公开(公告)号：US20190023984A1

公开(公告)日：2019-01-24

申请号：US16056772

申请日：2018-08-07

Applicant: INTELLIGENT MATERIAL SOLUTIONS, INC. ,  LEIDEN UNIVERSITY MEDICAL CENTER ,  UNITED STATES OF AMERICA, AS Represented by the Secretary,of the Dept of Health and Human Services

Inventor： Howard Y. BELL ,  Joshua E. COLLINS ,  Paul L.A.M. CORSTJENS ,  Sukwan HANDALI ,  Hans J. TANKE

IPC: C09K11/77 ,  B82Y30/00 ,  C30B7/08 ,  B42D15/00 ,  C01F17/00

Abstract: New methods and assays for multiplexed detection of analytes using phosphors that are uniform in morphology, size, and composition based on their unique optical lifetime signatures are described herein. The described assays and methods can be used for imaging or detection of multiple unique chemical or biological markers simultaneously in a single assay readout.

公开(公告)号：US20180344729A1

公开(公告)日：2018-12-06

申请号：US15778207

申请日：2016-12-02

Applicant: THE SCRIPPS RESEARCH INSTITUTE ,  LEIDEN UNIVERSITY

Inventor： Benjamin F. CRAVATT ,  Daisuke OGASAWARA ,  Andreu VIADER ,  Hui DENG ,  Tom VAN DER WEL ,  Marcelis VAN DER STELT

IPC: A61K31/496 ,  A61K31/454 ,  A61K31/4439 ,  A61K31/4192 ,  A61K31/506

CPC classification number: A61K31/496 ,  A61K31/4192 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/506 ,  A61P25/28 ,  C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  C07D513/12

Abstract: Provided herein are triazole compounds and pharmaceutical compositions comprising said compounds useful as modulators of DAGL(α) and DAGL(β). In some embodiments, the compounds described herein are selective DAGL(α) inhibitors. Furthermore, the subject compounds and compositions are useful for the treatment of neurodegenerative or neuroinflammatory disease.

公开(公告)号：US10054593B2

公开(公告)日：2018-08-21

申请号：US15174633

申请日：2016-06-06

Applicant: INTELLIGENT MATERIAL SOLUTIONS, INC. ,  LEIDEN UNIVERSITY MEDICAL CENTER ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： Howard Y. Bell ,  Joshua E. Collins ,  Paul L. A. M. Corstjens ,  Sukwan Handali ,  Hans J. Tanke

IPC: G01N33/58

CPC classification number: G01N33/582 ,  G01N2458/40

Abstract: New methods and assays for multiplexed detection of analytes using phosphors that are uniform in morphology, size, and composition based on their unique optical lifetime signatures are described herein. The described assays and methods can be used for imaging or detection of multiple unique chemical or biological markers simultaneously in a single assay readout.

公开(公告)号：US20180216060A1

公开(公告)日：2018-08-02

申请号：US15745537

申请日：2016-07-15

Applicant: ACADEMISCH ZIEKENHUIS LEIDEN (ALSO ACTING UNDER THE NAME OF LEIDEN UNIVERSITY MEDICAL CENTER)

Inventor： Fijs Willem Bernhard VAN LEEUWEN ,  Marcus Theodorus Maria ROOD

IPC: C12N5/00 ,  G01N33/532 ,  G01N33/569

CPC classification number: C12N5/0006 ,  A61K47/6901 ,  B82Y5/00 ,  G01N33/532 ,  G01N33/56966

Abstract: The invention relates to the utilization of specific cell surface biomarkers (preferably cell specific receptors) to generate a reversible layer-by-layer scaffold for the functionalization of cells. The cells of the present invention can be used in a wide variety of distinct applications, including cellular targeting, imaging, drug delivery, purification, cell sensing, diagnosis and waste stream/body fluid purification.

公开(公告)号：US09999660B2

公开(公告)日：2018-06-19

申请号：US15115377

申请日：2015-01-30

Applicant: UNIVERSITAT ZURICH ,  LEIDEN UNIVERSITY MEDICAL CENTER

Inventor： Anne Mueller ,  Daniela Engler-Anders ,  Christian Taube

IPC: A61K39/00 ,  A61K49/00 ,  A61K39/38 ,  A61K38/16 ,  A61K39/02 ,  A61K45/06 ,  C07K14/205

CPC classification number: A61K39/001 ,  A61K38/164 ,  A61K39/0208 ,  A61K45/06 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/577 ,  C07K14/205

Abstract: The present invention is directed to polypeptides and compositions thereof useful for the prevention and treatment of allergic disorders, in particular atopic asthma. More particularly, the invention relates to tolerogenic agents and compositions thereof that are useful for the prevention and treatment of hypersensitivity to allergens, in particular strategies of desensitization to allergens.

公开(公告)号：US20180015052A1

公开(公告)日：2018-01-18

申请号：US15546818

申请日：2016-01-28

Applicant: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY ,  KATHOLIEKE UNIVERSITEIT LEUVEN ,  LEIDEN UNIVERSITY MEDICAL CENTER

Inventor： KATHERINE L. RADTKE ,  HANNAH L. PETERS ,  JOHAN NEYTS ,  DIRK JOCHMANS ,  ERIC J. SNIJDER

IPC: A61K31/08 ,  A61K31/506 ,  A61K31/4178 ,  C07D403/04 ,  A61K45/06

CPC classification number: A61K31/08 ,  A61K31/4178 ,  A61K31/506 ,  A61K45/06 ,  A61K2300/00 ,  C07D403/04 ,  Y02P20/582

Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.

公开(公告)号：US09829489B2

公开(公告)日：2017-11-28

申请号：US14806515

申请日：2015-07-22

Applicant: Inova Diagnostics, Inc. ,  Leiden University Medical Center

Inventor： Michael Mahler ,  Leendert A Trouw ,  Jan Wouter Drijfhout ,  Tom Huizinga ,  René Toes ,  Peter Van Veelen

IPC: G01N33/564 ,  C07K14/81 ,  C07K1/107

CPC classification number: G01N33/564 ,  C07K1/1075 ,  C07K14/8125 ,  G01N2333/8125 ,  G01N2440/00 ,  G01N2800/102

Abstract: The present disclosure relates to the field of molecular biology and more specifically to methods for detecting anti-carbamylated protein (anti-CarP) antibodies in the serum of rheumatoid arthritis (RA) patients.

公开(公告)号：US20160244837A1

公开(公告)日：2016-08-25

申请号：US14971503

申请日：2015-12-16

Applicant: Celera Corporation ,  Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL)

Inventor： Lance BARE ,  James J. DEVLIN ,  Frits R. ROSENDAAL ,  Pieter H. REITSMA ,  Irene D. BEZEMER

IPC: C12Q1/68 ,  A61K31/366 ,  A61K31/40 ,  A61K31/22

CPC classification number: C12Q1/6883 ,  A61K31/00 ,  A61K31/137 ,  A61K31/22 ,  A61K31/366 ,  A61K31/37 ,  A61K31/40 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/5377 ,  A61K45/00 ,  A61K45/06 ,  C07H21/04 ,  C12Q2600/106 ,  C12Q2600/156 ,  A61K2300/00

Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment (particularly for reducing the risk of venous thrombosis). For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.

Abstract translation: 本发明提供了与对他汀类药物治疗（特别是降低静脉血栓形成风险）相关的遗传多态性的组合物和方法。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态型核酸分子和变体蛋白的试剂，以及使用核酸分子和蛋白质的方法以及方法 使用试剂进行检测。

公开(公告)号：US20150159216A1

公开(公告)日：2015-06-11

申请号：US14409192

申请日：2013-06-18

Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER ,  LEIDEN UNIVERSITY MEDICAL CENTER ,  UNIVERSITY OF ROCHESTER MEDICAL CENTER ,  UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Stephen Tapscott ,  Daniel G. Miller ,  Silvere M. van der Maarel ,  Rabi Tawil

IPC: C12Q1/68 ,  G01N33/68 ,  C12N15/113 ,  C07K14/47

CPC classification number: C12Q1/6883 ,  C07K14/47 ,  C07K14/4707 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/30 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6887 ,  G01N2333/4712 ,  G01N2800/10 ,  C12N2310/531

Abstract: The present invention relates generally to the field of molecular biology and genetics. More particularly, it concerns methods and compositions for detecting, diagnosing, and/or treating facioscapulohumeral dystrophy (FSHD2).

Abstract translation: 本发明一般涉及分子生物学和遗传学领域。 更具体地，涉及用于检测，诊断和/或治疗面积性营养不良症（FSHD2）的方法和组合物。

公开(公告)号：US20140323345A1

公开(公告)日：2014-10-30

申请号：US14359385

申请日：2012-11-23

Applicant: CHANEL PARFUMS BEAUTE ,  LEIDEN UNIVERSITY MEDICAL CENTER

Inventor： Gaelle Saintigny ,  Abdelouahab Elghalbzouri

IPC: C12Q1/68 ,  G01N33/569

CPC classification number: C12Q1/6876 ,  G01N33/5023 ,  G01N33/5044 ,  G01N33/56966 ,  G01N2333/4728 ,  G01N2800/7042

Abstract: An in vitro method for screening for candidate compounds for preventing and/or attenuating skin ageing, and/or hydrating skin, includes: a) contacting a test compound with a sample of papillary fibroblasts; b) measuring the expression of a gene selected from PDPN, CCRL1 and NTN1, in the papillary fibroblasts; and c) selecting compounds for which an activation of at least 1.5 fold of the expression of at least one of the genes is measured in the treated papillary fibroblasts compared with untreated papillary fibroblasts. Another in vitro method includes: a) contacting a test compound with a sample of reticular fibroblasts; b) measuring the expression of a gene selected from MGP, PPP1R14A and TGM2, in the reticular fibroblasts; and c) selecting compounds for which an activation of at most 1.0 fold of the expression of at least one of the genes is measured in the treated reticular fibroblasts compared with untreated reticular fibroblasts.

Abstract translation: 用于筛选用于预防和/或减弱皮肤老化和/或保湿皮肤的候选化合物的体外方法包括：a）使测试化合物与乳头状成纤维细胞样品接触; b）测量在乳头状成纤维细胞中选自PDPN，CCRL1和NTN1的基因的表达; 和c）选择化合物，与未处理的乳头状成纤维细胞相比，在经处理的乳头状成纤维细胞中测量至少一种基因表达的至少1.5倍的活化。 另一种体外方法包括：a）使测试化合物与网状成纤维细胞样品接触; b）测量网状成纤维细胞中选自MGP，PPP1R14A和TGM2的基因的表达; 和c）选择化合物，与未处理的网状成纤维细胞相比，在处理的网状成纤维细胞中测量至少一种基因表达的1.0倍以上的活化化合物。