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公开(公告)号：US11058761B2
公开(公告)日：2021-07-13
申请号：US15789936
申请日：2017-10-20
发明人： Teshome Mebatsion , Joyce Pritchard , David Swayne
IPC分类号： A61K39/145 , C12N7/00 , A61K39/00
摘要： The present invention provides recombinant viral vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant viral vectors, polyvalent vaccines comprising the recombinant viral vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant viral vectors.
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公开(公告)号：US10857121B2
公开(公告)日：2020-12-08
申请号：US15304018
申请日：2015-04-17
申请人： MERIAL INC. , BASF, SE
发明人： Charles Meng , Christian Miculka , Mark Soll , Ralph Paulini , Matthias Pohlman , Sebastian Sorgel , Henricus Maria Martinus Bastiaans , Sarah Rachel Devereux , Cecille Ebuenga Doyog , Anna Malveda Umali , Rhoel Suiza Cosare , Christopher Palmer , Takeo Hokama
IPC分类号： A61K31/277 , A01N37/34 , A01K11/00 , A61D7/00 , A61K9/00 , A61K31/357
摘要： The present invention provides uses of aryl alkyl malononitrile compounds of formula (I), or veterinarily acceptable salts thereof, for controlling and preventing parasite infestations in animals. The invention also provides methods for controlling and preventing parasite infestation in animals comprising administering an effective amount of at least one aryl alkyl malononitrile compound of formulae (I), or a veterinarily acceptable salt thereof, to the animal.
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公开(公告)号：US10463661B2
公开(公告)日：2019-11-05
申请号：US16054101
申请日：2018-08-03
申请人： MERIAL INC.
发明人： Alan Long , Srinivas Reddy Gurrala
IPC分类号： A61K31/496 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D487/06 , H05B41/06 , A61K31/06 , A61K31/423 , A61K31/4468 , A61K31/454 , A61K31/495 , A61K45/06
摘要： The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X6, X8, Q1, Q2, Q3, Q4, Q5, Q6, Ring A, Ring B, W, W′, R2, R3, R, R′, m, n and q are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
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公开(公告)号：US10345292B2
公开(公告)日：2019-07-09
申请号：US14849446
申请日：2015-09-09
申请人： MERIAL, INC. , Sanofi
发明人： Lance Hammerland , Brenda Bondesen , Jean-Marie Chambard , Thierry Vermat , Werner Dittrich , Michel Partiseti , Qing Zhou-Liu , Cathy Cojean , Rachid Boukaiba , Eric Tagat
IPC分类号： C07K14/47 , G01N33/50 , C07K14/435 , G01N33/68 , C07K14/705 , C12N5/071
摘要： The following discloses mammalian cells lines that stably express functional nematode acetylcholine receptor subunits. The resulting expression of functional ion channels has been made possible by the stable co-expression of the chaperone protein, RIC3. These cell lines are extremely useful for the high throughput screening (HTS) of compounds, to identify new candidate parasiticidal, including nematocidal, active ingredients.
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公开(公告)号：US20190133129A1
公开(公告)日：2019-05-09
申请号：US16182838
申请日：2018-11-07
申请人： MERIAL INC.
发明人： Chunhua Yang , Loic Patrick Le Hir de Fallois , Charles Q. Meng , Alan Long , Roelof Johannes Gorter de Vries , Bruno Baillon , Sylvaine Lafont , Myriam Gay de Saint Michel , Stephane Kozlovic
IPC分类号： A01N43/80 , C07D261/04 , A01N43/42 , A61K31/42 , C07D453/04
摘要： This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.
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公开(公告)号：US20180368406A1
公开(公告)日：2018-12-27
申请号：US16017880
申请日：2018-06-25
申请人： MERIAL, INC.
发明人： Kour Chand Jindal , Jian Han , Kim Agnew
摘要： The present invention encompasses a stabilized parasiticidal granule composition comprising a macrocyclic lactone compound and an insect growth regulator. The invention also encompasses methods of making and methods of using the granule for treating, controlling or preventing parasitic infestation or parasitic infection in an animal.
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公开(公告)号：US20180362589A1
公开(公告)日：2018-12-20
申请号：US16111027
申请日：2018-08-23
申请人： MERIAL INC.
发明人： Loic Le Hir de Fallois , Greg Pacofsky , Alan Long , Charles Meng , Hyoung Ik Lee , Cyprian O. Ogbu
IPC分类号： C07K11/02 , C07D273/00
摘要： The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.
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公开(公告)号：US20180338972A1
公开(公告)日：2018-11-29
申请号：US16054101
申请日：2018-08-03
申请人： MERIAL INC.
发明人： Alan Long , Srinivas Reddy Gurrala
IPC分类号： A61K31/496 , A61K45/06 , A61K31/495 , A61K31/454 , A61K31/4468 , A61K31/423 , C07D413/04 , H05B41/06 , C07D487/06 , C07D417/14 , C07D417/12 , C07D417/04 , A61K31/06
CPC分类号： A61K31/496 , A61K31/06 , A61K31/423 , A61K31/4468 , A61K31/454 , A61K31/495 , A61K45/06 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D487/06 , H05B41/06
摘要： The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X6, X8, Q1, Q2, Q3, Q4, Q5, Q6, Ring A, Ring B, W, W′, R2, R3, R, R′, m, n and q are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.
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公开(公告)号：US10081656B2
公开(公告)日：2018-09-25
申请号：US15160577
申请日：2016-05-20
申请人： MERIAL INC.
发明人： Loic Le Hir de Fallois , Greg Pacofsky , Alan Long , Charles Meng , Hyoung Ik Lee , Cyprian O. Ogbu
IPC分类号： A61P33/00 , C07K11/02 , A01N43/72 , C07D273/00 , A61K38/00
摘要： The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.
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公开(公告)号：US10076566B2
公开(公告)日：2018-09-18
申请号：US15084108
申请日：2016-03-29
申请人： MERIAL, INC.
IPC分类号： A61K39/175 , C12N7/00 , A61K39/12 , C07K14/005 , C07K14/535 , A61N5/06 , A61K39/00
CPC分类号： A61K39/175 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/552 , A61K2039/55522 , A61N5/0613 , C07K14/005 , C07K14/535 , C12N7/00 , C12N2710/24043 , C12N2750/14334 , C12N2760/18422 , C12N2760/18434 , C12N2760/18471 , C12N2800/22
摘要： The present invention provides vectors that contain and express in vivo or in vitro CDV polypeptides or antigens that elicit an immune response in animal against CDV, compositions comprising said vectors and/or CDV polypeptides, and methods of vaccination against CDV. The invention further provides methods for inducing an immunogenic or protective response against CDV and other canine virus, as well as methods for preventing or treating CDV and other canine virus or disease state(s) caused by CDV and other canine virus.
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