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公开(公告)号：US20170073775A1
公开(公告)日：2017-03-16
申请号：US15363822
申请日：2016-11-29
Applicant: ROSETTA GENOMICS LTD. , MOR RESEARCH APPLICATIONS
Inventor： Moshe Hosen , Gila Lithwick Yanai , Ram Eitan
IPC: C12Q1/68 , A61K45/00 , A61K31/713
CPC classification number: C12Q1/6886 , A61K31/713 , A61K45/00 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/16 , C12Q2600/178
Abstract: Described herein are compositions and methods for the prediction of the prognosis of ovarian cancer subjects. The present invention farther provides methods for distinguishing between histological subtypes of ovarian cancer tumors, and also methods and compositions liar the treatment or prevention of ovarian cancer. Specifically the invention relates to microRNA molecules associated with said methods and compositions, as well as various nucleic acid molecules relating thereto or derived therefrom.
Abstract translation: 本文描述了用于预测卵巢癌患者预后的组合物和方法。 本发明还提供了区分卵巢癌肿瘤的组织学亚型的方法，还涉及治疗或预防卵巢癌的方法和组合物。 具体地说，本发明涉及与所述方法和组合物相关的微小RNA分子，以及与之有关的或从其衍生的各种核酸分子。
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公开(公告)号：US09340823B2
公开(公告)日：2016-05-17
申请号：US14168981
申请日：2014-01-30
Inventor： Nitzan Rosenfeld , Yael Spector , Eddie Friedman , Zohar Dotan
IPC: C12Q1/68
CPC classification number: C12Q1/68 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention provides a method for classification of kidney tumors through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA expression framework allows optimization of treatment, and determination of specific therapy.
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公开(公告)号：US09334540B2
公开(公告)日：2016-05-10
申请号：US14063534
申请日：2013-10-25
Applicant: Rosetta Genomics Ltd. , Mor Research Applications
Inventor： Yaron Goren , Shlomit Gilad , Moshe Hod , Yariv Yogev
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention provides methods and compositions for identifying subjects at risk of developing a complication of pregnancy, such as preeclampsia or preterm labor. The compositions are microRNAs and associated nucleic acids.
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公开(公告)号：US20160115546A1
公开(公告)日：2016-04-28
申请号：US14284256
申请日：2014-05-21
Inventor： Nitzan ROSENFELD , Shai Rosenwald , Iris Barshack , Dvora Nass
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention provides a process for classification of specific cancers and tumors origin through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA expression framework allows optimization of treatment, and determination of specific therapy.
Abstract translation: 本发明通过分析与其相关的特定微小RNA和核酸分子的表达模式，提供了特异性癌症和肿瘤来源的分类方法。 根据microRNA表达框架进行分类可以优化治疗，并确定特异性治疗。
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公开(公告)号：US20150376695A1
公开(公告)日：2015-12-31
申请号：US14736521
申请日：2015-06-11
Applicant: Rosetta Genomics Ltd.
Inventor： Shlomit Gilad , Esther Meiri
IPC: C12Q1/68
CPC classification number: C12Q1/6876 , C12Q1/6816 , C12Q1/6832 , C12Q1/6853 , C12Q1/6886 , C12Q2600/136 , C12Q2600/178 , C12Q2545/101 , C12Q2563/149 , C12Q2565/501 , C12Q2565/626 , C12Q2521/107 , C12Q2525/207 , C12Q2525/301 , C12Q2561/101 , C12Q2525/161
Abstract: Described herein are methods and compositions for detecting, amplifying and labeling targeted nucleic acids, including microRNAs.
Abstract translation: 本文描述了用于检测，扩增和标记靶向核酸（包括微小RNA）的方法和组合物。
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Patent Agency Ranking
36.发明授权Gene expression signature for classification of tissue of origin of tumor samples 有权用于肿瘤样品来源组织分类的基因表达特征公开(公告)号：US09096906B2
公开(公告)日：2015-08-04
申请号：US13856190
申请日：2013-04-03
Applicant: Rosetta Genomics Ltd.
Inventor： Ranit Aharonov , Nitzan Rosenfeld , Shai Rosenwald , Nir Dromi
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention provides a process for classification of cancers and tissues of origin through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA tree-based expression framework allows optimization of treatment, and determination of specific therapy.
Abstract translation: 本发明通过分析与其有关的特异性微小RNA和核酸分子的表达模式，提供了对癌症和原始组织进行分类的方法。 根据基于microRNA树的表达框架进行分类可以优化治疗，并确定特异性治疗。
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37.发明申请公开(公告)号：US20140336241A1
公开(公告)日：2014-11-13
申请号：US14446505
申请日：2014-07-30
Applicant: ROSETTA GENOMICS LTD.
Inventor： Ayelet CHAJUT , Shai ROSENWALD
IPC: C12Q1/68 , C12N15/113
CPC classification number: C12Q1/6886 , C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2320/30 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , C12N2310/3521
Abstract: Described herein are compositions and methods for prognosis and treatment of prostate cancer patients. Specifically the invention relates to microRNA molecules associated with the prognosis of prostate cancer, as well as various nucleic acid molecules relating thereto or derived therefrom.
Abstract translation: 本文描述了用于预后和治疗前列腺癌患者的组合物和方法。 具体地说，本发明涉及与前列腺癌的预后相关的微小RNA分子以及与之相关的或从其衍生的各种核酸分子。
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38.发明申请GENE EXPRESSION SIGNATURE FOR CLASSIFICATION OF TISSUE OF ORIGIN OF TUMOR SAMPLES 审中-公开用于分类肿瘤样品原始组织的基因表达标签公开(公告)号：US20140315739A1
公开(公告)日：2014-10-23
申请号：US14320113
申请日：2014-06-30
Applicant: ROSETTA GENOMICS LTD.
Inventor： Ranit Aharonov , Nitzan Rosenfeld , Shai Rosenwald
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention provides a process for classification of cancers and tissues of origin through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA tree-based expression framework allows optimization of treatment, and determination of specific therapy.
Abstract translation: 本发明通过分析与其有关的特异性微小RNA和核酸分子的表达模式，提供了对癌症和原始组织进行分类的方法。 根据基于microRNA树的表达框架进行分类可以优化治疗，并确定特异性治疗。
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公开(公告)号：US20140087967A1
公开(公告)日：2014-03-27
申请号：US14063534
申请日：2013-10-25
Applicant: Mor Research Applications , Rosetta Genomics Ltd.
Inventor： Yaron GOREN , Shlomit Gilad , Moshe Hod , Yariv Yogev
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention provides methods and compositions for identifying subjects at risk of developing a complication of pregnancy, such as preeclampsia or preterm labor. The compositions are microRNAs and associated nucleic acids.
Abstract translation: 本发明提供了用于鉴定发生怀孕并发症风险的受试者的方法和组合物，例如先兆子痫或早产。 组合物是微小RNA和相关核酸。
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公开(公告)号：US20140017780A1
公开(公告)日：2014-01-16
申请号：US13986516
申请日：2013-05-08
Applicant: ROSETTA GENOMICS LTD
Inventor： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
IPC: C12N15/113
CPC classification number: C12N15/113 , A61K38/00 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2330/10 , C12Q1/6809 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , Y02A90/26
Abstract: Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.
Abstract translation: 本文描述了与前列腺和肺癌相关的新型多核苷酸。 多核苷酸是miRNA和miRNA前体。 公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。 本文还描述了可用于鉴定前列腺和肺癌调节剂的方法。
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