to the main controller. The main controller stops the flow of drive-current to and the emission of excitation light from the GaN semiconductor laser, and displays a message on the monitor that an irregularity has occurred in the output of the excitation light when the output of the excitation light is larger than a predetermined value, the emission of the excitation light is stopped and the patient is not irradiated by excitation light having an energy density above a predetermined value.

摘要翻译： 一种荧光灯图像显示装置，用于在监视器上显示从由激发光照射的目标区域发射的荧光图像。 光检测器将激发光的输出值输入到不规则控制器中，其确定激发光的输出是否小于设定值。 如果激发光的输出被确定为大于设定值，则将不规则检测信号输出到主控制器。 主控制器停止来自GaN半导体激光器的驱动电流和激发光的发射，并且当激发光的输出为激发光的输出时，在监视器上显示出在激发光的输出中发生不规则的消息 大于预定值，激发光的发射停止，并且患者不被具有高于预定值的能量密度的激发光照射。