公开(公告)号：US09974808B2

公开(公告)日：2018-05-22

申请号：US14660484

申请日：2015-03-17

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Maria Chiara Bonini ,  Attilio Bondanza

IPC: A61K48/00 ,  A61K35/17 ,  C12N5/0783 ,  G01N33/569 ,  G01N33/68 ,  A61K39/00

CPC classification number: A61K35/17 ,  A61K48/0091 ,  A61K2039/5156 ,  C12N5/0636 ,  C12N2501/23 ,  C12N2501/2302 ,  C12N2501/2306 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2506/11 ,  C12N2510/00 ,  G01N33/56972 ,  G01N33/6863 ,  Y02A50/412 ,  Y02A50/58

Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.

公开(公告)号：US20180044670A1

公开(公告)日：2018-02-15

申请号：US15693112

申请日：2017-08-31

Applicant: Ospedale San Raffaele S.R.L.

Inventor： Alessandra Biffi ,  Bernhard Rudolf Gentner ,  Luigi Naldini

IPC: C12N15/11 ,  A61K48/00

CPC classification number: C12N15/111 ,  A61K48/00 ,  C12N2310/141 ,  C12N2310/51 ,  C12N2320/32 ,  C12N2330/51 ,  C12N2799/027

Abstract: A gene vector for use in gene therapy comprising at least one miRNA sequence target operably linked to a nucleotide sequence having a corresponding miRNA in a hematopoietic progenitor cell (HSPC) or hematopoietic stem cell (HSC) which prevents or reduces expression of the nucleotide sequence in a HSPC or HSC but not in a differentiated cell.

公开(公告)号：US20160256492A1

公开(公告)日：2016-09-08

申请号：US15031169

申请日：2014-10-24

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  FONDAZIONE TELETHON

Inventor： Luigi Naldini ,  Bernhard Rudolf Gentner ,  Erika Zonari ,  Francesco Boccalatte

IPC: A61K35/28 ,  C12N15/86 ,  C12N7/00 ,  C12N5/0789

CPC classification number: A61K35/28 ,  A61K48/0091 ,  C12N5/0647 ,  C12N7/00 ,  C12N15/86 ,  C12N2510/00 ,  C12N2740/15043

Abstract: A method of preparing a therapeutic cell population for clinical use from a starting population of cells comprising haematopoietic stem cells, said method comprising separating a population of cells that substantially do not express CD38 but which express CD34 from the starting population of cells, and transducing the separated cell population with a vector to obtain the therapeutic cell population.

Abstract translation: 一种从包含造血干细胞的起始原始细胞群制备用于临床使用的治疗细胞群的方法，所述方法包括分离基本上不表达CD38但从起始细胞群体表达CD34的细胞群，并转导 用载体分离细胞群以获得治疗细胞群体。

公开(公告)号：US12194288B2

公开(公告)日：2025-01-14

申请号：US17275886

申请日：2019-09-13

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Federico Esposti ,  Filippo Consolo ,  Federico Severine Pappalardo

IPC: A61M60/148 ,  A61M60/178 ,  A61M60/216 ,  A61M60/515 ,  A61M60/538

Abstract: The present invention relates to a method for early detection of artificial pump dysfunction based on a time-frequency analysis of the pump motor power consumption (PRC). The method allows to prevent low output syndrome, cardiogenic shock, pump thrombus and/or cardiac arrest or death as well as to monitor the efficacy of a thrombolytic therapy and/or to optimize intensity and duration of a thrombolytic therapy.

公开(公告)号：US12152240B2

公开(公告)日：2024-11-26

申请号：US15521294

申请日：2015-10-23

Applicant: Ospedale San Raffaele S.R.L. ,  Fondazione Telethon

Inventor： Luigi Naldini ,  Angelo Leone Lombardo ,  Angelo Amabile ,  Alessandro Migliara

IPC: C12N15/113 ,  A61K35/12 ,  A61K38/00 ,  A61K38/17 ,  A61K38/45 ,  A61K48/00 ,  C07K14/47 ,  C12N9/10 ,  C12N9/22

Abstract: A product comprising two or more artificial transcription repressors (ATRs), or polynucleotides encoding therefor, selected from groups (a), (b), (c) or (d): (a) an ATR comprising a DNA-binding domain operably linked to a KRAB domain or homologue thereof; (b) an ATR comprising a DNA-binding domain operably linked to a DNMT3A, DNMT3B or DNMT1 domain or homologue thereof; (c) an ATR comprising a DNA-binding domain operably linked to a DNMT3L domain or homologue thereof; and (d) an ATR comprising a DNA-binding domain operably linked to a SETDB1 domain or homologue thereof, wherein at least two of the ATRs are selected from different groups (a), (b), (c) or (d).

公开(公告)号：US12000843B2

公开(公告)日：2024-06-04

申请号：US16477812

申请日：2018-01-16

Applicant: CHILDREN'S MEDICAL CENTER CORPORATION ,  OSPEDALE SAN RAFFAELE S.R.L. ,  DANA-FARBER CANCER INSTITUTE, INC. ,  Fondazione Telethon

Inventor： Alessandra Biffi ,  Eleonora Cavalca

IPC: G01N33/68 ,  A61K9/00 ,  A61K35/28 ,  A61K35/76

CPC classification number: G01N33/6893 ,  A61K9/0019 ,  A61K9/0085 ,  A61K35/28 ,  A61K35/76 ,  G01N2333/825 ,  G01N2800/04 ,  G01N2800/50

Abstract: The invention features compositions and methods for the treatment and prevention of peroxisomal diseases (e.g., neonatal adrenoleukodystrophy and Zellweger syndrome), including in a subject selected as having increased levels of metallothionein polypeptides. The invention also provides compositions and methods for identifying a subject having a peroxisomal disease involving detecting metallothionein polypeptides or polynucleotides.

公开(公告)号：US20240000892A1

公开(公告)日：2024-01-04

申请号：US18038140

申请日：2021-11-26

Applicant: Ospedale San Raffaele S.r.l.

Inventor： Luca Guidotti ,  Matteo Iannacone

IPC: A61K38/20 ,  A61K45/06 ,  A61P37/04

CPC classification number: A61K38/2013 ,  A61K38/2046 ,  A61K38/2086 ,  A61K45/06 ,  A61P37/04

Abstract: An agent that increases the number ofKupffer cells in a subject, or a nucleotide sequence encoding therefor, for use in a method of therapy by increasing liver immune response.

公开(公告)号：US20230332081A1

公开(公告)日：2023-10-19

申请号：US18042376

申请日：2021-08-13

Applicant: POLITECNICO DI MILANO ,  OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Gianfranco Beniamino FIORE ,  Monica SONCINI ,  Marco PIOLA ,  Lorenzo Pietro COPPADORO ,  Chiara FOGLIENI ,  Maria LOMBARDI

IPC: C12M3/00

CPC classification number: C12M23/42 ,  C12M23/48

Abstract: A cartridge is adapted to house at least one biological sample therein, where the cartridge contains at least two overlapping layers, and the layers include at least one layer of highly hydrophobic, inert, and biocompatible material, with contact angle Θc≥90°, hydrophobic layer, and optionally, at least one layer of double-sided adhesive material, where in the absence of the at least one layer of double-sided adhesive material, the overlapping layers are connected together by chemical and/or physical bonding, where each of the overlapping layers has at least one inner hole that is pervious when the layers overlap one another, and the at least one inner hole is closed by the at least one biological sample, where loaded in the cartridge.

公开(公告)号：US11753643B2

公开(公告)日：2023-09-12

申请号：US16004394

申请日：2018-06-10

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  Fondazione Telethon

Inventor： Luigi Naldini ,  Brian Brown

IPC: C12N15/113 ,  C12N15/63 ,  C12N15/86 ,  A61K48/00

CPC classification number: C12N15/1137 ,  C12N15/635 ,  C12N15/86 ,  A61K48/00 ,  C12N2310/141 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2760/20222 ,  C12N2810/6081

Abstract: A gene vector comprising a miRNA sequence target.

公开(公告)号：US20230181621A1

公开(公告)日：2023-06-15

申请号：US17272864

申请日：2019-09-04

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Alessandra BOLETTA ,  Christine PODRINI ,  Isaline Severine ROWE

IPC: A61K31/713 ,  C12N15/113

CPC classification number: A61K31/713 ,  C12N15/113

Abstract: The present invention relates to an inhibitor of asparagine synthase for use for the treatment of a disorder characterized by renal and/or liver cyst formation and relative pharmaceutical composition.