公开(公告)号：US20250161301A1

公开(公告)日：2025-05-22

申请号：US18954719

申请日：2024-11-21

Applicant: NOVMETAPHARMA CO., LTD

Inventor： Hoe Yune JUNG ,  Jongsu JEON ,  Do Hyun LEE ,  Seo Yeong BAEK ,  Shin Yu BAEK ,  Heon Jong LEE

IPC: A61K31/4985 ,  A61K33/30 ,  A61P3/04 ,  A61P3/10

Abstract: A composition for preventing, ameliorating or treating obesity and diabetes and its uses are disclosed. The composition includes zinc gluconate and cyclo-hispro (CHP) as active ingredients. More specifically, the composition includes the type of zinc salts and/or the content ratio of zinc components optimized for surprisingly significantly improved anti-obesity and anti-diabetic effects. A method of preventing, ameliorating or treating obesity and diabetes using the composition is also disclosed.

公开(公告)号：US20240317700A1

公开(公告)日：2024-09-26

申请号：US18577804

申请日：2022-07-15

Applicant: NovMetaPharma Co., Ltd.

Inventor： Soo Jin LEE ,  Min Kyu KIM ,  Gyun Ho SON ,  Hoe Yune JUNG ,  Heonjong LEE

IPC: C07D311/30 ,  C07H17/07

CPC classification number: C07D311/30 ,  C07H17/07

Abstract: A method for efficiently preparing gossypetin is disclosed. Gossypetin can be utilized as an ingredient in medicine, healthcare, cosmetics, health foods, dietary supplements, and the like. The method can produce gossypetin of formula (1) with high purity and high yield through a four-step process, in which the compound of formula (2) is employed as starting material.

公开(公告)号：US11890317B2

公开(公告)日：2024-02-06

申请号：US17856729

申请日：2022-07-01

Applicant: NovMetaPharma Co., Ltd.

Inventor： Hoe-Yune Jung ,  Heon-Jong Lee ,  Jong-Su Jeon ,  Yon-Su Kim ,  Seung-Hee Yang ,  Yong-Chul Kim ,  Jong-Joo Moon ,  Hwan-Soo Yoo ,  Kyeong-Mi Choi

IPC: A61K38/05 ,  A61K38/12 ,  A23L33/18 ,  A61P31/00 ,  A61P35/00 ,  C07K5/12 ,  A23L33/00 ,  A61P1/16

CPC classification number: A61K38/12 ,  A23L33/00 ,  A23L33/18 ,  A61K38/05 ,  A61P31/00 ,  A61P35/00 ,  C07K5/12 ,  A23V2002/00 ,  A23V2200/308 ,  A23V2250/55 ,  A61P1/16 ,  A61K38/12 ,  A61K2300/00

Abstract: A new use of a cyclo histidine-proline (Cyclo His-Pro, CHP) is disclosed. A composition including cyclo histidine-proline (CHP) as an active ingredient has an excellent protective effect to protect kidney and liver cells from damage and/or toxicity induced by various causes. The composition is useful and effective in protecting kidney and/or liver cells/tissues and in treating a subject with kidney and/or liver diseases and/or damages.

公开(公告)号：US20220362269A1

公开(公告)日：2022-11-17

申请号：US17852774

申请日：2022-06-29

Applicant: NovMetaPharma Co., Ltd.

Inventor： Heon Jong LEE ,  Heo Yune Jung ,  In-Kyu Lee ,  Jae-Han Jeon ,  Sung Jin Cho ,  Jina Kim ,  Hayoung Hwang ,  Yong Hyun Jeon ,  Jungwook Chin

IPC: A61K31/695 ,  A61K31/495 ,  A61K31/4453 ,  A61K31/5375 ,  A61K31/40 ,  A61K31/396 ,  A61K31/397 ,  A61K31/454 ,  A61K31/4025 ,  A61K31/407 ,  A61K31/443 ,  A61K31/403 ,  A61K31/433 ,  A61P1/18

Abstract: A composition for preventing and/or treating pancreatitis and a method of prevention and/or treatment of pancreatitis are disclosed. The composition include an aryl ethene compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, as an active ingredient. Also disclosed is a use of the aryl ethene compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, in manufacturing a medicament for preventing and/or treating pancreatitis or for treating one or more symptoms of pancreatitis in a patient. The method of prevention and/or treatment of pancreatitis includes administering the aryl ethene compound, an isomer, a pharmaceutically acceptable salt thereof, or a solvate thereof, in an effective amount to a subject in need thereof.

公开(公告)号：US11273196B2

公开(公告)日：2022-03-15

申请号：US16759554

申请日：2018-09-20

Applicant: National Institute for Korean Medicine Development ,  NovMetaPharma Co., Ltd.

Inventor： Hyo Jung Kim ,  Sun Gun Kim ,  Jai Hyun So ,  Hwa Dong Lee ,  Hye Ryung Kang

IPC: A61K36/704 ,  A61K9/00 ,  A61K36/54

Abstract: The present invention relates to an antithrombotic composition including Polygonum cuspidatum Sieb. et Zucc. and Cinnamomum cassia Blume as active ingredients, and preferably includes an extract obtained by mixing Polygonum cuspidatum Sieb. et Zucc. and Cinnamomum cassia Blume in a weight ratio of 1:2-2:1 and extracting the mixture. The composition of the present invention is highly effective in antithrombotic effects, identified as a platelet aggregation inhibitory effect, a thrombosis inhibitory effect, a thrombosis-delaying effect, and the like, and thus can be used as an effective herbal-medicine-based agent for preventing or treating thrombosis, an antithrombotic health food, and the like.

公开(公告)号：US20210393731A1

公开(公告)日：2021-12-23

申请号：US17350170

申请日：2021-06-17

Applicant: NovMetaPharma Co., Ltd.

Inventor： Hoe-Yune JUNG ,  Heonjong LEE ,  Dohyun LEE

IPC: A61K38/05 ,  A61K31/315 ,  A61K31/56 ,  A61K31/685

Abstract: Compositions and methods for treating viral infection are disclosed. The compositions contain a combination of zinc and a cyclo(His-Pro), in effective amounts. The composition containing a combination of zinc and a cyclo(His-Pro) can be used to treat viral infections including SARS-CoV-2 infections in mammals.

公开(公告)号：US20210161998A1

公开(公告)日：2021-06-03

申请号：US17172879

申请日：2021-02-10

Applicant: NovMetaPharma Co., Ltd.

Inventor： Hoe-Yune Jung ,  Heon-Jong Lee ,  Jong-Su Jeon ,  Yon-Su Kim ,  Seung-Hee Yang ,  Yong-Chul Kim ,  Jong-Joo Moon ,  Hwan-Soo Yoo ,  Kyeong-Mi Choi

IPC: A61K38/12 ,  A23L33/18 ,  A61P31/00 ,  A61P35/00 ,  C07K5/12 ,  A23L33/00 ,  A61K38/05

Abstract: A new use of a cyclo histidine-proline (Cyclo His-Pro, CHP) is disclosed. A composition including cyclo histidine-proline (CHP) as an active ingredient has an excellent protective effect to protect kidney and liver cells from damage and/or toxicity induced by various causes. The composition is useful and effective in protecting kidney and/or liver cells/tissues and in treating a subject with kidney and/or liver diseases and/or damages.

公开(公告)号：US20210061854A1

公开(公告)日：2021-03-04

申请号：US16901676

申请日：2020-06-15

Applicant: NovMetaPharma Co., Ltd.

Inventor： Kay OLMSTEAD ,  David PEARSON ,  Elaine MCPHERSON

IPC: C07K5/12 ,  A61K47/02 ,  A61K9/19

Abstract: The present disclosure relates to synthesis and characterization of novel polymorphic forms of Cyclo (-His-Pro) (“CHP”).

公开(公告)号：US10918693B2

公开(公告)日：2021-02-16

申请号：US16316595

申请日：2017-07-13

Applicant: NOVMETAPHARMA CO., LTD.

Inventor： Hoe-Yune Jung ,  Heon-Jong Lee ,  Jong-Su Jeon ,  Yon-Su Kim ,  Seung-Hee Yang ,  Yong-Chul Kim ,  Jong-Joo Moon ,  Hwan-Soo Yoo ,  Kyeong-Mi Choi

IPC: A61K38/05 ,  A61K38/12 ,  A23L33/18 ,  A61P31/00 ,  A61P35/00 ,  C07K5/12 ,  A23L33/00

Abstract: The present disclosure relates to a cell-protecting pharmaceutical composition including a cyclo histidine-proline (Cyclo His-Pro, CHP) as an active ingredient. The cell-protecting pharmaceutical composition including the present cyclo histidine-proline (CHP) as an active ingredient has an excellent protective effect to protect kidney and liver cells from toxicity. Thus, the composition may be useful for the prevention or treatment of kidney and liver diseases.

公开(公告)号：US20200338156A1

公开(公告)日：2020-10-29

申请号：US16764913

申请日：2018-11-20

Applicant: NovMetaPharma Co., Ltd.

Inventor： Hoe Yune JUNG ,  Heon Jong LEE ,  Do Hyun LEE

IPC: A61K38/12 ,  A61K35/52 ,  A61P19/10

Abstract: A composition containing cyclo-hispro (CHP) and its use in preventing, alleviating, or treating bone loss diseases are disclosed. The composition contains CHP or a CHP-containing prostate extract.